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  1. Article: Which antipsychotics should be chosen for the treatment of schizo-obsessive disorder?

    Garosi, A / Richieri, R / Boyer, L / Lancon, C / Fond, G

    L'Encephale

    2021  Volume 48, Issue 3, Page(s) 349–350

    MeSH term(s) Antipsychotic Agents/adverse effects ; Comorbidity ; Humans ; Schizophrenia/drug therapy ; Schizophrenia/epidemiology ; Schizophrenic Psychology
    Chemical Substances Antipsychotic Agents
    Language English
    Publishing date 2021-04-15
    Publishing country France
    Document type Letter
    ZDB-ID 214431-1
    ISSN 0013-7006
    ISSN 0013-7006
    DOI 10.1016/j.encep.2021.01.007
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  2. Article: The neuroinflammatory pathways of post-SARS-CoV-2 psychiatric disorders.

    Fond, G / Masson, M / Lançon, C / Richieri, R / Guedj, E

    L'Encephale

    2021  Volume 47, Issue 5, Page(s) 399–400

    MeSH term(s) COVID-19 ; Humans ; Mental Disorders/epidemiology ; SARS-CoV-2
    Language English
    Publishing date 2021-08-30
    Publishing country France
    Document type Editorial
    ZDB-ID 214431-1
    ISSN 0013-7006
    ISSN 0013-7006
    DOI 10.1016/j.encep.2021.08.001
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  3. Article: Creating a new chapter in the DSM for late-onset depressive disorders.

    Gerolymos, C / Masson, M / Lancon, C / Richieri, R / Boyer, L / Fond, G

    L'Encephale

    2022  Volume 48, Issue 3, Page(s) 229–231

    MeSH term(s) Depressive Disorder/diagnosis ; Diagnostic and Statistical Manual of Mental Disorders ; Humans
    Language English
    Publishing date 2022-06-03
    Publishing country France
    Document type Editorial
    ZDB-ID 214431-1
    ISSN 0013-7006
    ISSN 0013-7006
    DOI 10.1016/j.encep.2022.05.001
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  4. Article ; Online: Response to: "Consistent terminology for medication-related problems in pharmacogenomic cases".

    Korchia, Theo / Joober, Ridha / Richieri, Raphaelle / Sabesan, Priyadharshini / Palaniyappan, Lena

    Journal of psychiatry & neuroscience : JPN

    2023  Volume 48, Issue 3, Page(s) E153

    MeSH term(s) Humans ; Pharmacogenetics ; Precision Medicine
    Language English
    Publishing date 2023-05-12
    Publishing country Canada
    Document type Letter ; Comment
    ZDB-ID 1077443-9
    ISSN 1488-2434 ; 1180-4882
    ISSN (online) 1488-2434
    ISSN 1180-4882
    DOI 10.1503/jpn.230048-l
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  5. Article ; Online: Utilizing pharmacogenetics when treating first episode psychosis.

    Korchia, Theo / Joober, Ridha / Richieri, Raphaelle / Sabesan, Priyadharshini / Palaniyappan, Lena

    Journal of psychiatry & neuroscience : JPN

    2023  Volume 48, Issue 1, Page(s) E11–E12

    MeSH term(s) Humans ; Pharmacogenetics ; Psychotic Disorders/drug therapy ; Psychotic Disorders/genetics
    Language English
    Publishing date 2023-01-03
    Publishing country Canada
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1077443-9
    ISSN 1488-2434 ; 1180-4882
    ISSN (online) 1488-2434
    ISSN 1180-4882
    DOI 10.1503/jpn.220154
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  6. Article ; Online: Long-term remission following esketamine nasal spray sessions in a patient with severe and highly treatment-resistant depression: a single-case report.

    Arrighi, Lucas / Maakaron, Eloïse / Korchia, Théo / Lançon, Christophe / Richieri, Raphaëlle

    International clinical psychopharmacology

    2023  

    Abstract: About 30% of patients with major depressive disorder have treatment-resistant depression (TRD). Recently, intranasal esketamine was approved as a treatment option after the failure of two antidepressant trials. We report a patient with multiresistant ... ...

    Abstract About 30% of patients with major depressive disorder have treatment-resistant depression (TRD). Recently, intranasal esketamine was approved as a treatment option after the failure of two antidepressant trials. We report a patient with multiresistant depression that was successfully and safely treated with esketamine nasal spray. This 31-year-old inpatient with severe, chronic, and multi-TRD received an acute course of intranasal esketamine (84 mg). Previously, 14 different antidepressants, alone or in potentiation, and several neurostimulation techniques had been unsuccessful. Over 20 bi-weekly sessions, she had no significant adverse effects and was stabilized into remission. During the maintenance phase and 1 year after, she continues to be stable. This case report provides an example of a patient with severe TRD that showed significant improvement after treatment with intranasal esketamine.
    Language English
    Publishing date 2023-07-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 632837-4
    ISSN 1473-5857 ; 0268-1315
    ISSN (online) 1473-5857
    ISSN 0268-1315
    DOI 10.1097/YIC.0000000000000482
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  7. Article: You get psychotropic drugs, so you don't need vaccination against Covid 19?

    Fond, G / Masson, M / Richieri, R / Korchia, T / Lançon, C / Boyer, L

    L'Encephale

    2021  Volume 47, Issue 2, Page(s) 87–88

    MeSH term(s) COVID-19/prevention & control ; COVID-19/transmission ; COVID-19 Vaccines/administration & dosage ; Health Services Needs and Demand ; Humans ; Psychotropic Drugs/administration & dosage ; Risk Factors
    Chemical Substances COVID-19 Vaccines ; Psychotropic Drugs
    Language English
    Publishing date 2021-02-13
    Publishing country France
    Document type Editorial
    ZDB-ID 214431-1
    ISSN 0013-7006
    ISSN 0013-7006
    DOI 10.1016/j.encep.2021.02.001
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  8. Article: ADHD and addictive behavior in crack-cocaine users.

    Fond, G / El-Maamar, M / Korchia, T / Richieri, R / Lacoste, J / Boyer, L / Lancon, C

    L'Encephale

    2022  Volume 49, Issue 3, Page(s) 284–288

    Abstract: Background: Crack consumption is a major public health issue in Martinique with a poor prognosis. A preliminary study has found a high prevalence of history of childhood ADHD (C-ADHD) in crack users.: Objective: To determine the prevalence of C-ADHD ... ...

    Abstract Background: Crack consumption is a major public health issue in Martinique with a poor prognosis. A preliminary study has found a high prevalence of history of childhood ADHD (C-ADHD) in crack users.
    Objective: To determine the prevalence of C-ADHD and adult ADHD (A-ADHD) in crack users and their potential associations with substance use behavior.
    Methods: All consecutive patients consulting in the public academic hospital covering 376,000 inhabitants were included in the present study and received a comprehensive battery measuring addictive behavior, psychiatric and somatic comorbidities. C-ADHD groups and A-ADHD groups were defined with the Wender-Utah Rating Scale-25 and the Brown ADD Rating Scale, respectively. Impulsivity was evaluated with the Barratt Impulsiveness Scale (BIS-11).
    Findings: In total, 111 participants were evaluated. Among them, 50 (45%) were classified in the C-ADHD group and 20 (18%) in the A-ADHD group. Compared to the patients without ADHD, those with ADHD were found to have higher impulsivity (C-ADHD: BIS total score 67.90 (10.1) vs. 63.28 (10.5), P=0.021, BIS attentional score 17.5 (3.6) vs. 15.3 (3.4), P=0.002, A-ADHD: BIS total score 75.1 (11.3) vs. 63.4 (9.2), P<0.001, BIS motor impulsivity 26.9 (5.3) vs. 22.6 (4.3), P<0.001, BIS attentional score 19.3 (3.3) vs. 15.6 (3.5), P<0.001, BIS planification 28.9 (5.7) vs. 25.10 (4.7), P=0.003). Fifty percent of A-ADHD patients were found with high impulsivity vs. 15% of patients without A-ADHD (P<0.001). However, ADHD was not associated with more severe addictive behavior or history of legal consequences.
    Interpretation: ADHD prevalence is high in cocaine-crack users and associated with increased impulsivity. However, neither ADHD nor impulsivity explains addictive behaviors or legal consequences.
    MeSH term(s) Adult ; Humans ; Crack Cocaine/adverse effects ; Attention Deficit Disorder with Hyperactivity/complications ; Attention Deficit Disorder with Hyperactivity/epidemiology ; Attention Deficit Disorder with Hyperactivity/psychology ; Behavior, Addictive/epidemiology ; Behavior, Addictive/psychology ; Impulsive Behavior ; Attention
    Chemical Substances Crack Cocaine
    Language English
    Publishing date 2022-03-19
    Publishing country France
    Document type Journal Article
    ZDB-ID 214431-1
    ISSN 0013-7006
    ISSN 0013-7006
    DOI 10.1016/j.encep.2022.01.008
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  9. Article ; Online: Virtual Exercise in Medicine: A Proof of Concept in a Healthy Population.

    Le Roy, Barbara / Martin-Krumm, Charles / Poupon, Charlotte / Richieri, Raphaëlle / Malbos, Eric / Barthélémy, Fanny / Guedj, Eric / Trousselard, Marion

    JMIR formative research

    2024  Volume 8, Page(s) e45637

    Abstract: Background: Science is beginning to establish the benefits of the use of virtual reality (VR) in health care. This therapeutic approach may be an appropriate complementary treatment for some mental illnesses. It could prevent high levels of morbidity ... ...

    Abstract Background: Science is beginning to establish the benefits of the use of virtual reality (VR) in health care. This therapeutic approach may be an appropriate complementary treatment for some mental illnesses. It could prevent high levels of morbidity and improve the physical health of patients. For many years, the literature has shown the health benefits of physical exercise. Physical exercise in a VR environment may improve the management of mild to moderate mental health conditions. In this context, we developed a virtual environment combined with an ergocycle (the augmented physical training for isolated and confined environments [APTICE] system).
    Objective: This study aims to investigate the impact of physical exercise in a VR environment.
    Methods: A total of 14 healthy participants (11 men and 3 women; mean age 43.28, SD 10.60 years) undertook 15 minutes of immersive physical exercise using the system. Measures included mindfulness and immersion disposition, subjective perceptions of sensory information, user experience, and VR experience (ie, psychological state, flow, and presence).
    Results: First, the APTICE system appears to be a useful tool because the user experience is positive (subscales in the AttrakDiff questionnaire: pragmatic quality=0.99; hedonic quality-stimulation=1.90; hedonic quality-identification=0.67; attractiveness=1.58). Second, the system can induce a positive psychological state (negative emotion, P=.06) and an experience of flow and presence (P values ranging from <.001 to .04). Third, individual immersive and mindful disposition plays a role in the VR experience (P values ranging from <.02 to .04). Finally, our findings suggest that there is a link between the subjective perception of sensory information and the VR experience (P values ranging from <.02 to .04).
    Conclusions: These results indicate that the device is well accepted with positive psychological and exteroceptive outcomes. Overall, the APTICE system could be a proof of concept to explore the benefits of virtual physical exercise in clinical medicine.
    Language English
    Publishing date 2024-01-22
    Publishing country Canada
    Document type Journal Article
    ISSN 2561-326X
    ISSN (online) 2561-326X
    DOI 10.2196/45637
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Cross-Cultural Adaptation and Validation of the Quality of Life Questionnaire for Caregivers of Patients with Schizophrenia (S-CGQoL) in Latin America.

    Caqueo-Urízar, A / Urzúa, A / Mena-Chamorro, P / Boucekine, M / Richieri, R / Auquier, P / Fernandes, S / Fond, G / Boyer, L

    L'Encephale

    2021  Volume 47, Issue 4, Page(s) 291–298

    Abstract: Objectives: The aim of this study was to adapt and validate the Schizophrenia Caregiver's Quality of Life Questionnaire (S-CGQoL) for use in the Hispanic-American population from the caregiver's perspective.: Methods: A cross-sectional instrumental ... ...

    Abstract Objectives: The aim of this study was to adapt and validate the Schizophrenia Caregiver's Quality of Life Questionnaire (S-CGQoL) for use in the Hispanic-American population from the caregiver's perspective.
    Methods: A cross-sectional instrumental model was used, with a sample of 253 caregivers of patients suffering of Schizophrenia in Bolivia, Peru and Chile. The psychometric properties of the S-CGQoL were tested through construct validity, reliability and some aspects of external validity. In addition, in order to assess the nature of the different items across the three countries, a Differential Performance Analysis (DPA) was conducted.
    Results: A confirmatory factor analysis showed that the scale structure was well correlated to the initial structure of the QoL-MDS. The results confirmed the existence of adequate reliability indicators (α>.70 and ω>.80) and the absence of FIDs supporting the invariance of item calibrations among the three Latin American countries.
    Conclusions: The adaptation and validation of the S-CGQoL questionnaire demonstrate adequate psychometric properties to assess the quality of life of caregivers in samples of middle-income countries in Latin America.
    MeSH term(s) Caregivers ; Cross-Cultural Comparison ; Cross-Sectional Studies ; Humans ; Latin America ; Psychometrics ; Quality of Life ; Reproducibility of Results ; Schizophrenia ; Surveys and Questionnaires
    Language English
    Publishing date 2021-02-04
    Publishing country France
    Document type Journal Article
    ZDB-ID 214431-1
    ISSN 0013-7006
    ISSN 0013-7006
    DOI 10.1016/j.encep.2020.09.007
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