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  1. Article ; Online: Translation termination in human mitochondria - substrate specificity of mitochondrial release factors.

    Nadler, Franziska / Richter-Dennerlein, Ricarda

    Biological chemistry

    2023  Volume 404, Issue 8-9, Page(s) 769–779

    Abstract: Mitochondria are the essential players in eukaryotic ATP production by oxidative phosphorylation, which relies on the maintenance and accurate expression of the mitochondrial genome. Even though the basic principles of translation are conserved due to ... ...

    Abstract Mitochondria are the essential players in eukaryotic ATP production by oxidative phosphorylation, which relies on the maintenance and accurate expression of the mitochondrial genome. Even though the basic principles of translation are conserved due to the descendance from a bacterial ancestor, some deviations regarding translation factors as well as mRNA characteristics and the applied genetic code are present in human mitochondria. Together, these features are certain challenges during translation the mitochondrion has to handle. Here, we discuss the current knowledge regarding mitochondrial translation focusing on the termination process and the associated quality control mechanisms. We describe how mtRF1a resembles bacterial RF1 mechanistically and summarize
    MeSH term(s) Humans ; Codon, Terminator/metabolism ; Substrate Specificity ; Peptide Termination Factors/genetics ; Peptide Termination Factors/metabolism ; Protein Biosynthesis ; Mitochondria/metabolism
    Chemical Substances Codon, Terminator ; Peptide Termination Factors
    Language English
    Publishing date 2023-06-29
    Publishing country Germany
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1334659-3
    ISSN 1437-4315 ; 1431-6730 ; 1432-0355
    ISSN (online) 1437-4315
    ISSN 1431-6730 ; 1432-0355
    DOI 10.1515/hsz-2023-0127
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Cytochrome c oxidase biogenesis - from translation to early assembly of the core subunit COX1.

    Dennerlein, Sven / Rehling, Peter / Richter-Dennerlein, Ricarda

    FEBS letters

    2023  Volume 597, Issue 12, Page(s) 1569–1578

    Abstract: Mitochondria are the powerhouses of the cell as they produce the majority of ATP with their oxidative phosphorylation (OXPHOS) machinery. The OXPHOS system is composed of the ... ...

    Abstract Mitochondria are the powerhouses of the cell as they produce the majority of ATP with their oxidative phosphorylation (OXPHOS) machinery. The OXPHOS system is composed of the F
    MeSH term(s) Electron Transport Complex IV/metabolism ; Mitochondria/metabolism ; Mitochondrial Membranes/metabolism ; Protein Biosynthesis ; Protein Processing, Post-Translational ; Mitochondrial Proteins/metabolism ; Saccharomyces cerevisiae Proteins/metabolism
    Chemical Substances Electron Transport Complex IV (EC 1.9.3.1) ; Mitochondrial Proteins ; Saccharomyces cerevisiae Proteins
    Language English
    Publishing date 2023-05-31
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 212746-5
    ISSN 1873-3468 ; 0014-5793
    ISSN (online) 1873-3468
    ISSN 0014-5793
    DOI 10.1002/1873-3468.14671
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  3. Article ; Online: Cytochrome c oxidase biogenesis – from translation to early assembly of the core subunit COX1

    Dennerlein, Sven / Rehling, Peter / Richter‐Dennerlein, Ricarda

    FEBS Letters. 2023 June, v. 597, no. 12 p.1569-1578

    2023  

    Abstract: Mitochondria are the powerhouses of the cell as they produce the majority of ATP with their oxidative phosphorylation (OXPHOS) machinery. The OXPHOS system is composed of the F₁Fₒ ATP synthase and four mitochondrial respiratory chain complexes, the ... ...

    Abstract Mitochondria are the powerhouses of the cell as they produce the majority of ATP with their oxidative phosphorylation (OXPHOS) machinery. The OXPHOS system is composed of the F₁Fₒ ATP synthase and four mitochondrial respiratory chain complexes, the terminal enzyme of which is the cytochrome c oxidase (complex IV) that transfers electrons to oxygen, generating water. Complex IV comprises of 14 structural subunits of dual genetic origin: while the three core subunits are mitochondrial encoded, the remaining constituents are encoded by the nuclear genome. Hence, the assembly of complex IV requires the coordination of two spatially separated gene expression machinery. Recent efforts elucidated an increasing number of proteins involved in mitochondrial gene expression, which are linked to complex IV assembly. Additionally, several COX1 biogenesis factors have been intensively biochemically investigated and an increasing number of structural snapshots shed light on the organization of macromolecular complexes such as the mitoribosome or the cytochrome c oxidase. Here, we focus on COX1 translation regulation and highlight the advanced understanding of early steps during COX1 assembly and its link to mitochondrial translation regulation.
    Keywords H-transporting ATP synthase ; biogenesis ; gene expression ; mitochondria ; mitochondrial genes ; nuclear genome ; oxidative phosphorylation ; oxidoreductases ; oxygen
    Language English
    Dates of publication 2023-06
    Size p. 1569-1578.
    Publishing place John Wiley & Sons, Ltd
    Document type Article ; Online
    Note REVIEW
    ZDB-ID 212746-5
    ISSN 1873-3468 ; 0014-5793
    ISSN (online) 1873-3468
    ISSN 0014-5793
    DOI 10.1002/1873-3468.14671
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  4. Article ; Online: Maintaining mitochondrial ribosome function: The role of ribosome rescue and recycling factors

    Nadler, Franziska / Lavdovskaia, Elena / Richter-Dennerlein, Ricarda

    RNA Biology. 2022 Dec. 31, v. 19, no. 1 p.117-131

    2022  

    Abstract: The universally conserved process of protein biosynthesis is crucial for maintaining cellular homoeostasis and in eukaryotes, mitochondrial translation is essential for aerobic energy production. Mitochondrial ribosomes (mitoribosomes) are highly ... ...

    Abstract The universally conserved process of protein biosynthesis is crucial for maintaining cellular homoeostasis and in eukaryotes, mitochondrial translation is essential for aerobic energy production. Mitochondrial ribosomes (mitoribosomes) are highly specialized to synthesize 13 core subunits of the oxidative phosphorylation (OXPHOS) complexes. Although the mitochondrial translation machinery traces its origin from a bacterial ancestor, it has acquired substantial differences within this endosymbiotic environment. The cycle of mitoribosome function proceeds through the conserved canonical steps of initiation, elongation, termination and mitoribosome recycling. However, when mitoribosomes operate in the context of limited translation factors or on aberrant mRNAs, they can become stalled and activation of rescue mechanisms is required. This review summarizes recent advances in the understanding of protein biosynthesis in mitochondria, focusing especially on the mechanistic and physiological details of translation termination, and mitoribosome recycling and rescue.
    Keywords RNA ; ancestry ; energy ; eukaryotic cells ; mitochondria ; oxidative phosphorylation ; protein synthesis ; ribosomes ; Mitochondrial ribosome (mitoribosome) ; translation termination ; mitoribosome recycling ; mitoribosome rescue ; mitoribosome-associated quality control (mtRQC)
    Language English
    Dates of publication 2022-1231
    Size p. 117-131.
    Publishing place Taylor & Francis
    Document type Article ; Online
    ZDB-ID 2159587-2
    ISSN 1555-8584
    ISSN 1555-8584
    DOI 10.1080/15476286.2021.2015561
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  5. Book ; Online: Cytochrome c oxidase biogenesis – from translation to early assembly of the core subunit COX1

    Dennerlein, Sven / Rehling, Peter / Richter-Dennerlein, Ricarda

    2023  

    Abstract: 1569 ... 1578 ... Mitochondria are the powerhouses of the cell as they produce the majority of ATP with their oxidative phosphorylation (OXPHOS) machinery. The OXPHOS system is composed of the F1Fo ATP synthase and four mitochondrial respiratory chain ... ...

    Abstract 1569

    1578

    Mitochondria are the powerhouses of the cell as they produce the majority of ATP with their oxidative phosphorylation (OXPHOS) machinery. The OXPHOS system is composed of the F1Fo ATP synthase and four mitochondrial respiratory chain complexes, the terminal enzyme of which is the cytochrome c oxidase (complex IV) that transfers electrons to oxygen, generating water. Complex IV comprises of 14 structural subunits of dual genetic origin: while the three core subunits are mitochondrial encoded, the remaining constituents are encoded by the nuclear genome. Hence, the assembly of complex IV requires the coordination of two spatially separated gene expression machinery. Recent efforts elucidated an increasing number of proteins involved in mitochondrial gene expression, which are linked to complex IV assembly. Additionally, several COX1 biogenesis factors have been intensively biochemically investigated and an increasing number of structural snapshots shed light on the organization of macromolecular complexes such as the mitoribosome or the cytochrome c oxidase. Here, we focus on COX1 translation regulation and highlight the advanced understanding of early steps during COX1 assembly and its link to mitochondrial translation regulation.

    597

    12
    Keywords complex IV ; COX1 ; cytochrome c oxidase ; mitochondria ; OXPHOS
    Subject code 570
    Language English
    Publishing country de
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Maintaining mitochondrial ribosome function: The role of ribosome rescue and recycling factors.

    Nadler, Franziska / Lavdovskaia, Elena / Richter-Dennerlein, Ricarda

    RNA biology

    2021  Volume 19, Issue 1, Page(s) 117–131

    Abstract: The universally conserved process of protein biosynthesis is crucial for maintaining cellular homoeostasis and in eukaryotes, mitochondrial translation is essential for aerobic energy production. Mitochondrial ribosomes (mitoribosomes) are highly ... ...

    Abstract The universally conserved process of protein biosynthesis is crucial for maintaining cellular homoeostasis and in eukaryotes, mitochondrial translation is essential for aerobic energy production. Mitochondrial ribosomes (mitoribosomes) are highly specialized to synthesize 13 core subunits of the oxidative phosphorylation (OXPHOS) complexes. Although the mitochondrial translation machinery traces its origin from a bacterial ancestor, it has acquired substantial differences within this endosymbiotic environment. The cycle of mitoribosome function proceeds through the conserved canonical steps of initiation, elongation, termination and mitoribosome recycling. However, when mitoribosomes operate in the context of limited translation factors or on aberrant mRNAs, they can become stalled and activation of rescue mechanisms is required. This review summarizes recent advances in the understanding of protein biosynthesis in mitochondria, focusing especially on the mechanistic and physiological details of translation termination, and mitoribosome recycling and rescue.
    MeSH term(s) Animals ; Bacteria/genetics ; Bacteria/metabolism ; Eukaryota/physiology ; Humans ; Mitochondria/physiology ; Mitochondrial Proteins/genetics ; Mitochondrial Proteins/metabolism ; Mitochondrial Ribosomes/metabolism ; Protein Biosynthesis
    Chemical Substances Mitochondrial Proteins
    Language English
    Publishing date 2021-12-31
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ISSN 1555-8584
    ISSN (online) 1555-8584
    DOI 10.1080/15476286.2021.2015561
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Hierarchical folding of the catalytic core during mitochondrial ribosome biogenesis.

    Lavdovskaia, Elena / Hillen, Hauke S / Richter-Dennerlein, Ricarda

    Trends in cell biology

    2021  Volume 32, Issue 3, Page(s) 182–185

    Abstract: Final maturation steps during ribosome biogenesis require the assistance of assembly and quality control factors to ensure the folding of rRNA and proteins into a functional translation machinery. Here we integrate several recent structural snapshots of ... ...

    Abstract Final maturation steps during ribosome biogenesis require the assistance of assembly and quality control factors to ensure the folding of rRNA and proteins into a functional translation machinery. Here we integrate several recent structural snapshots of native large ribosomal subunit intermediates into the complex pathway of mitochondrial ribosome assembly.
    MeSH term(s) Catalytic Domain ; Humans ; Mitochondrial Ribosomes/chemistry ; Mitochondrial Ribosomes/metabolism ; Organelle Biogenesis ; RNA, Ribosomal/metabolism ; Ribosomal Proteins/analysis ; Ribosomal Proteins/genetics ; Ribosomal Proteins/metabolism ; Ribosomes/metabolism
    Chemical Substances RNA, Ribosomal ; Ribosomal Proteins
    Language English
    Publishing date 2021-10-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 30122-x
    ISSN 1879-3088 ; 0962-8924
    ISSN (online) 1879-3088
    ISSN 0962-8924
    DOI 10.1016/j.tcb.2021.09.004
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  8. Book ; Online ; Thesis: Translation Termination in Human Mitochondria: The Role of mtRF1 and mtRF1a

    Nadler, Franziska [Verfasser] / Richter-Dennerlein, Ricarda [Akademischer Betreuer] / Richter-Dennerlein, Ricarda [Gutachter] / Bohnsack, Markus [Gutachter]

    2022  

    Author's details Franziska Nadler ; Gutachter: Ricarda Richter-Dennerlein, Markus Bohnsack ; Betreuer: Ricarda Richter-Dennerlein
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher Niedersächsische Staats- und Universitätsbibliothek Göttingen
    Publishing place Göttingen
    Document type Book ; Online ; Thesis
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  9. Article ; Online: Role of GTPases in Driving Mitoribosome Assembly.

    Maiti, Priyanka / Lavdovskaia, Elena / Barrientos, Antoni / Richter-Dennerlein, Ricarda

    Trends in cell biology

    2021  Volume 31, Issue 4, Page(s) 284–297

    Abstract: Mitoribosomes catalyze essential protein synthesis within mitochondria. Mitoribosome biogenesis is assisted by an increasing number of assembly factors, among which guanosine triphosphate hydrolases (GTPases) are the most abundant class. Here, we review ... ...

    Abstract Mitoribosomes catalyze essential protein synthesis within mitochondria. Mitoribosome biogenesis is assisted by an increasing number of assembly factors, among which guanosine triphosphate hydrolases (GTPases) are the most abundant class. Here, we review recent progress in our understanding of mitoribosome assembly GTPases. We describe their shared and specific features and mechanisms of action, compare them with their bacterial counterparts, and discuss their possible roles in the assembly of small or large mitoribosomal subunits and the formation of the monosome by establishing quality-control checkpoints during these processes. Furthermore, following the recent unification of the nomenclature for the mitoribosomal proteins, we also propose a unified nomenclature for mitoribosome assembly GTPases.
    MeSH term(s) GTP Phosphohydrolases/metabolism ; Mitochondria ; Mitochondrial Proteins/metabolism ; Mitochondrial Ribosomes/metabolism ; Ribosomal Proteins/metabolism
    Chemical Substances Mitochondrial Proteins ; Ribosomal Proteins ; GTP Phosphohydrolases (EC 3.6.1.-)
    Language English
    Publishing date 2021-01-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 30122-x
    ISSN 1879-3088 ; 0962-8924
    ISSN (online) 1879-3088
    ISSN 0962-8924
    DOI 10.1016/j.tcb.2020.12.008
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  10. Book ; Online ; Thesis: Functional characterisation of DHX proteins in the regulation of RNA metabolism and genome stability

    Falk, Rebecca Rossen [Verfasser] / Bohnsack, Markus [Akademischer Betreuer] / Bohnsack, Markus [Gutachter] / Richter-Dennerlein, Ricarda [Gutachter]

    2023  

    Author's details Rebecca Rossen Falk ; Gutachter: Markus Bohnsack, Ricarda Richter-Dennerlein ; Betreuer: Markus Bohnsack
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher Niedersächsische Staats- und Universitätsbibliothek Göttingen
    Publishing place Göttingen
    Document type Book ; Online ; Thesis
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