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  1. Article: Prevalence of Maxillary and Mandibular Frenal Attachment and Its Association with Age, Gender, and Oral Hygiene Status in Nepalese Population Seeking Dental Treatment.

    Rijal, Arjun Hari / Humagain, Manoj / Lamichhane, Simant / Ghimire, Pratistha / Thapa, Sachita

    International journal of dentistry

    2024  Volume 2024, Page(s) 4870253

    Abstract: Objective: Frenum attachments are folds of mucous membrane that connect the lips to the alveolar mucosa and underlying periosteum. Aberrant positioning of the maxillary and mandibular labial frenum can lead to various clinical issues, including ... ...

    Abstract Objective: Frenum attachments are folds of mucous membrane that connect the lips to the alveolar mucosa and underlying periosteum. Aberrant positioning of the maxillary and mandibular labial frenum can lead to various clinical issues, including mucogingival problems and midline diastema. The objective of this study was to assess the prevalence of maxillary and mandibular frenal attachments and their association with age, gender, and oral hygiene status in the Nepalese population seeking dental treatment.
    Materials and methods: This descriptive cross-sectional study was conducted over a period of 6 months, from February 2023 to August 2023, among patients visiting the Department of Periodontology and Oral Implantology, aged 6 years and above, after obtaining official permission from the Institutional Review Committee (IRC-KUSMS Approval No. 8/23). The study collected data on morphological variations of frenal attachment and various periodontal parameters such as Oral Hygiene Index-Simplified (OHI-S), pocket depth, recession, and midline diastema in both arches. Descriptive statistics, including frequency and percentage, were used to analyze the data. The
    Results: Among 380 patients, the prevalence of frenal attachment was as follows: gingival 248 (65.30%), mucosal 71 (18.70%), papillary 42 (11.10%), and papillary penetrating 19 (5.00%) in the maxilla, and mucosal 225 (59.20%) and gingival 155 (40.78%) in mandible. Among the different morphological variations of frenal attachments, normal frenum was the most common, accounting for 231 cases (60.80%), followed by frenum with a nodule, with 101 cases (26.60%).
    Conclusions: The study found significant associations between frenal attachment and gender, as well as oral hygiene status. The prevalence of frenal attachments in this study was comparable to findings from previous research.
    Language English
    Publishing date 2024-01-11
    Publishing country Egypt
    Document type Journal Article
    ZDB-ID 2546524-7
    ISSN 1687-8736 ; 1687-8728
    ISSN (online) 1687-8736
    ISSN 1687-8728
    DOI 10.1155/2024/4870253
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Evaluating the feasibility and potential of unmanned aerial vehicles to monitor implementation of forestry best management practices in the coastal plain of the southeastern United States

    Rijal, Arjun / Cristan, Richard / Gallagher, Tom / Narine, Lana L. / Parajuli, Manisha

    Forest Ecology and Management. 2023 Oct., v. 545 p.121280-

    2023  

    Abstract: Compared to undisturbed areas, timber harvest activities, including road construction, skid trails, and stream crossings, exhibit the potential for causing erosion and sedimentation if forestry best management practices (BMPs) are not implemented. ... ...

    Abstract Compared to undisturbed areas, timber harvest activities, including road construction, skid trails, and stream crossings, exhibit the potential for causing erosion and sedimentation if forestry best management practices (BMPs) are not implemented. Forestry BMP monitoring serves as a tool to evaluate BMP implementation status. Conventional on-the-ground BMP monitoring has contributed substantially to assessing BMP implementation. However, conventional on-the-ground surveys can be time consuming. Unmanned aerial vehicles (UAVs) have been rapidly emerging as a new tool for local-scale monitoring. In this study, we evaluated the feasibility and potential of UAVs for monitoring forestry BMPs in the coastal plain of southeastern United States. We compared the performance of UAV-live feed surveys and UAV-created map surveys with conventional on-the-ground surveys across major BMP categories on 30 study sites using BMP guidelines and implementation survey questions from Alabama, Georgia, and Florida for the sites specific to that state (10 sites in each state). The UAV-live feed surveys involved real-time assessments conducted using the live feed function, enabling on-the-spot evaluations. Whereas the UAV-created map surveys entailed autonomous UAV flight to collect imagery specifically for generating maps and facilitating subsequent assessments. We found that using a UAV for monitoring BMPs efficiently provided an overview of a timber harvest area from above. UAV-live feed surveys were as effective as conventional on-the-ground surveys across all major BMP categories. Specifically, the Cramer's V correlation between the responses from UAV-live feed and conventional on-the-ground surveys for all BMP categories, was 0.95 (p < 0.0001) for detecting implemented BMPs and 0.86 (p < 0.0001) for detecting when BMPs were not implemented but needed to be. UAV-created map survey results vs. conventional on-the-ground surveys were not as effective (V of 0.79 for detecting implemented BMPs and 0.46 for detecting BMPs not implemented but needed). Waste and stream crossing BMP implementation were the most difficult to verify using the map surveys, which was not an issue with the live feed surveys due to the capability to evaluate those BMPs at different camera angles. While UAV-created map surveys may be less effective, they provide an observation record that includes a map of the site. This project also developed a standardized framework for using UAVs to monitor forestry BMPs, including instructions and procedures for conducting UAV-live feed and map surveys. In conclusion, a UAV using the live feed function in the field is a feasible option to monitor forestry BMPs.
    Keywords administrative management ; cameras ; coastal plains ; flight ; forest ecology ; forestry ; live feeds ; road construction ; surveys ; wastes ; Alabama ; Florida ; Georgia ; Timber harvesting ; Forestry BMPs ; Drones ; UAVs ; Remote sensing
    Language English
    Dates of publication 2023-10
    Publishing place Elsevier B.V.
    Document type Article ; Online
    ZDB-ID 751138-3
    ISSN 0378-1127
    ISSN 0378-1127
    DOI 10.1016/j.foreco.2023.121280
    Database NAL-Catalogue (AGRICOLA)

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  3. Article: Early Implant Placement with Immediate Loading in the Mandibular Anterior Region: A Rapid Solution to Edentulism.

    Rijal, Arjun Hari / Dhami, Bhageshwar / Ghimire, Pratistha / Humagain, Manoj / Lamichhane, Simant

    Case reports in dentistry

    2023  Volume 2023, Page(s) 8487094

    Abstract: The aim of this article is to present the case of an early implant placement with immediate loading in the mandibular anterior region as a rapid solution to edentulism. A 40-year-old healthy male patient reported with a chief complaint of loosening of ... ...

    Abstract The aim of this article is to present the case of an early implant placement with immediate loading in the mandibular anterior region as a rapid solution to edentulism. A 40-year-old healthy male patient reported with a chief complaint of loosening of tooth in the lower front region of the jaw. On intraoral examination, there was a mobile tooth with respect to 41. The mobile tooth was extracted, and early implant placement was done along with Bio-Oss bone grafts to fill the jumping distance with no barrier membrane. Immediate provisionalisation was done on early-placed dental implants. After 5 months of the healing period, the final implant-level impressions were made, and the provisional crown was replaced with the final zirconia crown. This case report demonstrates satisfactory esthetic and functional outcomes along with various other advantages.
    Language English
    Publishing date 2023-12-18
    Publishing country Egypt
    Document type Case Reports
    ZDB-ID 2627632-X
    ISSN 2090-6455 ; 2090-6447
    ISSN (online) 2090-6455
    ISSN 2090-6447
    DOI 10.1155/2023/8487094
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Why is the Private Forest Program Stunted in Nepal?

    Aryal, Kishor / Rijal, Arjun / Maraseni, Tek / Parajuli, Manisha

    Environmental management

    2020  Volume 66, Issue 4, Page(s) 535–548

    Abstract: Private forest (PF) program has the potential to be one of the most efficient forest management programs in Nepal but it has not gained the momentum compared to the other forest management regimes. Considering this, this paper aims to portray policy ... ...

    Abstract Private forest (PF) program has the potential to be one of the most efficient forest management programs in Nepal but it has not gained the momentum compared to the other forest management regimes. Considering this, this paper aims to portray policy provisions, existing institutional arrangements as well as landholder experiences and perceptions over the existing mechanisms of PF registration, management, and forest product harvesting. Using the Sudoorpashchim province of Nepal as a case study, we conducted policy and literature reviews, key informant interviews, household surveys, and field observations. We found only 300 PFs registered in the Sudoorpashchim province, with lowland districts having the highest proportion (87%). Institutional arrangements and procedures for timber harvesting and selling were found to be lengthy and complex, with this being a major issue for PF owners with small forest areas. Government initiatives are inadequate to facilitate PF development due to poor implementation of policy provisions, as well as the lack of appropriate incentives and program packages. Despite a very small government investment in PF development, we found the return from PFs in terms of timber supply to be substantially higher than other forest management regimes. Among others, PF owners perceive the cumbersome regulatory procedures and lack of technical support to be the most pertinent factors responsible for the limited growth of PFs. Based on our results, we have discussed and recommended a number of policy and institutional measures to mainstream PF development programs, in order to support economic prosperity of the nation.
    MeSH term(s) Conservation of Natural Resources ; Forestry ; Forests ; Nepal
    Language English
    Publishing date 2020-08-02
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1478932-2
    ISSN 1432-1009 ; 0364-152X
    ISSN (online) 1432-1009
    ISSN 0364-152X
    DOI 10.1007/s00267-020-01343-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Why is the Private Forest Program Stunted in Nepal?

    Aryal, Kishor / Rijal, Arjun / Maraseni, Tek / Parajuli, Manisha

    Environmental management. 2020 Oct., v. 66, no. 4

    2020  

    Abstract: Private forest (PF) program has the potential to be one of the most efficient forest management programs in Nepal but it has not gained the momentum compared to the other forest management regimes. Considering this, this paper aims to portray policy ... ...

    Abstract Private forest (PF) program has the potential to be one of the most efficient forest management programs in Nepal but it has not gained the momentum compared to the other forest management regimes. Considering this, this paper aims to portray policy provisions, existing institutional arrangements as well as landholder experiences and perceptions over the existing mechanisms of PF registration, management, and forest product harvesting. Using the Sudoorpashchim province of Nepal as a case study, we conducted policy and literature reviews, key informant interviews, household surveys, and field observations. We found only 300 PFs registered in the Sudoorpashchim province, with lowland districts having the highest proportion (87%). Institutional arrangements and procedures for timber harvesting and selling were found to be lengthy and complex, with this being a major issue for PF owners with small forest areas. Government initiatives are inadequate to facilitate PF development due to poor implementation of policy provisions, as well as the lack of appropriate incentives and program packages. Despite a very small government investment in PF development, we found the return from PFs in terms of timber supply to be substantially higher than other forest management regimes. Among others, PF owners perceive the cumbersome regulatory procedures and lack of technical support to be the most pertinent factors responsible for the limited growth of PFs. Based on our results, we have discussed and recommended a number of policy and institutional measures to mainstream PF development programs, in order to support economic prosperity of the nation.
    Keywords case studies ; environmental management ; forest management ; forests ; issues and policy ; landowners ; momentum ; private forestry ; timber supply ; Nepal
    Language English
    Dates of publication 2020-10
    Size p. 535-548.
    Publishing place Springer US
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 1478932-2
    ISSN 1432-1009 ; 0364-152X
    ISSN (online) 1432-1009
    ISSN 0364-152X
    DOI 10.1007/s00267-020-01343-z
    Database NAL-Catalogue (AGRICOLA)

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  6. Article: Role of histone variants H2BC1 and H2AZ.2 in H2AK119ub nucleosome organization and Polycomb gene silencing.

    Shen, Xiangyu / Chen, Chunxu / Wang, Yue / Zheng, Wan / Zheng, Jiahuan / Jones, Amanda E / Zhu, Bing / Zhang, Hao / Lyons, Charles / Rijal, Arjun / Moley, James A / Cao, Gengsheng / Liu, Kui / Winn, Robert / Dickinson, Amanda / Zhang, Kai / Wang, Hengbin

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Ubiquitination of histone H2A at lysine 119 residue (H2AK119ub) plays critical roles in a wide range of physiological processes, including Polycomb gene ... ...

    Abstract Ubiquitination of histone H2A at lysine 119 residue (H2AK119ub) plays critical roles in a wide range of physiological processes, including Polycomb gene silencing
    Language English
    Publishing date 2024-01-16
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.01.16.575234
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Cooperation between PRMT1 and PRMT6 drives lung cancer health disparities among Black/African American men.

    Wu, Pei-Ying / Van Scoyk, Michelle / McHale, Stephanie S / Chou, Chu-Fang / Riddick, Gregory / Farouq, Kamran / Hu, Bin / Kraskauskiene, Vita / Koblinski, Jennifer / Lyons, Charles / Rijal, Arjun / Vudatha, Vignesh / Zhang, Dongyu / Trevino, Jose G / Shah, Rachit D / Nana-Sinkam, Patrick / Huang, Yong / Ma, Shwu-Fan / Noth, Imre /
    Hughes-Halbert, Chanita / Seewaldt, Victoria L / Chen, Ching-Yi / Winn, Robert A

    iScience

    2024  Volume 27, Issue 2, Page(s) 108858

    Abstract: Lung cancer is the third most common cancer with Black/AA men showing higher risk and poorer outcomes than NHW men. Lung cancer disparities are multifactorial, driven by tobacco exposure, inequities in care access, upstream health determinants, and ... ...

    Abstract Lung cancer is the third most common cancer with Black/AA men showing higher risk and poorer outcomes than NHW men. Lung cancer disparities are multifactorial, driven by tobacco exposure, inequities in care access, upstream health determinants, and molecular determinants including biological and genetic factors. Elevated expressions of protein arginine methyltransferases (PRMTs) correlating with poorer prognosis have been observed in many cancers. Most importantly, our study shows that PRMT6 displays higher expression in lung cancer tissues of Black/AA men compared to NHW men. In this study, we investigated the underlying mechanism of PRMT6 and its cooperation with PRMT1 to form a heteromer as a driver of lung cancer. Disrupting PRMT1/PRMT6 heteromer by a competitive peptide reduced proliferation in non-small cell lung cancer cell lines and patient-derived organoids, therefore, giving rise to a more strategic approach in the treatment of Black/AA men with lung cancer and to eliminate cancer health disparities.
    Language English
    Publishing date 2024-01-11
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2024.108858
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Luseogliflozin, a sodium-glucose cotransporter-2 inhibitor, reverses cerebrovascular dysfunction and cognitive impairments in 18-mo-old diabetic animals.

    Wang, Shaoxun / Jiao, Feng / Border, Jane J / Fang, Xing / Crumpler, Reece F / Liu, Yedan / Zhang, Huawei / Jefferson, Joshua / Guo, Ya / Elliott, Parker S / Thomas, Kirby N / Strong, Luke B / Urvina, Austin H / Zheng, Baoying / Rijal, Arjun / Smith, Stanley V / Yu, Hongwei / Roman, Richard J / Fan, Fan

    American journal of physiology. Heart and circulatory physiology

    2021  Volume 322, Issue 2, Page(s) H246–H259

    Abstract: Diabetes mellitus (DM) is a leading risk factor for age-related dementia, but the mechanisms involved are not well understood. We previously discovered that hyperglycemia induced impaired myogenic response (MR) and cerebral blood flow (CBF) ... ...

    Abstract Diabetes mellitus (DM) is a leading risk factor for age-related dementia, but the mechanisms involved are not well understood. We previously discovered that hyperglycemia induced impaired myogenic response (MR) and cerebral blood flow (CBF) autoregulation in 18-mo-old DM rats associated with blood-brain barrier (BBB) leakage, impaired neurovascular coupling, and cognitive impairment. In the present study, we examined whether reducing plasma glucose with a sodium-glucose cotransporter-2 inhibitor (SGLT2i) luseogliflozin can ameliorate cerebral vascular and cognitive function in diabetic rats. Plasma glucose and HbA1c levels of 18-mo-old DM rats were reduced, and blood pressure was not altered after treatment with luseogliflozin. SGLT2i treatment restored the impaired MR of middle cerebral arteries (MCAs) and parenchymal arterioles and surface and deep cortical CBF autoregulation in DM rats. Luseogliflozin treatment also rescued neurovascular uncoupling, reduced BBB leakage and cognitive deficits in DM rats. However, SGLT2i did not have direct constrictive effects on vascular smooth muscle cells and MCAs isolated from normal rats, although it decreased reactive oxygen species production in cerebral vessels of DM rats. These results provide evidence that normalization of hyperglycemia with an SGLT2i can reverse cerebrovascular dysfunction and cognitive impairments in rats with long-standing hyperglycemia, possibly by ameliorating oxidative stress-caused vascular damage.
    MeSH term(s) Animals ; Arterioles/drug effects ; Arterioles/physiopathology ; Blood-Brain Barrier/drug effects ; Blood-Brain Barrier/physiopathology ; Cells, Cultured ; Cerebrovascular Circulation ; Cognition ; Dementia, Vascular/drug therapy ; Diabetic Angiopathies/drug therapy ; Male ; Middle Cerebral Artery/drug effects ; Middle Cerebral Artery/physiopathology ; Rats ; Rats, Sprague-Dawley ; Sodium-Glucose Transporter 2 Inhibitors/pharmacology ; Sodium-Glucose Transporter 2 Inhibitors/therapeutic use ; Sorbitol/analogs & derivatives ; Sorbitol/pharmacology ; Sorbitol/therapeutic use
    Chemical Substances Sodium-Glucose Transporter 2 Inhibitors ; Sorbitol (506T60A25R) ; 1,5-anhydro-1-(5-(4-ethoxybenzyl)-2-methoxy-4-methylphenyl)-1-thioglucitol (C596HWF74Z)
    Language English
    Publishing date 2021-12-24
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 603838-4
    ISSN 1522-1539 ; 0363-6135
    ISSN (online) 1522-1539
    ISSN 0363-6135
    DOI 10.1152/ajpheart.00438.2021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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