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  1. Article: Epidemiological and Clinical Features of

    Itzek, Andreas / Weißbach, Victoria / Meintrup, David / Rieß, Beate / van der Linden, Mark / Borgmann, Stefan

    Pathogens (Basel, Switzerland)

    2023  Volume 12, Issue 4

    Abstract: 1) Background: ...

    Abstract (1) Background:
    Language English
    Publishing date 2023-04-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens12040589
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Long-Lasting Decrease of the Acquisition of

    Borgmann, Stefan / Rieß, Beate / Meintrup, David / Klare, Ingo / Werner, Guido

    International journal of environmental research and public health

    2020  Volume 17, Issue 17

    Abstract: Previously it was shown that application of probiotics stopped the acquisition of vancomycin- ... ...

    Abstract Previously it was shown that application of probiotics stopped the acquisition of vancomycin-resistant
    MeSH term(s) Anti-Bacterial Agents ; Enterococcus faecium/drug effects ; Enterococcus faecium/isolation & purification ; Gram-Negative Bacteria/drug effects ; Gram-Negative Bacteria/isolation & purification ; Gram-Positive Bacterial Infections/prevention & control ; Humans ; Probiotics/pharmacology ; Vancomycin ; beta-Lactamases
    Chemical Substances Anti-Bacterial Agents ; Vancomycin (6Q205EH1VU) ; beta-Lactamases (EC 3.5.2.6)
    Language English
    Publishing date 2020-08-21
    Publishing country Switzerland
    Document type Journal Article
    ISSN 1660-4601
    ISSN (online) 1660-4601
    DOI 10.3390/ijerph17176100
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Treatment with

    Borgmann, Stefan / Rieß, Beate / Siegmund, Rabea / Werner, Guido / Klare, Ingo

    Therapeutics and clinical risk management

    2019  Volume 15, Page(s) 343–354

    Abstract: Purpose: According to the WHO vancomycin-resistant : Patients and methods: Rectal screening swabs were taken at admission and once per week on the early rehabilitation ward of Ingolstadt Hospital (ERWIN) but not at other wards. The number of VRE ... ...

    Abstract Purpose: According to the WHO vancomycin-resistant
    Patients and methods: Rectal screening swabs were taken at admission and once per week on the early rehabilitation ward of Ingolstadt Hospital (ERWIN) but not at other wards. The number of VRE colonized patients was evaluated by using appropriate computer software (LabCentre, Hybase). The Hybase program was also used to find out the number of
    Results: Between 2013 and 2015 the number of VRE increased from 30 to 78 per year whereas in 2016 and 2017 the number declined to 51. Systematic analysis of the laboratory data revealed that this increase was driven by oligoclonal transmission of
    Conclusion: Application of
    Language English
    Publishing date 2019-02-27
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2186560-7
    ISSN 1178-203X ; 1176-6336
    ISSN (online) 1178-203X
    ISSN 1176-6336
    DOI 10.2147/TCRM.S179208
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6067: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Treatment with Saccharomyces boulardii and Escherichia coli Nissle is safe and associated with reduced nosocomial transmission of vanB vancomycin-resistant Enterococcus faecium on an early rehabilitation ward in Germany

    Borgmann, Stefan / Rieß, Beate / Siegmund, Rabea / Werner, Guido / Klare, Ingo

    a retrospective analysis

    2019  

    Abstract: Purpose: According to the WHO vancomycin-resistant Enterococcus faecium (VRE) belongs to the microorganisms for which new antibiotics are urgently needed. Depending on the type of vancomycin resistance vanA gene VRE is differentiated from vanB VRE and ... ...

    Abstract Purpose: According to the WHO vancomycin-resistant Enterococcus faecium (VRE) belongs to the microorganisms for which new antibiotics are urgently needed. Depending on the type of vancomycin resistance vanA gene VRE is differentiated from vanB VRE and other types. In this retrospective analysis the results of VRE surveillance performed at a German tertiary hospital with approximately 1,200 beds between 2013 and 2017 are shown. Patients and methods: Rectal screening swabs were taken at admission and once per week on the early rehabilitation ward of Ingolstadt Hospital (ERWIN) but not at other wards. The number of VRE colonized patients was evaluated by using appropriate computer software (LabCentre, Hybase). The Hybase program was also used to find out the number of Saccharomyces boulardii and multi-susceptible Escherichia coli Nissle in blood cultures of patients at ERWIN. The mechanism of vancomycin resistance was examined by PCR and clonality of VRE strains was analyzed by pulsed-field gel electrophoresis. Results: Between 2013 and 2015 the number of VRE increased from 30 to 78 per year whereas in 2016 and 2017 the number declined to 51. Systematic analysis of the laboratory data revealed that this increase was driven by oligoclonal transmission of vanB VRE on ERWIN until August 2016 despite performing intensified infection control measures. However, afterward the number of VRE decreased at ERWIN and subsequently at the other wards. While searching for the reason behind this beneficial development we noticed that at ERWIN, patients treated with antibiotics received two probiotic medications simultaneously (S. boulardii, E. coli Nissle) for the duration of the antibiotic therapy plus an additional 2 days. There was no indication of side effects caused by these microorganisms, particularly no infections. Conclusion: Application of S. boulardii and E. coli Nissle was safe and associated with reduced transmission of VRE from patient to patient at ERWIN. Therefore, in our setting, probiotic treatment of patients ...
    Keywords microbiota ; oligoclonal spread ; outbreak ; probiotics ; vanB ; bacterial spread ; circuit model of bacterial transmission ; vanA ; 610 Medizin und Gesundheit ; ddc:610
    Subject code 616
    Language English
    Publishing date 2019-02-27
    Publisher Robert Koch-Institut
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Findings from an outbreak of carbapenem-resistant Klebsiella pneumoniae emphasize the role of antibiotic treatment for cross transmission.

    Borgmann, Stefan / Pfeifer, Yvonne / Becker, Laura / Rieß, Beate / Siegmund, Rabea / Sagel, Ulrich

    Infection

    2018  Volume 46, Issue 1, Page(s) 103–112

    Abstract: Purpose: In January 2015, we noticed by rectal swab analyses that seven of 23 patients at an early rehabilitation ward had been colonized with carbapenem-resistant Klebsiella pneumoniae (CKP). Here, we describe risk factors for CKP acquisition.: ... ...

    Abstract Purpose: In January 2015, we noticed by rectal swab analyses that seven of 23 patients at an early rehabilitation ward had been colonized with carbapenem-resistant Klebsiella pneumoniae (CKP). Here, we describe risk factors for CKP acquisition.
    Methods: In the present study, the outbreak is described and risk factors for CKP acquisition are examined, e.g., antibiotic treatment. Microbiological analyses including corresponding results were examined to study when colonization with CKP occurred and whether patients had suffered from diarrhea. To examine whether spread of bacteria was clonal, multi-locus sequence typing as well as Xbal macrorestriction and pulsed-field gel electrophoresis was performed. The presence of carbapenmase was examined by PCR analysis. Through univariate analysis of risk factors in the small study sample, the role of antibiotic consumption, isolation procedures, patient's age, gender, and Barthel index on colonization was elucidated.
    Results: Clonal spread of the novel sequence type (ST)2255 was identified. Additionally, one patient was colonized with Escherichia coli and Serratia marcescens, both resistant to carbapenems, while a further patient carried another carbapenem-resistant E. coli strain. In all isolates, carbapenemase gene bla
    Conclusions: In this small outbreak, antibiotic treatment seemed to be the predominant risk factor for monoclonal transmission of bla
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Carbapenems/pharmacology ; Cross Infection/epidemiology ; Cross Infection/microbiology ; Disease Outbreaks ; Drug Resistance, Bacterial ; Female ; Germany/epidemiology ; Humans ; Klebsiella Infections/epidemiology ; Klebsiella Infections/microbiology ; Klebsiella pneumoniae/physiology ; Male ; Microbial Sensitivity Tests ; Middle Aged ; Risk Factors ; beta-Lactamases/analysis
    Chemical Substances Carbapenems ; beta-Lactamases (EC 3.5.2.6) ; oxacillinase (EC 3.5.2.6)
    Language English
    Publishing date 2018-02
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 185104-4
    ISSN 1439-0973 ; 0300-8126 ; 0173-2129
    ISSN (online) 1439-0973
    ISSN 0300-8126 ; 0173-2129
    DOI 10.1007/s15010-017-1103-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 881: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 528: Show issues

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  6. Article: Recovery of a 10-year-old girl from methicillin-resistant Staphylococcus aureus sepsis in response to low-dose ceftaroline treatment.

    Borgmann, Stefan / Rieß, Beate / von Wernitz-Keibel, Thomas / Bühler, Matthias / Layer, Franziska / Strommenger, Birgit

    Therapeutics and clinical risk management

    2016  Volume 12, Page(s) 749–753

    Abstract: A 9-year-old girl was severely injured in a car accident in Afghanistan, in which both her lower legs were badly damaged. She was treated at the Hospital of Ingolstadt (Klinikum Ingolstadt) after she had undergone initial surgery at an Indian hospital. ... ...

    Abstract A 9-year-old girl was severely injured in a car accident in Afghanistan, in which both her lower legs were badly damaged. She was treated at the Hospital of Ingolstadt (Klinikum Ingolstadt) after she had undergone initial surgery at an Indian hospital. Various bacterial species were isolated from multiple wounds, and methicillin-resistant Staphylococcus aureus (MRSA) was one among them. After the amputation of her lower legs, she developed MRSA sepsis, which was successfully treated with a relatively low dosage of ceftaroline (Zinforo(®)/Teflaro(®); 2×9 mg/kg/d), although the bacterial isolate's minimal inhibitory concentration (1.5-4 mg/L) suggested a decreased susceptibility. In summary, ceftaroline was highly efficient and well tolerated by the patient suffering from MRSA sepsis.
    Language English
    Publishing date 2016-05-11
    Publishing country New Zealand
    Document type Case Reports
    ZDB-ID 2186560-7
    ISSN 1178-203X ; 1176-6336
    ISSN (online) 1178-203X
    ISSN 1176-6336
    DOI 10.2147/TCRM.S99987
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6067: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Recovery of a 10-year-old girl from methicillin-resistant Staphylococcus aureus sepsis in response to low-dose ceftaroline treatment

    Borgmann, Stefan / Rieß, Beate / von Wernitz-Keibel, Thomas / Bühler, Matthias / Layer, Franziska / Strommenger, Birgit

    2016  

    Abstract: A 9-year-old girl was severely injured in a car accident in Afghanistan, in which both her lower legs were badly damaged. She was treated at the Hospital of Ingolstadt (Klinikum Ingolstadt) after she had undergone initial surgery at an Indian hospital. ... ...

    Abstract A 9-year-old girl was severely injured in a car accident in Afghanistan, in which both her lower legs were badly damaged. She was treated at the Hospital of Ingolstadt (Klinikum Ingolstadt) after she had undergone initial surgery at an Indian hospital. Various bacterial species were isolated from multiple wounds, and methicillin-resistant Staphylococcus aureus (MRSA) was one among them. After the amputation of her lower legs, she developed MRSA sepsis, which was successfully treated with a relatively low dosage of ceftaroline (Zinforo®/Teflaro®; 2×9 mg/kg/d), although the bacterial isolate’s minimal inhibitory concentration (1.5–4 mg/L) suggested a decreased susceptibility. In summary, ceftaroline was highly efficient and well tolerated by the patient suffering from MRSA sepsis.
    Keywords Medizin ; side effects ; susceptibility ; ceftaroline ; minimal inhibitory concentration ; therapy ; ddc:610
    Language German
    Publishing date 2016-05-11
    Publisher Infektionskrankheiten / Erreger
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Recovery of a 10-year-old girl from methicillin-resistant Staphylococcus aureus sepsis in response to low-dose ceftaroline treatment

    Borgmann, Stefan / Rieß, Beate / Wernitz-Keibel, Thomas von / Bühler, Matthias / Layer, Franziska / Strommenger, Birgit

    2016  

    Abstract: A 9-year-old girl was severely injured in a car accident in Afghanistan, in which both her lower legs were badly damaged. She was treated at the Hospital of Ingolstadt (Klinikum Ingolstadt) after she had undergone initial surgery at an Indian hospital. ... ...

    Abstract A 9-year-old girl was severely injured in a car accident in Afghanistan, in which both her lower legs were badly damaged. She was treated at the Hospital of Ingolstadt (Klinikum Ingolstadt) after she had undergone initial surgery at an Indian hospital. Various bacterial species were isolated from multiple wounds, and methicillin-resistant Staphylococcus aureus (MRSA) was one among them. After the amputation of her lower legs, she developed MRSA sepsis, which was successfully treated with a relatively low dosage of ceftaroline (Zinforo®/Teflaro®; 2×9 mg/kg/d), although the bacterial isolate’s minimal inhibitory concentration (1.5–4 mg/L) suggested a decreased susceptibility. In summary, ceftaroline was highly efficient and well tolerated by the patient suffering from MRSA sepsis.
    Keywords side effects ; susceptibility ; ceftaroline ; minimal inhibitory concentration ; therapy ; 610 Medizin ; ddc:610
    Language German
    Publishing date 2016-05-11
    Publisher Robert Koch-Institut, Infektionskrankheiten / Erreger
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

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