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Article: Modular UV Curing Sol-Gel Coating for Invisible, Levelling and Easy to Clean Multi-Layer Systems.

Rico, Lucía Florentino / Conejero Iglesias, Olga / de la Rua García, Ramón Bernardo / Moriones Domeño, Jennifer / Fernández de Ara, Jonathan / Fuentes, Gonzalo G

Materials (Basel, Switzerland)

2023 Volume 16, Issue 15

Abstract: Current methods for the hardening step of functional coatings over different materials imply the use of high temperatures, high energy consumption or long periods of time, which have repercussions on the speed and cost of the product. We report here a ... ...

Abstract	Current methods for the hardening step of functional coatings over different materials imply the use of high temperatures, high energy consumption or long periods of time, which have repercussions on the speed and cost of the product. We report here a simple and low-cost methodology for the functionalization of low-cost stainless steel, which is modular, depending on the functionality pursued: a levelling layer for smoothing the surface of the material, an "easy to clean" property, or both of them. This research is based on sol-gel coatings cured under UV light without requiring high thermal hardening processes, making it applicable to plastics and other sensible materials and possessing high chemical and thermal stability. The film ensures lower processing costs and higher rates of hardening if adequate medium-pressure lamps are employed. This formulation is also well-defined for scaling up the process, so it is possible to perform a continuous coating in large areas by employing mild processing conditions (low temperature, atmospheric pressure). In addition, the sol-gel solution was fully characterized and studied in order to guarantee a long service life before deposition, with a focus on industrial applications in the domestic sector.
Language	English
Publishing date	2023-08-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma16155442
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Article ; Online: Association of CD14 rs2569190 polymorphism with mortality in shock septic patients who underwent major cardiac or abdominal surgery: A retrospective study.

Jiménez-Sousa, María Ángeles / Liu, Pilar / Medrano, Luz María / Fernández-Rodríguez, Amanda / Almansa, Raquel / Gómez-Sánchez, Esther / Rico, Lucía / Lorenzo, Mario / Fadrique, Alejandra / Tamayo, Eduardo / Resino, Salvador

Scientific reports

2018 Volume 8, Issue 1, Page(s) 2698

Abstract: The aim of this study was to investigate the relationship between the CD14 rs2569190 polymorphism and death related to septic shock in white European patients who underwent major cardiac or abdominal surgery. We carried out a retrospective study in 205 ... ...

Abstract	The aim of this study was to investigate the relationship between the CD14 rs2569190 polymorphism and death related to septic shock in white European patients who underwent major cardiac or abdominal surgery. We carried out a retrospective study in 205 septic shock patients. The septic shock diagnosis was established by international consensus definitions. The outcome variable was the death within 28, 60 and 90 days after septic shock diagnosis. The CD14 rs2569190 polymorphism was analyzed by Agena Bioscience's MassARRAY platform. For the genetic association analysis with survival was selected a recessive inheritance model (GG vs. AA/AG). One hundred thirteen out of 205 patients (55.1%) died with a survival median of 39 days (95%CI = 30.6; 47.4). Patients with rs2569190 GG genotype had shorter survival probability than rs2569190 AA/AG genotype at 60 days (62.3% vs 50%; p = 0.035), and 90 days (62.3% vs 52.6%; p = 0.046). The rs2569190 GG genotype was associated with increased risk of septic shock-related death in the first 60 days (adjusted hazard ratio (aHR) = 1.67; p = 0.016) and 90 days (aHR = 1.64; p = 0.020) compared to rs2569190 AA/AG genotype. In conclusion, the presence of CD14 rs2569190 GG genotype was associated with death in shock septic patients who underwent major surgery. Further studies with bigger sample size are required to verify this relationship.
MeSH term(s)	Aged ; Alleles ; Cardiac Surgical Procedures/adverse effects ; Case-Control Studies ; European Continental Ancestry Group/genetics ; Female ; Gene Frequency ; Genotype ; Humans ; Lipopolysaccharide Receptors/genetics ; Male ; Middle Aged ; Polymorphism, Single Nucleotide/genetics ; Retrospective Studies ; Risk Factors ; Sepsis/genetics ; Sepsis/mortality ; Shock, Septic/genetics ; Shock, Septic/mortality
Chemical Substances	CD14 protein, human ; Lipopolysaccharide Receptors
Language	English
Publishing date	2018-02-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-018-20766-7
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Article: Pulmonary transcriptomic responses indicate a dual role of inflammation in pneumonia development and viral clearance during 2009 pandemic influenza infection.

Almansa, Raquel / Martínez-Orellana, Pamela / Rico, Lucía / Iglesias, Verónica / Ortega, Alicia / Vidaña, Beatriz / Martínez, Jorge / Expósito, Ana / Montoya, María / Bermejo-Martin, Jesús F

PeerJ

2017 Volume 5, Page(s) e3915

Abstract: Background: The interaction between influenza virus and the host response to infection clearly plays an important role in determining the outcome of infection. While much is known on the participation of inflammation on the pathogenesis of severe A ( ... ...

Abstract	Background: The interaction between influenza virus and the host response to infection clearly plays an important role in determining the outcome of infection. While much is known on the participation of inflammation on the pathogenesis of severe A (H1N1) pandemic 09-influenza virus, its role in the course of non-fatal pneumonia has not been fully addressed. Methods: A systems biology approach was used to define gene expression profiles, histology and viral dynamics in the lungs of healthy immune-competent mice with pneumonia caused by a human influenza A (H1N1) pdm09 virus, which successfully resolved the infection. Results: Viral infection activated a marked pro-inflammatory response at the lung level paralleling the emergence of histological changes. Cellular immune response and cytokine signaling were the two signaling pathway categories more representative of our analysis. This transcriptome response was associated to viral clearance, and its resolution was accompanied by resolution of histopathology. Discussion: These findings suggest a dual role of pulmonary inflammation in viral clearance and development of pneumonia during non-fatal infection caused by the 2009 pandemic influenza virus. Understanding the dynamics of the host's transcriptomic and virological changes over the course of the infection caused by A (H1N1) pdm09 virus may help identifying the immune response profiles associated with an effective response against influenza virus.
Language	English
Publishing date	2017-10-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	2703241-3
ISSN	2167-8359
ISSN	2167-8359
DOI	10.7717/peerj.3915
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Article ; Online: IL-1B rs16944 polymorphism is related to septic shock and death.

Jiménez-Sousa, María Ángeles / Medrano, Luz M / Liu, Pilar / Almansa, Raquel / Fernández-Rodríguez, Amanda / Gómez-Sánchez, Esther / Rico, Lucía / Heredia-Rodríguez, María / Gómez-Pesquera, Estefanía / Tamayo, Eduardo / Resino, Salvador

European journal of clinical investigation

2017 Volume 47, Issue 1, Page(s) 53–62

Abstract: Background: IL-1β is a primary mediator of systemic inflammatory response syndrome (SIRS) and it may lead to shock septic. Our aim was to analyse whether IL-1B rs16944 polymorphism is associated with the onset of septic shock and death after major ... ...

Abstract	Background: IL-1β is a primary mediator of systemic inflammatory response syndrome (SIRS) and it may lead to shock septic. Our aim was to analyse whether IL-1B rs16944 polymorphism is associated with the onset of septic shock and death after major surgery. Materials and methods: We performed a case-control study on 467 patients who underwent major cardiac or abdominal surgery. Of them, 205 patients developed septic shock (cases, SS group) and 262 patients developed SIRS (controls, SIRS group). The primary outcome variables were the development of septic shock and death within 90 days after diagnosis of septic shock. The IL-1B rs16944 polymorphism was genotyped by Sequenom's MassARRAY platform. The association analysis was performed under a recessive genetic model (AA vs. GG/GC). Results: The frequency of septic shock was higher in patients with IL-1B rs16944 AA genotype than in patients with IL-1B rs16944 GG/AG genotype when all patients were taken into account (63·6% vs. 41·8%; P = 0·006), cardiac surgery (52·2% vs. 33·3%; P = 0·072) and abdominal surgery (76·2% vs. 50·2%; P = 0·023). However, the IL-1B rs16944 AA genotype was only associated with higher likelihood of septic shock in the analysis of all population [adjusted odds ratio (aOR) = 2·26 (95%CI = 1·03; 4·97; P = 0·042], but not when it was stratified by cardiac surgery (P = 0·175) or abdominal surgery (P = 0·467). Similarly, IL-1B rs16944 AA genotype was also associated with higher likelihood of septic shock-related death in all population [aOR = 2·67 (95%CI = 1·07; 4·97); P = 0·035]. Conclusions: IL-1B rs16944 AA genotype seems to be related to the onset of septic shock and death in patients who underwent major surgery.
MeSH term(s)	Aged ; Cardiac Surgical Procedures ; Case-Control Studies ; Female ; Gene Frequency ; Genotype ; Humans ; Interleukin-1beta/genetics ; Logistic Models ; Male ; Middle Aged ; Multivariate Analysis ; Odds Ratio ; Polymorphism, Single Nucleotide ; Postoperative Complications/genetics ; Postoperative Complications/mortality ; Shock, Septic/genetics ; Shock, Septic/mortality ; Surgical Procedures, Operative
Chemical Substances	IL1B protein, human ; Interleukin-1beta
Language	English
Publishing date	2017-01
Publishing country	England
Document type	Journal Article
ZDB-ID	186196-7
ISSN	1365-2362 ; 0014-2972 ; 0960-135X
ISSN (online)	1365-2362
ISSN	0014-2972 ; 0960-135X
DOI	10.1111/eci.12702
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Article: Transcriptomic depression of immunological synapse as a signature of ventilator-associated pneumonia.

Almansa, Raquel / Nogales, Leonor / Martín-Fernández, Marta / Batlle, Montse / Villareal, Esther / Rico, Lucia / Ortega, Alicia / López-Campos, Guillermo / Andaluz-Ojeda, David / Ramírez, Paula / Socias, Lorenzo / Tamayo, Luis / Vallés, Jordi / Bermejo-Martín, Jesús F / Martín-Loeches, Ignacio

Annals of translational medicine

2018 Volume 6, Issue 21, Page(s) 415

Abstract: Background: Ventilator-associated pneumonia (VAP) is one of the most commonly encountered intensive care unit (ICU) acquired infections worldwide. The objective of the study was to identify the immune alteration occurring in patients suffering from VAP ... ...

Abstract	Background: Ventilator-associated pneumonia (VAP) is one of the most commonly encountered intensive care unit (ICU) acquired infections worldwide. The objective of the study was to identify the immune alteration occurring in patients suffering from VAP at the transcriptomic level and explore its potential use for clinical diagnoses of this disease. Methods: We performed a prospective observational study in five medical ICUs. Immunological gene expression profiles in the blood of VAP patients were compared with those of controls by using whole transcriptome microarrays and droplet digital polymerase chain reaction (ddPCR) in the first 24 hours following diagnosis. Results: VAP patients showed significantly lower expression levels of HLA-DOA, HLA-DMA, HLA-DMB, ICOS, ICOSLG, IL2RA, CD1, CD3, CD28 and CD40LG. The molecules coded by these genes participate of the immunological synapse. CD1C, CD40LG and ICOS showed the highest values of area under the receiver operating characteristic curve (AUROC) with a good balance between sensibility and specificity. Conclusions: Patients with VAP show a transcriptomic depression of genes participating of the immunological synapse. It takes a commonplace event, namely VAP, and highlights a quite significant underlying immune suppressive state. In effect this small study will change how we regard VAP, and proposes that we regard it as an infection in an immune compromised host, and that immunity has a central role for ICU acquired infections. This may in time change clinical practice, as it has profound implications for the role of protocolised care, or bundles, in the prevention of VAP. Quantifying the expression in blood of this genes using ddPCR could be a useful approach for the diagnosis of VAP.
Language	English
Publishing date	2018-12-11
Publishing country	China
Document type	Journal Article
ZDB-ID	2893931-1
ISSN	2305-5847 ; 2305-5839
ISSN (online)	2305-5847
ISSN	2305-5839
DOI	10.21037/atm.2018.05.12
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Article ; Online: Can the Cytokine Profile According to ABO Blood Groups Be Related to Worse Outcome in COVID-19 Patients? Yes, They Can.

Tamayo-Velasco, Álvaro / Peñarrubia Ponce, María Jesús / Álvarez, Francisco Javier / Gonzalo-Benito, Hugo / de la Fuente, Ignacio / Pérez-González, Sonia / Rico, Lucía / Jiménez García, María Teresa / Sánchez Rodríguez, Alba / Hijas Villaizan, Milagros / Martín-Fernández, Marta / Dueñas, Carlos / Gómez-Sánchez, Esther / Heredia-Rodríguez, María / Gorgojo-Galindo, Óscar / Fernández, Itziar / Del Río, Lourdes / Carnicero-Frutos, Irene / Muñoz-Moreno, María Fe /

Tamayo, Eduardo / Bernardo, David / Martínez-Paz, Pedro

Frontiers in immunology

2021 Volume 12, Page(s) 726283

Abstract: Severe status of coronavirus disease 2019 (COVID-19) is extremely associated to cytokine release. Moreover, it has been suggested that blood group is also associated with the prevalence and severity of this disease. However, the relationship between the ... ...

Abstract	Severe status of coronavirus disease 2019 (COVID-19) is extremely associated to cytokine release. Moreover, it has been suggested that blood group is also associated with the prevalence and severity of this disease. However, the relationship between the cytokine profile and blood group remains unclear in COVID-19 patients. In this sense, we prospectively recruited 108 COVID-19 patients between March and April 2020 and divided according to ABO blood group. For the analysis of 45 cytokines, plasma samples were collected in the time of admission to hospital ward or intensive care unit and at the sixth day after hospital admission. The results show that there was a risk of more than two times lower of mechanical ventilation or death in patients with blood group O (log rank:
MeSH term(s)	ABO Blood-Group System ; Aged ; Biomarkers ; COVID-19/diagnosis ; COVID-19/immunology ; COVID-19/mortality ; Cytokines/blood ; Disease Progression ; Female ; Hepatocyte Growth Factor/blood ; Hospitalization ; Humans ; Male ; Middle Aged ; Prognosis ; Prospective Studies ; Respiration, Artificial ; SARS-CoV-2/physiology ; Severity of Illness Index ; Survival Analysis
Chemical Substances	ABO Blood-Group System ; Biomarkers ; Cytokines ; Hepatocyte Growth Factor (67256-21-7)
Language	English
Publishing date	2021-10-13
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2021.726283
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Article ; Online: Immunomodulatory nanoparticles from elastin-like recombinamers: single-molecules for tuberculosis vaccine development.

García-Arévalo, Carmen / Bermejo-Martín, Jesús F / Rico, Lucia / Iglesias, Verónica / Martín, Laura / Rodríguez-Cabello, J Carlos / Arias, F Javier

Molecular pharmaceutics

2013 Volume 10, Issue 2, Page(s) 586–597

Abstract: This study investigates both the physicochemical properties and immunogenicity of a genetically engineered elastin-like block corecombinamer (ELbcR) containing a major membrane protein sequence from Mycobacterium tuberculosis. The recombinant production ... ...

Abstract	This study investigates both the physicochemical properties and immunogenicity of a genetically engineered elastin-like block corecombinamer (ELbcR) containing a major membrane protein sequence from Mycobacterium tuberculosis. The recombinant production of this ELbcR allows the production of large quantities of safe, antigenic particle-based constructs that directly and reversibly self-assemble into highly biocompatible, multivalent, monodisperse, and stable nanovesicles with a diameter of 55 nm from the same gene product using a highly efficient and cost-effective inverse transition cycling (ITC) procedure. The compositional complexity of these vesicles is retained after secondary processes such as endotoxin removal, sterilization, and lyophilization. An initial pro-chemotactic cytokine response (IL-1β) followed by a pro-Th2/IL-5 response was observed in mice plasma following subcutaneous administration of the antigen-loaded nanovesicles in mice. This biphasic model of cytokine production was coupled with humoral isotype switching from IgM- to IgG-specific antibodies against the antigen, which was only observed in the presence of both the antigen and the polymer in the same construct and in the absence of additional adjuvants.
MeSH term(s)	Elastin/immunology ; Immunologic Factors/chemistry ; Immunologic Factors/immunology ; Mycobacterium tuberculosis/immunology ; Nanoparticles ; Tuberculosis Vaccines/chemistry ; Tuberculosis Vaccines/immunology
Chemical Substances	Immunologic Factors ; Tuberculosis Vaccines ; Elastin (9007-58-3)
Language	English
Publishing date	2013-02-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2138405-8
ISSN	1543-8392 ; 1543-8384
ISSN (online)	1543-8392
ISSN	1543-8384
DOI	10.1021/mp300325v
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Article: A combined score of pro- and anti-inflammatory interleukins improves mortality prediction in severe sepsis

Andaluz-Ojeda, David / Bobillo, Felipe / Iglesias, Verónica / Almansa, Raquel / Rico, Lucía / Gandía, Francisco / Resino, Salvador / Tamayo, Eduardo / de Lejarazu, Raul Ortiz / Bermejo-Martin, Jesús F

Cytokine. 2012 Mar., v. 57, no. 3

2012

Abstract: Identification of patients at increased risk of death is dramatically important in severe sepsis. Cytokines have been widely assessed as potential biomarkers in this disease, but none of the cytokines studied has evidenced a sufficient specificity or ... ...

Abstract	Identification of patients at increased risk of death is dramatically important in severe sepsis. Cytokines have been widely assessed as potential biomarkers in this disease, but none of the cytokines studied has evidenced a sufficient specificity or sensitivity to be routinely employed in clinical practice. In this pilot study, we profiled 17 immune mediators in the plasma of 29 consecutively recruited patients with severe sepsis or septic shock, during the first 24h following admission to the ICU, by using a Bio-Plex Human Cytokine 17-Plex Panel (Bio-Rad). Patients were 66.1year old in average. Twelve patients of our cohort died during hospitalization at the ICU, eight of them in the first 72h due to multiorganic dysfunction syndrom (MODS). Levels in plasma of three pro-inflammatory mediators (IL-6, IL-8, MCP-1) and of an immunosuppressive one (IL-10) were higher in those patients with fatal outcome. We developed a combined score with those cytokines showing to better predict mortality in our cohort based on the results of Cox regression analysis. This way, IL-6, IL-8 and IL-10 were included in the score. Patients were split into two groups based on the percentile 75 (P75) of the plasma levels of these three interleukins. Those patients showing at least one interleukin value higher than P75 were given the value “1”. Those patients showing IL-6, IL-8, IL-10 levels below P75 were given the value “0”. Hazard ratios for mortality at day 3 and day 28th obtained with the combined score were 2–3-fold higher than those obtained with the individual interleukins values. In conclusion, we have described a combined cytokine score associated with a worse outcome in patients with sepsis, which may represent a new avenue to be explored for guiding treatment decisions in this disease.
Keywords	biomarkers ; death ; humans ; interleukin-10 ; interleukin-6 ; interleukin-8 ; mortality ; patients ; prediction ; regression analysis ; risk ; septic shock
Language	English
Dates of publication	2012-03
Size	p. 332-336.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	1018055-2
ISSN	1096-0023 ; 1043-4666
ISSN (online)	1096-0023
ISSN	1043-4666
DOI	10.1016/j.cyto.2011.12.002
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Article ; Online: Evidence of Active Pro-Fibrotic Response in Blood of Patients with Cirrhosis.

Sanchez-Antolín, Gloria / Almohalla-Alvarez, Carolina / Bueno, Pilar / Almansa, Raquel / Iglesias, Verónica / Rico, Lucia / Ortega, Alicia / Muñoz-Conejero, Eva / García-Pajares, Felix / Bermejo-Martin, Jesus F

PloS one

2015 Volume 10, Issue 8, Page(s) e0137128

Abstract: The role of systemic immunity in the pathogenesis of cirrhosis is not fully understood. Analysis of transcriptomic profiles in blood is an easy approach to obtain a wide picture of immune response at the systemic level. We studied gene expression ... ...

Abstract	The role of systemic immunity in the pathogenesis of cirrhosis is not fully understood. Analysis of transcriptomic profiles in blood is an easy approach to obtain a wide picture of immune response at the systemic level. We studied gene expression profiles in blood from thirty cirrhotic patients and compared them against those of eight healthy volunteers. Most of our patients were male [n = 21, 70%] in their middle ages [57.4 ± 6.8 yr]. Alcohol abuse was the most frequent cause of cirrhosis (n = 22, 73%). Eleven patients had hepatocellular carcinoma (36.7%). Eight patients suffered from hepatitis C virus infection (26.7%). We found a signature constituted by 3402 genes which were differentially expressed in patients compared to controls (2802 over-expressed and 600 under-expressed). Evaluation of this signature evidenced the existence of an active pro-fibrotic transcriptomic program in the cirrhotic patients, involving the [extra-cellular matrix (ECM)-receptor interaction] & [TGF-beta signaling] pathways along with the [Cell adhesion molecules] pathway. This program coexists with alterations in pathways participating in [Glycine, serine and threonine metabolism], [Phenylalanine metabolism], [Tyrosine metabolism], [ABC transporters], [Purine metabolism], [Arachidonic acid metabolism]. In consequence, our results evidence the co-existence in blood of a genomic program mediating pro-fibrotic mechanisms and metabolic alterations in advanced cirrhosis. Monitoring expression levels of the genes involved in these programs could be of interest for predicting / monitoring cirrhosis evolution. These genes could constitute therapeutic targets in this disease.
MeSH term(s)	Female ; Gene Expression Profiling ; Humans ; Leukocytes/metabolism ; Liver Cirrhosis/blood ; Liver Cirrhosis/genetics ; Liver Cirrhosis/metabolism ; Liver Cirrhosis/virology ; Male ; Metabolomics ; Middle Aged
Language	English
Publishing date	2015
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0137128
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Article ; Online: Transcriptomic evidence of impaired immunoglobulin G production in fatal septic shock.

Almansa, Raquel / Tamayo, Eduardo / Heredia, María / Gutierrez, Sandra / Ruiz, Patricia / Alvarez, Elisa / Gomez-Sanchez, Esther / Andaluz-Ojeda, David / Ceña, Rafael / Rico, Lucia / Iglesias, Verónica / Gomez-Herreras, Jose Ignacio / Bermejo-Martin, Jesús F

Journal of critical care

2014 Volume 29, Issue 2, Page(s) 307–309

MeSH term(s)	Case-Control Studies ; Gene Expression Profiling ; Humans ; Immunoglobulin G/biosynthesis ; Immunoglobulin G/genetics ; Immunoglobulins/genetics ; Shock, Septic/genetics ; Shock, Septic/immunology ; Shock, Septic/mortality ; Systemic Inflammatory Response Syndrome/genetics ; Transcriptome
Chemical Substances	Immunoglobulin G ; Immunoglobulins
Language	English
Publishing date	2014-04
Publishing country	United States
Document type	Comparative Study ; Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	632818-0
ISSN	1557-8615 ; 0883-9441
ISSN (online)	1557-8615
ISSN	0883-9441
DOI	10.1016/j.jcrc.2013.11.020
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