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  1. Book: Dementia

    Ringman, John M.

    (Neurologic clinics ; volume 35, number 2 (May 2017))

    2017  

    Author's details editor John M. Ringman
    Series title Neurologic clinics ; volume 35, number 2 (May 2017)
    Collection
    Language English
    Size x Seiten, Seite 172-386, Illustrationen
    Publisher Elsevier
    Publishing place Philadelphia, Pennsylvania
    Publishing country United States
    Document type Book
    HBZ-ID HT019363921
    ISBN 978-0-323-52852-8 ; 0-323-52852-X
    Database Catalogue ZB MED Medicine, Health

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  2. Article ; Online: Alzheimer and the Dementias.

    Ringman, John M

    Neurologic clinics

    2017  Volume 35, Issue 2, Page(s) ix–x

    MeSH term(s) Alzheimer Disease ; Dementia ; Humans
    Language English
    Publishing date 2017
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 1013148-6
    ISSN 1557-9875 ; 0733-8619
    ISSN (online) 1557-9875
    ISSN 0733-8619
    DOI 10.1016/j.ncl.2017.02.001
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  3. Article ; Online: Update on Alzheimer's and the Dementias: Introduction.

    Ringman, John M

    Neurologic clinics

    2017  Volume 35, Issue 2, Page(s) 171–174

    Abstract: Though the numbers of dementia cases are rising worldwide, there is evidence that incidence rates are decreasing. We now know that the neuropathological changes of Alzheimer's disease (AD) precede overt clinical signs by 15 to 20 years and we have ... ...

    Abstract Though the numbers of dementia cases are rising worldwide, there is evidence that incidence rates are decreasing. We now know that the neuropathological changes of Alzheimer's disease (AD) precede overt clinical signs by 15 to 20 years and we have biochemical and imaging markers that enable us to identify them. The genetic complexity of AD suggests it is not a single entity but rather represents a group of related diseases. The amyloid cascade hypothesis has led to the development of putative disease-modifying interventions but these have not yet been demonstrated to be substantively effective and additional approaches are warranted.
    MeSH term(s) Alzheimer Disease ; Dementia ; Humans
    Language English
    Publishing date 2017-05
    Publishing country United States
    Document type Introductory Journal Article
    ZDB-ID 1013148-6
    ISSN 1557-9875 ; 0733-8619
    ISSN (online) 1557-9875
    ISSN 0733-8619
    DOI 10.1016/j.ncl.2017.01.009
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  4. Article ; Online: Are Late-Onset Autosomal Dominant and Sporadic Alzheimer Disease "Separate but Equal"?

    Ringman, John M

    JAMA neurology

    2016  Volume 73, Issue 9, Page(s) 1060–1061

    MeSH term(s) Age of Onset ; Alzheimer Disease ; Humans
    Language English
    Publishing date 2016-07-25
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2702023-X
    ISSN 2168-6157 ; 2168-6149
    ISSN (online) 2168-6157
    ISSN 2168-6149
    DOI 10.1001/jamaneurol.2016.1633
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  5. Article: Treatment Options for Agitation in Dementia.

    Ringman, John M / Schneider, Lon

    Current treatment options in neurology

    2019  Volume 21, Issue 7, Page(s) 30

    Abstract: Purpose of review: The goal of the current review is to provide an update on the management of agitation in persons with dementia with a focus on pharmacological management of persons with Alzheimer's disease.: Recent findings: As consistently ... ...

    Abstract Purpose of review: The goal of the current review is to provide an update on the management of agitation in persons with dementia with a focus on pharmacological management of persons with Alzheimer's disease.
    Recent findings: As consistently effective and safe pharmacologic interventions are still lacking, identifying and addressing medical and environmental precipitants remain a priority. Acetylcholinesterase inhibitors and memantine should be initiated to enhance cognition, and if present, management of insomnia or sundowning with trazodone is indicated. If agitation persists, treatment with citalopram can be initiated with attention paid to potential prolongation of the QT interval. Treatment with low doses of atypical antipsychotics such as risperidone or quetiapine can be effective after appropriate consideration of and disclosure of potential adverse effects. In light of the lack of consistently effective treatments for agitation in dementia, there have been renewed efforts to define the condition and improve the design of trials of medications to treat it. Considering the heterogeneity of patients and their comorbidities as well as the specific nature of their "agitation", there is no "one-size fits all" approach to agitation in AD. However, many options exist that can be prudently pursued for this common problem in this delicate population.
    Language English
    Publishing date 2019-06-24
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2057342-X
    ISSN 1534-3138 ; 1092-8480
    ISSN (online) 1534-3138
    ISSN 1092-8480
    DOI 10.1007/s11940-019-0572-3
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  6. Article ; Online: Vessel density mapping of small cerebral vessels on 3D high resolution black blood MRI.

    Sarabi, Mona Sharifi / Ma, Samantha J / Jann, Kay / Ringman, John M / Wang, Danny J J / Shi, Yonggang

    NeuroImage

    2024  Volume 286, Page(s) 120504

    Abstract: Small cerebral blood vessels are largely inaccessible to existing clinical in vivo imaging technologies. This study aims to present a novel analysis pipeline for vessel density mapping of small cerebral blood vessels from high-resolution 3D black-blood ... ...

    Abstract Small cerebral blood vessels are largely inaccessible to existing clinical in vivo imaging technologies. This study aims to present a novel analysis pipeline for vessel density mapping of small cerebral blood vessels from high-resolution 3D black-blood MRI at 3T. Twenty-eight subjects (10 under 35 years old, 18 over 60 years old) were imaged with the T1-weighted turbo spin-echo with variable flip angles (T1w TSE-VFA) sequence optimized for black-blood small vessel imaging with iso-0.5 mm spatial resolution (interpolated from 0.51×0.51×0.64 mm
    MeSH term(s) Humans ; Aged ; Adult ; Middle Aged ; Imaging, Three-Dimensional/methods ; Magnetic Resonance Imaging/methods ; Magnetic Resonance Angiography/methods ; Middle Cerebral Artery ; Brain
    Language English
    Publishing date 2024-01-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1147767-2
    ISSN 1095-9572 ; 1053-8119
    ISSN (online) 1095-9572
    ISSN 1053-8119
    DOI 10.1016/j.neuroimage.2023.120504
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  7. Article ; Online: Cognitive symptoms of Alzheimer's disease: clinical management and prevention.

    Joe, Elizabeth / Ringman, John M

    BMJ (Clinical research ed.)

    2019  Volume 367, Page(s) l6217

    Abstract: Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by the accumulation of amyloid β in the form of extracellular plaques and by intracellular neurofibrillary tangles, with eventual neurodegeneration and dementia. There is ... ...

    Abstract Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by the accumulation of amyloid β in the form of extracellular plaques and by intracellular neurofibrillary tangles, with eventual neurodegeneration and dementia. There is currently no disease-modifying treatment though several symptomatic medications exist with modest benefit on cognition. Acetylcholinesterase inhibitors have a consistent benefit across all stages of dementia; their benefit in mild cognitive impairment and prodromal AD is unproven. Memantine has a smaller benefit on cognition overall which is limited to the moderate to severe stages, and the combination of a cholinesterase inhibitor and memantine may have additional efficacy. Evidence for the efficacy of vitamin E supplementation and medical foods is weak but might be considered in the context of cost, availability, and safety in individual patients. Apparently promising disease-modifying interventions, mostly addressing the amyloid cascade hypothesis of AD, have recently failed to demonstrate efficacy so novel approaches must be considered.
    MeSH term(s) Alzheimer Disease/drug therapy ; Alzheimer Disease/physiopathology ; Alzheimer Disease/prevention & control ; Alzheimer Disease/psychology ; Amyloid beta-Peptides/pharmacology ; Amyloid beta-Peptides/therapeutic use ; Cholinesterase Inhibitors/pharmacology ; Cholinesterase Inhibitors/therapeutic use ; Delayed-Action Preparations ; Drug Therapy, Combination ; Humans ; Randomized Controlled Trials as Topic ; Treatment Outcome
    Chemical Substances Amyloid beta-Peptides ; Cholinesterase Inhibitors ; Delayed-Action Preparations
    Language English
    Publishing date 2019-12-06
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.l6217
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  8. Article ; Online: Enhanced Association of Tau Pathology and Cognitive Impairment in Mild Cognitive Impairment Subjects with Behavior Symptoms.

    Ge, Xinting / Qiao, Yuchuan / Choi, Jiyoon / Raman, Rema / Ringman, John M / Shi, Yonggang

    Journal of Alzheimer's disease : JAD

    2022  Volume 87, Issue 2, Page(s) 557–568

    Abstract: Background: Mild cognitive impairment (MCI) individuals with neuropsychiatric symptoms (NPS) are more likely to develop dementia.: Objective: We sought to understand the relationship between neuroimaging markers such as tau pathology and cognitive ... ...

    Abstract Background: Mild cognitive impairment (MCI) individuals with neuropsychiatric symptoms (NPS) are more likely to develop dementia.
    Objective: We sought to understand the relationship between neuroimaging markers such as tau pathology and cognitive symptoms both with and without the presence of NPS during the prodromal period of Alzheimer's disease.
    Methods: A total of 151 MCI subjects with tau positron emission tomographic (PET) scanning with 18F AV-1451, amyloid-β (Aβ) PET scanning with florbetapir or florbetaben, magnetic resonance imaging, and cognitive and behavioral evaluations were selected from the Alzheimer's Disease Neuroimaging Initiative. A 4-group division approach was proposed using amyloid (A-/A+) and behavior (B-/B+) status: A-B-, A-B+, A+B-, and A+B+. Pearson's correlation test was conducted for each group to examine the association between tau deposition and cognitive performance.
    Results: No statistically significant association between tau deposition and cognitive impairment was found for subjects without behavior symptoms in either the A-B-or A+B-groups after correction for false discovery rate. In contrast, tau deposition was found to be significantly associated with cognitive impairment in entorhinal cortex and temporal pole for the A-B+ group and nearly the whole cerebrum for the A+B+ group.
    Conclusion: Enhanced associations between tauopathy and cognitive impairment are present in MCI subjects with behavior symptoms, which is more prominent in the presence of elevated amyloid pathology. MCI individuals with NPS may thus be at greater risk for further cognitive decline with the increase of tau deposition in comparison to those without NPS.
    MeSH term(s) Alzheimer Disease/pathology ; Amyloid beta-Peptides ; Cognitive Dysfunction/psychology ; Humans ; Positron-Emission Tomography/methods ; tau Proteins
    Chemical Substances Amyloid beta-Peptides ; tau Proteins
    Language English
    Publishing date 2022-03-24
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1440127-7
    ISSN 1875-8908 ; 1387-2877
    ISSN (online) 1875-8908
    ISSN 1387-2877
    DOI 10.3233/JAD-215555
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  9. Article ; Online: Retinotopic degeneration of the retina and optic tracts in autosomal dominant Alzheimer's disease.

    Adhikari, Suman / Qiao, Yuchuan / Singer, Maxwell / Sagare, Abhay / Jiang, Xuejuan / Shi, Yonggang / Ringman, John M / Kashani, Amir H

    Alzheimer's & dementia : the journal of the Alzheimer's Association

    2023  Volume 19, Issue 11, Page(s) 5103–5113

    Abstract: Introduction: We investigated the correlation between retinal thickness and optic tract integrity in subjects with autosomal dominant Alzheimer's disease (ADAD) causing mutations.: Methods: Retinal thicknesses and diffusion tensor images (DTI) were ... ...

    Abstract Introduction: We investigated the correlation between retinal thickness and optic tract integrity in subjects with autosomal dominant Alzheimer's disease (ADAD) causing mutations.
    Methods: Retinal thicknesses and diffusion tensor images (DTI) were obtained using optical coherence tomography and magnetic resonance imaging, respectively. The association between retinal thickness and DTI measures was adjusted for age, sex, retinotopy, and correlation between eyes.
    Results: Optic tract mean diffusivity and axial diffusivity were negatively correlated with retinotopically defined ganglion cell inner plexiform thickness (GCIPL). Fractional anisotropy was negatively correlated with retinotopically defined retinal nerve fiber layer thickness. There was no correlation between outer nuclear layer (ONL) thickness and any DTI measure.
    Discussion: In ADAD, GCIPL thickness is significantly associated with retinotopic optic tract DTI measures even in minimally symptomatic subjects. Similar associations were not present with ONL thickness or when ignoring retinotopy. We provide in vivo evidence for optic tract changes resulting from ganglion cell pathology in ADAD.
    MeSH term(s) Humans ; Retinal Ganglion Cells/pathology ; Optic Tract/pathology ; Alzheimer Disease/diagnostic imaging ; Alzheimer Disease/genetics ; Alzheimer Disease/pathology ; Retina/diagnostic imaging ; Magnetic Resonance Imaging
    Language English
    Publishing date 2023-04-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2211627-8
    ISSN 1552-5279 ; 1552-5260
    ISSN (online) 1552-5279
    ISSN 1552-5260
    DOI 10.1002/alz.13100
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  10. Article ; Online: Age of onset predicted by Aβ profiling in a novel PSEN1 (I180F) mutation.

    Robbie, Leah / Fernández, Sara Gutiérrez / Montoya, Lucy / Sagare, Abhay / Barrera, Lilibeth / Sheikh-Bahaei, Nasim / Gutierrez, Lucia Chavez / Ringman, John M

    Neuroscience letters

    2023  Volume 820, Page(s) 137591

    Abstract: We describe a novel I180F mutation in PSEN1 in which biomarker-supported Alzheimer's disease (AD) segregated in two affected family members. The affected amino acid is highly conserved across species and in silico models predict pathogenicity for AD. The ...

    Abstract We describe a novel I180F mutation in PSEN1 in which biomarker-supported Alzheimer's disease (AD) segregated in two affected family members. The affected amino acid is highly conserved across species and in silico models predict pathogenicity for AD. The mean age of onset was 56 which was reasonably predicted by the pattern of Aβ species produced in an in vitro model.
    MeSH term(s) Humans ; Age of Onset ; Alzheimer Disease/diagnosis ; Alzheimer Disease/genetics ; Alzheimer Disease/metabolism ; Amino Acids ; Amyloid beta-Peptides/genetics ; Amyloid beta-Peptides/metabolism ; Biomarkers ; Mutation ; Presenilin-1/genetics ; Presenilin-1/metabolism
    Chemical Substances Amino Acids ; Amyloid beta-Peptides ; Biomarkers ; Presenilin-1 ; PSEN1 protein, human
    Language English
    Publishing date 2023-12-14
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 194929-9
    ISSN 1872-7972 ; 0304-3940
    ISSN (online) 1872-7972
    ISSN 0304-3940
    DOI 10.1016/j.neulet.2023.137591
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