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Abstract	The organization of immune cells in human tumors is not well understood. Immunogenic tumors harbor spatially-localized multicellular 'immunity hubs' defined by expression of the T cell-attracting chemokines
Language	English
Publishing date	2023-04-06
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.04.04.535379
Database	MEDical Literature Analysis and Retrieval System OnLINE

Article ; Online: Human lung cancer harbors spatially organized stem-immunity hubs associated with response to immunotherapy.

Chen, Jonathan H / Nieman, Linda T / Spurrell, Maxwell / Jorgji, Vjola / Elmelech, Liad / Richieri, Peter / Xu, Katherine H / Madhu, Roopa / Parikh, Milan / Zamora, Izabella / Mehta, Arnav / Nabel, Christopher S / Freeman, Samuel S / Pirl, Joshua D / Lu, Chenyue / Meador, Catherine B / Barth, Jaimie L / Sakhi, Mustafa / Tang, Alexander L /

Sarkizova, Siranush / Price, Colles / Fernandez, Nicolas F / Emanuel, George / He, Jiang / Van Raay, Katrina / Reeves, Jason W / Yizhak, Keren / Hofree, Matan / Shih, Angela / Sade-Feldman, Moshe / Boland, Genevieve M / Pelka, Karin / Aryee, Martin J / Mino-Kenudson, Mari / Gainor, Justin F / Korsunsky, Ilya / Hacohen, Nir

Nature immunology

2024 Volume 25, Issue 4, Page(s) 644–658

Abstract: The organization of immune cells in human tumors is not well understood. Immunogenic tumors harbor spatially localized multicellular 'immunity hubs' defined by expression of the T cell-attracting chemokines CXCL10/CXCL11 and abundant T cells. Here, we ... ...

Abstract	The organization of immune cells in human tumors is not well understood. Immunogenic tumors harbor spatially localized multicellular 'immunity hubs' defined by expression of the T cell-attracting chemokines CXCL10/CXCL11 and abundant T cells. Here, we examined immunity hubs in human pre-immunotherapy lung cancer specimens and found an association with beneficial response to PD-1 blockade. Critically, we discovered the stem-immunity hub, a subtype of immunity hub strongly associated with favorable PD-1-blockade outcome. This hub is distinct from mature tertiary lymphoid structures and is enriched for stem-like TCF7
MeSH term(s)	Humans ; Lung Neoplasms ; CD8-Positive T-Lymphocytes ; Programmed Cell Death 1 Receptor ; Chemokines/metabolism ; Immunotherapy/methods ; Tumor Microenvironment
Chemical Substances	Programmed Cell Death 1 Receptor ; Chemokines
Language	English
Publishing date	2024-03-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	2016987-5
ISSN	1529-2916 ; 1529-2908
ISSN (online)	1529-2916
ISSN	1529-2908
DOI	10.1038/s41590-024-01792-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Spatial analysis of human lung cancer reveals organized immune hubs enriched for stem-like CD8 T cells and associated with immunotherapy response.

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