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Article ; Online: Evaluation of a pharmacist-driven medication adherence enhancement service.

Rinehart, Sarah N / Collins, Candyce / Glover, Jon / Rice, Whitney M

Journal of managed care & specialty pharmacy

2021 Volume 27, Issue 4, Page(s) 507–515

Abstract: BACKGROUND: ...

Abstract	BACKGROUND:
MeSH term(s)	Aged ; Antihypertensive Agents/therapeutic use ; Arizona ; Cohort Studies ; Colorado ; Female ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Hypoglycemic Agents/therapeutic use ; Male ; Patient Compliance ; Pharmaceutical Services ; Retrospective Studies
Chemical Substances	Antihypertensive Agents ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Hypoglycemic Agents
Language	English
Publishing date	2021-04-12
Publishing country	United States
Document type	Evaluation Study ; Journal Article
ISSN	2376-1032
ISSN (online)	2376-1032
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Article ; Online: Opportunities for cancer prevention at syringe services programs: acceptability of HPV self-sampling and vaccination among people who inject drugs.

Hinkes, Samuel / Ciraldo, Katrina / Kobetz, Erin / Bartholomew, Tyler S / Rinehart, Sarah / Siringo, Nicolette / Barnett, Rebecca / Godbole, Neha / Jeanty, Frantzia / Frederick, Morgan / Tookes, Hansel E

Harm reduction journal

2024 Volume 21, Issue 1, Page(s) 70

Abstract: Introduction: Despite having a high risk of acquiring sexually transmitted infections, people who inject drugs (PWID) often do not receive recommended HPV screenings due to barriers to healthcare. Guideline-based cervical HPV screening and vaccination ... ...

Abstract	Introduction: Despite having a high risk of acquiring sexually transmitted infections, people who inject drugs (PWID) often do not receive recommended HPV screenings due to barriers to healthcare. Guideline-based cervical HPV screening and vaccination can prevent cervical cancer. Low-cost, low-barrier methods for cancer screening and prevention are important for vulnerable communities such as PWID. Methods: We examined acceptability of HPV self-sampling at a syringe services program (SSP). Participants with a cervix (n = 49) participated in patient education followed by a survey to assess willingness to perform HPV self-sampling versus standard of care. Results: 59% found self-sampling to be acceptable, citing privacy, ease, and quickness. Among those opting for HPV screening delivered by a provider (n = 16), participants cited concerns about adequate sampling (81%) and test accuracy (75%). Notably, only 18% of participants reported complete HPV vaccination. Conclusion: Cervical HPV self-sampling was acceptable to PWID. SSP-based efforts to provide preventative health services could place tools for cancer screening into the hands of PWID, a need-to-reach community.
MeSH term(s)	Female ; Humans ; Substance Abuse, Intravenous ; Drug Users ; Papillomavirus Infections/prevention & control ; Papillomavirus Infections/diagnosis ; Uterine Cervical Neoplasms/prevention & control ; Uterine Cervical Neoplasms/diagnosis ; Vaccination ; Patient Acceptance of Health Care
Language	English
Publishing date	2024-03-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2146691-9
ISSN	1477-7517 ; 1477-7517
ISSN (online)	1477-7517
ISSN	1477-7517
DOI	10.1186/s12954-024-00982-3
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Article ; Online: COVID-19 Vaccine Information and Infertility Posts on X: Insights on a Misinformation Pandemic.

Levy, Morgan S / Hunt, Kelby N / Rinehart, Sarah / Brown, Alyssa D / Kelly, Amelia G / Sundaram, Padmaja / Crump, Alisha / Sinclair, Tiffany J / Dey, Kally / Zoroufy, Alexander / Caban-Martinez, Alberto J / Plowden, Torie Comeaux

The Permanente journal

2024 , Page(s) 1–8

Abstract: Objective: This study aimed to evaluate misinformation surrounding infertility and the COVID-19 vaccine on X (formerly known as Twitter) by analyzing the prevalence and content of this misinformation across a sample of posts on X.: Methods: This ... ...

Abstract	Objective: This study aimed to evaluate misinformation surrounding infertility and the COVID-19 vaccine on X (formerly known as Twitter) by analyzing the prevalence and content of this misinformation across a sample of posts on X. Methods: This study is a retrospective review of posts on X (formerly known as tweets) from the COVID-19-TweetIDs dataset from July 2021 and November 2021. Included posts were from crucial time points in the COVID-19 vaccine discourse and contained at least one word related to COVID-19 vaccination and fertility. Posts were analyzed and categorized based on factuality, common words, and hashtags. Descriptive statistics on total followers, account verification status, and engagement were obtained. Differences between posts on X classified as factual and misinformation were examined using analysis of variance or χ Results: A total of 17,418 relevant posts on X were reviewed: 11,436 from timeframe 1 (July 2021) and 5982 from timeframe 2 (December 2021). Misinformation posts rose from 29.9% in July 2021 to 45.1% in November 2021. In both timeframes, accounts sharing factual information had more followers (p < 0.001), and verified users were more likely to share accurate posts (p ≤ 0.001). Factual and misinformation posts had similar engagement. Sentiment analysis identified that real posts were more positive and misinformation posts were more negative (p < 0.001). Conclusions and relevance: Misinformation about the COVID-19 vaccine and fertility is highly prevalent on X and threatens vaccine uptake in patients desiring future fertility. Accounts sharing factual information were likely to have more followers and be verified; therefore, verifying more physicians sharing accurate information is critical.
Language	English
Publishing date	2024-05-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2062823-7
ISSN	1552-5775 ; 1552-5775
ISSN (online)	1552-5775
ISSN	1552-5775
DOI	10.7812/TPP/23.142
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Article ; Online: Prospective Deep Learning-based Quantitative Assessment of Coronary Plaque by CT Angiography Compared with Intravascular Ultrasound.

Narula, Jagat / Stuckey, Thomas D / Nakazawa, Gaku / Ahmadi, Amir / Matsumura, Mitsuaki / Petersen, Kersten / Mirza, Saba / Ng, Nicholas / Mullen, Sarah / Schaap, Michiel / Leipsic, Jonathan / Rogers, Campbell / Taylor, Charles A / Yacoub, Harout / Gupta, Himanshu / Matsuo, Hitoshi / Rinehart, Sarah / Maehara, Akiko

European heart journal. Cardiovascular Imaging

2024

Abstract: Aims: Coronary computed tomography angiography provides noninvasive assessment of coronary stenosis severity and flow impairment. Automated artificial intelligence analysis may assist in precise quantification and characterization of coronary ... ...

Abstract	Aims: Coronary computed tomography angiography provides noninvasive assessment of coronary stenosis severity and flow impairment. Automated artificial intelligence analysis may assist in precise quantification and characterization of coronary atherosclerosis, enabling patient-specific risk determination and management strategies. This multicenter international study compared an automated deep-learning-based method for segmenting coronary atherosclerosis in coronary computed tomography angiography (CCTA) against the reference standard of intravascular ultrasound (IVUS). Methods and results: The study included clinically stable patients with known coronary artery disease from 15 centers in the U.S. and Japan. An artificial intelligence (AI)-enabled plaque analysis service was utilized to quantify and characterize total plaque (TPV), vessel, lumen, calcified plaque (CP), non-calcified plaque (NCP), and low attenuation plaque (LAP) volumes derived from CCTA and compared with IVUS measurements in a blinded, core laboratory-adjudicated fashion. In 237 patients, 432 lesions were assessed; mean lesion length was 24.5 mm. Mean IVUS-TPV was 186.0 mm3. AI-enabled plaque analysis on CCTA showed strong correlation and high accuracy when compared with IVUS; correlation coefficient, slope, and Y intercept for TPV were 0.91, 0.99, and 1.87, respectively; for CP volume 0.91, 1.05, and 5.32, respectively; and for NCP volume 0.87, 0.98, and 15.24, respectively. Bland-Altman analysis demonstrated strong agreement with little bias for these measurements. Conclusions: Artificial intelligence enabled CCTA quantification and characterization of atherosclerosis demonstrated strong agreement with IVUS reference standard measurements. This tool may prove effective for accurate evaluation of coronary atherosclerotic burden and cardiovascular risk assessment.[ClinicalTrails.gov identifier: NCT05138289].
Language	English
Publishing date	2024-05-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2638345-7
ISSN	2047-2412 ; 2047-2404
ISSN (online)	2047-2412
ISSN	2047-2404
DOI	10.1093/ehjci/jeae115
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Zs.A 5614: Show issues

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Article ; Online: Longitudinal Effects of Gendered Harassment Perpetration and Victimization on Mental Health Outcomes in Adolescence.

Rinehart, Sarah J / Espelage, Dorothy L / Bub, Kristen L

Journal of interpersonal violence

2017 Volume 35, Issue 23-24, Page(s) 5997–6016

Abstract: Gendered harassment, including sexual harassment and homophobic name-calling, is prevalent in adolescents and is linked to negative outcomes including depression, anxiety, suicidality, substance abuse, and personal distress. However, much of the extant ... ...

Abstract	Gendered harassment, including sexual harassment and homophobic name-calling, is prevalent in adolescents and is linked to negative outcomes including depression, anxiety, suicidality, substance abuse, and personal distress. However, much of the extant literature is cross-sectional and rarely are perpetrators of these behaviors included in studies of outcomes. Therefore, the current study examined the effects of longitudinal changes in gendered harassment perpetration and victimization on changes in mental health outcomes among a large sample of early adolescents. Given that these behaviors commonly occur in the context of a patriarchal society (males hold power), we also investigated the impact of gender on gendered harassment. Participants included 3,549 students from four Midwestern middle schools (50.4% female, 49% African American, 34% White) at two time points (13 and 17 years old). Results indicated that increases from age 13 to 17 years in sexual harassment perpetration and victimization and homophobic name-calling perpetration and victimization predicted increases in depression symptoms and substance use. Gender did not moderate these pathways. These findings highlight that negative outcomes are associated with changes in gendered harassment among adolescents and emphasize the importance of prevention efforts. Implications for school interventions are discussed.
MeSH term(s)	Adolescent ; Bullying ; Crime Victims ; Cross-Sectional Studies ; Female ; Humans ; Male ; Outcome Assessment, Health Care ; Peer Group ; Sexual Harassment
Language	English
Publishing date	2017-08-21
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	2028900-5
ISSN	1552-6518 ; 0886-2605
ISSN (online)	1552-6518
ISSN	0886-2605
DOI	10.1177/0886260517723746
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Article ; Online: Left ventricular noncompaction cardiomyopathy: adult association with 1p36 deletion syndrome.

Lee, James / Rinehart, Sarah / Polsani, Venkateshewar

Methodist DeBakey cardiovascular journal

2014 Volume 10, Issue 4, Page(s) 258–259

MeSH term(s)	Adult ; Cardiomyopathies/diagnosis ; Cardiomyopathies/genetics ; Chromosome Deletion ; Chromosome Disorders/complications ; Chromosomes, Human, Pair 1 ; Electrocardiography ; Female ; Genetic Predisposition to Disease ; Humans ; Isolated Noncompaction of the Ventricular Myocardium/diagnosis ; Isolated Noncompaction of the Ventricular Myocardium/genetics ; Magnetic Resonance Imaging ; Phenotype
Language	English
Publishing date	2014-10
Publishing country	United States
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2544079-2
ISSN	1947-6108 ; 1947-6094
ISSN (online)	1947-6108
ISSN	1947-6094
DOI	10.14797/mdcj-10-4-258
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Article ; Online: A lesion-specific coronary artery calcium quantification framework for the prediction of cardiac events.

Qian, Zhen / Marvasty, Idean / Rinehart, Sarah / Voros, Szilard

IEEE transactions on information technology in biomedicine : a publication of the IEEE Engineering in Medicine and Biology Society

2011 Volume 15, Issue 5, Page(s) 673–680

Abstract: CT-based coronary artery calcium (CAC) scanning has been introduced as a noninvasive, low-radiation imaging technique for the assessment of the overall coronary arterial atherosclerotic burden. A 3-D CAC volume contains significant clinically relevant ... ...

Abstract	CT-based coronary artery calcium (CAC) scanning has been introduced as a noninvasive, low-radiation imaging technique for the assessment of the overall coronary arterial atherosclerotic burden. A 3-D CAC volume contains significant clinically relevant information, which is unused by conventional whole-heart CAC quantification methods. In this paper, we have developed a novel distance-weighted lesion-specific CAC quantification framework that predicts cardiac events better than the conventional whole-heart CAC measures. This framework consists of 1) a novel lesion-specific CAC quantification tool that measures each calcific lesion's attenuation, morphologic and geometric statistics; 2) a distance-weighted event risk model to estimate the risk probability caused by each lesion; and 3) a Naive Bayesian-based technique for risk integration. We have tested our lesion-specific event predictor on 60 CAC positive scans (20 with events and 40 without events), and compared it with conventional whole-heart CAC scores. Experimental results showed that our novel approach significantly improves the predictive accuracy, indicated by an improved area under the curve of receiver operating characteristic analysis from 62% to 68%, an improved specificity by 23-55% at the 80% sensitivity level, and a net reclassification improvement of 30% .
MeSH term(s)	Bayes Theorem ; Calcium/metabolism ; Coronary Vessels/metabolism ; Coronary Vessels/pathology ; Humans ; Models, Theoretical ; Risk ; Software
Chemical Substances	Calcium (SY7Q814VUP)
Language	English
Publishing date	2011-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	1388257-0
ISSN	1558-0032 ; 1089-7771
ISSN (online)	1558-0032
ISSN	1089-7771
DOI	10.1109/TITB.2011.2162074
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Zs.A 5483: Show issues

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bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Coronary artery calcium: 0.5 mm slice-thickness reconstruction with adjusted attenuation threshold outperforms 3.0 mm by validating against spatially registered intravascular ultrasound with radiofrequency backscatter.

Qian, Zhen / Dhungel, Abinashi / Vazquez, Gustavo / Weeks, Michael / Voros, Szilard / Rinehart, Sarah

Academic radiology

2015 Volume 22, Issue 9, Page(s) 1128–1137

Abstract: Rationale and objectives: Coronary artery calcium (CAC) images can be reconstructed with thinner slice thickness on some modern multidetector-row computed tomography scanners without additional radiation. We hypothesized that the isotropic 0.5-mm CAC ... ...

Abstract	Rationale and objectives: Coronary artery calcium (CAC) images can be reconstructed with thinner slice thickness on some modern multidetector-row computed tomography scanners without additional radiation. We hypothesized that the isotropic 0.5-mm CAC reconstruction outperforms the conventional 3.0-mm reconstruction in detecting and quantifying coronary calcium, and we proposed to compare them by validating against spatially registered intravascular ultrasound with radiofrequency backscatter-virtual histology (IVUS-VH). Materials and methods: Twenty-seven patients were enrolled, and 5976 mm of coronary arteries were analyzed. A semiautomatic software was developed to coregister CAC and IVUS-VH on a detailed slice-by-slice basis. Calcium detection and calcium volume quantification were evaluated and compared using varying calcium attenuation thresholds. Algorithms for deriving individualized optimal threshold and comparable Agatston score on the 0.5-mm reconstruction were developed. Results: The isotropic 0.5-mm reconstruction achieved significantly higher area under receiver-operating curve than the conventional 3.0-mm reconstruction (0.9 vs. 0.74, P < .001). Using the optimal threshold, the 0.5-mm reconstruction had higher sensitivity (0.79 vs. 0.65), specificity (0.85 vs. 0.77), positive predictive value (0.42 vs. 0.29), and negative predictive value (0.97 vs. 0.94) than the 3.0 mm. Individualized optimal threshold was significantly correlated with the image noise (r = 0.66, P < .001) in the 0.5-mm reconstruction. Conclusions: By optimizing the calcium threshold, the 0.5-mm reconstruction is superior to the conventional 3.0-mm in detecting and quantifying calcium, which may improve the clinical value of CAC without additional radiation.
MeSH term(s)	Adult ; Aged ; Algorithms ; Area Under Curve ; Calcium/analysis ; Coronary Angiography/statistics & numerical data ; Coronary Artery Disease/diagnostic imaging ; Coronary Vessels/diagnostic imaging ; Female ; Humans ; Image Processing, Computer-Assisted/statistics & numerical data ; Male ; Middle Aged ; Multidetector Computed Tomography/statistics & numerical data ; Plaque, Atherosclerotic/diagnostic imaging ; Predictive Value of Tests ; Prospective Studies ; Reproducibility of Results ; Retrospective Studies ; Scattering, Radiation ; Sensitivity and Specificity ; Ultrasonography, Interventional/statistics & numerical data ; User-Computer Interface
Chemical Substances	Calcium (SY7Q814VUP)
Language	English
Publishing date	2015-09
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1355509-1
ISSN	1878-4046 ; 1076-6332
ISSN (online)	1878-4046
ISSN	1076-6332
DOI	10.1016/j.acra.2015.03.016
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Zs.A 4594: Show issues

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Article ; Online: Morphological analysis of the left ventricular endocardial surface using a bag-of-features descriptor.

Mukhopadhyay, Anirban / Qian, Zhen / Bhandarkar, Suchendra M / Liu, Tianming / Voros, Szilard / Rinehart, Sarah

IEEE journal of biomedical and health informatics

2014 Volume 19, Issue 4, Page(s) 1483–1493

Abstract: The limitations of conventional imaging techniques have hitherto precluded a thorough and formal investigation of the complex morphology of the left ventricular (LV) endocardial surface and its relation to the severity of coronary artery disease (CAD). ... ...

Abstract	The limitations of conventional imaging techniques have hitherto precluded a thorough and formal investigation of the complex morphology of the left ventricular (LV) endocardial surface and its relation to the severity of coronary artery disease (CAD). However, recent developments in high-resolution multirow-detector computed tomography (MDCT) scanner technology have enabled the imaging of the complex LV endocardial surface morphology in a single heartbeat. Analysis of high-resolution computed tomography images from a 320-MDCT scanner allows for the noninvasive study of the relationship between the percent diameter stenosis (DS) values of the major coronary arteries and localization of the cardiac segments affected by coronary arterial stenosis. In this paper, a novel approach for the analysis of the nonrigid LV endocardial surface from MDCT images, using a combination of rigid body transformation-invariant shape descriptors and a more generalized isometry-invariant Bag-of-Features descriptor, is proposed and implemented. The proposed approach is shown to be successful in identifying, localizing, and quantifying the incidence and extent of CAD and, thus, is seen to have a potentially significant clinical impact. Specifically, the association between the incidence and extent of CAD, determined via the percent DS measurements of the major coronary arteries, and the alterations in the endocardial surface morphology is formally quantified. The results of the proposed approach on 16 normal datasets and 16 abnormal datasets exhibiting CAD with varying levels of severity are presented. A multivariable regression test is employed to test the effectiveness of the proposed morphological analysis approach. Experiments performed on a strictly leave-one-out basis are shown to exhibit a distinct and interesting pattern in terms of the correlation coefficient values within the cardiac segments, where the incidence of coronary arterial stenosis is localized.
MeSH term(s)	Algorithms ; Animals ; Coronary Artery Disease/diagnostic imaging ; Databases, Factual ; Endocardium/pathology ; Heart Ventricles/pathology ; Humans ; Radiographic Image Interpretation, Computer-Assisted/methods ; Swine ; Tomography, X-Ray Computed/methods
Language	English
Publishing date	2014-09-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	2695320-1
ISSN	2168-2208 ; 2168-2194
ISSN (online)	2168-2208
ISSN	2168-2194
DOI	10.1109/JBHI.2014.2357472
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Zs.A 5483: Show issues

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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Coronary plaque imaging with multi-slice computed tomographic angiography and intravascular ultrasound: a close look inside and out.

Rinehart, Sarah / Vazquez, Gustavo / Qian, Zhen / Voros, Szilard

The Journal of invasive cardiology

2009 Volume 21, Issue 7, Page(s) 367–372

MeSH term(s)	Coronary Artery Disease/diagnosis ; Coronary Artery Disease/diagnostic imaging ; Coronary Artery Disease/pathology ; Coronary Vessels/pathology ; Hemodynamics ; Humans ; Tomography, X-Ray Computed/instrumentation ; Tomography, X-Ray Computed/methods ; Ultrasonography, Interventional
Language	English
Publishing date	2009-07
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1154372-3
ISSN	1557-2501 ; 1042-3931
ISSN (online)	1557-2501
ISSN	1042-3931
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