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Article: Neue technische Möglichkeiten in der Leberchirurgie

Riediger, C. / Weitz, J.

2021 Volume 12, Issue Febr., Page(s) 10

Language	German
Document type	Article
ZDB-ID	2761631-9
Database	Current Contents Medicine

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Article ; Online: Effectiveness of patient triage at the orthopedic hospital and the hygiene concept in a professional handball team in the first year of the SARS-CoV-2 pandemic.

Varganov, Pavel / Riediger, Christian / Lohmann, Christoph / Illiger, Sebastian

Orthopadie (Heidelberg, Germany)

2023 Volume 52, Issue 7, Page(s) 587–594

Abstract: The first severe acute respiratory syndrome coronavirus type 2 (SARS-CoV‑2) pandemic wave in Germany in spring 2020 challenged the largely unprepared healthcare system. A prevention concept was implemented to protect the vulnerable patient group at our ... ...

Title translation	Effektivität der Patiententriage in der Orthopädieambulanz einer Universitätsklinik und des Hygienekonzeptes einer Profi-Handballmannschaft im ersten Jahr der SARS-CoV-2-Pandemie.
Abstract	The first severe acute respiratory syndrome coronavirus type 2 (SARS-CoV‑2) pandemic wave in Germany in spring 2020 challenged the largely unprepared healthcare system. A prevention concept was implemented to protect the vulnerable patient group at our orthopedic department. The patient triage during the pre-admission process included screening for symptoms and obtaining information on travel, occupation, contact and cluster (TOCC) [16].In March 2020, all sporting events were also cancelled or postponed [12]. Mitigation strategies for sport activities were necessary to restart training and competition. For the professional handball team of the Sport Club Magdeburg (SCM), a hygiene concept including strict mitigation measures combined with a polymerase chain reaction (PCR) test regime was implemented.We reviewed 15,739 patient contacts in a 12-month period at orthopedic department during the SARS-CoV‑2 pandemic. This epidemiological, retrospective study presents the results of patient triage detecting cases with suspected SARS-CoV‑2 infections when entering the clinic. We also considered 2328 inpatient PCR test results and the infection rates among the medical staff. At the same period, professional athletes underwent 1428 PCR tests as a part of the hygiene concept.During the triage process, 333 cases (2.12%) with suspected SARS-CoV‑2 infections were detected at the orthopedic outpatient department. Three patients had a positive PCR test result after triage. Another four positive PCR tests were found among the inpatient group and one positive result among the medical staff. In the athletes' cohort, none of the 1428 PCR tests was positive.Patient triage as a part of the preadmission process is an effective tool to protect the maximum-care hospital from a SARS-CoV‑2 mass outbreak. A hygiene concept with a defined PCR test regime protects a professional athlete team from SARS-CoV‑2 infections during international competition and training.
MeSH term(s)	Humans ; SARS-CoV-2/genetics ; COVID-19/epidemiology ; Retrospective Studies ; Pandemics/prevention & control ; Triage ; Hospitals ; Hygiene ; Inpatients
Language	English
Publishing date	2023-04-24
Publishing country	Germany
Document type	Review ; Journal Article
ISSN	2731-7153
ISSN (online)	2731-7153
DOI	10.1007/s00132-023-04358-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Thesis: Lansoprazol und Azithromycin

Riediger, Christine

antibakterielle Aktivität allein und in Kombination gegen Helicobacter pylori in vitro

2000

Author's details	vorgelegt von Christine Riediger
Language	German
Size	83 Bl., Ill., graph. Darst., 30 cm
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Ulm, Univ., Diss., 2001
HBZ-ID	HT013334814
Database	Catalogue ZB MED Medicine, Health

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2002 E 1420	order for loan	Magazin

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Article ; Online: How we do it-the use of peritoneal patches for reconstruction of vena cava inferior and portal vein in hepatopancreatobiliary surgery.

Radulova-Mauersberger, O / Distler, M / Riediger, C / Weitz, J / Welsch, T / Kirchberg, J

Langenbeck's archives of surgery

2022 Volume 407, Issue 8, Page(s) 3819–3831

Abstract: Purpose: Extended resections in hepatopancreatobiliary (HPB) surgery frequently require vascular resection to obtain tumor clearance. The use of alloplastic grafts may increase postoperative morbidity due to septic or thrombotic complications. The use ... ...

Abstract	Purpose: Extended resections in hepatopancreatobiliary (HPB) surgery frequently require vascular resection to obtain tumor clearance. The use of alloplastic grafts may increase postoperative morbidity due to septic or thrombotic complications. The use of suitable autologous venous interponates (internal jugular vein, great saphenous vein) is frequently associated with additional incisions. The aim of this study was to report on our experience with venous reconstruction using the introperative easily available parietal peritoneum, focusing on key technical aspects. Methods: All patients who underwent HPB resections with venous reconstruction using peritoneal patches at our department between January 2017 and November 2021 were included in this retrospective analysis with median follow-up of 2 months (IQR: 1-8 months). We focused on technical aspects of the procedure and evaluated vascular patency and perioperative morbidity. Results: Parietal peritoneum patches (PPPs) were applied for reconstruction of the inferior vena cava (IVC) (13 patients) and portal vein (PV) (4 patients) during major hepatic (n = 14) or pancreatic (n = 2) resections. There were no cases of postoperative bleeding due to anastomotic leakage. Following PV reconstruction, two patients showed postoperative vascular stenosis after severe pancreatitis with postoperative pancreatic fistula and bile leakage, respectively. In patients with reconstruction of the IVC, no relevant perioperative vascular complications occurred. Conclusions: The use of a peritoneal patch for reconstruction of the IVC in HPB surgery is a feasible, effective, and low-cost alternative to alloplastic, xenogenous, or venous grafts. The graft can be easily harvested and tailored to the required size. More evidence is still needed to confirm the safety of this procedure for the portal vein regarding long-term results.
Language	English
Publishing date	2022-09-22
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1423681-3
ISSN	1435-2451 ; 1435-2443
ISSN (online)	1435-2451
ISSN	1435-2443
DOI	10.1007/s00423-022-02662-x
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Article ; Online: Influence of humeral position of the Affinis short® stemless shoulder arthroplasty system on long-term survival and clinical outcome.

Halm-Pozniak, Agnieszka / Riediger, Christian / Kopsch, Elisabeth / Awiszus, Friedemann / Lohmann, Christoph H / Berth, Alexander

Journal of shoulder and elbow surgery

2024

Abstract: Background: The purpose of this study was to evaluate the influence of humeral position of Affinis short implant in stemless anatomic total shoulder arthroplasties (STSA) on clinical and radiological results and mid- to long-term survival in the ... ...

Abstract	Background: The purpose of this study was to evaluate the influence of humeral position of Affinis short implant in stemless anatomic total shoulder arthroplasties (STSA) on clinical and radiological results and mid- to long-term survival in the treatment of primary osteoarthritis (OA) of the shoulder. Methods: 80 patients treated with a stemless shoulder arthroplasty for OA of the shoulder were evaluated with a mean follow-up (FU) of 92 ± 14 months (range 69 to 116 months) by Constant (CS)-Score, Disability of Shoulder, Arm and Hand (DASH)-Score and active range of motion (ROM). Radiographic assessment for bone adaptations and humeral implant position was performed by plain X-rays. Determination of pre- and postoperative center of rotation (COR) was used to assess the restoration of the geometry of the humeral head. The appraisal of proper humeral component positioning was correlated with the functional outcomes. A Kaplan-Meier analysis was calculated, investigating the influence of humeral implant position compared to survival time. Complications were noted. Results: The ROM (p < 0.001), CS-Score (p < 0.001) and DASH-Score (p < 0.001) showed significant improvements after surgery for the entire series. The COR restoration was anatomical in 75 % (n = 60) of all implants and in 25 % (n = 20) non-anatomical (pre- and postoperative COR deviation of 2.7 ± 1.8 mm vs. 5.1 ± 3.2 mm, p = 0.0380). The humeral component position did not affect the functional outcome whereas the ten-year unadjusted cumulative survival rate for the anatomic group was significant higher in comparison with the non-anatomical group (96.7 % vs. 75 %, p = 0.002). The radiological evaluation revealed minor periprosthetic bone adaptions in various forms without clinical significance or further intervention. No revision was necessary due to a failed fixation of the stemless humeral component. Conclusions: Regarding primary OA of the shoulder, STSA derives excellent long-term survival and clinical outcome. These types of implants are able to restore the geometry of the humeral head. Non-anatomical reconstruction may influence the survival over a long-term period on different pathways. Further studies are necessary to elucidate the effect of humeral component position in STSA on functionality, pain and implant survival rate.
Language	English
Publishing date	2024-03-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	1170782-3
ISSN	1532-6500 ; 1058-2746
ISSN (online)	1532-6500
ISSN	1058-2746
DOI	10.1016/j.jse.2024.01.051
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Book ; Thesis: Adenoviral-vermittelte Immuntherapie des kolorektalen Karzinoms mit Flt3-Ligand im Mausmodell

Riediger, Carina

2005

Author's details	vorgelegt von Carina Riediger
Language	German
Size	86 Bl. : Ill., graph. Darst.
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Heidelberg, Univ., Diss., 2005
HBZ-ID	HT014504486
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: Prädiktoren für erfolgreiche Lebertransplantationen und Risikofaktoren.

Riediger, Carina / Schweipert, Johannes / Weitz, Jürgen

Zentralblatt fur Chirurgie

2022 Volume 147, Issue 4, Page(s) 369–380

Abstract: Liver transplantation is the only curative treatment option for end stage liver disease. Moreover, oncological liver disease (hepatocellular carcinoma) is an important relevant indication for liver transplantation, together with acute liver failure.Since ...

Title translation	Predictors for Successful Liver Transplantation and Risk Factors.
Abstract	Liver transplantation is the only curative treatment option for end stage liver disease. Moreover, oncological liver disease (hepatocellular carcinoma) is an important relevant indication for liver transplantation, together with acute liver failure.Since the first successful liver transplantation by Professor Thomas Starzl in 1967, liver transplantation has changed in many aspects. This concerns not only surgical, anaesthesiological and immunological improvements and further technical developments, but also altered patient characteristics. Patients undergoing liver transplantation are nowadays often more challenging, due to their age and relevant comorbidities.The number of liver transplantations is constantly rising. However, there are more patients in need of liver transplantation than donor grafts are available. Discrepancies between liver transplant candidates and organ supply can only partially be compensated by split liver transplantation and liver transplantation from living donors.To boost the pool of donor grafts, even marginal organs within the extended donor criteria (EDC) are being increasingly allocated. In some countries, even "donation after cardiac death (DCD) organs" are allocated as well.Marginal donor grafts are often associated with reduced graft and patient survival after liver transplantation. To improve the quality of poor liver grafts, innovations in organ conservation with development of new techniques as the machine perfusion techniques have been established in recent years.In summary, the constellation of risk factors of donor grafts as well as transplant recipients has become more challenging in recent decades. It is important to know the specific risk factors and predictors for liver transplantation, in order to obtain the best possible graft and patient survival after liver transplantation.This review gives an overview of predictors for liver transplantation, specific risk scores and indices for donor/recipient match as well as new technical devices in liver transplantation.
MeSH term(s)	End Stage Liver Disease ; Graft Survival ; Humans ; Liver Transplantation/methods ; Living Donors ; Risk Factors ; Tissue Donors ; Tissue and Organ Procurement
Language	German
Publishing date	2022-07-21
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	200935-3
ISSN	1438-9592 ; 0044-409X
ISSN (online)	1438-9592
ISSN	0044-409X
DOI	10.1055/a-1866-4197
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Uk I Zs.25: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Comparative analysis of radiomics and deep-learning algorithms for survival prediction in hepatocellular carcinoma.

Schön, Felix / Kieslich, Aaron / Nebelung, Heiner / Riediger, Carina / Hoffmann, Ralf-Thorsten / Zwanenburg, Alex / Löck, Steffen / Kühn, Jens-Peter

Scientific reports

2024 Volume 14, Issue 1, Page(s) 590

Abstract: To examine the comparative robustness of computed tomography (CT)-based conventional radiomics and deep-learning convolutional neural networks (CNN) to predict overall survival (OS) in HCC patients. Retrospectively, 114 HCC patients with pretherapeutic ... ...

Abstract	To examine the comparative robustness of computed tomography (CT)-based conventional radiomics and deep-learning convolutional neural networks (CNN) to predict overall survival (OS) in HCC patients. Retrospectively, 114 HCC patients with pretherapeutic CT of the liver were randomized into a development (n = 85) and a validation (n = 29) cohort, including patients of all tumor stages and several applied therapies. In addition to clinical parameters, image annotations of the liver parenchyma and of tumor findings on CT were available. Cox-regression based on radiomics features and CNN models were established and combined with clinical parameters to predict OS. Model performance was assessed using the concordance index (C-index). Log-rank tests were used to test model-based patient stratification into high/low-risk groups. The clinical Cox-regression model achieved the best validation performance for OS (C-index [95% confidence interval (CI)] 0.74 [0.57-0.86]) with a significant difference between the risk groups (p = 0.03). In image analysis, the CNN models (lowest C-index [CI] 0.63 [0.39-0.83]; highest C-index [CI] 0.71 [0.49-0.88]) were superior to the corresponding radiomics models (lowest C-index [CI] 0.51 [0.30-0.73]; highest C-index [CI] 0.66 [0.48-0.79]). A significant risk stratification was not possible (p > 0.05). Under clinical conditions, CNN-algorithms demonstrate superior prognostic potential to predict OS in HCC patients compared to conventional radiomics approaches and could therefore provide important information in the clinical setting, especially when clinical data is limited.
MeSH term(s)	Humans ; Carcinoma, Hepatocellular/diagnostic imaging ; Deep Learning ; Radiomics ; Retrospective Studies ; Liver Neoplasms/diagnostic imaging ; Algorithms
Language	English
Publishing date	2024-01-05
Publishing country	England
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-50451-3
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Article ; Online: Preoperative IL-8 levels as prognostic indicators of overall survival: an extended follow-up in a prospective cohort with colorectal liver metastases.

Pecqueux, Mathieu / Brückner, Frederik / Oehme, Florian / Hempel, Sebastian / Baenke, Franziska / Riediger, Carina / Distler, Marius / Weitz, Jürgen / Kahlert, Christoph

BMC cancer

2024 Volume 24, Issue 1, Page(s) 90

Abstract: Introduction: CRC with liver metastases is a major contributor to cancer-related mortality. Despite advancements in liver resection techniques, patient survival remains a concern due to high recurrence rates. This study seeks to uncover prognostic ... ...

Abstract	Introduction: CRC with liver metastases is a major contributor to cancer-related mortality. Despite advancements in liver resection techniques, patient survival remains a concern due to high recurrence rates. This study seeks to uncover prognostic biomarkers that predict overall survival in patients undergoing curative hepatic resection for CRC liver metastases. Methods: Prospectively collected serum samples from a cohort of 49 patients who received curative hepatic resection for CRC liver metastases were studied. The patients are part of a cohort, previously analyzed for perioperative complications (see methods). Various preoperative serum markers, clinical characteristics, and factors were analyzed. Univariate and multivariate Cox regression analyses were conducted to determine associations between these variables and disease-free survival as well as overall survival. Results: For disease-free survival, univariate analysis highlighted the correlation between poor outcomes and advanced primary tumor stage, high ASA score, and synchronous liver metastases. Multivariate analysis identified nodal-positive primary tumors and synchronous metastases as independent risk factors for disease-free survival. Regarding overall survival, univariate analysis demonstrated significant links between poor survival and high preoperative IL-8 levels, elevated neutrophil-lymphocyte ratio (NLR), and presence of metastases in other organs. Multivariate analysis confirmed preoperative IL-8 and having three or more liver metastases as independent risk factors for overall survival. The impact of IL-8 on survival was particularly noteworthy, surpassing the influence of established clinical factors. Conclusion: This study establishes preoperative IL-8 levels as a potential prognostic biomarker for overall survival in patients undergoing curative liver resection for CRC liver metastases. This study underscores the importance of incorporating IL-8 and other biomarkers into clinical decision-making, facilitating improved patient stratification and tailored treatment approaches. Further research and validation studies are needed to solidify the clinical utility of IL-8 as a prognostic marker.
MeSH term(s)	Humans ; Biomarkers ; Colorectal Neoplasms/pathology ; Follow-Up Studies ; Hepatectomy ; Interleukin-8 ; Liver Neoplasms/secondary ; Prognosis ; Prospective Studies ; Retrospective Studies
Chemical Substances	Biomarkers ; Interleukin-8 ; CXCL8 protein, human
Language	English
Publishing date	2024-01-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2041352-X
ISSN	1471-2407 ; 1471-2407
ISSN (online)	1471-2407
ISSN	1471-2407
DOI	10.1186/s12885-023-11787-1
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Article ; Online: Transfusions of packed red blood cells in surgery for liver cancer: predictor of impaired overall survival but not recurrence-free survival - impact of blood transfusions in liver surgery.

Giehl-Brown, Esther / Geipel, Eileen / Löck, Steffen / Dehlke, Karolin / Schweipert, Johannes / Weitz, Jürgen / Riediger, Carina

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract

2024 Volume 28, Issue 4, Page(s) 402–411

Abstract: Background: Liver surgery remains a cornerstone of potentially curative multimodal treatments for primary malignancies of the liver and hepatic metastases. Improving perioperative safety is a prerequisite in this context. Perioperative blood ... ...

Abstract	Background: Liver surgery remains a cornerstone of potentially curative multimodal treatments for primary malignancies of the liver and hepatic metastases. Improving perioperative safety is a prerequisite in this context. Perioperative blood transfusions negatively influence postoperative recovery. This study aimed to identify risk factors for perioperative packed red blood cell (PRBC) transfusion and to elucidate its effect on postoperative outcomes. Methods: This was an observational study of a prospective data collection. A monocentric, retrospective analysis of 1118 hepatectomies at the University Hospital Carl Gustav Carus between 2013 and 2020 was conducted to compare postoperative short- and long-term outcomes in patients undergoing curative intended liver resection of hepatic primary or secondary malignancies. The outcomes were compared between 356 patients (31.8%) who received PRBC transfusions during surgery or within 7 days after surgery and 762 patients (68.2%) who did not receive PRBC transfusions. Results: Preoperative anemia could be observed in 45.0% of the whole cohort: 65.7% in the PRBC transfusion group and 35.3% in the nontransfused group. Postoperative complications were significantly more common in the PRBC transfusion group in association with prolonged lengths of hospital stay and increased 30-day mortality than in the nontransfused group. After adjustment for possible confounders, preexisting kidney failure, preoperative hemoglobin and albumin levels outside of the reference range, intraoperative plasma transfusions, and overall surgery time were recognized as negative predictors for perioperative PRBC transfusions. PRBC transfusion increased the risk of death by approximately 38.8% (hazard ratio, 1.388; 95% CI, 1.027-1.876; P = .033), whereas no influence on recurrence-free survival (RFS) was observed. Conclusion: PRBC transfusions were associated with postoperative morbidity and mortality after curative-intended surgery for liver cancers and represented an independent poor prognostic indicator for overall survival but not for RFS.
MeSH term(s)	Humans ; Retrospective Studies ; Blood Transfusion ; Liver Neoplasms/surgery ; Erythrocytes
Language	English
Publishing date	2024-01-23
Publishing country	Netherlands
Document type	Observational Study ; Journal Article
ZDB-ID	2012365-6
ISSN	1873-4626 ; 1934-3213 ; 1091-255X
ISSN (online)	1873-4626 ; 1934-3213
ISSN	1091-255X
DOI	10.1016/j.gassur.2023.12.019
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