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  1. AU="Riis, Kamilla R"
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  1. Artikel ; Online: Nutrients, Diet, and Other Factors in Prenatal Life and Bone Health in Young Adults: A Systematic Review of Longitudinal Studies.

    Jensen, Karina H / Riis, Kamilla R / Abrahamsen, Bo / Händel, Mina N

    Nutrients

    2020  Band 12, Heft 9

    Abstract: Optimizing skeletal health in early life has potential effects on bone health later in childhood and in adulthood. We aimed to evaluate the existing evidence that maternal exposures during pregnancy have an impact on the subsequent bone health among ... ...

    Abstract Optimizing skeletal health in early life has potential effects on bone health later in childhood and in adulthood. We aimed to evaluate the existing evidence that maternal exposures during pregnancy have an impact on the subsequent bone health among offspring in young adults aged between 16 and 30 years. The protocol is registered in the International Prospective Register of Systematic Reviews (PROSPERO) (ID: CRD42019126890). The search was conducted up to 2 April 2019. We included seven observational prospective cohort studies that examined the association between maternal dietary factors, vitamin D concentration, age, preeclampsia, and smoking with any bone indices among offspring. The results indicated that high concentrations of maternal vitamin D; low fat intake; and high intakes of calcium, phosphorus, and magnesium may increase the bone mineral density in offspring at age 16. Evidence also suggests that the offspring of younger mothers may have a higher peak bone mass. It remains inconclusive whether there is an influence of preeclampsia or maternal smoking on bone health among young adults. Our assessment of internal validity warrants a cautious interpretation of these results, as all of the included studies were judged to have serious risks of bias. High-quality studies assessing whether prenatal prognostic factors are associated with bone health in young adults are needed.
    Mesh-Begriff(e) Adolescent ; Adult ; Bone Density ; Diet ; Female ; Humans ; Pregnancy ; Prenatal Nutritional Physiological Phenomena ; Young Adult
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-09-19
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Systematic Review
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu12092866
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Nutrients, Diet, and Other Factors in Prenatal Life and Bone Health in Young Adults: A Systematic Review of Longitudinal Studies

    Jensen, Karina H / Riis, Kamilla R / Abrahamsen, Bo / Händel, Mina N

    Nutrients. 2020 Sept. 19, v. 12, no. 9

    2020  

    Abstract: Optimizing skeletal health in early life has potential effects on bone health later in childhood and in adulthood. We aimed to evaluate the existing evidence that maternal exposures during pregnancy have an impact on the subsequent bone health among ... ...

    Abstract Optimizing skeletal health in early life has potential effects on bone health later in childhood and in adulthood. We aimed to evaluate the existing evidence that maternal exposures during pregnancy have an impact on the subsequent bone health among offspring in young adults aged between 16 and 30 years. The protocol is registered in the International Prospective Register of Systematic Reviews (PROSPERO) (ID: CRD42019126890). The search was conducted up to 2 April 2019. We included seven observational prospective cohort studies that examined the association between maternal dietary factors, vitamin D concentration, age, preeclampsia, and smoking with any bone indices among offspring. The results indicated that high concentrations of maternal vitamin D; low fat intake; and high intakes of calcium, phosphorus, and magnesium may increase the bone mineral density in offspring at age 16. Evidence also suggests that the offspring of younger mothers may have a higher peak bone mass. It remains inconclusive whether there is an influence of preeclampsia or maternal smoking on bone health among young adults. Our assessment of internal validity warrants a cautious interpretation of these results, as all of the included studies were judged to have serious risks of bias. High-quality studies assessing whether prenatal prognostic factors are associated with bone health in young adults are needed.
    Schlagwörter adulthood ; age ; bias ; bone density ; bone health ; calcium ; childhood ; diet ; fat intake ; magnesium ; phosphorus ; pre-eclampsia ; pregnancy ; progeny ; protocols ; systematic review ; validity
    Sprache Englisch
    Erscheinungsverlauf 2020-0919
    Erscheinungsort Multidisciplinary Digital Publishing Institute
    Dokumenttyp Artikel
    Anmerkung NAL-light
    ZDB-ID 2518386-2
    ISSN 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu12092866
    Datenquelle NAL Katalog (AGRICOLA)

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  3. Artikel ; Online: Hypothyroid women have persistently higher oxidative stress compared to healthy controls.

    Riis, Kamilla R / Larsen, Camilla B / Medici, Bjarke R / Jensen, Christian Z / Winther, Kristian H / Larsen, Emil L / Ellervik, Christina / la Cour, Jeppe L / Hegedüs, Laszlo / Brix, Thomas H / Poulsen, Henrik E / Knop, Filip K / Nygaard, Birte / Bonnema, Steen J

    European thyroid journal

    2023  Band 12, Heft 6

    Abstract: Objective: Some studies suggest that hypothyroidism is associated with increased oxidative stress. Urinary excretion of 8-oxo-7,8-dihydroguanosine (8-oxoGuo) and 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) represents whole-body RNA and DNA oxidation, ... ...

    Abstract Objective: Some studies suggest that hypothyroidism is associated with increased oxidative stress. Urinary excretion of 8-oxo-7,8-dihydroguanosine (8-oxoGuo) and 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) represents whole-body RNA and DNA oxidation, respectively. These biomarkers have only been explored sparsely in patients with thyroid disorders.
    Methods: In 45 Danish women with newly diagnosed hypothyroidism, we compared 8-oxoGuo and 8-oxodG before or shortly after initiating levothyroxine with the excretion rates at euthyroidism. We also compared the excretion of 8-oxoGuo and 8-oxodG in the patients after restored euthyroidism with 18 healthy control subjects.
    Results: Compared with baseline, none of the biomarkers changed significantly in the patients after becoming euthyroid. The geometric mean of 8-oxoGuo was 1.63 (95% CI: 1.49-1.78) nmol/mmol creatinine at baseline and 1.67 nmol/mmol at euthyroidism (95% CI: 1.53-1.83) (P = 0.39), while that of 8-oxodG was 1.28 nmol/mmol creatinine at baseline (95% CI: 1.14-1.44) and 1.32 nmol/mmol at euthyroidism (95% CI: 1.18-1.48), respectively (P = 0.47). The relative mean differences were 0.97 (95% CI: 0.91-1.04) for 8-oxoGuo and 0.97 (95% CI: 0.88-1.06) for 8-oxodG. At baseline, multiple linear regression revealed a positive association between free thyroxine and both biomarkers (8-oxoGuo, P < 0.001; 8-oxodG, P = 0.04). Furthermore, 8-oxoGuo was positively associated with age (P = 0.04) and negatively associated with thyrotropin (P = 0.02). In the control group, the geometric mean of 8-oxoGuo was 1.23 nmol/mmol creatinine (95% CI: 1.07-1.42), while that of 8-oxodG was 1.04 nmol/mmol creatinine (95% CI: 0.88-1.23). Thus, compared with control subjects, euthyroid patients showed a significantly higher level of both 8-oxoGuo (P < 0.001) and 8-oxodG (P = 0.03).
    Conclusion: In hypothyroid women, no significant effect of levothyroxine treatment on the oxidative stress biomarkers 8-oxoGuo and 8-oxodG could be demonstrated. However, the excretion of these biomarkers was significantly higher than in healthy controls.
    Mesh-Begriff(e) Humans ; Female ; 8-Hydroxy-2'-Deoxyguanosine/urine ; Thyroxine ; Creatinine/urine ; Oxidative Stress/genetics ; Biomarkers/urine ; Hypothyroidism/drug therapy
    Chemische Substanzen 8-Hydroxy-2'-Deoxyguanosine (88847-89-6) ; Thyroxine (Q51BO43MG4) ; Creatinine (AYI8EX34EU) ; Biomarkers
    Sprache Englisch
    Erscheinungsdatum 2023-11-03
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2659767-6
    ISSN 2235-0802 ; 2235-0640
    ISSN (online) 2235-0802
    ISSN 2235-0640
    DOI 10.1530/ETJ-23-0167
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Treatment of Hyperthyroidism Reduces Systemic Oxidative Stress, as Measured by Markers of RNA and DNA Damage.

    Larsen, Camilla B / Riis, Kamilla R / Winther, Kristian H / Larsen, Emil L / Ellervik, Christina / Hegedüs, Laszlo / Brix, Thomas H / Poulsen, Henrik E / Bonnema, Steen J

    The Journal of clinical endocrinology and metabolism

    2021  Band 106, Heft 7, Seite(n) e2512–e2520

    Abstract: Background: Whole-body oxidative stress can be estimated by the urine excretion of oxidized guanosine species, 8-oxo-7,8-dihydroguanosine (8-oxoGuo) and 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG), derived from RNA and DNA, respectively. These ... ...

    Abstract Background: Whole-body oxidative stress can be estimated by the urine excretion of oxidized guanosine species, 8-oxo-7,8-dihydroguanosine (8-oxoGuo) and 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG), derived from RNA and DNA, respectively. These oxidative stress markers are not well explored in thyroid disorders.
    Objective: We aimed to determine whether treatment of hyperthyroid patients affects the levels of these oxidative stress markers.
    Methods: Urinary excretion of 8-oxoGuo and 8-oxodG was measured in 51 hyperthyroid patients (toxic nodular goiter [TNG], n = 30; Graves disease [GD], n = 21) before or shortly after initiation of therapy and when stable euthyroidism had been achieved for at least 12 months.
    Results: Adjusting for age, the baseline urinary excretion of oxidative stress markers correlated positively with plasma thyroxine (8-oxoGuo, P = 0.002; 8-oxodG, P = 0.021) and was significantly higher in GD than in TNG patients (P = 0.001 for both oxidative stress markers). Restoration of euthyroidism significantly affected the excretion of the oxidative stress markers. In TNG, 8-oxoGuo decreased from geometric mean 2.11 nmol/mmol creatinine (95% CI, 1.85-2.39) to 1.91 nmol/mmol (95% CI, 1.67-2.19; P = 0.001), while 8-oxodG decreased from 1.65 nmol/mmol (95% CI, 1.41-1.93) to 1.48 nmol/mmol (95% CI, 1.27-1.74; P = 0.026). In GD, 8-oxoGuo decreased from 2.25 nmol/mmol (95% CI, 1.95-2.59) to 1.79 nmol/mmol (95% CI, 1.63-1.97; P = 0.0003), while 8-oxodG decreased from 2.02 nmol/mmol (95% CI, 1.73-2.38) to 1.54 nmol/mmol (95% CI, 1.31-1.81; P = 0.001). In the euthyroid state, there were no differences between groups.
    Conclusion: Restoration of euthyroidism in patients with hyperthyroidism significantly decreased the systemic oxidative stress load by 10% to 25%. Our findings may help to explain the higher morbidity and mortality linked to hyperthyroid diseases, as shown in observational studies.
    Mesh-Begriff(e) 8-Hydroxy-2'-Deoxyguanosine/urine ; Adult ; Aged ; Aged, 80 and over ; Antithyroid Agents/therapeutic use ; Biomarkers/urine ; DNA Damage ; Female ; Guanosine/analogs & derivatives ; Guanosine/urine ; Humans ; Hyperthyroidism/blood ; Hyperthyroidism/drug therapy ; Hyperthyroidism/urine ; Middle Aged ; Oxidative Stress ; Prospective Studies ; Thyroxine/blood ; Treatment Outcome ; Young Adult
    Chemische Substanzen Antithyroid Agents ; Biomarkers ; Guanosine (12133JR80S) ; 8-hydroxyguanosine (3868-31-3) ; 8-Hydroxy-2'-Deoxyguanosine (88847-89-6) ; Thyroxine (Q51BO43MG4)
    Sprache Englisch
    Erscheinungsdatum 2021-04-15
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/clinem/dgab273
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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