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  1. Article ; Online: Infecção sistêmica e lesão cerebral no recém-nascido pré-termo Systemic infection and brain injury in the preterm infant

    Richard A. Polin

    Jornal de Pediatria, Vol 84, Iss 3, Pp 188-

    2008  Volume 191

    Keywords Pediatrics ; RJ1-570 ; Medicine ; R ; DOAJ:Pediatrics ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Language English
    Publishing date 2008-06-01T00:00:00Z
    Publisher Sociedade Brasileira de Pediatria
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: The NICU Antibiotics and Outcomes (NANO) trial

    Michael J. Morowitz / Anup C. Katheria / Richard A. Polin / Elizabeth Pace / David T. Huang / Chung-Chou H. Chang / Johathan G. Yabes

    Trials, Vol 23, Iss 1, Pp 1-

    a randomized multicenter clinical trial assessing empiric antibiotics and clinical outcomes in newborn preterm infants

    2022  Volume 16

    Abstract: Abstract Background Early-onset sepsis is an important cause of neonatal morbidity and mortality in the preterm population. Infants perceived to be at increased risk for early-onset sepsis are often treated empirically with broad-spectrum antibiotics ... ...

    Abstract Abstract Background Early-onset sepsis is an important cause of neonatal morbidity and mortality in the preterm population. Infants perceived to be at increased risk for early-onset sepsis are often treated empirically with broad-spectrum antibiotics while awaiting confirmatory blood cultures, despite an overall incidence of early-onset sepsis of 2–3% among extremely-low-birthweight (ELBW) infants. Recent observational studies associate perinatal antibiotic use with an increased incidence of necrotizing enterocolitis, late-onset sepsis, and mortality among ELBW infants. Given currently available data and variability in clinical practice, we designed a prospective multi-institutional randomized controlled trial to determine the safety of early antibiotic use in ELBW infants. Methods The NICU Antibiotics and Outcomes (NANO) trial is a multicenter, double-blinded, randomized controlled trial. A sample of 802 ELBW preterm infants will undergo web-based stratified block randomization to receive empiric antibiotics (EA; ampicillin and gentamicin) or placebo during routine evaluation for early-onset sepsis. Participating sites will use preexisting institutional protocols for antibiotic dosage and duration. Infants born at participating sites with a gestational age of 29 weeks or less are eligible for enrollment. Exclusion criteria include maternal intrauterine infection, hemodynamic or respiratory instability, delivery by caesarean section for maternal indications without labor or prolonged rupture of membranes, and prior administration of antibiotics. The primary outcome is the composite incidence of necrotizing enterocolitis, late-onset sepsis, or death during participants’ index hospitalization. Maternal and infant samples will be collected longitudinally and assessed for differences in microbiome composition and diversity. Discussion The NANO trial is designed to compare the rate of adverse outcomes of EA use at birth versus placebo in ELBW preterm infants. If EA at birth worsens clinical outcomes, then the results ...
    Keywords Microbial colonization ; Extremely-low-birthweight ; Prematurity ; Early-onset neonatal sepsis ; Late-onset neonatal sepsis ; Necrotizing enterocolitis ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Antibiotics and the developing intestinal microbiome, metabolome and inflammatory environment in a randomized trial of preterm infants

    Jordan T. Russell / J. Lauren Ruoss / Diomel de la Cruz / Nan Li / Catalina Bazacliu / Laura Patton / Kelley Lobean McKinley / Timothy J. Garrett / Richard A. Polin / Eric W. Triplett / Josef Neu

    Scientific Reports, Vol 11, Iss 1, Pp 1-

    2021  Volume 16

    Abstract: Abstract Antibiotic use in neonates can have detrimental effects on the developing gut microbiome, increasing the risk of morbidity. A majority of preterm neonates receive antibiotics after birth without clear evidence to guide this practice. Here ... ...

    Abstract Abstract Antibiotic use in neonates can have detrimental effects on the developing gut microbiome, increasing the risk of morbidity. A majority of preterm neonates receive antibiotics after birth without clear evidence to guide this practice. Here microbiome, metabolomic, and immune marker results from the routine early antibiotic use in symptomatic preterm Neonates (REASON) study are presented. The REASON study is the first trial to randomize symptomatic preterm neonates to receive or not receive antibiotics in the first 48 h after birth. Using 16S rRNA sequencing of stool samples collected longitudinally for 91 neonates, the effect of such antibiotic use on microbiome diversity is assessed. The results illustrate that type of nutrition shapes the early infant gut microbiome. By integrating data for the gut microbiome, stool metabolites, stool immune markers, and inferred metabolic pathways, an association was discovered between Veillonella and the neurotransmitter gamma-aminobutyric acid (GABA). These results suggest early antibiotic use may impact the gut-brain axis with the potential for consequences in early life development, a finding that needs to be validated in a larger cohort. Trial Registration This project is registered at clinicaltrials.gov under the name “Antibiotic ‘Dysbiosis’ in Preterm Infants” with trial number NCT02784821.
    Keywords Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Protocol for the development of a core outcome set for neonatal sepsis (NESCOS)

    Petek Eylul Taneri / Jamie J. Kirkham / Eleanor J. Molloy / Linda Biesty / Richard A. Polin / James L. Wynn / Barbara J. Stoll / Niranjan Kissoon / Kondwani Kawaza / Mandy Daly / Aoife Branagan / Lívia Nagy Bonnard / Eric Giannoni / Tobias Strunk / Magdalena Ohaja / Kenneth Mugabe / Denise Suguitani / Fiona Quirke / Declan Devane

    PLoS ONE, Vol 18, Iss

    2023  Volume 12

    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Protocol for the development of a core outcome set for neonatal sepsis (NESCOS).

    Petek Eylul Taneri / Jamie J Kirkham / Eleanor J Molloy / Linda Biesty / Richard A Polin / James L Wynn / Barbara J Stoll / Niranjan Kissoon / Kondwani Kawaza / Mandy Daly / Aoife Branagan / Lívia Nagy Bonnard / Eric Giannoni / Tobias Strunk / Magdalena Ohaja / Kenneth Mugabe / Denise Suguitani / Fiona Quirke / Declan Devane

    PLoS ONE, Vol 18, Iss 12, p e

    2023  Volume 0295325

    Abstract: Neonatal sepsis is a serious public health problem; however, there is substantial heterogeneity in the outcomes measured and reported in research evaluating the effectiveness of the treatments. Therefore, we aim to develop a Core Outcome Set (COS) for ... ...

    Abstract Neonatal sepsis is a serious public health problem; however, there is substantial heterogeneity in the outcomes measured and reported in research evaluating the effectiveness of the treatments. Therefore, we aim to develop a Core Outcome Set (COS) for studies evaluating the effectiveness of treatments for neonatal sepsis. Since a systematic review of key outcomes from randomised trials of therapeutic interventions in neonatal sepsis was published recently, we will complement this with a qualitative systematic review of the key outcomes of neonatal sepsis identified by parents, other family members, parent representatives, healthcare providers, policymakers, and researchers. We will interpret the outcomes of both studies using a previously established framework. Stakeholders across three different groups i.e., (1) researchers, (2) healthcare providers, and (3) patients' parents/family members and parent representatives will rate the importance of the outcomes in an online Real-Time Delphi Survey. Afterwards, consensus meetings will be held to agree on the final COS through online discussions with key stakeholders. This COS is expected to minimize outcome heterogeneity in measurements and publications, improve comparability and synthesis, and decrease research waste.
    Keywords Medicine ; R ; Science ; Q
    Subject code 306
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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