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  1. Article ; Online: Clinical efficacy of complement C5a inhibition by IFX-1 in hidradenitis suppurativa: an open-label single-arm trial in patients not eligible for adalimumab.

    Giamarellos-Bourboulis, E J / Argyropoulou, M / Kanni, T / Spyridopoulos, T / Otto, I / Zenker, O / Guo, R / Riedemann, N C

    The British journal of dermatology

    2020  Volume 183, Issue 1, Page(s) 176–178

    MeSH term(s) Adalimumab/therapeutic use ; Antibodies, Monoclonal ; Complement C5a ; Hidradenitis Suppurativa/drug therapy ; Humans ; Treatment Outcome
    Chemical Substances Antibodies, Monoclonal ; Complement C5a (80295-54-1) ; vilobelimab (F5T0RF9ZJA) ; Adalimumab (FYS6T7F842)
    Language English
    Publishing date 2020-03-04
    Publishing country England
    Document type Clinical Trial ; Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 80076-4
    ISSN 1365-2133 ; 0007-0963
    ISSN (online) 1365-2133
    ISSN 0007-0963
    DOI 10.1111/bjd.18877
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Aktuelle Aspekte zur Pathophysiologie der Sepsis

    Riedemann, N. C.

    Journal für Anästhesie und Intensivbehandlung

    2005  Volume -, Issue 2, Page(s) 109

    Language German
    Document type Article
    ZDB-ID 1232203-9
    ISSN 0941-4223
    Database Current Contents Medicine

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  3. Article: Kommunikation im Team und Burnout

    Schwarzkopf, D. / Meissner, W. / Wedding, U. / Riedemann, N. C. / Pfeifer, R. / Fritzenwanger, M. / Günther, A. / Egerland, K. / Henkel, M. / Skupin, H. / Muecke, M. / Hartog, C. S.

    Zeitschrift für Palliativmedizin

    2012  Volume 13, Issue 06, Page(s) 293–300

    Abstract: Fragestellung: : Kommunikation über Therapiebeschränkung ist ein wesentliches Element der Zusammenarbeit im interdisziplinären Team auf Intensiv- und Palliativstationen. Ziel der Untersuchung war, Aspekte der Kommunikation im Kontext von ... ...

    Abstract Fragestellung: : Kommunikation über Therapiebeschränkung ist ein wesentliches Element der Zusammenarbeit im interdisziplinären Team auf Intensiv- und Palliativstationen. Ziel der Untersuchung war, Aspekte der Kommunikation im Kontext von Therapiebeschränkungen (TB) und Burnout bei den Mitarbeitern beider Stationen zu vergleichen.
    Methode: : Mitarbeiterbefragung auf Intensivstationen (ITS, 72 Betten) und Palliativstation (PS, 12 Betten). Der Fragebogen enthielt das Maslach Burnout Inventar (MBI) und 40 selbst entwickelte Fragen zu Kommunikation und Zusammenarbeit. Es wurde ein 2:1 Propensity Score Matching von ITS- und PS-Mitarbeitern nach demografischen Variablen durchgeführt.
    Ergebnisse: : Von insgesamt 191 Fragebögen (Rücklauf 60 %) und nach Matching wurden Antworten von 29 (ITS-) und 15 (PS-Mitarbeitern) analysiert. Bei 21 % der ITS-Mitarbeiter, aber keinem PS-Mitarbeiter, war ein erhöhtes Burnout-Risiko gegeben (p = 0,08). ITS-Mitarbeiter werteten die Interaktion im Team, die Rollenklarheit im Kontext von TB und die emotionale Unterstützung signifikant schlechter als PS-Mitarbeiter. Dies war vor allem darauf zurückzuführen, dass ITS-Pflegekräfte hier signifikant schlechter werteten als ITS-Ärzte, während es zwischen den PS-Ärzten und -Pflegekräften keine Unterschiede gab. Bezüglich der Kommunikation zu TB waren ITS-Mitarbeiter seltener zufrieden (42 vs. 80 %; p = 0,025), insbesondere waren ITS-Pflegekräfte seltener zufrieden als -Ärzte (11 vs. 67 %; p = 0,013), bei den PS-Mitarbeitern gab es keine Unterschiede.
    Schlussfolgerungen: : Die Unterschiede in der Bewertung von Aspekten der Kommunikation zwischen Ärzten und Pflegekräften nur auf der Intensivstation, nicht auf der Palliativstation, sind durch unterschiedliche Arbeitsanforderungen allein nicht zu erklären. Interventionen zur Verbesserung der Zusammenarbeit auf ITS sind zu empfehlen, die sich an der Kommunikationskultur auf Palliativstationen orientieren.
    Keywords Burnout ; Kommunikation ; Therapie am Lebensende ; emotionale Erschöpfung ; burnout ; communication ; end-of-life therapy ; emotional exhaustion
    Language German
    Publishing date 2012-11-01
    Publisher © Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2072361-1
    ISSN 1615-293X ; 1615-2921
    ISSN (online) 1615-293X
    ISSN 1615-2921
    DOI 10.1055/s-0032-1327221
    Database Thieme publisher's database

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  4. Article: Kommunikation im Team und Burnout - Eine Befragung von intensiv- und palliativmedizinischen Pflegekräften und Ärzten zu Therapiebeschränkungen am Lebensende. Communication within the Team and Burnout - A Survey Among Nurses and Physicians from Intensive and Palliative Care Units on End-of-Live Decision Making

    Schwarzkopf, D. / Meissner, W. / Wedding, U. / Riedemann, N. C. / Pfeifer, R. / Fritzenwanger, M. / Günther, A. / Egerland, K. / Henkel, M. / Skupin, H. / Muecke, M. / Harto, C. S.

    Zeitschrift für Palliativmedizin

    2012  Volume 13, Issue 6, Page(s) 293

    Language German
    Document type Article
    ZDB-ID 2036692-9
    ISSN 1615-2921
    Database Current Contents Medicine

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  5. Article: Sepsis: Komplement-abhängige Mechanismen

    Riedemann, N. C. / Guo, R.-F. / Pape, H. C. / v. Griensven, M. / Ward, P. A. / Krettek, C.

    Journal für Anästhesie und Intensivbehandlung

    2005  Volume -, Issue 1, Page(s) 286

    Language German
    Document type Article
    ZDB-ID 1232203-9
    ISSN 0941-4223
    Database Current Contents Medicine

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  6. Article: Protective effects of anti-C5a peptide antibodies in experimental sepsis.

    Huber-Lang, M S / Sarma, J V / McGuire, S R / Lu, K T / Guo, R F / Padgaonkar, V A / Younkin, E M / Laudes, I J / Riedemann, N C / Younger, J G / Ward, P A

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology

    2001  Volume 15, Issue 3, Page(s) 568–570

    Abstract: We evaluated antibodies to different peptide regions of rat C5a in the sepsis model of cecal ligation and puncture (CLP) for their protective effects in rats. Rabbit polyclonal antibodies were developed to the following peptide regions of rat C5a: amino- ... ...

    Abstract We evaluated antibodies to different peptide regions of rat C5a in the sepsis model of cecal ligation and puncture (CLP) for their protective effects in rats. Rabbit polyclonal antibodies were developed to the following peptide regions of rat C5a: amino-terminal region (A), residues 1-16; middle region (M), residues 17-36; and the carboxyl-terminal region (C), residues 58-77. With rat neutrophils, the chemotactic activity of rat C5a was significantly inhibited by antibodies with the following rank order: anti-C > anti-M >> anti-A. In vivo, antibodies to the M and C (but not A) regions of C5a were protective in experimental sepsis, as determined by survival over a 10-day period, in a dose-dependent manner. The relative protective efficacies of anti-C5a preparations (in descending order of efficacy) were anti-C > anti-M >> anti-A. In CLP rats, a delay in infusion of antibodies, which were injected at 6 or 12 h after CLP, still resulted in significant improvement in survival rates. These in vivo and in vitro data suggest that there are optimal targets on C5a for blockade during sepsis and that delayed infusion of anti-C5a antibody until after onset of clinical evidence of sepsis still provides protective effects.
    MeSH term(s) Animals ; Antibodies/immunology ; Antibodies/metabolism ; Antibodies/therapeutic use ; Cells, Cultured ; Chemotaxis, Leukocyte/drug effects ; Complement C5a/immunology ; Erythrocytes/drug effects ; Hemolysis ; Models, Biological ; Neutrophils/drug effects ; Peptides/immunology ; Peptides/metabolism ; Protein Structure, Tertiary ; Rats ; Sepsis/chemically induced ; Sepsis/drug therapy ; Sepsis/immunology ; Sheep ; Survival Rate
    Chemical Substances Antibodies ; Peptides ; Complement C5a (80295-54-1)
    Language English
    Publishing date 2001-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639186-2
    ISSN 1530-6860 ; 0892-6638
    ISSN (online) 1530-6860
    ISSN 0892-6638
    DOI 10.1096/fj.00-0653fje
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    Zs.MO 296: Show issues

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  7. Article: Protective effects of anti-C5a in sepsis-induced thymocyte apoptosis.

    Guo, R F / Huber-Lang, M / Wang, X / Sarma, V / Padgaonkar, V A / Craig, R A / Riedemann, N C / McClintock, S D / Hlaing, T / Shi, M M / Ward, P A

    The Journal of clinical investigation

    2000  Volume 106, Issue 10, Page(s) 1271–1280

    Abstract: Multiorgan apoptosis occurs during sepsis. Following cecal ligation and puncture (CLP) in rats, thymocytes underwent apoptosis in a time-dependent manner. C5a blockade dramatically reduced thymocyte apoptosis as measured by thymic weight, binding of ... ...

    Abstract Multiorgan apoptosis occurs during sepsis. Following cecal ligation and puncture (CLP) in rats, thymocytes underwent apoptosis in a time-dependent manner. C5a blockade dramatically reduced thymocyte apoptosis as measured by thymic weight, binding of annexin V to thymocytes, and laddering of thymocyte DNA. When C5a was generated in vivo by infusion of purified cobra venom factor (CVF), thymocyte apoptosis was significantly increased. Similar results were found when CVF was injected in vivo during the early stages of CLP. In animals 12 hours after induction of CLP, there was an increase in the activities of caspase-3, -6, and -9, but not caspase-1 and -8. Cytosolic cytochrome c levels increased by twofold, whereas mitochondrial levels showed a 50% decrease. Western blot analysis revealed that the content of Bcl-X(L) (but not of Bcl-2, BAX, Bad, and Bim) significantly decreased in thymocytes after CLP. C5a blockade in the sepsis model almost completely inhibited caspase-3, -6, and -9 activation, significantly preserved cytochrome c in the mitochondrial fraction, and restored Bcl-X(L) expression. These data suggest that systemic activation of complement induces C5a-dependent apoptosis of thymocytes and that the blockade of C5a during sepsis rescues thymocytes from apoptosis.
    MeSH term(s) Animals ; Apoptosis ; Apoptosis Regulatory Proteins ; Bcl-2-Like Protein 11 ; Carrier Proteins/biosynthesis ; Caspase 3 ; Caspase 6 ; Caspase 9 ; Caspases/metabolism ; Complement C5a/immunology ; Complement C5a/metabolism ; Cytochrome c Group/metabolism ; Enzyme Activation ; Male ; Membrane Proteins ; Mitochondria/metabolism ; NF-kappa B/metabolism ; Organ Size ; Proto-Oncogene Proteins/biosynthesis ; Proto-Oncogene Proteins c-bcl-2/biosynthesis ; Rabbits ; Rats ; Rats, Long-Evans ; Sepsis/metabolism ; Thymus Gland/cytology ; Thymus Gland/metabolism ; bcl-2-Associated X Protein ; bcl-Associated Death Protein ; bcl-X Protein
    Chemical Substances Apoptosis Regulatory Proteins ; Bad protein, rat ; Bax protein, rat ; Bcl-2-Like Protein 11 ; Bcl2l1 protein, rat ; Bcl2l11 protein, rat ; Carrier Proteins ; Cytochrome c Group ; Membrane Proteins ; NF-kappa B ; Proto-Oncogene Proteins ; Proto-Oncogene Proteins c-bcl-2 ; bcl-2-Associated X Protein ; bcl-Associated Death Protein ; bcl-X Protein ; Complement C5a (80295-54-1) ; Casp3 protein, rat (EC 3.4.22.-) ; Casp6 protein, rat (EC 3.4.22.-) ; Casp9 protein, rat (EC 3.4.22.-) ; Caspase 3 (EC 3.4.22.-) ; Caspase 6 (EC 3.4.22.-) ; Caspase 9 (EC 3.4.22.-) ; Caspases (EC 3.4.22.-)
    Language English
    Publishing date 2000-11
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI10793
    Database MEDical Literature Analysis and Retrieval System OnLINE

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