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  1. AU="Richards, Emily D"
  2. AU="Cho, Kyung-Jin"
  3. AU=Hodos Rachel A
  4. AU="Sahin, Kazim"
  5. AU="Bieri, Jan"
  6. AU="Procter-Murphy, R"
  7. AU=Hauguel-Moreau Marie
  8. AU="Cheng, Delfine"
  9. AU="Stephanie C. Pennington"
  10. AU="O'Hanlon, Karen A"
  11. AU="Heide Glaesmer"
  12. AU="Paget-Bailly, Philippe"
  13. AU="Rory J McCrimmon"
  14. AU="Ahdoot, Aaron I."
  15. AU="Neote, Kuldeep S"
  16. AU="Shen, Congcong"
  17. AU="Rahi, Kosar"
  18. AU="Channabasavaiah, Jagadish Puralae"
  19. AU="Anselmi, Maurizio"
  20. AU="Chauhan, D."
  21. AU="Nicoll, Roger A"
  22. AU="Kwon, Young-Sam"
  23. AU="Mihwa Lee"
  24. AU="Yuanting Jin"
  25. AU="Ter Haar, Eva"
  26. AU="Wolin, Dan L"
  27. AU="Zhang, Tenan"
  28. AU="Piedrafita, Lídia"
  29. AU="Nandy, Ananya"
  30. AU="Bansemer, Sven"
  31. AU="Kochetov, O"
  32. AU="Liu, Fen"

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  1. Artikel: Antibacterial Drug Residues in Small Ruminant Edible Tissues and Milk: A Literature Review of Commonly Used Medications in Small Ruminants.

    Richards, Emily D / Martin, Krysta L / Donnell, Catherine E / Clapham, Maaike O / Tell, Lisa A

    Animals : an open access journal from MDPI

    2022  Band 12, Heft 19

    Abstract: This review provides a summary of extracted data from the published literature that contains drug residue depletion data for edible tissues and milk following treatment of sheep and goats. Out of 20,234 records obtained during the initial search, data ... ...

    Abstract This review provides a summary of extracted data from the published literature that contains drug residue depletion data for edible tissues and milk following treatment of sheep and goats. Out of 20,234 records obtained during the initial search, data from 177 records were included in this review. The data is separated by antibiotic class for ease of comparison between studies. Extracted data includes the active ingredient, dosing information, animal health status, analytical method and limits of detection, tolerance and maximum residue limit information, and time frames relative to residue absence or detection. This information is useful for understanding drug residue depletion profiles following extra-label use and for estimating withdrawal intervals, in order to protect the human food chain.
    Sprache Englisch
    Erscheinungsdatum 2022-09-28
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2606558-7
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani12192607
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Pharmacokinetic Parameters and Estimating Extra-Label Tissue Withdrawal Intervals Using Three Approaches and Various Matrices for Domestic Laying Chickens Following Meloxicam Administration.

    Richards, Emily D / Dutch, Rachel S / Burmas, Nathaniel C / Davis, Jennifer L / Lin, Zhoumeng / Clapham, Maaike O / Wetzlich, Scott E / Tell, Lisa A

    Frontiers in veterinary science

    2022  Band 9, Seite(n) 826367

    Abstract: Meloxicam is commonly prescribed for treating chickens in backyard or small commercial operations despite a paucity of scientific data establishing tissue withdrawal interval recommendations following extra-label drug use (ELDU). Historically, ELDU ... ...

    Abstract Meloxicam is commonly prescribed for treating chickens in backyard or small commercial operations despite a paucity of scientific data establishing tissue withdrawal interval recommendations following extra-label drug use (ELDU). Historically, ELDU withdrawal intervals (WDIs) following meloxicam administration to chickens have been based on the time when meloxicam concentrations fall below detectable concentrations in plasma and egg samples. To date, no studies have addressed tissue residues. ELDU WDIs are commonly calculated using terminal elimination half-lives derived from pharmacokinetic studies. This study estimated pharmacokinetic parameters for laying hens following meloxicam administration and compared ELDU WDIs calculated using tissue terminal elimination half-lives vs. those calculated using FDA tolerance and EMA's maximum regulatory limit statistical methods, respectively. In addition, ELDU WDIs were calculated using plasma meloxicam concentrations from live birds to determine if plasma data could be used as a proxy for estimating tissue WDIs. Healthy domestic hens were administered meloxicam at 1 mg/kg intravenous (IV) once, 1 mg/kg orally (PO) once daily for eight doses or 1 mg/kg PO twice daily for 20 doses. Analytical method validation was performed and meloxicam concentrations were quantified using high-performance liquid chromatography. In general, the terminal elimination technique resulted in the longest ELDU WDIs, followed by the FDA tolerance and then EMA's maximum residue limit methods. The longest ELDU WDIs were 72, 96, and 384 (or 120 excluding fat) h for the IV, PO once daily for eight doses, and PO twice daily for 20 doses, respectively. Plasma data are a possible dataset for estimating a baseline for tissue ELDU WDI estimations when tissue data are not available for chickens treated with meloxicam. Finally, pharmacokinetic parameters were similar in laying hens to those published for other avian species.
    Sprache Englisch
    Erscheinungsdatum 2022-03-03
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2834243-4
    ISSN 2297-1769
    ISSN 2297-1769
    DOI 10.3389/fvets.2022.826367
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Comparison of florfenicol depletion in dairy goat milk using ultra-performance liquid chromatography with tandem mass spectrometry and a commercial on-farm test.

    Richards, Emily D / Pereira, Richard V / Davis, Jennifer L / Rowe, Joan D / Clapham, Maaike O / Wetzlich, Scott E / Rupchis, Benjamin A / Tell, Lisa A

    Frontiers in veterinary science

    2022  Band 9, Seite(n) 991772

    Abstract: Florfenicol is a broad-spectrum antibiotic commonly prescribed in an extra-label manner for treating meat and dairy goats. Scientific data in support of a milk withdrawal interval recommendation is limited to plasma pharmacokinetic data and minimal milk ... ...

    Abstract Florfenicol is a broad-spectrum antibiotic commonly prescribed in an extra-label manner for treating meat and dairy goats. Scientific data in support of a milk withdrawal interval recommendation is limited to plasma pharmacokinetic data and minimal milk residue data that is limited to cattle. Therefore, a rapid residue detection test (RRDT) could be a useful resource to determine if milk samples are free of drug residues and acceptable for sale. This study compared a commercially available RRDT (Charm
    Sprache Englisch
    Erscheinungsdatum 2022-08-29
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2834243-4
    ISSN 2297-1769
    ISSN 2297-1769
    DOI 10.3389/fvets.2022.991772
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: A web-based interactive physiologically based pharmacokinetic (iPBPK) model for meloxicam in broiler chickens and laying hens.

    Yuan, Long / Chou, Wei-Chun / Richards, Emily D / Tell, Lisa A / Baynes, Ronald E / Davis, Jennifer L / Riviere, Jim E / Lin, Zhoumeng

    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

    2022  Band 168, Seite(n) 113332

    Abstract: Meloxicam is a non-steroidal anti-inflammatory drug (NSAID) commonly used in food-producing animals, including chickens in an extralabel manner. This study aimed to develop a physiologically based pharmacokinetic (PBPK) model for meloxicam in broiler ... ...

    Abstract Meloxicam is a non-steroidal anti-inflammatory drug (NSAID) commonly used in food-producing animals, including chickens in an extralabel manner. This study aimed to develop a physiologically based pharmacokinetic (PBPK) model for meloxicam in broiler chickens and laying hens to facilitate withdrawal interval (WDI) estimations. The model structure for broiler chickens contained six compartments including plasma, muscle, liver, kidney, fat and rest of body, while an additional compartment of ovary was included for laying hens. The model adequately simulated available pharmacokinetic data of meloxicam in plasma of broiler chickens as well as tissue and egg data of laying hens. The model was converted to a web-based interface and used to predict WDIs following extralabel administrations. The results showed that the estimated WDIs were 50, 44, 11, 3, 3, 22 and 4 days for liver, kidney, muscle, fat, ovary, yolk and white, respectively in laying hens after 14 repeated oral administrations of meloxicam (1 mg/kg) at 24-h intervals. This model provides a useful and flexible tool for risk assessment and management of residues for meat and eggs from chickens treated with meloxicam and will serve as a basis for extrapolation to other NSAID drugs and other poultry species to aid animal-derived food safety assessment.
    Mesh-Begriff(e) Animal Feed ; Animals ; Anti-Inflammatory Agents, Non-Steroidal ; Chickens ; Eggs ; Female ; Internet ; Meloxicam
    Chemische Substanzen Anti-Inflammatory Agents, Non-Steroidal ; Meloxicam (VG2QF83CGL)
    Sprache Englisch
    Erscheinungsdatum 2022-08-05
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 782617-5
    ISSN 1873-6351 ; 0278-6915
    ISSN (online) 1873-6351
    ISSN 0278-6915
    DOI 10.1016/j.fct.2022.113332
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

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  5. Artikel ; Online: Residue depletion profiles and withdrawal interval estimations of meloxicam in eggs and ovarian follicles following intravenous (Meloxicam solution for injection) and oral (Meloxidyl®) administration in domestic chickens (Gallus domesticus).

    Yuan, Long / Lin, Zhoumeng / Dutch, Rachel S / Richards, Emily D / Clapham, Maaike O / Burmas, Nathaniel / Wetzlich, Scott E / Tell, Lisa A

    Regulatory toxicology and pharmacology : RTP

    2022  Band 132, Seite(n) 105170

    Abstract: Meloxicam is a non-steroidal anti-inflammatory drug (NSAID) commonly prescribed in an extralabel manner for treating chickens in urbanized settings. The objectives of this study were to determine meloxicam depletion profiles in eggs and ovarian follicles ...

    Abstract Meloxicam is a non-steroidal anti-inflammatory drug (NSAID) commonly prescribed in an extralabel manner for treating chickens in urbanized settings. The objectives of this study were to determine meloxicam depletion profiles in eggs and ovarian follicles and to estimate associated withdrawal intervals (WDI) in laying hens following a single intravenous or repeated oral administration. The observed peak concentration of meloxicam in ovarian follicles were consistently higher than in egg yolk and egg white samples. Terminal half-lives were 31-h, 113-h and 12-h in ovarian follicles, egg yolk and egg white samples, respectively, for repeated oral administrations at 1 mg/kg for 20 doses at 12-h intervals. The terminal half-life following a single intravenous administration at 1 mg/kg was 50-h for ovarian follicles. Meloxicam WDI estimations using ovarian follicle and egg yolk concentration data following 20 doses at 12-h intervals were 36 and 12 days, respectively. Meloxicam WDI estimation using egg yolk concentration data following 8 doses at 24-h intervals was 12 days. These results improve our understanding on the residue depletion of meloxicam from chickens' reproductive tracts and egg products and provide WDIs to help ensure food safety for humans consuming eggs from treated laying hens.
    Mesh-Begriff(e) Administration, Intravenous ; Administration, Oral ; Animals ; Chickens ; Drug Residues/analysis ; Egg Yolk ; Eggs/analysis ; Female ; Meloxicam/analysis ; Ovarian Follicle
    Chemische Substanzen Meloxicam (VG2QF83CGL)
    Sprache Englisch
    Erscheinungsdatum 2022-04-20
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 604672-1
    ISSN 1096-0295 ; 0273-2300
    ISSN (online) 1096-0295
    ISSN 0273-2300
    DOI 10.1016/j.yrtph.2022.105170
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  6. Artikel: A web-based interactive physiologically based pharmacokinetic (iPBPK) model for meloxicam in broiler chickens and laying hens

    Yuan, Long / Chou, Wei-Chun / Richards, Emily D. / Tell, Lisa A. / Baynes, Ronald E. / Davis, Jennifer L. / Riviere, Jim E. / Lin, Zhoumeng

    Food and chemical toxicology. 2022 Oct., v. 168

    2022  

    Abstract: Meloxicam is a non-steroidal anti-inflammatory drug (NSAID) commonly used in food-producing animals, including chickens in an extralabel manner. This study aimed to develop a physiologically based pharmacokinetic (PBPK) model for meloxicam in broiler ... ...

    Abstract Meloxicam is a non-steroidal anti-inflammatory drug (NSAID) commonly used in food-producing animals, including chickens in an extralabel manner. This study aimed to develop a physiologically based pharmacokinetic (PBPK) model for meloxicam in broiler chickens and laying hens to facilitate withdrawal interval (WDI) estimations. The model structure for broiler chickens contained six compartments including plasma, muscle, liver, kidney, fat and rest of body, while an additional compartment of ovary was included for laying hens. The model adequately simulated available pharmacokinetic data of meloxicam in plasma of broiler chickens as well as tissue and egg data of laying hens. The model was converted to a web-based interface and used to predict WDIs following extralabel administrations. The results showed that the estimated WDIs were 50, 44, 11, 3, 3, 22 and 4 days for liver, kidney, muscle, fat, ovary, yolk and white, respectively in laying hens after 14 repeated oral administrations of meloxicam (1 mg/kg) at 24-h intervals. This model provides a useful and flexible tool for risk assessment and management of residues for meat and eggs from chickens treated with meloxicam and will serve as a basis for extrapolation to other NSAID drugs and other poultry species to aid animal-derived food safety assessment.
    Schlagwörter Internet ; animal-based foods ; eggs ; food safety ; kidneys ; liver ; meat ; meloxicam ; models ; muscles ; nonsteroidal anti-inflammatory agents ; pharmacokinetics ; risk assessment ; safety assessment ; toxicology
    Sprache Englisch
    Erscheinungsverlauf 2022-10
    Erscheinungsort Elsevier Ltd
    Dokumenttyp Artikel
    ZDB-ID 782617-5
    ISSN 1873-6351 ; 0278-6915
    ISSN (online) 1873-6351
    ISSN 0278-6915
    DOI 10.1016/j.fct.2022.113332
    Datenquelle NAL Katalog (AGRICOLA)

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  7. Artikel ; Online: Honey bee medicine for veterinarians and guidance for avoiding violative chemical residues in honey.

    Richards, Emily D / Tell, Lisa A / Davis, Jennifer L / Baynes, Ronald E / Lin, Zhoumeng / Maunsell, Fiona P / Riviere, Jim E / Jaberi-Douraki, Majid / Martin, Krysta L / Davidson, Gigi

    Journal of the American Veterinary Medical Association

    2021  Band 259, Heft 8, Seite(n) 860–873

    Mesh-Begriff(e) Animals ; Bees ; Honey ; Humans ; Veterinarians
    Sprache Englisch
    Erscheinungsdatum 2021-10-05
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 390811-2
    ISSN 1943-569X ; 0003-1488
    ISSN (online) 1943-569X
    ISSN 0003-1488
    DOI 10.2460/javma.259.8.860
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