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Article ; Online: Wall between neurology and psychiatry. Neuropsychiatry is alive and well..

Ring, Howard A

2002 Volume 325, Issue 7367, Page(s) 778

MeSH term(s)	Humans ; Interprofessional Relations ; Neurodegenerative Diseases/therapy ; Neuropsychology/organization & administration ; Psychiatry/organization & administration
Language	English
Publishing date	2002-09-26
Publishing country	England
Document type	Comment ; Letter
ZDB-ID	1362901-3
ISSN	1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
ISSN (online)	1756-1833
ISSN	0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
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Article ; Online: Understanding self-reported difficulties in decision-making by people with autism spectrum disorders.

Vella, Lydia / Ring, Howard A / Aitken, Mike Rf / Watson, Peter C / Presland, Alexander / Clare, Isabel Ch

Autism : the international journal of research and practice

2017 Volume 22, Issue 5, Page(s) 549–559

Abstract: Autobiographical accounts and a limited research literature suggest that adults with autism spectrum disorders can experience difficulties with decision-making. We examined whether some of the difficulties they describe correspond to quantifiable ... ...

Abstract	Autobiographical accounts and a limited research literature suggest that adults with autism spectrum disorders can experience difficulties with decision-making. We examined whether some of the difficulties they describe correspond to quantifiable differences in decision-making when compared to adults in the general population. The participants (38 intellectually able adults with autism spectrum disorders and 40 neurotypical adults) were assessed on three tasks of decision-making (Iowa Gambling Task, Cambridge Gamble Task and Information Sampling Task), which quantified, respectively, decision-making performance and relative attention to negative and positive outcomes, speed and flexibility, and information sampling. As a caution, all analyses were repeated with a subset of participants ( n
MeSH term(s)	Adolescent ; Adult ; Attention ; Autism Spectrum Disorder/psychology ; Case-Control Studies ; Decision Making ; Female ; Humans ; Male ; Middle Aged ; Neuropsychological Tests ; Self Report ; Task Performance and Analysis ; Young Adult
Language	English
Publishing date	2017-04-20
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1338513-6
ISSN	1461-7005 ; 1362-3613
ISSN (online)	1461-7005
ISSN	1362-3613
DOI	10.1177/1362361316687988
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Zs.A 5838: Show issues

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Article ; Online: How to get the most from a consultation with a person who has a learning disability.

Bradley, Paul / Byrne, Katie / Ring, Howard A

Practical neurology

2012 Volume 12, Issue 1, Page(s) 44–48

MeSH term(s)	Humans ; Learning Disorders/diagnosis ; Learning Disorders/therapy ; Referral and Consultation
Language	English
Publishing date	2012-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2170881-2
ISSN	1474-7766 ; 1474-7758
ISSN (online)	1474-7766
ISSN	1474-7758
DOI	10.1136/practneurol-2011-000140
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Article ; Online: Transcutaneous vagus nerve stimulation (t-VNS): A novel effective treatment for temper outbursts in adults with Prader-Willi Syndrome indicated by results from a non-blind study.

Manning, Katherine E / Beresford-Webb, Jessica A / Aman, Lucie C S / Ring, Howard A / Watson, Peter C / Porges, Stephen W / Oliver, Chris / Jennings, Sally R / Holland, Anthony J

PloS one

2019 Volume 14, Issue 12, Page(s) e0223750

Abstract: Temper outbursts are a severe problem for people with Prader-Willi Syndrome (PWS). Previous reports indicate that vagus nerve stimulation (VNS) may reduce maladaptive behaviour in neurodevelopmental disorders, including PWS. We systematically ... ...

Abstract	Temper outbursts are a severe problem for people with Prader-Willi Syndrome (PWS). Previous reports indicate that vagus nerve stimulation (VNS) may reduce maladaptive behaviour in neurodevelopmental disorders, including PWS. We systematically investigated the effectiveness of transcutaneous VNS (t-VNS) in PWS. Using a non-blind single case repeat measures modified ABA design, with participants as their own controls, t-VNS was evaluated in five individuals with PWS [three males; age 22-41 (M = 26.8)]. After a baseline phase, participants received four-hours of t-VNS daily for 12 months, followed by one month of daily t-VNS for two-hours. The primary outcome measure was the mean number of behavioural outbursts per day. Secondary outcomes included findings from behavioural questionnaires and both qualitative and goal attainment interviews. Four of the five participants who completed the study exhibited a statistically significant reduction in number and severity of temper outbursts after approximately nine months of daily four-hour t-VNS. Subsequent two-hour daily t-VNS was associated with increased outbursts for all participants, two reaching significance. Questionnaire and interview data supported these findings, the latter indicating potential mechanisms of action. No serious safety issues were reported. t-VNS is an effective, novel and safe intervention for chronic temper outbursts in PWS. We propose these changes are mediated through vagal projections and their effects both centrally and on the functioning of the parasympathetic nervous system. These findings challenge our present biopsychosocial understanding of such behaviours suggesting that there is a single major mechanism that is modifiable using t-VNS. This intervention is potentially generalizable across other clinical groups. Future research should address the lack of a sham condition in this study along with the prevalence of high drop out rates, and the potential effects of different stimulation intensities, frequencies and pulse widths.
MeSH term(s)	Adult ; Anger ; Female ; Humans ; Male ; Prader-Willi Syndrome/therapy ; Self Report ; Surveys and Questionnaires ; Temperament ; Transcutaneous Electric Nerve Stimulation/methods ; Treatment Outcome ; Vagus Nerve/physiology ; Vagus Nerve Stimulation/methods
Language	English
Publishing date	2019-12-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0223750
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Article: Making sense of non-epileptic seizures.

Gene-Cos, Nuri / Ring, Howard A

Epileptic disorders : international epilepsy journal with videotape

2005 Volume 7, Issue 2, Page(s) 123–130

Abstract: Background: Non-epileptic seizures (NES) are a chronic condition that is frequently misdiagnosed. Limited awareness of the condition may contribute to mismanagement and poor outcome.: Methods: Medline and PsycLit review of clinical and laboratory ... ...

Abstract	Background: Non-epileptic seizures (NES) are a chronic condition that is frequently misdiagnosed. Limited awareness of the condition may contribute to mismanagement and poor outcome. Methods: Medline and PsycLit review of clinical and laboratory studies. Results: The concept of NES is clarified, common clinical presentations are reviewed and the differential diagnoses considered. A general overview of possible mechanisms and pathological findings is presented. Finally, epidemiological, prognostic, and treatment issues are described. Conclusions: Clinicians increased awareness of NES, together with new diagnostic techniques will improve diagnosis and outcome of this condition. Further research is needed into the pathophysiology, etiology and maintenance mechanisms of non-epileptic seizures.
MeSH term(s)	Diagnosis, Differential ; Electroencephalography ; Humans ; Psychophysiologic Disorders/complications ; Psychophysiologic Disorders/diagnosis ; Psychophysiologic Disorders/therapy ; Seizures/diagnosis ; Seizures/etiology ; Seizures/therapy
Language	English
Publishing date	2005-06
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	2086797-9
ISSN	1950-6945 ; 1294-9361
ISSN (online)	1950-6945
ISSN	1294-9361
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Zs.A 5740: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Prevalence, associations, and predictors of apathy in adult survivors of infantile (<5 years of age) posterior fossa brain tumors.

Carroll, Cliodhna / Watson, Peter / Spoudeas, Helen A / Hawkins, Michael M / Walker, David A / Clare, Isabel C H / Holland, Anthony J / Ring, Howard A

Neuro-oncology

2013 Volume 15, Issue 4, Page(s) 497–505

Abstract: Background: Apathy is associated with pervasive and disadvantageous effects on daily functioning. It has been observed transiently in some children after surgery for posterior fossa tumors. In this study, our objective was to examine prevalence, ... ...

Abstract	Background: Apathy is associated with pervasive and disadvantageous effects on daily functioning. It has been observed transiently in some children after surgery for posterior fossa tumors. In this study, our objective was to examine prevalence, associations, and predictors of apathy in adult survivors of an infantile posterior fossa brain tumor (PFT). Methods: One hundred seventeen adult survivors of a childhood PFT diagnosed before age 5 years and 60 of their siblings were assessed in a cross-sectional study a mean of 32 years (range, 18-53 years) after survivors' initial tumor diagnoses, using the Marin Apathy Evaluation Scale (AES), the Weschler Abbreviated Scale of Intelligence and the Composite International Diagnostic Interview for psychiatric disorders. Results: Marin Apathy Evaluation Scale, the Weschler Abbreviated Scale of Intelligence reached or exceeded a criterion score for clinically significant apathy in 35% of survivors, compared with 18% in a sibling comparison group. In both siblings and survivors, apathy was associated with lower verbal and full-scale IQ and, among survivors, with having undergone partial rather than total tumor resection (independent of irradiation status). Apathy was not related to presence of concurrent International Classification of Diseases, 10(th) Revision, depression. Female sex was associated with late apathy after a PFT, with increased likelihood of women reaching the apathy criterion relative to men if they were survivors. Conclusions: Clinically significant and potentially treatable apathy occurs relatively commonly in adult survivors of an infantile childhood PFT, particularly women. Clinicians, including those managing posterior fossa pathology in very young children, should be aware of this association, and future research should clarify whether specific treatment-related variables are implicated in increasing this risk of apathy.
MeSH term(s)	Adolescent ; Adult ; Apathy ; Child, Preschool ; Cross-Sectional Studies ; Female ; Follow-Up Studies ; Humans ; Infratentorial Neoplasms/complications ; Infratentorial Neoplasms/mortality ; Infratentorial Neoplasms/therapy ; Male ; Middle Aged ; Prevalence ; Prognosis ; Siblings ; Survival Rate ; Survivors ; United Kingdom/epidemiology ; Young Adult
Language	English
Publishing date	2013-03-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2028601-6
ISSN	1523-5866 ; 1522-8517
ISSN (online)	1523-5866
ISSN	1522-8517
DOI	10.1093/neuonc/nos320
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Zs.A 5307: Show issues

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Article: Evidence supporting a cognitive model of depression in Parkinson's disease.

Serra-Mestres, Jordi / Ring, Howard A

The Journal of nervous and mental disease

2002 Volume 190, Issue 6, Page(s) 407–410

Abstract: The objective of this study was to explore the possibility that depression in Parkinson disease (PD) arises from an illness-related vulnerability to negative emotional stimuli. The Color-Word and Emotional Stroop tasks were performed by 27 nondepressed ... ...

Abstract	The objective of this study was to explore the possibility that depression in Parkinson disease (PD) arises from an illness-related vulnerability to negative emotional stimuli. The Color-Word and Emotional Stroop tasks were performed by 27 nondepressed patients with PD and 27 healthy volunteers. Patients with PD showed greater interference to the sad words of the Emotional Stroop than did control patients, despite similar performances to the controls on the neutral and Color-Word Stroop tasks. Nondepressed patients with PD may have attentional mechanisms that are vulnerable to negative stimuli. This vulnerability might arise out of a common involvement of anterior cingulate regions in both selective attention and mood regulation, and could in turn predispose to cognitive distortions that may lead to depression.
MeSH term(s)	Adult ; Aged ; Cerebral Cortex/physiopathology ; Cognition/physiology ; Corpus Striatum/physiopathology ; Depressive Disorder/diagnosis ; Depressive Disorder/etiology ; Depressive Disorder/physiopathology ; Emotions/physiology ; Female ; Gyrus Cinguli/physiology ; Gyrus Cinguli/physiopathology ; Humans ; Male ; Middle Aged ; Models, Neurological ; Neural Pathways/physiopathology ; Neuropsychological Tests/statistics & numerical data ; Parkinson Disease/complications ; Parkinson Disease/diagnosis ; Parkinson Disease/physiopathology ; Personality Inventory/statistics & numerical data
Language	English
Publishing date	2002-06
Publishing country	United States
Document type	Comparative Study ; Journal Article
ZDB-ID	3020-x
ISSN	1539-736X ; 0022-3018
ISSN (online)	1539-736X
ISSN	0022-3018
DOI	10.1097/00005053-200206000-00011
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Ui II Zs.22: Show issues

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Article ; Online: Atypical movement performance and sensory integration in Asperger's syndrome.

Siaperas, Panagiotis / Ring, Howard A / McAllister, Catherine J / Henderson, Sheila / Barnett, Anna / Watson, Peter / Holland, Anthony J

Journal of autism and developmental disorders

2011 Volume 42, Issue 5, Page(s) 718–725

Abstract: The aims of this study were to investigate whether individuals with AS have impaired motor abilities and sensorimotor processing and whether these impairments were age-related. Sensorimotor abilities were examined using the Movement Assessment Battery ... ...

Abstract	The aims of this study were to investigate whether individuals with AS have impaired motor abilities and sensorimotor processing and whether these impairments were age-related. Sensorimotor abilities were examined using the Movement Assessment Battery for Children-2, and the Sensory Integration Praxis Test. Fifty boys with AS aged 7-14 years old were compared with typically developing boys. Overall, children with AS showed significant impairment of movement performance as well as proprioceptive and vestibular processing. There were no interaction effects of age and clinical group on level of performance deficit in any of the modalities tested. Increasing our understanding of motor and sensory impairment in AS could have treatment implications for those supporting individuals with AS.
MeSH term(s)	Adolescent ; Asperger Syndrome/physiopathology ; Child ; Humans ; Male ; Movement/physiology ; Proprioception/physiology ; Psychomotor Performance/physiology
Language	English
Publishing date	2011-06-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	391999-7
ISSN	1573-3432 ; 0162-3257
ISSN (online)	1573-3432
ISSN	0162-3257
DOI	10.1007/s10803-011-1301-2
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Zs.A 765: Show issues

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Article: A comparative study of mismatch negativity (MMN) in epilepsy and non-epileptic seizures.

Gene-Cos, Nuri / Pottinger, Richard / Barrett, Geoff / Trimble, Michael R / Ring, Howard A

Epileptic disorders : international epilepsy journal with videotape

2005 Volume 7, Issue 4, Page(s) 363–372

Abstract: This study investigated mismatch negativity (MMN) differences between subjects with non-epileptic seizures (NES), subjects with epilepsy, and healthy controls. Event-related potentials (ERPs) were obtained from 14 patients with NES, 15 patients with ... ...

Abstract	This study investigated mismatch negativity (MMN) differences between subjects with non-epileptic seizures (NES), subjects with epilepsy, and healthy controls. Event-related potentials (ERPs) were obtained from 14 patients with NES, 15 patients with epilepsy and 16 healthy control subjects. A conventional MMN procedure was used with a random sequence of 12% deviant tones (922 Hz) and 88% standard tones (1000 Hz). Subjects were instructed to ignore the tones delivered through headphones whilst reading a book. Significant differences in distribution of the mismatch negativity (MMN) in patients with NES compared to controls were obtained (F3, p <or= 0.019; Cz, p <or= 0.044) and longer MMN duration in patients with epilepsy compared with patients with NES (p <or= 0.039) was observed. The change that has been analyzed is one of relative (or scaled) amplitude rather than absolute amplitude. These differences observed at Cz/F3 suggest an increase in emphasis of the MMN in the frontocentral region in patients with NES compared to healthy controls, suggesting that the MMN is generated in a different way in NES compared with controls. This could indicate that one of the normal MMN generator areas does not function normally in NES. Increased absolute amplitude of the MMN has previously been observed in anxiety disorders particularly in post-traumatic stress disorder (PTSD). We discuss similarities between NES and PTSD, suggesting that the increased relative amplitude obtained in this study may be related to mechanisms of generation of NES. The prolonged duration of the MMN in epilepsy could be related to difficulties in processes associated with novelty discrimination (closure of MMN generating mechanism). This information processing dysfunction could be associated with the concentration and memory difficulties that are observed in some patients with epilepsy. This study provides electrophysiological evidence of abnormal processing of auditory stimuli in both clinical conditions when compared to healthy controls, and interictal differences between a group of patients with epilepsy and a group of patients with non-epileptic seizures, as measured by the MMN.<br />
MeSH term(s)	Acoustic Stimulation ; Adult ; Affect ; Auditory Pathways/physiopathology ; Auditory Perception/physiology ; Diagnosis, Differential ; Electrooculography ; Epilepsy/diagnosis ; Epilepsy/physiopathology ; Epilepsy/psychology ; Epilepsy, Complex Partial/physiopathology ; Epilepsy, Complex Partial/psychology ; Epilepsy, Generalized/physiopathology ; Epilepsy, Generalized/psychology ; Evoked Potentials, Auditory ; Female ; Humans ; Intelligence ; Male ; Memory/physiology ; Middle Aged ; Reaction Time ; Seizures/diagnosis ; Seizures/physiopathology ; Seizures/psychology
Language	English
Publishing date	2005-12
Publishing country	France
Document type	Comparative Study ; Journal Article
ZDB-ID	2086797-9
ISSN	1950-6945 ; 1294-9361
ISSN (online)	1950-6945
ISSN	1294-9361
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Zs.A 5740: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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