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  1. Book ; Online: Cargar y descargar en el desierto de Atacama

    Ballester, Benjamín / Richard, Nicolas

    (Colectivo)

    2022  

    Series title Colectivo
    Keywords General studies ; Chile ; extractivism
    Language Spanish
    Size 1 electronic resource (286 pages)
    Publisher Éditions de l'IHEAL
    Publishing place Paris
    Document type Book ; Online
    Note Spanish
    HBZ-ID HT030379870
    ISBN 9782371541665 ; 2371541664
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: La misión de la máquina

    Richard, Nicolas / Zelda, Alice Franceschini / Cordoba, Lorena

    2021  

    Keywords Sociology & anthropology
    Size 1 Online-Ressource
    Publisher Bononia University Press
    Document type Book ; Online
    Note Spanish ; Open Access
    HBZ-ID HT021048109
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Letter: tricky reactions to switch back from subcutaneous to intravenous vedolizumab in patients with inflammatory bowel disease.

    Richard, Nicolas / Vuitton, Lucine / Fumery, Mathurin

    Alimentary pharmacology & therapeutics

    2023  Volume 57, Issue 6, Page(s) 741–742

    MeSH term(s) Humans ; Inflammatory Bowel Diseases/drug therapy ; Antibodies, Monoclonal, Humanized/therapeutic use ; Administration, Intravenous ; Gastrointestinal Agents/therapeutic use ; Treatment Outcome ; Colitis, Ulcerative/drug therapy
    Chemical Substances vedolizumab (9RV78Q2002) ; Antibodies, Monoclonal, Humanized ; Gastrointestinal Agents
    Language English
    Publishing date 2023-02-20
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 639012-2
    ISSN 1365-2036 ; 0269-2813 ; 0953-0673
    ISSN (online) 1365-2036
    ISSN 0269-2813 ; 0953-0673
    DOI 10.1111/apt.17395
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2206: Show issues Location:
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  4. Book ; Online: Les Indiens des frontières coloniales : Amérique australe, XVIe siècle-temps présent

    Capdevila, Luc / Iturra, Jimena Paz Obregón / Richard, Nicolas

    2011  

    Abstract: En quoi l'Amérique australe serait-elle traversée par des « frontières coloniales » jusqu'au XXe siècle ? En effet, si la conquête de l'Amérique par les Européens s'est concrétisée par leur prise de possession rapide de territoires répartis sur l' ... ...

    Abstract En quoi l'Amérique australe serait-elle traversée par des « frontières coloniales » jusqu'au XXe siècle ? En effet, si la conquête de l'Amérique par les Européens s'est concrétisée par leur prise de possession rapide de territoires répartis sur l'ensemble du continent, dès le XVIe siècle ils se heurtent à des limites qui marquent le pas de l'expansion coloniale. Celles-ci sont imposées par des peuples amérindiens qui résistent à leur avancée ; elles sont aussi environnementales, des milieux sont difficiles à pénétrer ou à contrôler. D'autres territoires restent éloignés des grandes voies de circulation. De sorte qu'au milieu du XIXe siècle, une grande partie des terres américaines demeure à l'écart de l'expansion européenne. Les années 1860-1880 marquent la fin du processus de conquête des terres amérindiennes, qui se prolonge néanmoins jusqu'au XXe siècle dans des espaces plus difficiles d'accès.-

    ----------------------Cet ouvrage analyse en quoi les régions de l'entre-deux restent dans la longue durée des espaces mouvants, des points de rencontre, où se font face l'autonomie indienne et le pouvoir colonial hispanique. Ces espaces ne sont pas une ligne radicale, mais une zone poreuse faite d'échanges, de négociations et de conflits. Le Cône sud constitue un observatoire privilégié permettant de travailler des régions qui transcendent les limites administratives des empires hispano-portugais, puis celles des États-nations. Le livre s'ouvre sur les systèmes classificatoires des altérités indiennes fabriqués par le monde colonial en fonction de son entreprise hégémonique. La deuxième partie se situe à l'époque républicaine, au XIXe siècle, qui scelle l'encerclement puis la défaite militaire des derniers groupes indiens souverains.-

    L'ouvrage se clôt sur le cas singulier du Chaco qui connaît la poursuite, encore au XXe siècle, d'un état de choses rejoignant par bien des aspects le plus classique des colonialismes de l'époque impériale
    Keywords History (General)
    Size 1 electronic resource ( pages)
    Publisher Presses universitaires de Rennes
    Document type Book ; Online
    Note French ; Open Access
    HBZ-ID HT020322856
    ISBN 9782753568099 ; 275356809X
    DOI 10.4000/books.pur.110043
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  5. Book ; Online: Les hommes transparents : Indiens et militaires dans la guerre du Chaco (1932-1935)

    Capdevila, Luc / Richard, Nicolas / Barbosa, Pablo / Combès, Isabelle

    2010  

    Abstract: La guerre du Chaco (1932-1935) est le conflit international le plus meurtrier qui s'est déroulé en Amérique au XXe siècle. Pendant trois ans les armées paraguayenne et bolivienne - près de 400 000 hommes au total - s'affrontèrent pour 300 000 km2 de ... ...

    Abstract La guerre du Chaco (1932-1935) est le conflit international le plus meurtrier qui s'est déroulé en Amérique au XXe siècle. Pendant trois ans les armées paraguayenne et bolivienne - près de 400 000 hommes au total - s'affrontèrent pour 300 000 km2 de brousse dont elles revendiquaient la souveraineté au nom de « droits » remontant à la colonisation espagnole. Aux alentours de 80 000 soldats paraguayens et boliviens sont tombés durant cette « Grande Guerre américaine ». La guerre du Chaco a fermé le cycle de la formation territoriale des républiques d'Amérique latine ouvert au début du XIXe siècle à la suite de l'implosion de l'empire espagnol. Elle marqua plus encore l'aboutissement de l'absorption par les États des territoires indiens restés à l'écart de la conquête depuis le XVIe siècle. Fondé sur une méthode pluridisciplinaire, ce livre interroge le processus de colonisation du Chaco Boréal dans les années 1920 et 1930 correspondant à l'installation des armées paraguayenne et bolivienne, puis à l'épisode de la guerre. L'analyse des relations Indiens/militaires a été privilégiée. Elles constituent le prisme permettant d'observer avec le plus d'acuité l'implantation des États dans la région, de saisir la relation que les républiques ont envisagé de nouer avec les Indigènes à cette époque, et de savoir comment les nations indiennes ont conçu cette relation de leur côté
    Keywords History (General)
    Size 1 electronic resource ( pages)
    Publisher Presses universitaires de Rennes
    Document type Book ; Online
    Note French ; Open Access
    HBZ-ID HT020322809
    ISBN 9782753567344 ; 2753567344
    DOI 10.4000/books.pur.102218
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  6. Article ; Online: Which magnetic resonance imaging feature is associated with treatment response in perianal fistulizing Crohn's disease?

    Richard, Nicolas / Derinck, Antonin / Bridoux, Valérie / Charpentier, Cloé / Savoye Collet, Céline / Savoye, Guillaume

    Abdominal radiology (New York)

    2024  

    Abstract: Purpose: Perianal fistulae are disabling complications of Crohn's Disease. Magnetic resonance imaging features could predict treatment response. This study aimed to determine which magnetic resonance imaging features were predictive of long-term ... ...

    Abstract Purpose: Perianal fistulae are disabling complications of Crohn's Disease. Magnetic resonance imaging features could predict treatment response. This study aimed to determine which magnetic resonance imaging features were predictive of long-term clinical outcome in real life.
    Methods: Consecutive patients with magnetic resonance imaging performed in a tertiary center were retrospectively analyzed. Clinical outcome was defined as a need for surgical drainage of perianal fistulae or hospitalization. Clinical data and magnetic resonance imaging features (MAGNIFI-CD and Van Assche indices, degree of fibrosis) were studied.
    Results: Fifty-two patients were included between 2016 and 2019 with a mean follow-up of 38 months [29;48]. A higher MAGNIFI-CD index (17/25 versus 11/25; p < 0.01) was associated with an unfavorable long-term clinical outcome. The MAGNIFI-CD index showed an area under the curve of 0.74 (p = 0.006) to predict the clinical outcome of perianal Crohn's disease, compared to 0.67 (p < 0.05) for the Van Assche index. At a threshold of 13 for the MAGNIFI-CD index, sensitivity was 75% (CI95% [59%; 86%]) and specificity was 69% (CI95% [44%; 86%]). No association was found between the degree of fibrosis and clinical outcome, but the association of a high degree of fibrosis (≥ 80%) and of a low MAGNIFI-CD index (≤ 13) was predictive of clinical outcome (p < 0.01).
    Conclusion: The MAGNIFI-CD index could be used to predict clinical outcome in perianal Crohn's disease. In combination with a high degree of fibrosis, a low MAGNIFI-CD index, may help to identify patients with the best prognosis.
    Language English
    Publishing date 2024-03-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2839786-1
    ISSN 2366-0058 ; 2366-004X
    ISSN (online) 2366-0058
    ISSN 2366-004X
    DOI 10.1007/s00261-024-04238-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1262: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Selecting Machine Learning Models to Support the Design of Al/CuO Nanothermites.

    Sami, Yasser / Richard, Nicolas / Gauchard, David / Estève, Alain / Rossi, Carole

    The journal of physical chemistry. A

    2022  Volume 126, Issue 7, Page(s) 1245–1254

    Abstract: Novel properties associated with nanothermites have attracted great interest for several applications, including lead-free primers and igniters. However, the prediction of quantitative structure-energetic performance relationships is still challenging. ... ...

    Abstract Novel properties associated with nanothermites have attracted great interest for several applications, including lead-free primers and igniters. However, the prediction of quantitative structure-energetic performance relationships is still challenging. This study investigates machine learning methods as tools to surrogate complex physical models to design novel nanothermites with optimized burning rates chosen for energetic performance. The study focuses on Al/CuO nanolaminates, for which nine supervised regressors commonly used in ML applied to materials science are investigated. For each, an ML model is built using a database containing a set of 2700 Al/CuO nanolaminate systems, specifically generated for this study. We demonstrate the superiority of the multilayer perceptron algorithm to surrogate conventional physical-based models and predict the Al/CuO nanolaminate microstructure-burn rate relationship with good efficiency: the burn rate is estimated with less than 1% error (0.07 m·s
    MeSH term(s) Algorithms ; Copper/chemistry ; Machine Learning
    Chemical Substances Copper (789U1901C5) ; cupric oxide (V1XJQ704R4)
    Language English
    Publishing date 2022-02-14
    Publishing country United States
    Document type Journal Article
    ISSN 1520-5215
    ISSN (online) 1520-5215
    DOI 10.1021/acs.jpca.1c09520
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Botulinum toxin: endoscopic treatment in fecal incontinence after ileoanal anastomosis.

    Richard, Nicolas / Basile, Paul / Gourcerol, Guillaume

    Endoscopy

    2021  Volume 54, Issue 8, Page(s) E460–E461

    MeSH term(s) Anal Canal/surgery ; Anastomosis, Surgical/adverse effects ; Botulinum Toxins ; Fecal Incontinence/etiology ; Fecal Incontinence/surgery ; Humans
    Chemical Substances Botulinum Toxins (EC 3.4.24.69)
    Language English
    Publishing date 2021-09-27
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 80120-3
    ISSN 1438-8812 ; 0013-726X
    ISSN (online) 1438-8812
    ISSN 0013-726X
    DOI 10.1055/a-1625-4613
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 669: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 162: Show issues

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  9. Article: Real-World Effectiveness of Upadacitinib for Treatment of Rheumatoid Arthritis in Canadian Patients: Interim Results from the Prospective Observational CLOSE-UP Study.

    Bessette, Louis / Chan, Jonathan / Chow, Andrew / Lisnevskaia, Larissa / Richard, Nicolas / Fournier, Pierre-Andre / Liazoghli, Dalinda / Girard, Tanya / Haaland, Derek

    Rheumatology and therapy

    2024  

    Abstract: Introduction: Upadacitinib (UPA), a selective, reversible, oral Janus kinase (JAK)-1 inhibitor, was approved in 2019 in Canada for the treatment of adults with moderately to severely active rheumatoid arthritis (RA). This phase 4 prospective study aimed ...

    Abstract Introduction: Upadacitinib (UPA), a selective, reversible, oral Janus kinase (JAK)-1 inhibitor, was approved in 2019 in Canada for the treatment of adults with moderately to severely active rheumatoid arthritis (RA). This phase 4 prospective study aimed to characterise the effectiveness of UPA in the real-world population of patients with RA.
    Methods: Adults with RA who initiated treatment with once daily UPA (15 mg) and enrolled in the Canadian Real-Life post-marketing Observational Study assessing the Effectiveness of UPadacitinib for treating rheumatoid arthritis (CLOSE-UP) and who completed a 6-month assessment as of 28 February 2023 were included. The primary endpoint of the CLOSE-UP study is the proportion of patients achieving a Disease Activity Score-28 Joint Count C-reactive protein (DAS28-CRP) < 2.6 at 6 months. Data was collected at routine visits. Data analysed and summarised descriptively for the overall interim population and for subgroups based on prior therapy included remission or low disease activity, patient-reported outcomes (PROs), and adverse events.
    Results: A total of 392 patients were included in the interim analysis. Overall, 63.5% (191/301) of patients achieved a DAS28-CRP score < 2.6 at month 6, with similar rates observed for all subgroups analysed according to prior therapy including those with prior JAK inhibitor exposure (range 57.4-71.0%), and in patients who received UPA monotherapy (71.6% [48/67]). Early (month 3) and sustained improvements up to 6 months were observed for all PROs. The safety profile was consistent with previous reports.
    Conclusion: Real-world improvements in disease activity and PROs in response to UPA treatment were consistent with clinical trial data across a range of Canadian patients with prior therapy exposure and with UPA monotherapy, with an overall favourable benefit-risk profile.
    Trial registration: NCT04574492.
    Language English
    Publishing date 2024-03-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2783278-8
    ISSN 2198-6584 ; 2198-6576
    ISSN (online) 2198-6584
    ISSN 2198-6576
    DOI 10.1007/s40744-024-00651-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Deep Levels and Electron Paramagnetic Resonance Parameters of Substitutional Nitrogen in Silicon from First Principles.

    Simha, Chloé / Herrero-Saboya, Gabriela / Giacomazzi, Luigi / Martin-Samos, Layla / Hemeryck, Anne / Richard, Nicolas

    Nanomaterials (Basel, Switzerland)

    2023  Volume 13, Issue 14

    Abstract: Nitrogen is commonly implanted in silicon to suppress the diffusion of self-interstitials and the formation of voids through the creation of nitrogen-vacancy complexes and nitrogen-nitrogen pairs. Yet, identifying a specific N-related defect via ... ...

    Abstract Nitrogen is commonly implanted in silicon to suppress the diffusion of self-interstitials and the formation of voids through the creation of nitrogen-vacancy complexes and nitrogen-nitrogen pairs. Yet, identifying a specific N-related defect via spectroscopic means has proven to be non-trivial. Activation energies obtained from deep-level transient spectroscopy are often assigned to a subset of possible defects that include non-equivalent atomic structures, such as the substitutional nitrogen and the nitrogen-vacancy complex. Paramagnetic N-related defects were the object of several electron paramagnetic spectroscopy investigations which assigned the so-called SL5 signal to the presence of substitutional nitrogen (NSi). Nevertheless, its behaviour at finite temperatures has been imprecisely linked to the metastability of the NSi center. In this work, we build upon the robust identification of the SL5 signature and we establish a theoretical picture of the substitutional nitrogen. Through an understanding of its symmetry-breaking mechanism, we provide a model of its fundamental physical properties (e.g., its energy landscape) based on ab initio calculations. Moreover by including more refined density functional theory-based approaches, we calculate EPR parameters (↔g and ↔A tensors), elucidating the debate on the metastability of NSi. Finally, by computing thermodynamic charge transition levels within the GW method, we present reference values for the donor and acceptor levels of NSi.
    Language English
    Publishing date 2023-07-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662255-5
    ISSN 2079-4991
    ISSN 2079-4991
    DOI 10.3390/nano13142123
    Database MEDical Literature Analysis and Retrieval System OnLINE

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