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  1. Article: Can Nigerian horse owners effectively estimate body condition and cresty neck scores?

    Akinniyi, Olumide Odunayo / Mshelia, Philip Wayuta / Edeh, Richard Emmanuel

    Journal of equine science

    2024  Volume 35, Issue 1, Page(s) 9–14

    Abstract: A horse's body condition impacts every aspect of its life, including reproduction, performance, and health. Obesity and equine metabolic syndrome (EMS) are common in Nigeria; hence, early identification of a horse's obesity status by the owner is key to ... ...

    Abstract A horse's body condition impacts every aspect of its life, including reproduction, performance, and health. Obesity and equine metabolic syndrome (EMS) are common in Nigeria; hence, early identification of a horse's obesity status by the owner is key to avoiding associated health issues such as EMS. Our study aimed to determine whether horse owners could effectively estimate their horses' body condition scores (BCSs) and cresty neck scores (CNSs). A total of 50 adult sedentary West African Barb horses owned by 50 different people were enrolled in the study. Body condition scores (BCSs) and cresty neck scores (CNSs) were assessed on scales of 1-9 and 0-5, respectively, by an experienced veterinarian and owners. The latter had no veterinary background, received no prior education, and assessed their horses based on provided visual aids and descriptions. The BCS estimates of the experienced veterinarian and owners were slightly in agreement (k=0.209), while there was moderate agreement (k=0.547) between the CNS estimates of the experienced veterinarian and the owners. The proportion of obesity based on the experienced veterinarian's estimation (32%) was higher than that of the owners (18%). The proportion of nuchal crest adiposity based on the experienced veterinarian's (38%) estimation was slightly lower than that of the owners (42%). A larger proportion of the owners underestimated their horses' BCSs and CNSs. We conclude that owners cannot effectively estimate their horses' BCSs and CNSs. It is imperative that they are informed about the health issues associated with obesity and are taught how to effectively estimate BCS and CNS.
    Language English
    Publishing date 2024-03-19
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2038890-1
    ISSN 1347-7501 ; 1340-3516
    ISSN (online) 1347-7501
    ISSN 1340-3516
    DOI 10.1294/jes.35.9
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  2. Article ; Online: Cholesterol microcrystals in rheumatoid arthritis synovial liquid.

    Blouin, Jean-Marc / Poursac, Nicolas / Gad, Sophie / Richard, Emmanuel

    Annales de biologie clinique

    2024  Volume 82, Issue 1, Page(s) 112–113

    Title translation Microcristaux de cholestérol dans le liquide synovial et polyarthrite rhumatoïde.
    MeSH term(s) Humans ; Cholesterol
    Chemical Substances Cholesterol (97C5T2UQ7J)
    Language French
    Publishing date 2024-04-19
    Publishing country France
    Document type Journal Article
    ZDB-ID 418098-7
    ISSN 1950-6112 ; 0003-3898
    ISSN (online) 1950-6112
    ISSN 0003-3898
    DOI 10.1684/abc.2024.1870
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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.203: Show issues Location:
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  3. Article ; Online: Jet Colliding and Mixing Efficiency

    Christophe Allemann / Massimo Varisco / Gianni De Luca / Richard-Emmanuel Estes

    CHIMIA, Vol 75, Iss

    2021  Volume 12

    Abstract: Two experimental methods, the Nile Red dye extraction and the Williamson ether synthesis in biphasic conditions, were used to characterize the mixing performance of a new cheap impinging jet colliding mixer from Gjosa and to compare it to other ... ...

    Abstract Two experimental methods, the Nile Red dye extraction and the Williamson ether synthesis in biphasic conditions, were used to characterize the mixing performance of a new cheap impinging jet colliding mixer from Gjosa and to compare it to other commercial micromixers (Caterpillar CPMM-R300, T-mixer, LTF MR-MX and LTF MR-MS). The Nile Red method shows that the Caterpillar mixer is the best one. Excellent results are also achieved with two Gjosa mixers in series. These results are not reflected in the Williamson ether synthesis, where the best mixer is the Gjosa one.
    Keywords Jet colliding ; Nile Red ; Mixing ; Williamson ether synthesis ; Chemistry ; QD1-999
    Language German
    Publishing date 2021-12-01T00:00:00Z
    Publisher Swiss Chemical Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Jet Colliding and Mixing Efficiency.

    De Lucia, Gianni / Varisco, Massimo / Eastes, Richard-Emmanuel / Allemann, Christophe

    Chimia

    2021  Volume 75, Issue 12, Page(s) 1054–1057

    Abstract: Two experimental methods, the Nile Red dye extraction and the Williamson ether synthesis in biphasic conditions, were used to characterize the mixing performance of a new cheap impinging jet colliding mixer from Gjosa and to compare it to other ... ...

    Abstract Two experimental methods, the Nile Red dye extraction and the Williamson ether synthesis in biphasic conditions, were used to characterize the mixing performance of a new cheap impinging jet colliding mixer from Gjosa and to compare it to other commercial micromixers (Caterpillar CPMM-R300, T-mixer, LTF MR-MX and LTF MR-MS). The Nile Red method shows that the Caterpillar mixer is the best one. Excellent results are also achieved with two Gjosa mixers in series. These results are not reflected in the Williamson ether synthesis, where the best mixer is the Gjosa one.
    MeSH term(s) Research Design
    Language English
    Publishing date 2021-12-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1516-7
    ISSN 0009-4293
    ISSN 0009-4293
    DOI 10.2533/chimia.2021.1054
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    In stock of ZB MED Bonn / Germany

    Z 4.5: Show issues

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  5. Article: Severe Perinatal Presentations of Günther's Disease: Series of 20 Cases and Perspectives.

    Goudet, Claire / Ged, Cécile / Petit, Audrey / Desage, Chloe / Mahe, Perrine / Salhi, Aicha / Harzallah, Ines / Blouin, Jean-Marc / Mercie, Patrick / Schmitt, Caroline / Poli, Antoine / Gouya, Laurent / Barlogis, Vincent / Richard, Emmanuel

    Life (Basel, Switzerland)

    2024  Volume 14, Issue 1

    Abstract: 1) Background: Congenital erythropoietic porphyria (CEP), named Günther's disease, is a rare recessive type of porphyria, resulting from deficient uroporphyrinogen III synthase (UROS), the fourth enzyme of heme biosynthesis. The phenotype ranges from ... ...

    Abstract (1) Background: Congenital erythropoietic porphyria (CEP), named Günther's disease, is a rare recessive type of porphyria, resulting from deficient uroporphyrinogen III synthase (UROS), the fourth enzyme of heme biosynthesis. The phenotype ranges from extremely severe perinatal onset, with life-threatening hemolytic anaemia, to mild or moderate cutaneous involvement in late-onset forms. This work reviewed the perinatal CEP cases recorded in France in order to analyse their various presentations and evolution. (2) Methods: Clinical and biological data were retrospectively collected through medical and published records. (3) Results: Twenty CEP cases, who presented with severe manifestations during perinatal period, were classified according to the main course of the disease: antenatal features, acute neonatal distress and postnatal diagnosis. Antenatal symptoms (seven patients) were mainly hydrops fetalis, hepatosplenomegaly, anemia, and malformations. Six of them died prematurely. Five babies showed acute neonatal distress, associated with severe anemia, thrombocytopenia, hepatosplenomegaly, liver dysfunction, and marked photosensitivity leading to diagnosis. The only two neonates who survived underwent hematopoietic stem cell transplantation (HSCT). Common features in post-natal diagnosis (eight patients) included hemolytic anemia, splenomegaly, skin sensitivity, and discoloured teeth and urine. All patients underwent HSCT, with success for six of them, but with fatal complications in two patients. The frequency of the missense variant named C73R is striking in antenatal and neonatal presentations, with 9/12 and 7/8 independent alleles, respectively. (4) Conclusions: The most recent cases in this series are remarkable, as they had a less fatal outcome than expected. Regular transfusions from the intrauterine period and early access to HSCT are the main objectives.
    Language English
    Publishing date 2024-01-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life14010130
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  6. Article: CRISPR editing to mimic porphyria combined with light: A new preclinical approach for prostate cancer.

    Boutin, Julian / Genevois, Coralie / Couillaud, Franck / Lamrissi-Garcia, Isabelle / Guyonnet-Duperat, Veronique / Bibeyran, Alice / Lalanne, Magalie / Amintas, Samuel / Moranvillier, Isabelle / Richard, Emmanuel / Blouin, Jean-Marc / Dabernat, Sandrine / Moreau-Gaudry, François / Bedel, Aurélie

    Molecular therapy. Oncology

    2024  Volume 32, Issue 1, Page(s) 200772

    Abstract: Thanks to its very high genome-editing efficiency, CRISPR-Cas9 technology could be a promising anticancer weapon. Clinical trials using CRISPR-Cas9 nuclease ... ...

    Abstract Thanks to its very high genome-editing efficiency, CRISPR-Cas9 technology could be a promising anticancer weapon. Clinical trials using CRISPR-Cas9 nuclease to
    Language English
    Publishing date 2024-02-08
    Publishing country United States
    Document type Journal Article
    ISSN 2950-3299
    ISSN 2950-3299
    DOI 10.1016/j.omton.2024.200772
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  7. Article: Preventing hyperhomocysteinemia using vitamin B

    Redonnet-Vernhet, Isabelle / Mercié, Patrick / Lebreton, Louis / Blouin, Jean-Marc / Bronnimann, Didier / Mesli, Samir / Guibet, Claire / Ribeiro, Emmanuel / Gensous, Noémie / Duffau, Pierre / Gouya, Laurent / Richard, Emmanuel

    Molecular genetics and metabolism reports

    2024  Volume 39, Page(s) 101076

    Abstract: Acute hepatic porphyrias are inherited metabolic disorders of heme biosynthesis characterized by the accumulation of toxic intermediate metabolites responsible for disabling acute neurovisceral attacks. Givosiran is a newly approved siRNA-based treatment ...

    Abstract Acute hepatic porphyrias are inherited metabolic disorders of heme biosynthesis characterized by the accumulation of toxic intermediate metabolites responsible for disabling acute neurovisceral attacks. Givosiran is a newly approved siRNA-based treatment of acute hepatic porphyria targeting the first and rate-limiting δ-aminolevulinic acid synthase 1 (ALAS1) enzyme of heme biosynthetic pathway. We described a 72-year old patient who presented with severe inaugural neurological form of acute intermittent porphyria evolving for several years which made her eligible for givosiran administration. On initiation of treatment, the patient developed a major hyperhomocysteinemia (>400 μmol/L) which necessitated to discontinue the siRNA-based therapy. A thorough metabolic analysis in the patient suggests that hyperhomocysteinemia could be attributed to a functional deficiency of cystathionine β-synthase (CBS) enzyme induced by givosiran. Long-term treatment with vitamin B
    Language English
    Publishing date 2024-04-04
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2821908-9
    ISSN 2214-4269
    ISSN 2214-4269
    DOI 10.1016/j.ymgmr.2024.101076
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  8. Article: Preventive Vitamin A Supplementation Improves Striatal Function in 6-Hydroxydopamine Hemiparkinsonian Rats.

    Marie, Anaïs / Leroy, Julien / Darricau, Morgane / Alfos, Serge / De Smedt-Peyrusse, Veronique / Richard, Emmanuel / Vancassel, Sylvie / Bosch-Bouju, Clementine

    Frontiers in nutrition

    2022  Volume 9, Page(s) 811843

    Abstract: Background: The mechanisms leading to a loss of dopaminergic (DA) neurons from the substantia nigra : Objective: The hypothesis tested in this study is that preventive vitamin A supplementation can protect DA neurons in a rat model of PD.: Methods!# ...

    Abstract Background: The mechanisms leading to a loss of dopaminergic (DA) neurons from the substantia nigra
    Objective: The hypothesis tested in this study is that preventive vitamin A supplementation can protect DA neurons in a rat model of PD.
    Methods: The impact of a 5-week preventive supplementation with vitamin A (20 IU/g of diet) was measured on motor and neurobiological alterations induced by 6-hydroxydopamine (6-OHDA) unilateral injections in the striatum of rats. Rotarod, step test and cylinder tests were performed up to 3 weeks after the lesion. Post-mortem analyses (retinol and monoamines dosages, western blots, immunofluorescence) were performed to investigate neurobiological processes.
    Results: Vitamin A supplementation improved voluntary movements in the cylinder test. In 6-OHDA lesioned rats, a marked decrease of dopamine levels in striatum homogenates was measured. Tyrosine hydroxylase labeling in the SNc and in the striatum was significantly decreased by 6-OHDA injection, without effect of vitamin A. By contrast, vitamin A supplementation increased striatal expression of D2 and RXR receptors in the striatum of 6-OHDA lesioned rats.
    Conclusions: Vitamin A supplementation partially alleviates motor alterations and improved striatal function, revealing a possible beneficial preventive approach for PD.
    Language English
    Publishing date 2022-02-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2776676-7
    ISSN 2296-861X
    ISSN 2296-861X
    DOI 10.3389/fnut.2022.811843
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  9. Article ; Online: Problematic rise of vitamin B6 supplementation overuse and potential risk to bariatric surgery patients.

    Bossard, Valentin / Bourmeyster, Nicolas / Pasini, Sophie / Dupuis, Pierre / El Balkhi, Souleiman / Richard, Emmanuel / Alarcan, Hugo / Hauet, Thierry / Thuillier, Raphael

    Nutrition (Burbank, Los Angeles County, Calif.)

    2022  Volume 102, Page(s) 111738

    Abstract: Objectives: Due to the increased prevalence of obesity in the world, bariatric surgeries are on the rise and necessitate life-long surveillance for deficiencies; hence the recommended vitamin supplementation in these patients. However, inadequate ... ...

    Abstract Objectives: Due to the increased prevalence of obesity in the world, bariatric surgeries are on the rise and necessitate life-long surveillance for deficiencies; hence the recommended vitamin supplementation in these patients. However, inadequate multivitamin supplementation may induce vitamin B6 overload.
    Methods: We reviewed all vitamin B6 dosages at the university hospitals of Poitiers, Tours, Bordeaux, and Limoges for the past 5 to 8 years. Analyses were performed by high-performance liquid chromatography, coupled with a fluorescence detector on whole blood samples.
    Results: During the study period, there was an increase in the number of vitamin B6 dosages. Deficiencies were detected early in Poitiers and Limoges, but were negligible by 2020. However, during the same time period, the number of overdoses increased, reaching close to 40% of dosages at all centers.
    Conclusions: Pyridoxin overload is not possible through food-derived pyridoxin; hence, combined with the fact that most vitamin supplements contain vitamin B6, inadequate vitamin supplementation is likely the cause of the observed increase in overdoses. High doses of vitamin B6 can induce polyneuropathy, particularly targeting motor neurons; thus, the increase of overdoses is worrying. In light of the possible risks and the ease with which these could be averted (better formulation of supplements), the precaution principle requires a definition of clear guidelines for vitamin supplementation, especially in patients undergoing bariatric surgery.
    MeSH term(s) Bariatric Surgery/adverse effects ; Dietary Supplements ; Humans ; Pyridoxine ; Vitamin B 12 ; Vitamin B 6 ; Vitamins
    Chemical Substances Vitamins ; Vitamin B 6 (8059-24-3) ; Pyridoxine (KV2JZ1BI6Z) ; Vitamin B 12 (P6YC3EG204)
    Language English
    Publishing date 2022-05-20
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 639259-3
    ISSN 1873-1244 ; 0899-9007
    ISSN (online) 1873-1244
    ISSN 0899-9007
    DOI 10.1016/j.nut.2022.111738
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2290: Show issues Location:
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  10. Article ; Online: Deep morphological recognition of kidney stones using intra-operative endoscopic digital videos.

    Estrade, Vincent / Daudon, Michel / Richard, Emmanuel / Bernhard, Jean-Christophe / Bladou, Franck / Robert, Gregoire / Facq, Laurent / Denis de Senneville, Baudouin

    Physics in medicine and biology

    2022  Volume 67, Issue 16

    Abstract: Objective. ...

    Abstract Objective.
    MeSH term(s) Artificial Intelligence ; Calcium Oxalate/chemistry ; Endoscopy ; Humans ; Kidney Calculi/diagnostic imaging ; Kidney Calculi/surgery
    Chemical Substances Calcium Oxalate (2612HC57YE)
    Language English
    Publishing date 2022-08-16
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 208857-5
    ISSN 1361-6560 ; 0031-9155
    ISSN (online) 1361-6560
    ISSN 0031-9155
    DOI 10.1088/1361-6560/ac8592
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    In stock of ZB MED Cologne/Königswinter

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