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  1. AU="Rienecker, Kira D A"
  2. AU="Neumaier, Bernd"
  3. AU="Boxhorn, Christine E."
  4. AU="Vignati M."
  5. AU=Sehn Laurie H
  6. AU="States, Richard"
  7. AU="Chao, Christine P"
  8. AU="Jegathisawaran, Jathishinie"
  9. AU="Inoue, Fumitaka"
  10. AU="Moore, Duncan T"
  11. AU="van Leeuwen, Nikki"
  12. AU="Anthony, James"
  13. AU="Abakay, Osman"
  14. AU="Ripà, Paola"
  15. AU="Harvey, P J"
  16. AU="Chopra, Jyoti"
  17. AU="Felitti, V. J."
  18. AU=Bleasel Martin D AU=Bleasel Martin D
  19. AU="Singh, Vimal Shankar"
  20. AU="Zanzottera, Milena"
  21. AU="Gössl, Mario"
  22. AU=Marshall Keri
  23. AU="Nava, M"
  24. AU="Banville, Allyson C"
  25. AU="Riethmuller, Didier"
  26. AU="Schoenbaechler, Valérie"
  27. AU="Liu, Shaohui"
  28. AU="Wennen, Myrte"

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  1. Article ; Online: Merits and Limitations of Studying Neuronal Depolarization-Dependent Processes Using Elevated External Potassium.

    Rienecker, Kira D A / Poston, Robert G / Saha, Ramendra N

    ASN neuro

    2020  Volume 12, Page(s) 1759091420974807

    Abstract: Elevated extracellular potassium chloride is widely used to achieve membrane depolarization of cultured neurons. This technique has illuminated mechanisms of calcium influx through L-type voltage sensitive calcium channels, activity-regulated signaling, ... ...

    Abstract Elevated extracellular potassium chloride is widely used to achieve membrane depolarization of cultured neurons. This technique has illuminated mechanisms of calcium influx through L-type voltage sensitive calcium channels, activity-regulated signaling, downstream transcriptional events, and many other intracellular responses to depolarization. However, there is enormous variability in these treatments, including durations from seconds to days and concentrations from 3mM to 150 mM KCl. Differential effects of these variable protocols on neuronal activity and transcriptional programs are underexplored. Furthermore, potassium chloride treatments
    MeSH term(s) Action Potentials/drug effects ; Action Potentials/physiology ; Animals ; Calcium Channels, L-Type/physiology ; Humans ; Membrane Potentials/drug effects ; Membrane Potentials/physiology ; Neuromuscular Depolarizing Agents/pharmacology ; Neurons/drug effects ; Neurons/physiology ; Potassium Chloride/pharmacology
    Chemical Substances Calcium Channels, L-Type ; Neuromuscular Depolarizing Agents ; Potassium Chloride (660YQ98I10)
    Language English
    Publishing date 2020-11-30
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2485467-0
    ISSN 1759-0914 ; 1759-0914
    ISSN (online) 1759-0914
    ISSN 1759-0914
    DOI 10.1177/1759091420974807
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Microglia: Ally and Enemy in Deep Space.

    Rienecker, Kira D A / Paladini, Maria Serena / Grue, Katherine / Krukowski, Karen / Rosi, Susanna

    Neuroscience and biobehavioral reviews

    2021  Volume 126, Page(s) 509–514

    Abstract: In 2024 the first female astronaut will land on the moon, advancing our preparations for human missions to Mars. While on Earth we are protected from space radiation by our planet's magnetic field, on such deep space voyages astronauts will be exposed to ...

    Abstract In 2024 the first female astronaut will land on the moon, advancing our preparations for human missions to Mars. While on Earth we are protected from space radiation by our planet's magnetic field, on such deep space voyages astronauts will be exposed to high energy particles from solar flares and galactic cosmic rays (GCR). This exposure carries risks to the central nervous system (CNS) that could jeopardize the mission and astronaut health. Earth-bound studies have employed a variety of single-beam and sequential radiation exposures to simulate the effects of GCR exposure in rodents. Multiple studies have shown that GCR simulation induces a maladaptive activation of microglia - the brain-resident immune cells. GCR simulation also induced synaptic changes resulting in lasting cognitive and behavioral defects. Female and male mice show different susceptibilities to GCR exposure, and evidence suggests this sexually dimorphic response is linked to microglia. Manipulating microglia can prevent the development of cognitive deficits in male mice exposed to components of GCR. This discovery may provide clues towards how to protect astronauts' cognitive and behavioral health both during deep space missions and upon return to Earth.
    MeSH term(s) Animals ; Astronauts ; Cosmic Radiation ; Female ; Humans ; Male ; Mice ; Microglia ; Space Flight
    Language English
    Publishing date 2021-04-16
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 282464-4
    ISSN 1873-7528 ; 0149-7634
    ISSN (online) 1873-7528
    ISSN 0149-7634
    DOI 10.1016/j.neubiorev.2021.03.036
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1371: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Combined space stressors induce independent behavioral deficits predicted by early peripheral blood monocytes.

    Rienecker, Kira D A / Grue, Katherine / Paladini, Maria Serena / Frias, Elma S / Frattini, Valentina / Borlongan, Mia C / Chou, Austin / Torres-Espin, Abel / Krukowski, Karen / Ferguson, Adam R / Rosi, Susanna

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 1749

    Abstract: Interplanetary space travel poses many hazards to the human body. To protect astronaut health and performance on critical missions, there is first a need to understand the effects of deep space hazards, including ionizing radiation, confinement, and ... ...

    Abstract Interplanetary space travel poses many hazards to the human body. To protect astronaut health and performance on critical missions, there is first a need to understand the effects of deep space hazards, including ionizing radiation, confinement, and altered gravity. Previous studies of rodents exposed to a single such stressor document significant deficits, but our study is the first to investigate possible cumulative and synergistic impacts of simultaneous ionizing radiation, confinement, and altered gravity on behavior and cognition. Our cohort was divided between 6-month-old female and male mice in group, social isolation, or hindlimb unloading housing, exposed to 0 or 50 cGy of 5 ion simplified simulated galactic cosmic radiation (GCRsim). We report interactions and independent effects of GCRsim exposure and housing conditions on behavioral and cognitive performance. Exposure to GCRsim drove changes in immune cell populations in peripheral blood collected early after irradiation, while housing conditions drove changes in blood collected at a later point. Female mice were largely resilient to deficits observed in male mice. Finally, we used principal component analysis to represent total deficits as principal component scores, which were predicted by general linear models using GCR exposure, housing condition, and early blood biomarkers.
    MeSH term(s) Humans ; Female ; Male ; Animals ; Mice ; Infant ; Monocytes ; Cognition ; Social Isolation ; Astronauts ; Cosmic Radiation
    Language English
    Publishing date 2023-01-31
    Publishing country England
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-28508-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Detailed analysis of paternal knockout Grb10 mice suggests effects on stability of social behavior, rather than social dominance.

    Rienecker, Kira D A / Chavasse, Alexander T / Moorwood, Kim / Ward, Andrew / Isles, Anthony R

    Genes, brain, and behavior

    2019  Volume 19, Issue 1, Page(s) e12571

    Abstract: Imprinted genes are highly expressed in monoaminergic regions of the midbrain and their functions in this area are thought to have an impact on mammalian social behaviors. One such imprinted gene is Grb10, of which the paternal allele is generally ... ...

    Abstract Imprinted genes are highly expressed in monoaminergic regions of the midbrain and their functions in this area are thought to have an impact on mammalian social behaviors. One such imprinted gene is Grb10, of which the paternal allele is generally recognized as mediating social dominance behavior. However, there has been no detailed study of social dominance in Grb10
    MeSH term(s) Animals ; Female ; GRB10 Adaptor Protein/genetics ; Gene Deletion ; Male ; Mice ; Paternal Inheritance ; Social Dominance ; Social Isolation ; Stress, Psychological/genetics
    Chemical Substances Grb10 protein, mouse ; GRB10 Adaptor Protein (151441-47-3)
    Language English
    Publishing date 2019-04-29
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2075819-4
    ISSN 1601-183X ; 1601-1848
    ISSN (online) 1601-183X
    ISSN 1601-1848
    DOI 10.1111/gbb.12571
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5642: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Aberrant cortical spine dynamics after concussive injury are reversed by integrated stress response inhibition.

    Frias, Elma S / Hoseini, Mahmood S / Krukowski, Karen / Paladini, Maria Serena / Grue, Katherine / Ureta, Gonzalo / Rienecker, Kira D A / Walter, Peter / Stryker, Michael P / Rosi, Susanna

    Proceedings of the National Academy of Sciences of the United States of America

    2022  Volume 119, Issue 42, Page(s) e2209427119

    Abstract: Traumatic brain injury (TBI) is a leading cause of long-term neurological disability in the world and the strongest environmental risk factor for the development of dementia. Even mild TBI (resulting from concussive injuries) is associated with a greater ...

    Abstract Traumatic brain injury (TBI) is a leading cause of long-term neurological disability in the world and the strongest environmental risk factor for the development of dementia. Even mild TBI (resulting from concussive injuries) is associated with a greater than twofold increase in the risk of dementia onset. Little is known about the cellular mechanisms responsible for the progression of long-lasting cognitive deficits. The integrated stress response (ISR), a phylogenetically conserved pathway involved in the cellular response to stress, is activated after TBI, and inhibition of the ISR-even weeks after injury-can reverse behavioral and cognitive deficits. However, the cellular mechanisms by which ISR inhibition restores cognition are unknown. Here, we used longitudinal two-photon imaging in vivo after concussive injury in mice to study dendritic spine dynamics in the parietal cortex, a brain region involved in working memory. Concussive injury profoundly altered spine dynamics measured up to a month after injury. Strikingly, brief pharmacological treatment with the drug-like small-molecule ISR inhibitor ISRIB entirely reversed structural changes measured in the parietal cortex and the associated working memory deficits. Thus, both neural and cognitive consequences of concussive injury are mediated in part by activation of the ISR and can be corrected by its inhibition. These findings suggest that targeting ISR activation could serve as a promising approach to the clinical treatment of chronic cognitive deficits after TBI.
    MeSH term(s) Animals ; Brain Concussion/complications ; Brain Injuries, Traumatic/complications ; Cognitive Dysfunction/etiology ; Dementia ; Memory Disorders ; Mice
    Language English
    Publishing date 2022-10-13
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2209427119
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1148: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  6. Article ; Online: Mice lacking paternal expression of imprinted Grb10 are risk-takers.

    Dent, Claire L / Rienecker, Kira D A / Ward, Andrew / Wilkins, Jon F / Humby, Trevor / Isles, Anthony R

    Genes, brain, and behavior

    2020  Volume 19, Issue 7, Page(s) e12679

    Abstract: The imprinted genes Grb10 and Nesp influence impulsive behavior on a delay discounting task in an opposite manner. A recently developed theory suggests that this pattern of behavior may be representative of predicted effects of imprinted genes on ... ...

    Abstract The imprinted genes Grb10 and Nesp influence impulsive behavior on a delay discounting task in an opposite manner. A recently developed theory suggests that this pattern of behavior may be representative of predicted effects of imprinted genes on tolerance to risk. Here we examine whether mice lacking paternal expression of Grb10 show abnormal behavior across a number of measures indicative of risk-taking. Although Grb10
    MeSH term(s) Animals ; Fear ; Female ; GRB10 Adaptor Protein/genetics ; Genomic Imprinting ; Male ; Mice ; Motivation ; Risk-Taking
    Chemical Substances Grb10 protein, mouse ; GRB10 Adaptor Protein (151441-47-3)
    Language English
    Publishing date 2020-06-22
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2075819-4
    ISSN 1601-183X ; 1601-1848
    ISSN (online) 1601-183X
    ISSN 1601-1848
    DOI 10.1111/gbb.12679
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5642: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  7. Article ; Online: Mild membrane depolarization in neurons induces immediate early gene transcription and acutely subdues responses to a successive stimulus.

    Rienecker, Kira D A / Poston, Robert G / Segales, Joshua S / Finholm, Isabelle W / Sono, Morgan H / Munteanu, Sorina J / Ghaninejad-Esfahani, Mina / Rejepova, Ayna / Tejeda-Garibay, Susana / Wickman, Kevin / Marron Fernandez de Velasco, Ezequiel / Thayer, Stanley A / Saha, Ramendra N

    The Journal of biological chemistry

    2022  Volume 298, Issue 9, Page(s) 102278

    Abstract: Immediate early genes (IEGs) are transcribed in response to neuronal activity from sensory stimulation during multiple adaptive processes in the brain. The transcriptional profile of IEGs is indicative of the duration of neuronal activity, but its ... ...

    Abstract Immediate early genes (IEGs) are transcribed in response to neuronal activity from sensory stimulation during multiple adaptive processes in the brain. The transcriptional profile of IEGs is indicative of the duration of neuronal activity, but its sensitivity to the strength of depolarization remains unknown. Also unknown is whether activity history of graded potential changes influence future neuronal activity. In this work with dissociated rat cortical neurons, we found that mild depolarization-mediated by elevated extracellular potassium (K
    MeSH term(s) Action Potentials/drug effects ; Action Potentials/physiology ; Animals ; Bicuculline/pharmacology ; Calcineurin/genetics ; Calcineurin/metabolism ; Calcium/metabolism ; GABA-A Receptor Antagonists/pharmacology ; Genes, Immediate-Early/drug effects ; Mitogen-Activated Protein Kinases/metabolism ; Neurons/drug effects ; Neurons/physiology ; Potassium/metabolism ; Potassium/pharmacology ; Rats ; Receptors, N-Methyl-D-Aspartate/genetics ; Receptors, N-Methyl-D-Aspartate/metabolism ; Transcription, Genetic
    Chemical Substances GABA-A Receptor Antagonists ; Receptors, N-Methyl-D-Aspartate ; Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; Calcineurin (EC 3.1.3.16) ; Potassium (RWP5GA015D) ; Calcium (SY7Q814VUP) ; Bicuculline (Y37615DVKC)
    Language English
    Publishing date 2022-07-19
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1016/j.jbc.2022.102278
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uc I Zs.108: Show issues Location:
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