Article ; Online: Small GTPases modulate intrinsic and extrinsic forces that control epithelial folding in
2021 Volume 12, Issue 5-6, Page(s) 416–428
Abstract: Epithelial folding is a common means to execute morphogenetic movements. The gastrulating Drosophila embryo offers many examples of epithelial folding events, including the ventral, cephalic, and dorsal furrows. Each of these folding events is associated ...
Abstract | Epithelial folding is a common means to execute morphogenetic movements. The gastrulating Drosophila embryo offers many examples of epithelial folding events, including the ventral, cephalic, and dorsal furrows. Each of these folding events is associated with changes in intracellular contractility and/or cytoskeleton structures that autonomously promote epithelial folding. Here, we review accumulating evidence that suggests the progression and final form of ventral, cephalic, and dorsal furrows are also influenced by the behaviour of cells neighbouring these folds. We further discuss the prevalence and importance of junctional rearrangements during epithelial folding events, suggesting adherens junction components are prime candidates to modulate the transmission of the intercellular forces that influence folding events. Finally, we discuss how recently developed methods that enable precise spatial and/or temporal control of protein activity allow direct testing of molecular models of morphogenesis in vivo. |
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MeSH term(s) | Animals ; Cytoskeleton/enzymology ; Cytoskeleton/physiology ; Drosophila/enzymology ; Drosophila/physiology ; Drosophila Proteins/metabolism ; Embryo, Nonmammalian/cytology ; Embryo, Nonmammalian/enzymology ; Embryo, Nonmammalian/physiology ; Epithelial Cells/enzymology ; Epithelial Cells/physiology ; Microtubules/enzymology ; Microtubules/physiology ; Monomeric GTP-Binding Proteins/metabolism ; Morphogenesis |
Chemical Substances | Drosophila Proteins ; Monomeric GTP-Binding Proteins (EC 3.6.5.2) |
Language | English |
Publishing date | 2021-06-28 |
Publishing country | United States |
Document type | Journal Article ; Research Support, N.I.H., Extramural ; Review |
ZDB-ID | 2682247-7 |
ISSN | 2154-1256 ; 2154-1248 |
ISSN (online) | 2154-1256 |
ISSN | 2154-1248 |
DOI | 10.1080/21541248.2021.1926879 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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