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  1. AU="Ring, Melanie"
  2. AU="Richardson, Malcolm D"
  3. AU="Morgan, Mari"
  4. AU="Namazi Shabestari, Alireza"
  5. AU="Binny, Simon" AU="Binny, Simon"
  6. AU="Payabyab, Eden C"
  7. AU="Kwon, Soon-Chan"
  8. AU="Vaidya, Harshit"
  9. AU="Shan, Chongxin"
  10. AU="Arora, Vineet M"
  11. AU="Carey, Alanna"
  12. AU="Habash, Khader I"
  13. AU="Angela Ribeiro"
  14. AU="Radomir Živadinović"
  15. AU=Shakeri Ahmad

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  1. Artikel ; Online: Association between anxiety, depression and quality of life in male and female German students during the COVID-19 pandemic.

    Wilzer, Emily / Zeisel, Annalena / Roessner, Veit / Ring, Melanie

    BMC psychiatry

    2024  Band 24, Heft 1, Seite(n) 212

    Abstract: Background: Studies show that three-quarters of mental disorders appear during young adulthood, which makes students a risk group. Especially people with anxiety and depression experience lower Quality of Life (QoL) compared to healthy persons. ... ...

    Abstract Background: Studies show that three-quarters of mental disorders appear during young adulthood, which makes students a risk group. Especially people with anxiety and depression experience lower Quality of Life (QoL) compared to healthy persons. Furthermore, previous research found that there was a wide range of negative mental consequences triggered by the COVID-19 pandemic. This study aimed to examine the association between anxiety, depression and QoL in male and female students at the time of the COVID-19 pandemic.
    Methods: 297 German students (121 men, age span
    Results: While women showed higher raw anxiety scores, groups did not differ in terms of their raw depression scores. Furthermore, we found main effects of anxiety and depression on the four QoL subscales. Students´ QoL was highest if they were not affected by anxiety and depression, independently of gender. Psychological and social QoL was worst if the students reported marginal and particularly clinically significant levels of anxiety and depression. Men experienced worse psychological and social QoL than women for clinically significant anxiety levels.
    Conclusions: Interventions should target especially the psychological and the social subscales of QoL, as these areas are most affected by anxiety and depression. Possible interventions could be psychoeducational programs or participation in sports because it offers an opportunity for social interaction and goal-directed activity.
    Mesh-Begriff(e) Humans ; Male ; Female ; Young Adult ; Adult ; Depression/psychology ; Quality of Life/psychology ; COVID-19/epidemiology ; Pandemics ; Anxiety/psychology ; Students ; Surveys and Questionnaires
    Sprache Englisch
    Erscheinungsdatum 2024-03-18
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2050438-X
    ISSN 1471-244X ; 1471-244X
    ISSN (online) 1471-244X
    ISSN 1471-244X
    DOI 10.1186/s12888-024-05611-8
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  2. Artikel ; Online: The impact of depressive and anxious symptoms on quality of life in adults on the autism spectrum.

    Thiel, Tobias / Riedelbauch, Saskia / Gaigg, Sebastian / Roessner, Veit / Ring, Melanie

    Autism research : official journal of the International Society for Autism Research

    2024  

    Abstract: Quality of life (QoL) is lower in adults on the autism spectrum (AS) compared with typically developing (TD) adults. In this context, recent studies have examined the role of depression and anxiety in reducing QoL in AS adults. The aim of this study was ... ...

    Abstract Quality of life (QoL) is lower in adults on the autism spectrum (AS) compared with typically developing (TD) adults. In this context, recent studies have examined the role of depression and anxiety in reducing QoL in AS adults. The aim of this study was to (1) replicate these findings of lower QoL and (2) assess the negative influence of depressive and anxious symptoms on QoL in an adult AS (N = 86) and TD (N = 87) German sample with a broad age range (18-70 years). For this, we used questionnaires that have been validated for the AS and TD population: the World Health Organization Quality of Life Brief Version, the Autism-Specific QoL items, and the Hospital Anxiety and Depression Scale. We replicated previous findings and extended them to autism-specific QoL. Our AS sample had lower QoL compared with the TD adults. However, depressive symptoms were the largest contributor to lower QoL in both samples, more so than group membership and anxious symptoms. We conclude that interventions to improve QoL in AS adults should specifically target depressive symptoms and for this, improvements to the diagnostic process and treatment of depression in AS are necessary.
    Sprache Englisch
    Erscheinungsdatum 2024-05-24
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2481338-2
    ISSN 1939-3806 ; 1939-3792
    ISSN (online) 1939-3806
    ISSN 1939-3792
    DOI 10.1002/aur.3144
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  3. Artikel ; Online: Emotions and worries during 1.5 years of the COVID-19 pandemic - how adults with and without mental health conditions coped with the crisis.

    Rothe, Josefine / Brückner, Greta / Ring, Melanie / Roessner, Veit / Wolff, Nicole / Vetter, Nora C

    BMC psychiatry

    2024  Band 24, Heft 1, Seite(n) 114

    Abstract: Background: During the COVID 19 pandemic, there were social restrictions with severe mental stress for a long time. Most studies on mental health consequences of the pandemic focused primarily on the beginning of the pandemic. The present study on ... ...

    Abstract Background: During the COVID 19 pandemic, there were social restrictions with severe mental stress for a long time. Most studies on mental health consequences of the pandemic focused primarily on the beginning of the pandemic. The present study on families of patients or study participants of a child and adolescent psychiatry aimed to examine long-term profiles of emotions and worries in adults with and without mental health condition (mhc) during the first 1.5 years of the COVID-19 pandemic.
    Methods: We surveyed emotions and worries of 128 adults with (n = 32) and without (n = 96) pre-pandemic mhc over a 1.5-year study period from spring 2020 until summer/autumn 2021. Emotions and worries were captured at four time points: [i] pre-pandemic, [ii] spring 2020 (first lockdown was implemented), [iii] December 2020 (hard lockdown at Christmas time) and [iv] summer/autumn 2021 (considerable ease of regulations); [i] pre-pandemic and [iii] December 2020 were measured retrospectively). First, we run non-parametric tests to compare emotions and worries between adults with and without pre-pandemic mhc at the four time points. Next, we conducted latent profile analysis to identify subgroups from the total sample who share similar trajectories of emotions and worries. Finally, a logistic regression analysis was run to examine whether socio-demographic and psycho-social factors were related to identified trajectories of emotions and worries.
    Results: Adults without pre-pandemic mhc reported a strong worsening of emotions and worries at the beginning of the pandemic and a lower worsening during the course, while adults with pre-pandemic mhc reported a constant worsening of emotions and worries. The latent profile analysis revealed three profiles of adults who show either i) an adaption, ii) no adaption or iii) a continuous high condition. With increasing age, higher perceived stress and pre-pandemic mhc, the likelihood of an adaption was increased.
    Conclusion: The results of the present study suggested that adults (both with and without pre-pandemic mhc) coped the crisis with different strategies and that most of them returned to their initial, pre-pandemic levels of emotions and worries when social restrictions were considerably eased or stopped.
    Mesh-Begriff(e) Adolescent ; Adult ; Child ; Humans ; Pandemics ; Mental Health ; Retrospective Studies ; COVID-19 ; Communicable Disease Control ; Emotions
    Sprache Englisch
    Erscheinungsdatum 2024-02-09
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2050438-X
    ISSN 1471-244X ; 1471-244X
    ISSN (online) 1471-244X
    ISSN 1471-244X
    DOI 10.1186/s12888-024-05573-x
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Introduction to the Special Collection on "Memory in Autism Spectrum Disorder".

    Ring, Melanie / Solomon, Marjorie

    Autism research : official journal of the International Society for Autism Research

    2020  Band 13, Heft 11, Seite(n) 1913–1914

    Sprache Englisch
    Erscheinungsdatum 2020-11-08
    Erscheinungsland United States
    Dokumenttyp Letter
    ZDB-ID 2481338-2
    ISSN 1939-3806 ; 1939-3792
    ISSN (online) 1939-3806
    ISSN 1939-3792
    DOI 10.1002/aur.2426
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  5. Artikel ; Online: Validation of the German Glasgow Sensory Questionnaire and replication of sensory processing differences in students with higher and lower Autism-Spectrum Quotient.

    Zeisel, Annalena / Thiel, Tobias / Gaigg, Sebastian B / Roessner, Veit / Ring, Melanie

    BMC psychiatry

    2023  Band 23, Heft 1, Seite(n) 426

    Abstract: Background: The Glasgow Sensory Questionnaire (GSQ) gives insight into sensory processing differences (hypo- and hyper-sensitivity across modalities), which is a clinically defining characteristic of autism spectrum disorder (ASD). Because there is no ... ...

    Abstract Background: The Glasgow Sensory Questionnaire (GSQ) gives insight into sensory processing differences (hypo- and hyper-sensitivity across modalities), which is a clinically defining characteristic of autism spectrum disorder (ASD). Because there is no validated German version of this instrument, this study aimed at validating the German GSQ. Further, a replication of the GSQ's sensory processing differences was intended.
    Methods: University students of Technische Universität or Universitätsklinikum in Dresden, Germany, were recruited via email distribution or the university homepage and 297 German-speaking students completed the online survey, comprising the German GSQ, Autism-Spectrum Quotient (AQ) and Symptom-Checklist (SCL-90). For validation of the German GSQ, confirmatory factor analyses followed by exploratory factor analyses were applied.
    Results: The German GSQ has moderate to low validity, good to acceptable reliability, and a different internal structure from the original GSQ. Replicating the sensory processing differences in students with higher and lower AQ was not successful.
    Conclusions: Results indicate that the GSQ, developed especially for individuals with ASD, is less informative for the general population if there are not enough individuals with higher AQ scores in the sample.
    Mesh-Begriff(e) Humans ; Autism Spectrum Disorder/diagnosis ; Autistic Disorder ; Reproducibility of Results ; Students ; Surveys and Questionnaires ; Perception
    Sprache Englisch
    Erscheinungsdatum 2023-06-14
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2050438-X
    ISSN 1471-244X ; 1471-244X
    ISSN (online) 1471-244X
    ISSN 1471-244X
    DOI 10.1186/s12888-023-04903-9
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Examining a model of anxiety in autistic adults.

    Riedelbauch, Saskia / Gaigg, Sebastian B / Thiel, Tobias / Roessner, Veit / Ring, Melanie

    Autism : the international journal of research and practice

    2023  Band 28, Heft 3, Seite(n) 565–579

    Abstract: Abstract: Anxiety disorders commonly occur in autism. Existing studies implicate intolerance of uncertainty, alexithymia, sensory processing differences and emotion regulation difficulties as influencing factors of anxiety in autism. To date, a few ... ...

    Abstract Abstract: Anxiety disorders commonly occur in autism. Existing studies implicate intolerance of uncertainty, alexithymia, sensory processing differences and emotion regulation difficulties as influencing factors of anxiety in autism. To date, a few studies have considered the combination of these factors within the same sample. This study used structural equation modelling to test the prediction that intolerance of uncertainty and emotion regulation constitute more direct causes of anxiety in autism that mediate the influences of sensory processing difference and alexithymia as more sequential contributing factors. Autistic (n = 86) and non-autistic adults (n = 100) completed a battery of self-report questionnaires. Only when applied to each group separately, the broad predictions of the model were confirmed for the autistic group following data-driven additions of paths between sensory processing difference and anxiety and alexithymia implying that sensory processing difference contribute indirectly as well as directly to individual differences in anxiety. For the non-autistic group, model fit could only be achieved after removing autism-related traits and sensory processing differences as predictors of anxiety. These results suggest that aetiology and expression of anxiety in autism partially overlap with what is observed in the general population except that sensory processing differences appear to play a relatively unique role in the context of autism.
    Mesh-Begriff(e) Adult ; Humans ; Autistic Disorder/psychology ; Autism Spectrum Disorder/psychology ; Anxiety/psychology ; Emotions ; Anxiety Disorders/psychology
    Sprache Englisch
    Erscheinungsdatum 2023-06-16
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1338513-6
    ISSN 1461-7005 ; 1362-3613
    ISSN (online) 1461-7005
    ISSN 1362-3613
    DOI 10.1177/13623613231177777
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel: Examining a model of anxiety in autistic adults

    Riedelbauch, Saskia / Gaigg, Sebastian B. / Thiel, Tobias / Roessner, Veit / Ring, Melanie

    Autism - The International Journal for Research and Practice

    2024  Band 28, Heft 3, Seite(n) 565–579

    Abstract: Anxiety disorders commonly occur in autism. Existing studies implicate intolerance of uncertainty, alexithymia, sensory processing differences and emotion regulation difficulties as influencing factors of anxiety in autism. To date, a few studies have ... ...

    Titelübersetzung Untersuchung eines Modells der Angst bei autistischen Erwachsenen
    Abstract Anxiety disorders commonly occur in autism. Existing studies implicate intolerance of uncertainty, alexithymia, sensory processing differences and emotion regulation difficulties as influencing factors of anxiety in autism. To date, a few studies have considered the combination of these factors within the same sample. This study used structural equation modelling to test the prediction that intolerance of uncertainty and emotion regulation constitute more direct causes of anxiety in autism that mediate the influences of sensory processing difference and alexithymia as more sequential contributing factors. Autistic (n = 86) and non-autistic adults (n = 100) completed a battery of self-report questionnaires. Only when applied to each group separately, the broad predictions of the model were confirmed for the autistic group following data-driven additions of paths between sensory processing difference and anxiety and alexithymia implying that sensory processing difference contribute indirectly as well as directly to individual differences in anxiety. For the non-autistic group, model fit could only be achieved after removing autism-related traits and sensory processing differences as predictors of anxiety. These results suggest that aetiology and expression of anxiety in autism partially overlap with what is observed in the general population except that sensory processing differences appear to play a relatively unique role in the context of autism.
    Schlagwörter Alexithymia ; Alexithymie ; Angst ; Angststörungen ; Anxiety ; Anxiety Disorders ; Autism Spectrum Disorders ; Autismus-Spektrum-Störungen ; Cognitive Appraisal ; Emotional Regulation ; Emotionsregulation ; Gedankenunterdrückung ; Intolerance of Uncertainty ; Intrapersonale Persönlichkeitsprozesse ; Kognitive Bewertung (Emotionspsychologie) ; Personality Processes ; Sensorisch-integrative Dysfunktion ; Sensory Integration Dysfunction ; Thought Suppression ; Unsicherheitsintoleranz
    Sprache Englisch
    Dokumenttyp Artikel
    ZDB-ID 1338513-6
    ISSN 1362-3613
    ISSN 1362-3613
    DOI 10.1177/13623613231177777
    Datenquelle PSYNDEX

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  8. Artikel ; Online: Arousal-modulated memory encoding and retrieval in adults with autism spectrum disorder.

    Bast, Nico / Gaigg, Sebastian B / Bowler, Dermot M / Roessner, Veit / Freitag, Christine M / Ring, Melanie

    Autism research : official journal of the International Society for Autism Research

    2022  Band 15, Heft 9, Seite(n) 1609–1620

    Abstract: Recently, we have shown that pupil dilation during a recognition memory task can serve as an index of memory retrieval difficulties in autism. At the time of publication, we were unaware of specific data-analysis methods that can be used to shed further ... ...

    Abstract Recently, we have shown that pupil dilation during a recognition memory task can serve as an index of memory retrieval difficulties in autism. At the time of publication, we were unaware of specific data-analysis methods that can be used to shed further light on the origins of such memory related pupil dilation. Specifically, by distinguishing "tonic" from "phasic" changes in pupil dilation and considering their temporal progression, it is possible to draw inferences about the functional integrity of a locus coeruleus-norepinephrine system (LC-NE) that is known to play a key role in regulating memory encoding and retrieval processes. We therefore apply these analyses to our previously published eye-tracking data of adults with ASD (N = 24) and neurotypical development (TD, N = 30) during the recognition memory task. In this re-analysis, we related pupil dilation during encoding and retrieval to recognition accuracy in a per-trial analysis of linear mixed models. In ASD, we replicated attenuated recognition accuracy, which was accompanied by attenuated pupil dilation during encoding and retrieval. Group differences in pupil dilation during retrieval occurred late during the trial (after 1.75 s) and indicated an altered top-down processing like attenuated attribution of semantic salience in response to previously encoded stimuli. In addition, only in the ASD group were higher pupil dilation during encoding and lower pupil dilation during retrieval associated with decreased recognition accuracy. This supports altered modulation of memory encoding and retrieval in ASD, with LC-NE phasic activity as promising underlying mechanism. LAY SUMMARY: We investigated the changes of pupil size during memory testing in autism spectrum disorder. Adults with ASD remembered fewer items correctly than neurotypical individuals (TD). This reduced memory was related to increased pupillary responses at study and decreased pupil dilation at test only for adults with ASD indicating a different modulation of memory by the locus coeruleus.
    Mesh-Begriff(e) Adult ; Arousal/physiology ; Autism Spectrum Disorder/complications ; Humans ; Locus Coeruleus ; Pupil/physiology ; Recognition, Psychology
    Sprache Englisch
    Erscheinungsdatum 2022-07-30
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2481338-2
    ISSN 1939-3806 ; 1939-3792
    ISSN (online) 1939-3806
    ISSN 1939-3792
    DOI 10.1002/aur.2784
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: A Physiological Marker of Recognition Memory in Adults with Autism Spectrum Disorder? - The Pupil Old/New Effect.

    Ring, Melanie / Bowler, Dermot M / Gaigg, Sebastian B

    Autism research : official journal of the International Society for Autism Research

    2019  Band 13, Heft 4, Seite(n) 627–640

    Abstract: This study investigated the pupil Old/New effect in individuals with Autism Spectrum Disorder (ASD) and typical development (TD). Participants studied verbal and visual meaningful and meaningless materials in black and white on a computer screen. Pupil ... ...

    Abstract This study investigated the pupil Old/New effect in individuals with Autism Spectrum Disorder (ASD) and typical development (TD). Participants studied verbal and visual meaningful and meaningless materials in black and white on a computer screen. Pupil sizes were measured while participants performed a Remember (episodic memory with context)/Know (semantic memory, no context) recognition memory test. ASD compared to TD individuals showed significantly reduced recognition rates for all materials. Both groups showed better memory for visual compared to verbal (picture superiority effect) and meaningful compared to meaningless materials. A pupil size ratio (pupil size for test item divided by baseline) for old (studied) and new (unstudied) materials indicated larger pupils for old compared to new materials only for the TD but not the ASD group. Pupil size in response to old versus new items was positively related to recognition accuracy, confirming that the pupil Old/New effect reflects a memory phenomenon in the ASD group. In addition, this study suggests an involvement of the noradrenergic neurotransmitter system in the abnormal hippocampal functioning in ASD. Implications of these findings, as well as their underlying neurophysiology, will be discussed in relation to current theories of memory in ASD. Autism Res 2020, 13: 627-640. © 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Most measures of memory in Autism Spectrum Disorder (ASD) depend on verbal answers. In addition to these verbal answers, this study measured the size of the participants' pupil in response to studied and unfamiliar materials revealing memory difficulties in ASD. Measuring pupil size works nonverbally, outside of conscious awareness and forms the basis of studies on less verbal persons with ASD. Mechanisms and brain regions underlying memory differences in ASD are discussed.
    Mesh-Begriff(e) Acoustic Stimulation/methods ; Adult ; Aged ; Autism Spectrum Disorder/physiopathology ; Female ; Humans ; Male ; Middle Aged ; Photic Stimulation/methods ; Pupil/physiology ; Recognition, Psychology/physiology
    Sprache Englisch
    Erscheinungsdatum 2019-12-20
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2481338-2
    ISSN 1939-3806 ; 1939-3792
    ISSN (online) 1939-3806
    ISSN 1939-3792
    DOI 10.1002/aur.2251
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: What Can Performance in the IEDS Task Tell Us About Attention Shifting in Clinical Groups?

    Yearsley, James M / Gaigg, Sebastian B / Bowler, Dermot M / Ring, Melanie / Haenschel, Corinna

    Autism research : official journal of the International Society for Autism Research

    2021  Band 14, Heft 6, Seite(n) 1237–1251

    Abstract: The Intra-Extra-dimensional set shift task (IEDS) is a widely used test of learning and attention, believed to be sensitive to aspects of executive function. The task proceeds through a number of stages, and it is generally claimed that patterns of ... ...

    Abstract The Intra-Extra-dimensional set shift task (IEDS) is a widely used test of learning and attention, believed to be sensitive to aspects of executive function. The task proceeds through a number of stages, and it is generally claimed that patterns of errors across stages can be used to discriminate between reduced attention switching and more general reductions in rates of learning. A number of papers have used the IEDS task to argue for specific attention shifting difficulties in Autism Spectrum Disorder (ASD) and Schizophrenia, however, it remains unclear how well the IEDS really differentiates between reduced attention shifting and other causes of impaired performance. To address this issue, we introduce a simple computational model of performance in the IEDS task, designed to separate the competing effects of attention shifting and general learning rate. We fit the model to data from ASD and comparison individuals matched on age and IQ, as well as to data from four previous studies which used the IEDS task. Model fits do not show consistent evidence for reductions in attention shifting rates in ASD and Schizophrenia. Instead, we find performance is better explained by differences in learning rate, particularly from punishment, which we show correlates with IQ. We, therefore, argue that the IEDS task is not a good measure of attention shifting in clinical groups. LAY SUMMARY: The Intra-Extra-Dimensional Set shift task (IEDS) is often given to autistic individuals, who tend to make more errors relative to comparison groups. This higher error rate is taken to mean that autistic individuals struggle with attention control. Our computational model of the IEDS shows that the performance of ASD and some other clinical groups can be explained instead by differences in learning rate, rather than differences in attention control.
    Mesh-Begriff(e) Attention ; Autism Spectrum Disorder ; Autistic Disorder ; Executive Function ; Humans ; Schizophrenia
    Sprache Englisch
    Erscheinungsdatum 2021-02-11
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2481338-2
    ISSN 1939-3806 ; 1939-3792
    ISSN (online) 1939-3806
    ISSN 1939-3792
    DOI 10.1002/aur.2484
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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