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  1. Article ; Online: In Vitro Generation of Human Neutrophilic Myeloid-Derived Suppressor Cells.

    Singh, Anurag / Rieber, Nikolaus

    Methods in molecular biology (Clifton, N.J.)

    2020  Volume 2236, Page(s) 77–83

    Abstract: Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of cells of myeloid origin. MDSC are functionally defined by their capacity to suppress T, NK, and B cell responses and henceforth altering the disease outcome in various pathological ...

    Abstract Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of cells of myeloid origin. MDSC are functionally defined by their capacity to suppress T, NK, and B cell responses and henceforth altering the disease outcome in various pathological conditions. MDSC are further subdivided into three distinct subsets: monocytic (M-) MDSC, neutrophilic or polymorphonuclear (PMN-) MDSC, and early-stage (e-) MDSC. However, since surface markers utilized to define MDSC are expressed on other myeloid cells too, it is mandatory to functionally assess the suppressive activity for characterizing these cells. Here, we provide a protocol for generation of PMN-MDSC in vitro from freshly isolated human peripheral blood mononuclear cells. These MDSC can be used further to perform functional assays to determine their immunosuppressive potential or test their activities in various biological conditions, for instance in infection and cancer.
    MeSH term(s) Cell Culture Techniques/methods ; Cells, Cultured ; Flow Cytometry ; Humans ; Myeloid-Derived Suppressor Cells/cytology ; Neutrophils/cytology ; Staining and Labeling
    Language English
    Publishing date 2020-11-25
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-1060-2_8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Online ; Thesis: Komplette und inkomplette Kawasaki-Syndrome

    Wenig, Martina Viktoria [Verfasser] / Rieber, Nikolaus [Akademischer Betreuer]

    Welche klinischen und laborchemischen Parameter helfen bei Diagnose und Therapieentscheidung?

    2023  

    Author's details Martina Viktoria Wenig ; Betreuer: Nikolaus Rieber
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitätsbibliothek Tübingen
    Publishing place Tübingen
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  3. Article ; Online: Cough-induced chylothorax in a two-year-old boy - case report and review of the literature.

    Anger, Melanie / Hofmann, Julian / Ruf, Bettina / Steinborn, Marc / Reber, Daniela / Warncke, Katharina / Rieber, Nikolaus

    BMC pediatrics

    2023  Volume 23, Issue 1, Page(s) 416

    Abstract: Background: Chylothorax is a very rare form of pleural effusion in children, especially after the neonatal period, and predominantly occurs secondary to cardiothoracic surgery. It can lead to significant respiratory distress, immunodeficiency, and ... ...

    Abstract Background: Chylothorax is a very rare form of pleural effusion in children, especially after the neonatal period, and predominantly occurs secondary to cardiothoracic surgery. It can lead to significant respiratory distress, immunodeficiency, and malnutrition. Effective treatment strategies are therefore required to reduce morbidity.
    Case presentation: A previously healthy two-year old boy was admitted with history of heavy coughing followed by progressive dyspnea. The chest X-ray showed an extensive opacification of the right lung. Ultrasound studies revealed a large pleural effusion of the right hemithorax. Pleural fluid analysis delivered the unusual diagnosis of chylothorax, most likely induced by preceded excessive coughing. After an unsuccessful treatment attempt with a fat-free diet and continuous pleural drainage for two weeks, therapy with octreotide was initiated. This led to complete and permanent resolution of his pleural effusion within 15 days, without any side effects.
    Conclusions: Severe cough may be a rare cause of chylothorax in young children. Octreotide seems to be an effective and safe treatment of spontaneous or traumatic chylothorax in children. There is, however, a lack of comprehensive studies for chylothorax in children and many issues concerning diagnostic strategies and treatment algorithms remain.
    MeSH term(s) Male ; Child ; Infant, Newborn ; Humans ; Child, Preschool ; Chylothorax/etiology ; Chylothorax/therapy ; Cough/etiology ; Octreotide/therapeutic use ; Pleural Effusion/diagnostic imaging ; Pleural Effusion/etiology ; Pleural Effusion/therapy ; Algorithms ; Dyspnea
    Chemical Substances Octreotide (RWM8CCW8GP)
    Language English
    Publishing date 2023-08-23
    Publishing country England
    Document type Review ; Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2041342-7
    ISSN 1471-2431 ; 1471-2431
    ISSN (online) 1471-2431
    ISSN 1471-2431
    DOI 10.1186/s12887-023-04221-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book ; Online ; Thesis: Wissenschaftliche Evaluation eines Antibiotic Stewardship Programms an der Kinderklinik München Schwabing

    Oehler, Philipp Andreas [Verfasser] / Rieber, Nikolaus [Akademischer Betreuer]

    2022  

    Author's details Philipp Andreas Oehler ; Betreuer: Nikolaus Rieber
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitätsbibliothek Tübingen
    Publishing place Tübingen
    Document type Book ; Online ; Thesis
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  5. Article ; Online: Eat and suppress: The two-faced role of myeloid-derived suppressor cells in tuberculosis.

    Rieber, Nikolaus / Hartl, Dominik

    American journal of respiratory and critical care medicine

    2014  Volume 190, Issue 9, Page(s) 975–977

    MeSH term(s) Animals ; Myeloid Cells/physiology ; Tuberculosis, Pulmonary/immunology
    Language English
    Publishing date 2014-11-01
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.201410-1764ED
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  6. Article: Improvement of Guideline Adherence After the Implementation of an Antibiotic Stewardship Program in a Secondary Care Pediatric Hospital.

    Metz, Jakob / Oehler, Philipp / Burggraf, Manuela / Burdach, Stefan / Behrends, Uta / Rieber, Nikolaus

    Frontiers in pediatrics

    2019  Volume 7, Page(s) 478

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2019-11-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2019.00478
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  7. Book ; Online ; Thesis: Analyse der Zielgene von Notch bei der Regulation von Proliferation und Differenzierung myeloischer Stamm- und Vorläuferzellen

    Rieber, Nikolaus Peter

    2005  

    Author's details vorgelegt von Nikolaus Peter Rieber
    Language German
    Size Online-Ressource
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Univ., Diss--München, 2005
    Database Former special subject collection: coastal and deep sea fishing

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  8. Article ; Online: AHR activation by tryptophan--pathogenic hallmark of Th17-mediated inflammation in eosinophilic fasciitis, eosinophilia-myalgia-syndrome and toxic oil syndrome?

    Rieber, Nikolaus / Belohradsky, Bernd H

    Immunology letters

    2010  Volume 128, Issue 2, Page(s) 154–155

    Abstract: The aryl-hydrocarbon-receptor (AHR) is involved as receptor and transcription factor in dioxin toxicity. Recently, its role in Th17-mediated autoimmunity and autoinflammation has been described, yet a disease-associated AHR ligand is still elusive. L- ... ...

    Abstract The aryl-hydrocarbon-receptor (AHR) is involved as receptor and transcription factor in dioxin toxicity. Recently, its role in Th17-mediated autoimmunity and autoinflammation has been described, yet a disease-associated AHR ligand is still elusive. L-tryptophan and its metabolites are assumed to trigger the autoinflammatory disorders eosinophilic fasciitis, eosinophilia-myalgia-syndrome and toxic oil syndrome. Since L-tryptophan and metabolites are well known as AHR ligands we hypothesize that it is their interaction with AHR that induces Th17 cell differentiation and autoinflammation in these disorders. This, for the first time would link disease-causing environmental factors to a well-defined cellular receptor and the subsequent pathogenic pathway.
    MeSH term(s) Brassica/chemistry ; Canola Oil ; Eosinophilia/etiology ; Eosinophilia-Myalgia Syndrome/etiology ; Fasciitis/etiology ; Fasciitis/immunology ; Fasciitis/physiopathology ; Fatty Acids, Monounsaturated ; Humans ; Inflammation/etiology ; Inflammation/immunology ; Inflammation/physiopathology ; Interleukin-17/metabolism ; Plant Oils/toxicity ; Receptors, Aryl Hydrocarbon/metabolism ; Syndrome ; T-Lymphocytes, Helper-Inducer/cytology ; T-Lymphocytes, Helper-Inducer/immunology ; T-Lymphocytes, Helper-Inducer/metabolism ; Tryptophan/metabolism
    Chemical Substances Canola Oil ; Fatty Acids, Monounsaturated ; Interleukin-17 ; Plant Oils ; Receptors, Aryl Hydrocarbon ; Tryptophan (8DUH1N11BX)
    Language English
    Publishing date 2010-02-16
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 445150-8
    ISSN 1879-0542 ; 0165-2478
    ISSN (online) 1879-0542
    ISSN 0165-2478
    DOI 10.1016/j.imlet.2009.11.008
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    Zs.A 1512: Show issues Location:
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  9. Conference proceedings: Läuse-Rückfallfieber: eine fast vergessene Erkrankung mit aktueller Brisanz

    Rieber, Nikolaus / Warncke, Katharina / Seilmaier, Michael / Behrends, Uta

    2016  , Page(s) 16dgpi24

    Event/congress 24. Jahrestagung der Deutschen Gesellschaft für Pädiatrische Infektiologie (DGPI); Frankfurt am Main; Deutsche Gesellschaft für Pädiatrische Infektiologie; 2016
    Keywords Medizin, Gesundheit
    Publishing date 2016-04-28
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/16dgpi24
    Database German Medical Science

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  10. Article ; Online: Human monocytic myeloid-derived suppressor cells impair B-cell phenotype and function in vitro.

    Jaufmann, Jennifer / Lelis, Felipe J N / Teschner, Annkathrin C / Fromm, Katja / Rieber, Nikolaus / Hartl, Dominik / Beer-Hammer, Sandra

    European journal of immunology

    2019  Volume 50, Issue 1, Page(s) 33–47

    Abstract: Myeloid-derived suppressor cells (MDSCs) are key regulators of immunity that initially have been defined by their ability to potently suppress T-cell responses. Recent studies collectively demonstrate that the suppressive activity of MDSCs is not limited ...

    Abstract Myeloid-derived suppressor cells (MDSCs) are key regulators of immunity that initially have been defined by their ability to potently suppress T-cell responses. Recent studies collectively demonstrate that the suppressive activity of MDSCs is not limited to T cells, but rather affects a broad range of immune cell subsets. However, relatively few studies have assessed the impact of MDSCs on B cells, particularly in the human context. Here, we report that human monocytic MDSCs (M-MDSCs) significantly interfere with human B-cell proliferation and function in vitro. We further show that the inhibition occurs independent of direct cell-contact and involves the expression of suppressive mediators such as indoleamine 2, 3-dioxygenase (IDO), arginase-1 (Arg1), and nitric oxide (NO). In addition, our studies demonstrate that the suppression of B cells by M-MDSCs is paralleled by a skewing in B-cell phenotype and gene expression signatures. M-MDSCs induced the downregulation of key surface markers on activated B cells, including IgM, HLA-DR, CD80, CD86, TACI, and CD95. Concurrently, M-MDSCs but not conventional monocytes elicited alterations in the transcription of genes involved in apoptosis induction, class-switch regulation, and B-cell differentiation and function. In summary, this study expands our understanding of the regulatory role of M-MDSCs for human B-cell responses.
    MeSH term(s) B-Lymphocytes/immunology ; B-Lymphocytes/metabolism ; Cell Proliferation/physiology ; Cells, Cultured ; Humans ; Lymphocyte Activation/immunology ; Myeloid-Derived Suppressor Cells/immunology ; Myeloid-Derived Suppressor Cells/metabolism ; Phenotype
    Language English
    Publishing date 2019-10-02
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 120108-6
    ISSN 1521-4141 ; 0014-2980
    ISSN (online) 1521-4141
    ISSN 0014-2980
    DOI 10.1002/eji.201948240
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