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  1. Article ; Online: Smart sensing flexible sutures for glucose monitoring in house sparrows.

    Alsaedi, Mossab K / Riccio, Rachel E / Sharma, Atul / Xia, Junfei / Owyeung, Rachel E / Romero, L Michael / Sonkusale, Sameer

    The Analyst

    2023  Volume 148, Issue 22, Page(s) 5714–5723

    Abstract: There is a need for flexible chemical sensors for the ecological and physiological research of avian species such as house sparrows ( ...

    Abstract There is a need for flexible chemical sensors for the ecological and physiological research of avian species such as house sparrows (
    MeSH term(s) Animals ; Blood Glucose ; Sparrows ; Blood Glucose Self-Monitoring ; Glucose ; Gold/chemistry ; Sutures
    Chemical Substances Blood Glucose ; Glucose (IY9XDZ35W2) ; Gold (7440-57-5)
    Language English
    Publishing date 2023-11-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 210747-8
    ISSN 1364-5528 ; 0003-2654
    ISSN (online) 1364-5528
    ISSN 0003-2654
    DOI 10.1039/d3an01488f
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: Erratum for Riccio et al., "Characterization of Sex Differences in Ocular Herpes Simplex Virus 1 Infection and Herpes Stromal Keratitis Pathogenesis of Wild-Type and Herpesvirus Entry Mediator Knockout Mice".

    Riccio, Rachel E / Park, Seo J / Longnecker, Richard / Kopp, Sarah J

    mSphere

    2019  Volume 4, Issue 3

    Language English
    Publishing date 2019-05-15
    Publishing country United States
    Document type Journal Article ; Published Erratum
    ISSN 2379-5042
    ISSN (online) 2379-5042
    DOI 10.1128/mSphere.00322-19
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Characterization of Sex Differences in Ocular Herpes Simplex Virus 1 Infection and Herpes Stromal Keratitis Pathogenesis of Wild-Type and Herpesvirus Entry Mediator Knockout Mice.

    Riccio, Rachel E / Park, Seo J / Longnecker, Richard / Kopp, Sarah J

    mSphere

    2019  Volume 4, Issue 2

    Abstract: Sex differences related to immune response and inflammation play a role in the susceptibility and pathogenesis of a variety of viral infections and disease (S. L. Klein, Bioessays 34:1050-1059, 2012, https://doi.org/10.1002/bies.201200099). Herpes ... ...

    Abstract Sex differences related to immune response and inflammation play a role in the susceptibility and pathogenesis of a variety of viral infections and disease (S. L. Klein, Bioessays 34:1050-1059, 2012, https://doi.org/10.1002/bies.201200099). Herpes simplex virus 1 (HSV-1) causes chronic inflammatory disease in the cornea, an immune-privileged tissue, resulting in irreversible damage and blindness in affected individuals (A. Rowe, A. St Leger, S. Jeon, D. K. Dhaliwal, et al., Prog Retin Eye Res 32:88-101, 2013, https://doi.org/10.1016/j.preteyeres.2012.08.002). Our research focuses on the role of herpesvirus entry mediator (HVEM) as an immune regulator during ocular HSV-1 infection. Mice lacking HVEM (HVEM knockout [KO] mice) exhibit lower levels of immune cell infiltrates and less severe ocular disease in the cornea than wild-type (WT) mice. As sex differences contribute to pathogenesis in many inflammatory diseases, we tested whether sex acts as a biological variable in the immune response to HSV-1 infection and herpes stromal keratitis (HSK) pathogenesis. Adult male and female WT and HVEM KO mice were inoculated with HSV-1 via corneal scarification and monitored daily for disease course. Viral titers were determined, and immune cell infiltrates were collected and analyzed. Our results indicated no significant differences in viral titers in tear film or affected tissues, in immune cell infiltration, or in clinical symptoms between males and females of either genotype. These results suggest that sex is not a significant biological variable in this experimental model and that male and female mice of the C57BL/6 background can be used similarly in studies of ocular HSV-1 pathogenesis.
    MeSH term(s) Animals ; Eye/pathology ; Eye/virology ; Female ; Gene Knockout Techniques ; Herpesvirus 1, Human/immunology ; Inflammation ; Keratitis, Herpetic/immunology ; Keratitis, Herpetic/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Receptors, Tumor Necrosis Factor, Member 14/genetics ; Sex Factors ; Viral Load
    Chemical Substances Receptors, Tumor Necrosis Factor, Member 14
    Language English
    Publishing date 2019-03-27
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 2379-5042
    ISSN (online) 2379-5042
    DOI 10.1128/mSphere.00073-19
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Herpesvirus Entry Mediator Binding Partners Mediate Immunopathogenesis of Ocular Herpes Simplex Virus 1 Infection.

    Park, Seo J / Riccio, Rachel E / Kopp, Sarah J / Ifergan, Igal / Miller, Stephen D / Longnecker, Richard

    mBio

    2020  Volume 11, Issue 3

    Abstract: Ocular herpes simplex virus 1 (HSV-1) infection leads to an immunopathogenic disease called herpes stromal keratitis (HSK), in which ... ...

    Abstract Ocular herpes simplex virus 1 (HSV-1) infection leads to an immunopathogenic disease called herpes stromal keratitis (HSK), in which CD4
    MeSH term(s) Animals ; Cornea/immunology ; Cornea/pathology ; Cornea/virology ; Disease Models, Animal ; Female ; Herpesvirus 1, Human/immunology ; Herpesvirus 1, Human/physiology ; Host Microbial Interactions/immunology ; Inflammation ; Keratitis, Herpetic/immunology ; Keratitis, Herpetic/pathology ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; Receptors, Tumor Necrosis Factor, Member 14/immunology ; Receptors, Tumor Necrosis Factor, Member 14/physiology ; Signal Transduction ; T-Lymphocytes/immunology ; Virus Internalization
    Chemical Substances Receptors, Tumor Necrosis Factor, Member 14
    Language English
    Publishing date 2020-05-12
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mBio.00790-20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Targeted deletion of the zebrafish actin-bundling protein L-plastin (lcp1).

    Kell, Margaret J / Riccio, Rachel E / Baumgartner, Emily A / Compton, Zachary J / Pecorin, Paul J / Mitchell, Taylor A / Topczewski, Jacek / LeClair, Elizabeth E

    PloS one

    2018  Volume 13, Issue 1, Page(s) e0190353

    Abstract: Regulation of the cytoskeleton is essential for cell migration in health and disease. Lymphocyte cytosolic protein 1 (lcp1, also called L-plastin) is a hematopoietic-specific actin-bundling protein that is highly conserved in zebrafish, mice and humans. ... ...

    Abstract Regulation of the cytoskeleton is essential for cell migration in health and disease. Lymphocyte cytosolic protein 1 (lcp1, also called L-plastin) is a hematopoietic-specific actin-bundling protein that is highly conserved in zebrafish, mice and humans. In addition, L-plastin expression is documented as both a genetic marker and a cellular mechanism contributing to the invasiveness of tumors and transformed cell lines. Despite L-plastin's role in both immunity and cancer, in zebrafish there are no direct studies of its function, and no mutant, knockout or reporter lines available. Using CRISPR-Cas9 genome editing, we generated null alleles of zebrafish lcp1 and examined the phenotypes of these fish throughout the life cycle. Our editing strategy used gRNA to target the second exon of lcp1, producing F0 mosaic fish that were outcrossed to wild types to confirm germline transmission. F1 heterozygotes were then sequenced to identify three unique null alleles, here called 'Charlie', 'Foxtrot' and 'Lima'. In silico, each allele truncates the endogenous protein to less than 5% normal size and removes both essential actin-binding domains (ABD1 and ABD2). Although none of the null lines express detectable LCP1 protein, homozygous mutant zebrafish (-/-) can develop and reproduce normally, a finding consistent with that of the L-plastin null mouse (LPL -/-). However, such mice do have a profound immune defect when challenged by lung bacteria. Interestingly, we observed reduced long-term survival of zebrafish lcp1 -/- homozygotes (~30% below the expected numbers) in all three of our knockout lines, with greatest mortality corresponding to the period (4-6 weeks post-fertilization) when the innate immune system is functional, but the adaptive immune system is not yet mature. This suggests that null zebrafish may have reduced capacity to combat opportunistic infections, which are more easily transmissible in the aquatic environment. Overall, our novel mutant lines establish a sound genetic model and an enhanced platform for further studies of L-plastin gene function in hematopoiesis and cancer.
    MeSH term(s) Alleles ; Amino Acid Sequence ; Animals ; Cloning, Molecular ; Clustered Regularly Interspaced Short Palindromic Repeats ; Gene Deletion ; Humans ; Membrane Glycoproteins/genetics ; Mice ; Microfilament Proteins/genetics ; Sequence Homology, Amino Acid ; Zebrafish/genetics ; Zebrafish Proteins/genetics
    Chemical Substances Membrane Glycoproteins ; Microfilament Proteins ; Zebrafish Proteins ; plastin
    Language English
    Publishing date 2018-01-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0190353
    Database MEDical Literature Analysis and Retrieval System OnLINE

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