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  1. Article ; Online: Striving to improve

    Rimoldi, Ornella

    Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology

    2018  Volume 26, Issue 6, Page(s) 1943–1945

    MeSH term(s) Myocardial Perfusion Imaging ; Positron-Emission Tomography ; Rubidium ; Rubidium Radioisotopes ; Stomach
    Chemical Substances Rubidium Radioisotopes ; Rubidium-82 (9K730EL8KU) ; Rubidium (MLT4718TJW)
    Language English
    Publishing date 2018-08-22
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1212505-2
    ISSN 1532-6551 ; 1071-3581
    ISSN (online) 1532-6551
    ISSN 1071-3581
    DOI 10.1007/s12350-018-1419-0
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    Zs.A 4121: Show issues Location:
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  2. Article ; Online: Interconnection of coronary macro- and microcirculation to each other: each component has relations that express all the others.

    Rimoldi, Ornella

    European heart journal. Cardiovascular Imaging

    2017  Volume 18, Issue 11, Page(s) 1214–1215

    MeSH term(s) Angina, Stable ; Coronary Circulation ; Heart Diseases ; Humans ; Microcirculation ; Multimodal Imaging
    Language English
    Publishing date 2017-09-06
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 2638345-7
    ISSN 2047-2412 ; 2047-2404
    ISSN (online) 2047-2412
    ISSN 2047-2404
    DOI 10.1093/ehjci/jex209
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    Zs.A 5614: Show issues Location:
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  3. Article ; Online: Assessing the activity of cardiac sympathetic innervation with a novel PET tracer.

    Rimoldi, Ornella

    European journal of nuclear medicine and molecular imaging

    2012  Volume 39, Issue 12, Page(s) 1901–1903

    MeSH term(s) Animals ; Arrhythmias, Cardiac/diagnostic imaging ; Autonomic Nerve Block ; Fluorobenzenes ; Guanidines ; Heart/diagnostic imaging ; Humans ; Positron-Emission Tomography ; Radiopharmaceuticals
    Chemical Substances Fluorobenzenes ; Guanidines ; Radiopharmaceuticals ; flubrobenguane (XCG95AYX3B)
    Language English
    Publishing date 2012-10-19
    Publishing country Germany
    Document type Editorial ; Comment
    ZDB-ID 8236-3
    ISSN 1619-7089 ; 0340-6997 ; 1619-7070
    ISSN (online) 1619-7089
    ISSN 0340-6997 ; 1619-7070
    DOI 10.1007/s00259-012-2264-z
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    Zs.A 1227: Show issues Location:
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  4. Article ; Online: The beginning at the end: non-invasive assessment of post-transplant coronary allograft vasculopathy at the microcirculatory level.

    Rimoldi, Ornella / Camici, Paolo G

    European heart journal

    2018  Volume 39, Issue 4, Page(s) 324–326

    MeSH term(s) Allografts ; Coronary Angiography ; Heart Transplantation ; Microcirculation ; Prognosis
    Language English
    Publishing date 2018-01-19
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehx738
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1563: Show issues Location:
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  5. Article ; Online: Microvascular dysfunction in infiltrative cardiomyopathies.

    Rimoldi, Ornella / Maranta, Francesco

    Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology

    2017  Volume 26, Issue 1, Page(s) 200–207

    Abstract: Infiltrative heart diseases are characterized by myocardial tissue alterations leading to mechanical dysfunction which in turn develops into bi-ventricular congestive heart failure. Also the coronary microvasculature undergoes significant remodeling and ... ...

    Abstract Infiltrative heart diseases are characterized by myocardial tissue alterations leading to mechanical dysfunction which in turn develops into bi-ventricular congestive heart failure. Also the coronary microvasculature undergoes significant remodeling and dysfunction. The effects of the unbalance of the mechanical cross-talk between cardiac muscle and vessels and of the impairment of vasodilatory function can be measured non-invasively by means of positron emission tomography and cardiac magnetic resonance.
    MeSH term(s) Arterioles/pathology ; Cardiomyopathies/pathology ; Coronary Circulation ; Coronary Vessels/physiopathology ; Fabry Disease/pathology ; Female ; Heart/physiology ; Heart Failure/pathology ; Humans ; Male ; Microcirculation ; Microvessels/physiopathology ; Myocardium/pathology ; Oxidative Stress ; Positron-Emission Tomography ; Sarcoidosis/pathology ; Tomography, X-Ray Computed
    Language English
    Publishing date 2017-07-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1212505-2
    ISSN 1532-6551 ; 1071-3581
    ISSN (online) 1532-6551
    ISSN 1071-3581
    DOI 10.1007/s12350-017-0991-z
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    Zs.A 4121: Show issues Location:
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  6. Article ; Online: Coronary microvascular dysfunction in heart failure with preserved ejection fraction - adding new pieces to the jigsaw puzzle.

    Van Linthout, Sophie / Rimoldi, Ornella / Tschöpe, Carsten / Camici, Paolo G

    European journal of heart failure

    2020  Volume 22, Issue 3, Page(s) 442–444

    MeSH term(s) Endothelium ; Heart Failure ; Humans ; Stroke Volume ; Ventricular Dysfunction, Left ; Ventricular Function, Left
    Language English
    Publishing date 2020-01-07
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1483672-5
    ISSN 1879-0844 ; 1388-9842
    ISSN (online) 1879-0844
    ISSN 1388-9842
    DOI 10.1002/ejhf.1720
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    Zs.A 5299: Show issues Location:
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  7. Article ; Online: Coronary stenosis and transmural perfusion across the left ventricular wall.

    Camici, Paolo G / Rimoldi, Ornella E

    European heart journal

    2014  Volume 35, Issue 31, Page(s) 2058–2059

    MeSH term(s) Coronary Artery Disease/physiopathology ; Coronary Stenosis/physiopathology ; Female ; Humans ; Male ; Plaque, Atherosclerotic/physiopathology
    Language English
    Publishing date 2014-08-14
    Publishing country England
    Document type Comment ; Editorial
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehu206
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  8. Article ; Online: Coronary microvascular dysfunction in hypertrophy and heart failure.

    Camici, Paolo G / Tschöpe, Carsten / Di Carli, Marcelo F / Rimoldi, Ornella / Van Linthout, Sophie

    Cardiovascular research

    2020  Volume 116, Issue 4, Page(s) 806–816

    Abstract: Left ventricular (LV) hypertrophy (LVH) is a growth in left myocardial mass mainly caused by increased cardiomyocyte size. LVH can be a physiological adaptation to physical exercise or a pathological condition either primary, i.e. genetic, or secondary ... ...

    Abstract Left ventricular (LV) hypertrophy (LVH) is a growth in left myocardial mass mainly caused by increased cardiomyocyte size. LVH can be a physiological adaptation to physical exercise or a pathological condition either primary, i.e. genetic, or secondary to LV overload. Patients with both primary and secondary LVH have evidence of coronary microvascular dysfunction (CMD). The latter is mainly due to capillary rarefaction and adverse remodelling of intramural coronary arterioles due to medial wall thickening with an increased wall/lumen ratio. An important feature of this phenomenon is the diffuse nature of this remodelling, which generally affects the coronary microvessels in the whole of the left ventricle. Patients with LVH secondary to arterial hypertension can develop both heart failure with preserved ejection fraction (HFpEF) and heart failure with reduced ejection fraction (HFrEF). These patients can develop HFrEF via a 'direct pathway' with an interval myocardial infarction and also in its absence. On the other hand, patients can develop HFpEF that can then progress to HFrEF with or without interval myocardial infarction. A similar evolution towards LV dysfunction and both HFpEF and HFrEF can occur in patients with hypertrophic cardiomyopathy, the most common genetic cardiomyopathy with a phenotype characterized by massive LVH. In this review article, we will discuss both the experimental and clinical studies explaining the mechanisms responsible for CMD in LVH as well as the evidence linking CMD with HFpEF and HFrEF.
    MeSH term(s) Animals ; Coronary Circulation ; Coronary Vessels/diagnostic imaging ; Coronary Vessels/physiopathology ; Heart Failure/diagnostic imaging ; Heart Failure/epidemiology ; Heart Failure/physiopathology ; Humans ; Hypertrophy, Left Ventricular/diagnostic imaging ; Hypertrophy, Left Ventricular/epidemiology ; Hypertrophy, Left Ventricular/physiopathology ; Microcirculation ; Microvessels/diagnostic imaging ; Microvessels/physiopathology ; Prognosis ; Risk Factors ; Stroke Volume ; Ventricular Function, Left ; Ventricular Remodeling
    Language English
    Publishing date 2020-01-30
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/cvaa023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 565: Show issues Location:
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  9. Article ; Online: Prognostic value of cardiovascular magnetic resonance T1 mapping techniques in non-ischemic dilated cardiomyopathy: A systematic review and meta-analysis.

    Kiaos, Apostolos / Antonakaki, Dimitra / Bazmpani, Maria-Anna / Karvounis, Charalambos / Rimoldi, Ornella / Karamitsos, Theodoros D

    International journal of cardiology

    2020  Volume 312, Page(s) 110–116

    Abstract: Background: Cardiovascular magnetic resonance T1 mapping is a non-invasive tool for quantifying tissue alterations in the myocardium. Its prognostic value in non-ischemic dilated cardiomyopathy (DCM) remains unclear. The purpose of this study was to ... ...

    Abstract Background: Cardiovascular magnetic resonance T1 mapping is a non-invasive tool for quantifying tissue alterations in the myocardium. Its prognostic value in non-ischemic dilated cardiomyopathy (DCM) remains unclear. The purpose of this study was to synthetize available data and explore the prognostic value of T1 mapping in DCM.
    Methods: We searched Pubmed, Embase, Cochrane Library and Scopus for cohort studies up to 28 March 2020 that reported prognostic data for cardiovascular magnetic resonance T1 mapping in patients with DCM. Hazard ratios (HRs) were pooled using random-effects meta-analysis. Values were expressed as standard deviation (SD) of normal controls. Heterogeneity was assessed with the I
    Results: Eight studies were included in the meta-analysis, with a total of 1242 patients. Extracellular volume fraction (ECV) had high prognostic value for a composite outcome of mortality and morbidity with HR 1.38 (95% confidence interval, 1.18-1.61). Native T1 was also shown to have high prognostic value for a composite outcome of mortality and morbidity with HR 1.20 (95% confidence interval, 1.14-1.27). Heterogeneity was moderate for the ECV analysis (I
    Conclusions: ECV and native T1 could potentially be used to improve risk stratification in DCM. Future studies should investigate the prognostic value of T1 mapping by separating mortality and morbidity as primary outcomes and evaluate its incremental value in addition to standard risk stratification criteria.
    MeSH term(s) Cardiomyopathy, Dilated/diagnostic imaging ; Contrast Media ; Humans ; Magnetic Resonance Imaging ; Magnetic Resonance Imaging, Cine ; Magnetic Resonance Spectroscopy ; Myocardium ; Predictive Value of Tests ; Prognosis
    Chemical Substances Contrast Media
    Language English
    Publishing date 2020-04-19
    Publishing country Netherlands
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 779519-1
    ISSN 1874-1754 ; 0167-5273
    ISSN (online) 1874-1754
    ISSN 0167-5273
    DOI 10.1016/j.ijcard.2020.04.052
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  10. Article ; Online: Risk stratification of patients with normal myocardial perfusion imaging: help comes from the periphery.

    Rimoldi, Ornella / Camici, Paolo G

    European heart journal

    2013  Volume 34, Issue 27, Page(s) 2028–2030

    MeSH term(s) Blood Pressure/physiology ; Coronary Artery Disease/diagnosis ; Exercise/physiology ; Female ; Humans ; Male
    Language English
    Publishing date 2013-07
    Publishing country England
    Document type Comment ; Editorial
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/eht138
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