LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 5 of total 5

Search options

  1. Article ; Online: Intra- and inter-fraction relative range verification in heavy-ion therapy using filtered interaction vertex imaging.

    Hymers, Devin / Kasanda, Eva / Bildstein, Vinzenz / Easter, Joelle / Richard, Andrea / Spyrou, Artemis / Höhr, Cornelia / Mücher, Dennis

    Physics in medicine and biology

    2021  Volume 66, Issue 24

    Abstract: Heavy-ion therapy, particularly using scanned (active) beam delivery, provides a precise and highly conformal dose distribution, with maximum dose deposition for each pencil beam at its endpoint (Bragg peak), and low entrance and exit dose. To take full ... ...

    Abstract Heavy-ion therapy, particularly using scanned (active) beam delivery, provides a precise and highly conformal dose distribution, with maximum dose deposition for each pencil beam at its endpoint (Bragg peak), and low entrance and exit dose. To take full advantage of this precision, robust range verification methods are required; these methods ensure that the Bragg peak is positioned correctly in the patient and the dose is delivered as prescribed. Relative range verification allows intra-fraction monitoring of Bragg peak spacing to ensure full coverage with each fraction, as well as inter-fraction monitoring to ensure all fractions are delivered consistently. To validate the proposed filtered interaction vertex imaging (IVI) method for relative range verification, a
    MeSH term(s) Diagnostic Imaging ; Heavy Ion Radiotherapy/methods ; Humans ; Phantoms, Imaging ; Polymethyl Methacrylate ; Radiotherapy Dosage ; Silicon
    Chemical Substances Polymethyl Methacrylate (9011-14-7) ; Silicon (Z4152N8IUI)
    Language English
    Publishing date 2021-12-16
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 208857-5
    ISSN 1361-6560 ; 0031-9155
    ISSN (online) 1361-6560
    ISSN 0031-9155
    DOI 10.1088/1361-6560/ac3b33
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 199: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Book ; Online: Constraining the Astrophysical p Process

    Palmisano-Kyle, Alicia / Spyrou, Artemis / DeYoung, Paul / Gastis, Panagiotis / Olivas-Gomez, Orlando / Harris, Caley / Liddick, Sean / Lyons, Stephanie / Pereira, Jorge / Richard, Andrea / Simon, Anna / Smith, Mallory / Tsantiri, Artemis / Zegers, Remco

    Cross Section Measurement of the 84Kr(p,g)85Rb Reaction in Inverse Kinematics

    2023  

    Abstract: One of the biggest questions in nuclear astrophysics is understanding where the elements come from and how they are made. This work focuses on the p process, a nucleosynthesis process that consists of a series of photodisintegration reactions responsible ...

    Abstract One of the biggest questions in nuclear astrophysics is understanding where the elements come from and how they are made. This work focuses on the p process, a nucleosynthesis process that consists of a series of photodisintegration reactions responsible for producing stable isotopes on the proton-rich side of stability. These nuclei, known as the p nuclei, cannot be made through the well-known neutron-capture processes. Currently p-process models rely heavily on theory to provide the relevant reaction rates to predict the final p-nuclei abundances and more experimental data is needed. The present work reports on an experiment performed with the SuN detector at the National Superconducting Cyclotron Laboratory, NSCL, at Michigan State University using the ReA facility to measure the $^{84}$Kr(p,$\gamma$)$^{85}$Rb reaction cross section in inverse kinematics. The reverse $^{85}$Rb($\gamma$,p)$^{84}$Kr reaction is a branching point in the p-process reaction network that was highlighted as an important reaction in sensitivity studies in the production of the $^{78}$Kr p nucleus. A new hydrogen gas target was designed and fabricated and a new analysis technique for background subtraction and efficiency calculations of the detector were developed. The experimental cross section is compared to standard statistical model calculations using the NON-SMOKER and TALYS codes.
    Keywords Nuclear Experiment
    Subject code 660
    Publishing date 2023-03-13
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Book ; Online: Intra- and Inter-Fraction Relative Range Verification in Heavy-Ion Therapy Using Filtered Interaction Vertex Imaging

    Hymers, Devin / Kasanda, Eva / Bildstein, Vinzenz / Easter, Joelle / Richard, Andrea / Spyrou, Artemis / Höhr, Cornelia / Mücher, Dennis

    2021  

    Abstract: Heavy-ion therapy, particularly using scanned (active) beam delivery, provides a precise and highly conformal dose distribution, with maximum dose deposition for each pencil beam at its endpoint (Bragg peak), and low entrance and exit dose. To take full ... ...

    Abstract Heavy-ion therapy, particularly using scanned (active) beam delivery, provides a precise and highly conformal dose distribution, with maximum dose deposition for each pencil beam at its endpoint (Bragg peak), and low entrance and exit dose. To take full advantage of this precision, robust range verification methods are required; these methods ensure that the Bragg peak is positioned correctly in the patient and the dose is delivered as prescribed. Relative range verification allows intra-fraction monitoring of Bragg peak spacing to ensure full coverage with each fraction, as well as inter-fraction monitoring to ensure all fractions are delivered consistently. To validate the proposed filtered Interaction Vertex Imaging method for relative range verification, a ${}^{16}$O beam was used to deliver 12 Bragg peak positions in a 40 mm poly-(methyl methacrylate) phantom. Secondary particles produced in the phantom were monitored using position-sensitive silicon detectors. Events recorded on these detectors, along with a measurement of the treatment beam axis, were used to reconstruct the sites of origin of these secondary particles in the phantom. The distal edge of the depth distribution of these reconstructed points was determined with logistic fits, and the translation in depth required to minimize the $\chi^2$ statistic between these fits was used to compute the range shift between any two Bragg peak positions. In all cases, the range shift was determined with sub-millimeter precision, to a standard deviation of 200 $\mu$m. This result validates filtered Interaction Vertex Imaging as a reliable relative range verification method, which should be capable of monitoring each energy step in each fraction of a scanned heavy-ion treatment plan.
    Keywords Physics - Medical Physics
    Subject code 621
    Publishing date 2021-06-16
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article: Baseline cardiovascular comorbidities, and the influence on cancer treatment decision-making in women with breast cancer.

    Subramaniam, Shridevi / Kong, Yek-Ching / Zaharah, Hafizah / Uiterwaal, Cuno S P M / Richard, Andrea / Taib, Nur Aishah / Deniel, Azura / Chee, Kok-Han / Bustamam, Ros Suzanna / See, Mee-Hoong / Fong, Alan / Yip, Cheng-Har / Bhoo-Pathy, Nirmala

    Ecancermedicalscience

    2021  Volume 15, Page(s) 1293

    Abstract: Purpose: To measure the baseline prevalence of cardiovascular disease (CVD), its modifiable and non-modifiable risk factors in breast cancer patients, and determine their association with adjuvant treatment decision-making.: Method: From 2016 to 2017, ...

    Abstract Purpose: To measure the baseline prevalence of cardiovascular disease (CVD), its modifiable and non-modifiable risk factors in breast cancer patients, and determine their association with adjuvant treatment decision-making.
    Method: From 2016 to 2017, 2,127 women newly-diagnosed with breast cancer were prospectively recruited. Participants' cardiovascular biomarkers were measured prior to adjuvant treatment decision-making. Clinical data and medical histories were obtained from hospital records. Adjuvant treatment decisions were collated 6-8 months after recruitment. A priori risk of cardiotoxicity was predicted using the Cardiotoxicity Risk Score.
    Results: Mean age was 54 years. Eighty-five patients had pre-existing cardiac diseases and 30 had prior stroke. Baseline prevalence of hypertension was 47.8%. Close to 20% had diabetes mellitus, or were obese. Dyslipidaemia was present in 65.3%. The proportion of women presenting with ≥2 modifiable CVD risk factors at initial cancer diagnosis was substantial, irrespective of age. Significant ethnic variations were observed. Multivariable analyses showed that pre-existing CVD was consistently associated with lower administration of adjuvant breast cancer therapies (odds ratio for chemotherapy: 0.32, 95% confidence interval: 0.17-0.58). However, presence of multiple risk factors of CVD did not appear to influence adjuvant treatment decision-making. In this study, 63.6% of patients were predicted to have high risks of developing cardiotoxicities attributed to a high baseline burden of CVD risk factors and anthracycline administration.
    Conclusion: While recent guidelines recommend routine assessment of cardiovascular comorbidities in cancer patients prior to initiation of anticancer therapies, this study highlights the prevailing gap in knowledge on how such data may be used to optimise cancer treatment decision-making.
    Language English
    Publishing date 2021-09-21
    Publishing country England
    Document type Journal Article
    ISSN 1754-6605
    ISSN 1754-6605
    DOI 10.3332/ecancer.2021.1293
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Book ; Online: SiNx:Tb3+--Yb3+, an efficient down-conversion layer compatible with a silicon solar cell process

    Dumont, Lucile / Cardin, Julien / Benzo, Patrizio / Carrada, Marzia / Labbe, Christophe / Richard, Andrea L. / Ingram, David C. / Jadwisienczak, Wojciech M. / Gourbilleau, Fabrice

    2015  

    Abstract: SiN x : Tb 3+-Yb 3+, an efficient down-conversion layer compatible with silicon solar cell process Abstract Tb 3+-Yb 3+ co-doped SiN x down-conversion layers compatible with silicon Photovoltaic Technology were prepared by reactive magnetron co- ... ...

    Abstract SiN x : Tb 3+-Yb 3+, an efficient down-conversion layer compatible with silicon solar cell process Abstract Tb 3+-Yb 3+ co-doped SiN x down-conversion layers compatible with silicon Photovoltaic Technology were prepared by reactive magnetron co-sputtering. Efficient sensitization of Tb 3+ ions through a SiN x host matrix and cooperative energy transfer between Tb 3+ and Yb 3+ ions were evidenced as driving mechanisms of the down-conversion process. In this paper, the film composition and microstructure are investigated alongside their optical properties, with the aim of maximizing the rare earth ions incorporation and emission efficiency. An optimized layer achieving the highest Yb 3+ emission intensity was obtained by reactive magnetron co-sputtering in a nitride rich atmosphere for 1.2 W/cm${}^2$ and 0.15 W/cm${}^2$ power density applied on the Tb and Yb targets, respectively. It was determined that depositing at 200 {\textdegree}C and annealing at 850 {\textdegree}C leads to comparable Yb 3+ emission intensity than depositing at 500 {\textdegree}C and annealing at 600 {\textdegree}C, which is promising for applications toward silicon solar cells.

    Comment: Solar Energy Materials and Solar Cells, Elsevier, 2015
    Keywords Condensed Matter - Materials Science ; Physics - Optics
    Subject code 660
    Publishing date 2015-11-15
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top