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  1. Article ; Online: Rift Valley Fever.

    Kimble, J Brian / Noronha, Leela / Trujillo, Jessie D / Mitzel, Dana / Richt, Juergen A / Wilson, William C

    The Veterinary clinics of North America. Food animal practice

    2024  

    Abstract: Rift Valley fever (RVF) is a zoonotic viral disease that affects domestic and wild ruminants such as cattle, sheep, goats, camels, and buffaloes. Rift valley fever virus (RVFV), the causative agent of RVF, can also infect humans. RVFV is an arthropod- ... ...

    Abstract Rift Valley fever (RVF) is a zoonotic viral disease that affects domestic and wild ruminants such as cattle, sheep, goats, camels, and buffaloes. Rift valley fever virus (RVFV), the causative agent of RVF, can also infect humans. RVFV is an arthropod-borne virus (arbovirus) that is primarily spread through the bites of infected mosquitoes or exposure to infected blood. RVFV was first isolated and characterized in the Rift Valley of Kenya in 1931 and is endemic throughout sub-Saharan Africa, including Comoros and Madagascar, the Arabian Peninsula (Saudi Arabia and Yemen), and Mayotte.
    Language English
    Publishing date 2024-03-06
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 286086-7
    ISSN 1558-4240 ; 0749-0720
    ISSN (online) 1558-4240
    ISSN 0749-0720
    DOI 10.1016/j.cvfa.2024.01.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Se 1088: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Molecular Characterisation and Antibody Response to Bovine Respiratory Syncytial Virus in Vaccinated and Infected Cattle in Turkey.

    Aydin, Ozge / Yilmaz, Aysun / Turan, Nuri / Richt, Juergen A / Yilmaz, Huseyin

    Pathogens (Basel, Switzerland)

    2024  Volume 13, Issue 4

    Abstract: Bovine respiratory syncytial virus (BRSV) is one of the most important respiratory pathogens of cattle. In this study, frequency of infection, analysis of variants, and the immune status of vaccinated and non-vaccinated cattle were studied. Blood ( ...

    Abstract Bovine respiratory syncytial virus (BRSV) is one of the most important respiratory pathogens of cattle. In this study, frequency of infection, analysis of variants, and the immune status of vaccinated and non-vaccinated cattle were studied. Blood (
    Language English
    Publishing date 2024-04-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens13040304
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Fomite Transmission of SARS-CoV-2 and Its Contributing Factors.

    Kwon, Taeyong / Osterrieder, Nikolaus / Gaudreault, Natasha N / Richt, Juergen A

    Pathogens (Basel, Switzerland)

    2023  Volume 12, Issue 3

    Abstract: The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has drastically changed our lives, from our personal freedoms and habits to public health and socioeconomics [ ... ]. ...

    Abstract The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has drastically changed our lives, from our personal freedoms and habits to public health and socioeconomics [...].
    Language English
    Publishing date 2023-02-22
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens12030364
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Professor Dr. Hans-Dieter Klenk (1938-2021).

    Becker, Stephan / Feldmann, Heinz / Richt, Jürgen A

    Emerging microbes & infections

    2022  Volume 10, Issue 1, Page(s) 1429–1430

    Language English
    Publishing date 2022-02-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2681359-2
    ISSN 2222-1751 ; 2222-1751
    ISSN (online) 2222-1751
    ISSN 2222-1751
    DOI 10.1080/22221751.2021.1949249
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Development of a sensitive, high-throughput extraction protocol for qPCR detection of African swine fever virus in formalin-fixed, paraffin-embedded tissues

    Urbaniak, Kinga / Meekins, David A. / Davis, A. Sally / Richt, Juergen A. / Trujillo, Jessie D.

    Journal of Veterinary Diagnostic Investigation. 2023 May, v. 35, no. 3 p.284-288

    2023  

    Abstract: African swine fever (ASF) causes fatal disease in pigs and is an escalating threat to the global swine industry. ASF has re-emerged from Africa as a transcontinental epidemic spreading through the Caucasus into Europe, Russia, China, numerous Asian ... ...

    Abstract African swine fever (ASF) causes fatal disease in pigs and is an escalating threat to the global swine industry. ASF has re-emerged from Africa as a transcontinental epidemic spreading through the Caucasus into Europe, Russia, China, numerous Asian countries, and the Caribbean. ASF virus (ASFV) is a U.S. select agent requiring handling in high-containment biosafety level 3 (BSL-3) laboratories for pathogen work. Formalin-fixation eliminates infectivity and preserves the genome, providing noninfectious specimens for BSL-2 work. Recovery of DNA from formalin-fixed, paraffin-embedded tissue (FFPET) is challenging and cumbersome. A reliable and easy-to-perform method for DNA recovery from FFPET would facilitate surveillance. To meet this objective, we developed a high-throughput protocol for the recovery of ASFV DNA from FFPET. Deparaffinization, tissue lysis, and reversal of cross-linking were performed in a single tube, followed by DNA purification via automated magnetic bead extraction. Quantitative PCR (qPCR) detection was used to determine the copy number of the B646L gene that encodes for the ASFV p72 protein in tissues (5 pigs, 4 tissues) from pigs with lesions consistent with acute ASF. Copy numbers obtained from FFPET were within one log of copy numbers obtained from fresh tissue, thus enabling ASF qPCR surveillance from formalin-inactivated and preserved tissues at BSL-2 at diagnostic sensitivity similar to fresh tissues tested at BSL-3.
    Keywords African swine fever ; African swine fever virus ; DNA ; Russia ; automation ; biosafety ; crosslinking ; diagnostic sensitivity ; genes ; magnetism ; monitoring ; pathogenicity ; pathogens ; pork industry ; quantitative polymerase chain reaction ; viruses ; Africa ; Caribbean ; Caucasus region ; China ; formalin-fixed, paraffin-embedded tissue ; qPCR
    Language English
    Dates of publication 2023-05
    Size p. 284-288.
    Publishing place SAGE Publications
    Document type Article ; Online
    ZDB-ID 287603-6
    ISSN 1943-4936 ; 1040-6387
    ISSN (online) 1943-4936
    ISSN 1040-6387
    DOI 10.1177/10406387231158534
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3645: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Subunit Vaccine Approaches for African Swine Fever Virus.

    Gaudreault, Natasha N / Richt, Juergen A

    Vaccines

    2019  Volume 7, Issue 2

    Abstract: African swine fever virus (ASFV) is the cause of a highly fatal disease in swine, for which there is no available vaccine. The disease is highly contagious and poses a serious threat to the swine industry worldwide. Since its introduction to the Caucasus ...

    Abstract African swine fever virus (ASFV) is the cause of a highly fatal disease in swine, for which there is no available vaccine. The disease is highly contagious and poses a serious threat to the swine industry worldwide. Since its introduction to the Caucasus region in 2007, a highly virulent, genotype II strain of ASFV has continued to circulate and spread into Eastern Europe and Russia, and most recently into Western Europe, China, and various countries of Southeast Asia. This review summarizes various ASFV vaccine strategies that have been investigated, with focus on antigen-, DNA-, and virus vector-based vaccines. Known ASFV antigens and the determinants of protection against ASFV versus immunopathological enhancement of infection and disease are also discussed.
    Language English
    Publishing date 2019-06-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines7020056
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Environmental Stability of SARS-CoV-2 on Different Types of Surfaces under Indoor and Seasonal Climate Conditions.

    Kwon, Taeyong / Gaudreault, Natasha N / Richt, Juergen A

    Pathogens (Basel, Switzerland)

    2021  Volume 10, Issue 2

    Abstract: Transmission of severe acute respiratory coronavirus 2 (SARS-CoV-2) mainly occurs through direct contact with an infected person via droplets. A potential role of contaminated surfaces in SARS-CoV-2 transmission has been suggested since the virus has ... ...

    Abstract Transmission of severe acute respiratory coronavirus 2 (SARS-CoV-2) mainly occurs through direct contact with an infected person via droplets. A potential role of contaminated surfaces in SARS-CoV-2 transmission has been suggested since the virus has been extensively detected on environmental surfaces. These findings have driven the investigation of virus stability on surfaces under several conditions. However, it remains unclear how long the infectious virus survives on surfaces under different climate conditions, which could play a role in predicting the seasonality of SARS-CoV-2. Therefore, the aim of this study was to estimate the virus stability and its biological half-life on various types of surfaces under indoor and seasonal climate conditions. This study revealed that SARS-CoV-2 survived the longest on surfaces under winter conditions, with a survival post-contamination on most surfaces up to 21 days, followed by spring/fall conditions, with a survival up to 7 days. Infectious virus was isolated up to 4 days post-contamination under indoor conditions, whereas no infectious virus was found at 3 days post-contamination under summer conditions. Our study demonstrates the remarkable persistence of SARS-CoV-2 on many different common surfaces, especially under winter conditions, and raises awareness to the potential risk of contaminated surfaces to spread the virus.
    Language English
    Publishing date 2021-02-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens10020227
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Natural and Experimental SARS-CoV-2 Infection in Domestic and Wild Animals.

    Meekins, David A / Gaudreault, Natasha N / Richt, Juergen A

    Viruses

    2021  Volume 13, Issue 10

    Abstract: SARS-CoV-2 is the etiological agent responsible for the ongoing COVID-19 pandemic, which continues to spread with devastating effects on global health and socioeconomics. The susceptibility of domestic and wild animal species to infection is a critical ... ...

    Abstract SARS-CoV-2 is the etiological agent responsible for the ongoing COVID-19 pandemic, which continues to spread with devastating effects on global health and socioeconomics. The susceptibility of domestic and wild animal species to infection is a critical facet of SARS-CoV-2 ecology, since reverse zoonotic spillover events resulting in SARS-CoV-2 outbreaks in animal populations could result in the establishment of new virus reservoirs. Adaptive mutations in the virus to new animal species could also complicate ongoing mitigation strategies to combat SARS-CoV-2. In addition, animal species susceptible to SARS-CoV-2 infection are essential as standardized preclinical models for the development and efficacy testing of vaccines and therapeutics. In this review, we summarize the current findings regarding the susceptibility of different domestic and wild animal species to experimental SARS-CoV-2 infection and provide detailed descriptions of the clinical disease and transmissibility in these animals. In addition, we outline the documented natural infections in animals that have occurred at the human-animal interface. A comprehensive understanding of animal susceptibility to SARS-CoV-2 is crucial to inform public health, veterinary, and agricultural systems, and to guide environmental policies.
    MeSH term(s) Animals ; Animals, Domestic/virology ; Animals, Wild/virology ; COVID-19/pathology ; COVID-19/veterinary ; Disease Reservoirs/veterinary ; Disease Reservoirs/virology ; Host Specificity/genetics ; Host Specificity/physiology ; SARS-CoV-2/genetics ; Zoonoses
    Language English
    Publishing date 2021-10-04
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v13101993
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Seasonal Stability of SARS-CoV-2 in Biological Fluids.

    Kwon, Taeyong / Gaudreault, Natasha N / Richt, Juergen A

    Pathogens (Basel, Switzerland)

    2021  Volume 10, Issue 5

    Abstract: The transmission of SARS-CoV-2 occurs by close contact with infected persons through droplets, the inhalation of infectious aerosols, and the exposure to contaminated surfaces. Previously, we determined the virus stability on different types of surfaces ... ...

    Abstract The transmission of SARS-CoV-2 occurs by close contact with infected persons through droplets, the inhalation of infectious aerosols, and the exposure to contaminated surfaces. Previously, we determined the virus stability on different types of surfaces under indoor and seasonal climatic conditions. SARS-CoV-2 survived the longest on surfaces under winter conditions, followed by spring/fall and summer conditions, suggesting the seasonal pattern of stability on surfaces. However, under natural conditions, the virus is secreted in various biological fluids from infected humans. In this respect, it remains unclear how long the virus survives in various types of biological fluids. This study explores SARS-CoV-2 stability in virus-spiked human biological fluids under different environmental conditions by determining the virus half-life. The virus was stable for up to 21 days in nasal mucus, sputum, saliva, tear, urine, blood, and semen; it remained infectious significantly longer under winter and spring/fall conditions than under summer conditions. In contrast, the virus was only stable up to 24 h in feces and breast milk. These findings demonstrate the potential risk of infectious biological fluids in SARS-CoV-2 transmission and have implications for its seasonality.
    Language English
    Publishing date 2021-04-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens10050540
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Seasonal stability of SARS-CoV-2 in biological fluids.

    Kwon, Taeyong / Gaudreault, Natasha N / Richt, Juergen A

    bioRxiv : the preprint server for biology

    2021  

    Abstract: Transmission of SARS-CoV-2 occurs by close contact with infected persons through droplets, the inhalation of infectious aerosols and the exposure to contaminated surface. Previously, we determined the virus stability on different types of surfaces under ... ...

    Abstract Transmission of SARS-CoV-2 occurs by close contact with infected persons through droplets, the inhalation of infectious aerosols and the exposure to contaminated surface. Previously, we determined the virus stability on different types of surfaces under indoor and seasonal climatic conditions. SARS-CoV-2 survived the longest on surfaces under winter conditions, followed by spring/fall and summer conditions, suggesting the seasonal pattern of stability on surfaces. However, under natural conditions, the virus is secreted in various biological fluids from infected humans. In this respect, it remains unclear how long the virus survives in various types of biological fluids. This study explored the SARS-CoV-2 stability in human biological fluids under different environmental conditions and estimated the half-life. The virus was stable for up to 21 days in nasal mucus, sputum, saliva, tear, urine, blood, and semen; it remained infectious significantly longer under winter and spring/fall conditions than under summer conditions. In contrast, the virus was only stable up to 24 hours in feces and breast milk. These findings demonstrate the potential risk of infectious biological fluids in SARS-CoV-2 transmission and have implications for its seasonality.
    Language English
    Publishing date 2021-04-08
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2021.04.07.438866
    Database MEDical Literature Analysis and Retrieval System OnLINE

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