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  1. Article: Quantitative NMR Spectrometry of Phenylpropanoids, including Isoeugenol in Herbs, Spices, and Essential Oils.

    Fabry, Pascal / Weber, Sandra / Teipel, Jan / Richling, Elke / Walch, Stephan G / Lachenmeier, Dirk W

    Foods (Basel, Switzerland)

    2024  Volume 13, Issue 5

    Abstract: Isoeugenol (2-methoxy-4-(1-propenyl)phenol) has been recently classified as possibly carcinogenic to humans (Group 2B) by the International Agency for Research on Cancer (IARC). This study conducted an analysis of isoeugenol in common herbs and spices, ... ...

    Abstract Isoeugenol (2-methoxy-4-(1-propenyl)phenol) has been recently classified as possibly carcinogenic to humans (Group 2B) by the International Agency for Research on Cancer (IARC). This study conducted an analysis of isoeugenol in common herbs and spices, including basil, cinnamon, ginger, and nutmeg, using
    Language English
    Publishing date 2024-02-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods13050720
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  2. Article: Characterization of brewer's spent grain extracts by tandem mass spectrometry and HPLC-DAD: Ferulic acid dehydrodimers, phenolamides, and oxylipins.

    Becker, Daniela / Stegmüller, Simone / Richling, Elke

    Food science & nutrition

    2022  Volume 11, Issue 5, Page(s) 2298–2320

    Abstract: Brewer's spent grain (BSG) is a major by-product of the brewing industry which is generated in high amounts. In recent years, sustainable food production has become more and more important. BSG mainly used as cattle feed has gained high interest due to ... ...

    Abstract Brewer's spent grain (BSG) is a major by-product of the brewing industry which is generated in high amounts. In recent years, sustainable food production has become more and more important. BSG mainly used as cattle feed has gained high interest due to not only its valuable ingredients such as fiber and proteins but also secondary metabolites remaining in BSG after the brewing process and known for many biological effects. In the present study, various methods were applied, such as acetone extraction (A), alkaline hydrolysis followed by ethyl acetate extraction (HE), and acetone extraction of alkaline hydrolysis residue (HA). Compounds present in the respective bioactive extracts were characterized by mass spectrometry to identify the active compounds. Various hydroxycinnamic acid derivatives as well as oxylipins and some dicarboxylic acids, such as azelaic acid, were present in HE and HA extracts. In contrast, some catechins and phenolamides, such as numerous hordatines, as well as oxylipins and phospholipids were detected in A extracts. Quantification using HPLC-DAD revealed hordatine contents up to 172.2 ± 2.1 μg
    Language English
    Publishing date 2022-12-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2703010-6
    ISSN 2048-7177
    ISSN 2048-7177
    DOI 10.1002/fsn3.3178
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  3. Book ; Online ; Thesis: In vitro Untersuchungen zum Einfluss von Biertreber-Inhaltsstoffen auf Enzyme des Glucosestoffwechsels

    Becker, Daniela [Verfasser] / Richling, Elke [Akademischer Betreuer]

    2023  

    Author's details Daniela Becker ; Betreuer: Elke Richling
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Rheinland-Pfälzische Technische Universität Kaiserslautern-Landau
    Publishing place Kaiserslautern-Landau
    Document type Book ; Online ; Thesis
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  4. Book ; Online ; Thesis: Advancing The Applications of In vitro Metabolomics in Toxicology

    Ramirez Hincapie, Sabina [Verfasser] / Richling, Elke [Akademischer Betreuer]

    2023  

    Author's details Sabina Ramirez Hincapie ; Betreuer: Elke Richling
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Rheinland-Pfälzische Technische Universität Kaiserslautern-Landau
    Publishing place Kaiserslautern-Landau
    Document type Book ; Online ; Thesis
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  5. Article: DNA Protection by an Aronia Juice-Based Food Supplement.

    Bakuradze, Tamara / Meiser, Peter / Galan, Jens / Richling, Elke

    Antioxidants (Basel, Switzerland)

    2021  Volume 10, Issue 6

    Abstract: Background: This study investigated the effects of an aronia juice-based food supplement on background and total DNA strand breaks in whole blood, and on H: Methods: Ninety-one healthy volunteers were randomly selected to consume either the food ... ...

    Abstract Background: This study investigated the effects of an aronia juice-based food supplement on background and total DNA strand breaks in whole blood, and on H
    Methods: Ninety-one healthy volunteers were randomly selected to consume either the food supplement (2 × 25 mL drinking ampules,
    Results: Background DNA strand breaks decreased significantly after four and eight weeks of supplement consumption, compared to baseline (
    Conclusions: Thus, although consuming antioxidant supplements might produce only marginal immediate benefits under healthy conditions, potential preventive effects warrant further investigation.
    Language English
    Publishing date 2021-05-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox10060857
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  6. Article ; Online: Transcriptomic profiling of TLR-7-mediated immune-challenge in zebrafish embryos in the presence and absence of glucocorticoid-induced immunosuppression.

    Luckner, Benedikt / Essfeld, Fabian / Ayobahan, Steve U / Richling, Elke / Eilebrecht, Elke / Eilebrecht, Sebastian

    Ecotoxicology and environmental safety

    2023  Volume 266, Page(s) 115570

    Abstract: Although numerous studies imply a correlation between chemical contamination and an impaired immunocompetence of wildlife populations, the assessment of immunomodulatory modes of action is currently not covered in the regulatory requirements for the ... ...

    Abstract Although numerous studies imply a correlation between chemical contamination and an impaired immunocompetence of wildlife populations, the assessment of immunomodulatory modes of action is currently not covered in the regulatory requirements for the approval of new substances. This is not least due to the complexity of the immune system and a lack of standardised methods and validated biomarkers. To tackle this issue, in this study, the transcriptomic profiles of zebrafish embryos were analysed in response to the immunosuppressive compound clobetasol propionate, a synthetic glucocorticoid, and/or the immunostimulatory compound imiquimod (IMQ), a TLR-7 agonist. Using IMQ, known for its potential to induce psoriasis-like effects in mice and human, this study additionally aimed at evaluating the usability of the zebrafish embryo model as an alternative and 3R conform system for the IMQ-induced psoriasis mouse model. Our study substantiates the suitability of previously proposed genes as possible biomarkers for immunotoxicity, such as socs3, nfkbia, anxa1c, fkbp5 and irg1l. Likewise, however, our findings indicate that these genes may be less suitable to distinguish a suppressive from stimulating fashion of action. In contrast, based on a differential regulation in opposite direction in response to both compounds, krt17, rtn4a, and1, smhyc1 and gmpr were identified as potential novel biomarkers with said power to differentiate. Observed IMQ-induced alterations in the expression of genes previously associated with the pathogenesis of psoriasis such as krt17, nfkbia, parp1, pparg, nfil3-6, per2, stat4, klf2, rtn4a, anxa1c and nr1d2 indicate the inducibility of psoriatic effects in the zebrafish embryo. Our work contributes to the establishment of an approach for a 3R-compliant investigation of immunotoxic mechanisms of action in aquatic vertebrates. The validated and newly identified biomarker candidates of specific immunotoxic effects can be used in future studies in the context of environmental hazard assessment of substances or also for human-relevant immunotoxicological questions.
    MeSH term(s) Humans ; Animals ; Mice ; Glucocorticoids/toxicity ; Glucocorticoids/metabolism ; Zebrafish/genetics ; Zebrafish/metabolism ; Toll-Like Receptor 7/metabolism ; Transcriptome ; Psoriasis/pathology ; Imiquimod/toxicity ; Immunosuppression Therapy ; Biomarkers/metabolism ; Skin/metabolism
    Chemical Substances Glucocorticoids ; Toll-Like Receptor 7 ; Imiquimod (P1QW714R7M) ; Biomarkers
    Language English
    Publishing date 2023-10-14
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 436536-7
    ISSN 1090-2414 ; 0147-6513
    ISSN (online) 1090-2414
    ISSN 0147-6513
    DOI 10.1016/j.ecoenv.2023.115570
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    In stock of ZB MED Cologne/Königswinter

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  7. Article ; Online: Polyphenol-Rich Beverage Consumption Affecting Parameters of the Lipid Metabolism in Healthy Subjects.

    Rahn, Celina / Bakuradze, Tamara / Stegmüller, Simone / Galan, Jens / Niesen, Sonja / Winterhalter, Peter / Richling, Elke

    International journal of molecular sciences

    2023  Volume 24, Issue 1

    Abstract: Polyphenols are a diverse and widely distributed class of secondary metabolites, which possess numerous beneficial properties including a modulation of glucose and lipid metabolism. This placebo-controlled human intervention study was performed to ... ...

    Abstract Polyphenols are a diverse and widely distributed class of secondary metabolites, which possess numerous beneficial properties including a modulation of glucose and lipid metabolism. This placebo-controlled human intervention study was performed to explore effects of polyphenol-rich beverage (PRB) uptake on lipid metabolism, as well as DNA integrity. In this case, 36 healthy men were randomly divided to consume either 750 mL of a PRB (containing 51% chokeberry, cranberry, and pomegranate) or a placebo drink daily for eight weeks. Only PRB consumption was found to decrease fat and protein intakes significantly compared to the preceding one-week washout period. During the intervention with PRB an increased fat-free mass was shown after four weeks, whereas a significant elevation in body weight and leptin was observed in placebo group. Blood lipids were not significantly altered after PRB consumption, while triglyceride levels increased after placebo drink intake. In platelets, a significant inhibition of phosphodiesterase (PDE) activity was observed, more pronounced in test group. Consuming the PRB decreased total DNA strand breaks in whole blood as well as H
    MeSH term(s) Humans ; Male ; Beverages/analysis ; Double-Blind Method ; Healthy Volunteers ; Hydrogen Peroxide ; Lipid Metabolism ; Polyphenols/administration & dosage ; Photinia ; Vaccinium macrocarpon ; Pomegranate
    Chemical Substances Hydrogen Peroxide (BBX060AN9V) ; Polyphenols
    Language English
    Publishing date 2023-01-03
    Publishing country Switzerland
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24010841
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  8. Article: DNA Protection by an Aronia Juice-Based Food Supplement

    Bakuradze, Tamara / Meiser, Peter / Galan, Jens / Richling, Elke

    Antioxidants. 2021 May 27, v. 10, no. 6

    2021  

    Abstract: Background: This study investigated the effects of an aronia juice-based food supplement on background and total DNA strand breaks in whole blood, and on H₂O₂-induced DNA strand breaks in isolated peripheral blood lymphocytes. Methods: Ninety-one healthy ...

    Abstract Background: This study investigated the effects of an aronia juice-based food supplement on background and total DNA strand breaks in whole blood, and on H₂O₂-induced DNA strand breaks in isolated peripheral blood lymphocytes. Methods: Ninety-one healthy volunteers were randomly selected to consume either the food supplement (2 × 25 mL drinking ampules, n = 45) or no supplement (n = 46) daily for eight weeks. Results: Background DNA strand breaks decreased significantly after four and eight weeks of supplement consumption, compared to baseline (p < 0.05), but the overall effect was low, and neither group showed a decrease in total DNA strand breaks. Conversely, supplement consumption clearly reduced H₂O₂-induced DNA strand breaks ex vivo (p < 0.001), with statistically significant reductions after four and eight weeks, compared to the control group (p < 0.05). Conclusions: Thus, although consuming antioxidant supplements might produce only marginal immediate benefits under healthy conditions, potential preventive effects warrant further investigation.
    Keywords Aronia ; DNA ; antioxidants ; dietary supplements
    Language English
    Dates of publication 2021-0527
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox10060857
    Database NAL-Catalogue (AGRICOLA)

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  9. Book ; Online ; Thesis: Exogene und endogene Einflussfaktoren auf die Bildung von Acrylamid-Expositionsbiomarkern

    Goerke, Katharina [Verfasser] / Richling, Elke [Akademischer Betreuer]

    2022  

    Author's details Katharina Goerke ; Betreuer: Elke Richling
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Technische Universität Kaiserslautern
    Publishing place Kaiserslautern
    Document type Book ; Online ; Thesis
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  10. Article: Fractionation of Extracts from Black Chokeberry, Cranberry, and Pomegranate to Identify Compounds That Influence Lipid Metabolism

    Niesen, Sonja / Göttel, Celina / Becker, Hanna / Bakuradze, Tamara / Winterhalter, Peter / Richling, Elke

    Foods. 2022 Feb. 16, v. 11, no. 4

    2022  

    Abstract: Polyphenols show a spectrum of bioactive effects, including an influence on lipid metabolism. In this study, we performed activity-guided fractionations of black chokeberry (aronia), cranberry, and pomegranate extracts to identify the biologically active ...

    Abstract Polyphenols show a spectrum of bioactive effects, including an influence on lipid metabolism. In this study, we performed activity-guided fractionations of black chokeberry (aronia), cranberry, and pomegranate extracts to identify the biologically active compounds. The extracts were prepared from fruit juice concentrates with the adsorbent resin Amberlite XAD-7 and were separated into a copigment and an anthocyanin fraction, followed by fractionation into a polymer and monomeric fraction by means of hexane precipitation. For further fractionation of the cranberry and pomegranate copigment fractions, high-performance countercurrent chromatography (HPCCC) was used. The compounds in each fraction were identified by high-performance liquid chromatography/electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS), and the quantification was performed by ultra high-performance liquid chromatography-diode array detector (UHPLC-DAD) analyses. Each of the (sub-)fractions was tested in three in vitro assays: phosphodiesterase 3B (PDE) activity, lipid accumulation, and lipolysis in 3T3-L1 cells. The results showed that various fractions and subfractions can inhibit lipid accumulation and PDE activity as well as increase lipolysis, particularly copigments. Overall, our results indicate an influence of polyphenol-rich (sub-)fractions on the lipid metabolism.
    Keywords Aronia melanocarpa ; adsorbents ; amberlite ; anthocyanins ; countercurrent chromatography ; cranberries ; electrospray ionization mass spectrometry ; fractionation ; fruit juices ; hexane ; high performance liquid chromatography ; lipids ; lipolysis ; polymers ; polyphenols ; pomegranates
    Language English
    Dates of publication 2022-0216
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods11040570
    Database NAL-Catalogue (AGRICOLA)

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