Article ; Online: One-Year Follow-Up of Seroprevalence of SARS-CoV-2 Infection and Anxiety among Health Workers of a French Cancer Center: The PRO-SERO-COV Study.
International journal of environmental research and public health
2023 Volume 20, Issue 11
Abstract: Infection of SARS-CoV-2 among health workers (HWs) in contact with cancer patients has been a major issue since the beginning of the pandemic. We aimed to assess the serological immune status of SARS-CoV-2 infection among these HWs. A prospective cohort ... ...
| Abstract | Infection of SARS-CoV-2 among health workers (HWs) in contact with cancer patients has been a major issue since the beginning of the pandemic. We aimed to assess the serological immune status of SARS-CoV-2 infection among these HWs. A prospective cohort study was initiated in the comprehensive cancer center of the Nouvelle-Aquitaine region (NA, France). Volunteer HWs working on March 2020 without active infection or symptoms of COVID-19 completed a self-questionnaire and had a blood test at inclusion, at 3 and 12 months. Positive serological status of SARS-CoV-2 infection was defined by anti-nucleocapsid antibodies and/or IgG anti-spike antibodies, except at 12 months due to vaccine. Half of the HWs were included (N = 517) and 89% were followed for three months (N = 500) and one year (N = 462). Seroprevalence of SARS-CoV-2 infection was 3.5% (95% CI: 1.9-5.1), 6.2% (95% CI: 4.1-8.3), and 10% (95% CI: 7.2-12.7) on June-September 2020, September 2020-January 2021, and June-October 2021, respectively. At 12 months, 93.3% had detectable antibodies with 80% vaccinated in the first three months of vaccine availability. The COVID-19-free policy of the institution, respect for barrier gestures, high and early vaccination of HWs, and low prevalence of SARS-CoV-2 in NA may explain the low rate of seropositivity among the HWs of the Institut Bergonié. |
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| MeSH term(s) | Humans ; Seroepidemiologic Studies ; Follow-Up Studies ; Prospective Studies ; COVID-19/epidemiology ; SARS-CoV-2 ; Anxiety/epidemiology ; Health Personnel ; Immunoglobulin G ; Antibodies, Viral ; Neoplasms/epidemiology |
| Chemical Substances | Immunoglobulin G ; Antibodies, Viral |
| Language | English |
| Publishing date | 2023-05-25 |
| Publishing country | Switzerland |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2175195-X |
| ISSN | 1660-4601 ; 1661-7827 |
| ISSN (online) | 1660-4601 |
| ISSN | 1661-7827 |
| DOI | 10.3390/ijerph20115949 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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