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  1. Article ; Online: Human colorectal cancer: upregulation of the adaptor protein Rai in TILs leads to cell dysfunction by sustaining GSK-3 activation and PD-1 expression.

    Montecchi, Tommaso / Nannini, Giulia / De Tommaso, Domiziana / Cassioli, Chiara / Coppola, Federica / Ringressi, Maria Novella / Carraro, Fabio / Naldini, Antonella / Taddei, Antonio / Marotta, Giuseppe / Amedei, Amedeo / Baldari, Cosima T / Ulivieri, Cristina

    Cancer immunology, immunotherapy : CII

    2024  Volume 73, Issue 1, Page(s) 2

    Abstract: Background: The immunosuppressive tumor microenvironment (TME) of colorectal cancer (CRC) is a major hurdle for immune checkpoint inhibitor-based therapies. Hence characterization of the signaling pathways driving T cell exhaustion within TME is a ... ...

    Abstract Background: The immunosuppressive tumor microenvironment (TME) of colorectal cancer (CRC) is a major hurdle for immune checkpoint inhibitor-based therapies. Hence characterization of the signaling pathways driving T cell exhaustion within TME is a critical need for the discovery of novel therapeutic targets and the development of effective therapies. We previously showed that (i) the adaptor protein Rai is a negative regulator of T cell receptor signaling and T helper 1 (Th1)/Th17 cell differentiation; and (ii) Rai deficiency is implicated in the hyperactive phenotype of T cells in autoimmune diseases.
    Methods: The expression level of Rai was measured by qRT-PCR in paired peripheral blood T cells and T cells infiltrating tumor tissue and the normal adjacent tissue in CRC patients. The impact of hypoxia-inducible factor (HIF)-1α on Rai expression was evaluated in T cells exposed to hypoxia and by performing chromatin immunoprecipitation assays and RNA interference assays. The mechanism by which upregulation of Rai in T cells promotes T cell exhaustion were evaluated by flow cytometric, qRT-PCR and western blot analyses.
    Results: We show that Rai is a novel HIF-1α-responsive gene that is upregulated in tumor infiltrating lymphocytes of CRC patients compared to patient-matched circulating T cells. Rai upregulation in T cells promoted Programmed cell Death protein (PD)-1 expression and impaired antigen-dependent degranulation of CD8
    Conclusions: Our data identify Rai as a hitherto unknown regulator of the TME-induced exhausted phenotype of human T cells.
    MeSH term(s) Humans ; CD8-Positive T-Lymphocytes ; Colorectal Neoplasms/genetics ; Glycogen Synthase Kinase 3 ; Hypoxia ; Lymphocytes, Tumor-Infiltrating ; Programmed Cell Death 1 Receptor/genetics ; Tumor Microenvironment ; Up-Regulation
    Chemical Substances Glycogen Synthase Kinase 3 (EC 2.7.11.26) ; Programmed Cell Death 1 Receptor ; PDCD1 protein, human ; PPP1R13L protein, human
    Language English
    Publishing date 2024-01-04
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 195342-4
    ISSN 1432-0851 ; 0340-7004
    ISSN (online) 1432-0851
    ISSN 0340-7004
    DOI 10.1007/s00262-023-03614-0
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  2. Article: A Comparison between Open and Minimally Invasive Techniques for the Resection of Colorectal Liver Metastasis.

    Bartolini, Ilenia / Fortuna, Laura / Risaliti, Matteo / Tirloni, Luca / Buccianti, Simone / Luceri, Cristina / Ringressi, Maria Novella / Batignani, Giacomo / Taddei, Antonio

    Healthcare (Basel, Switzerland)

    2022  Volume 10, Issue 12

    Abstract: The liver is the most common site of colorectal cancer metastasis. Liver surgery is a cornerstone in treatment, with progressive expansion of minimally invasive surgery (MIS). This study aims to compare short- and long-term outcomes of open surgery and ... ...

    Abstract The liver is the most common site of colorectal cancer metastasis. Liver surgery is a cornerstone in treatment, with progressive expansion of minimally invasive surgery (MIS). This study aims to compare short- and long-term outcomes of open surgery and MIS for the treatment of colorectal adenocarcinoma liver metastasis during the first three years of increasing caseload and implementation of MIS use in liver surgery. All patients treated between November 2018 and August 2021 at Careggi Teaching Hospital in Florence, Italy, were prospectively entered into a database and retrospectively reviewed. Fifty-one patients were resected (41 open, 10 MIS). Considering that patients with a significantly higher number of lesions underwent open surgery and operative results were similar, postoperative morbidity rate and length of hospital stay were significantly higher in the open group. No differences were found in the pathological specimen. The postoperative mortality rate was 2%. Mean overall survival and disease-free survival were 46 months (95% CI 42-50) and 22 months (95% CI 15.6-29), respectively. The use of minimally invasive techniques in liver surgery is safe and feasible if surgeons have adequate expertise. MIS and parenchymal sparing resections should be preferred whenever technically feasible.
    Language English
    Publishing date 2022-12-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2721009-1
    ISSN 2227-9032
    ISSN 2227-9032
    DOI 10.3390/healthcare10122433
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  3. Article ; Online: Impact of microbiota-immunity axis in pancreatic cancer management.

    Bartolini, Ilenia / Nannini, Giulia / Risaliti, Matteo / Matarazzo, Francesco / Moraldi, Luca / Ringressi, Maria Novella / Taddei, Antonio / Amedei, Amedeo

    World journal of gastroenterology

    2022  Volume 28, Issue 32, Page(s) 4527–4539

    Abstract: The microbiota impact on human diseases is well-known, and a growing body of literature is providing evidence about the complex interplay between microbiota-immune system-human physiology/pathology, including cancers. Together with the defined risk ... ...

    Abstract The microbiota impact on human diseases is well-known, and a growing body of literature is providing evidence about the complex interplay between microbiota-immune system-human physiology/pathology, including cancers. Together with the defined risk factors (
    MeSH term(s) Biomarkers ; Dysbiosis ; Humans ; Microbiota ; Pancreatic Neoplasms/therapy ; Smoking ; Pancreatic Neoplasms
    Chemical Substances Biomarkers
    Language English
    Publishing date 2022-09-14
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v28.i32.4527
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  4. Article ; Online: From adenoma to CRC stages: the oral-gut microbiome axis as a source of potential microbial and metabolic biomarkers of malignancy.

    Russo, Edda / Gloria, Leandro Di / Nannini, Giulia / Meoni, Gaia / Niccolai, Elena / Ringressi, Maria Novella / Baldi, Simone / Fani, Renato / Tenori, Leonardo / Taddei, Antonio / Ramazzotti, Matteo / Amedei, Amedeo

    Neoplasia (New York, N.Y.)

    2023  Volume 40, Page(s) 100901

    Abstract: Background: Approximately 95% of Colorectal cancers (CRC) consist of adenocarcinomas originating from colonic Adenomatous polyps (AP). Increasing importance in CRC occurrence and progression has been attributed to the gut microbiota; however, a huge ... ...

    Abstract Background: Approximately 95% of Colorectal cancers (CRC) consist of adenocarcinomas originating from colonic Adenomatous polyps (AP). Increasing importance in CRC occurrence and progression has been attributed to the gut microbiota; however, a huge proportion of microorganisms inhabit the human digestive system. So, to comprehensively study the microbial spatial variations and their role in CRC progression, from AP to the different CRC phases, a holistic vision is imperative, including the simultaneous evaluation of multiple niches from the gastrointestinal system. Through an integrated approach, we identified potential microbial and metabolic biomarkers, able to discriminate human CRC from AP and/or also the different Tumor node metastasis (TNM) staging. In addition, as the microbiota contributes to the production of essential metabolic products detectable in fecal samples, we analysed and compared metabolites obtained from CRC and AP patients by using a Nuclear magnetic resonance (NMR) approach.
    Methods: In this observational study, saliva, tissue and stool samples from 61 patients, have been collected, including 46 CRC and 15 AP patients, age and sex-matched, undergoing surgery in 2018 at the Careggi University Hospital (Florence, Italy). First, the microbiota in the three-district between CRC and AP patients has been characterized, as well as in different CRC TNM stages. Subsequently, proton NMR spectroscopy has been used in combination with multivariate and univariate statistical approaches, to define the fecal metabolic profile of a restricted group of CRC and AP patients.
    Results: CRC patients display a different profile of tissue and fecal microbiota with respect to AP patients. Significant differences have been observed in CRC tissue microbial clades, with a rise of the Fusobacterium genus. In addition, significant taxa increase at the genus level has been observed in stool samples of CRC patients. Furthermore, Fusobacterium found in intestinal tissue has been positively correlated with fecal Parvimonas, for the first time. Moreover, as predicted by metagenomics pathway analysis, a significant increase of lactate (p=0.037) has been observed in the CRC fecal metabolic profiles, and positively correlated with Bifidobacterium (p=0.036). Finally, minor bacterial differences in CRC patients at stage T2 (TNM classification) have been detected, with a raise of the Spirochaetota phylum in CRC samples, with a slight increase of the Alphaproteobacteria class in fecal samples.
    Conclusion: Our results suggest the importance of microbiota communities and oncometabolites in CRC development. Further studies on CRC/AP management with a focus on CRC assessment are needed to investigate novel microbial-related diagnostic tools aimed to improve therapeutic interventions.
    MeSH term(s) Humans ; Gastrointestinal Microbiome ; Colorectal Neoplasms/pathology ; Adenoma/diagnosis ; Microbiota ; Bacteria ; Rectal Neoplasms ; Biomarkers
    Chemical Substances Biomarkers
    Language English
    Publishing date 2023-04-12
    Publishing country United States
    Document type Observational Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1483840-0
    ISSN 1476-5586 ; 1522-8002
    ISSN (online) 1476-5586
    ISSN 1522-8002
    DOI 10.1016/j.neo.2023.100901
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    Zs.A 5203: Show issues Location:
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  5. Article ; Online: A Wearable Sensor-Based Platform for Surgeon Posture Monitoring: A Tool to Prevent Musculoskeletal Disorders.

    Carbonaro, Nicola / Mascherini, Gabriele / Bartolini, Ilenia / Ringressi, Maria Novella / Taddei, Antonio / Tognetti, Alessandro / Vanello, Nicola

    International journal of environmental research and public health

    2021  Volume 18, Issue 7

    Abstract: Surgeons are workers that are particularly prone to the development of musculoskeletal disorders. Recent advances in surgical interventions, such as laparoscopic procedures, have caused a worsening of the scenario, given the harmful static postures that ... ...

    Abstract Surgeons are workers that are particularly prone to the development of musculoskeletal disorders. Recent advances in surgical interventions, such as laparoscopic procedures, have caused a worsening of the scenario, given the harmful static postures that have to be kept for long periods. In this paper, we present a sensor-based platform specifically aimed at monitoring the posture during actual surgical operations. The proposed system adopts a limited number of Inertial Measurement Units (IMUs) to obtain information about spine and neck angles across time. Such a system merges the reliability of sensor-based approaches and the validity of state-of-the-art scoring procedure, such as RULA. Specifically, three IMUs are used to estimate the flexion, lateral bending, and twisting angles of spine and neck. An ergonomic risk index is thus estimated in a time varying fashion borrowing relevant features from the RULA scoring system. The detailed functioning of the proposed systems is introduced, and the assessment results related to a real surgical procedure, consisting of a laparoscopy and mini-laparotomy sections, are shown and discussed. In the exemplary case study introduced, the surgeon kept a high score, indicating the need for an intervention on the working procedures, for a large time fraction. The system allows separately analyzing the contribution of spine and neck, also specifying the angle configuration. It is shown how the proposed approach can provide further information, as related to dynamical analysis, which could be used to enlarge the features taken into account by currently available approaches for ergonomic risk assessment. The proposed system could be adopted both for training purposes, as well as for alerting surgeons during actual surgical operations.
    MeSH term(s) Ergonomics ; Humans ; Musculoskeletal Diseases/prevention & control ; Occupational Diseases/prevention & control ; Posture ; Reproducibility of Results ; Surgeons ; Wearable Electronic Devices
    Language English
    Publishing date 2021-04-02
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1660-4601
    ISSN (online) 1660-4601
    DOI 10.3390/ijerph18073734
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  6. Article: Evaluation of prognostic factors and clinicopathological patterns of recurrence after curative surgery for colorectal cancer.

    Melli, Filippo / Bartolini, Ilenia / Risaliti, Matteo / Tucci, Rosaria / Ringressi, Maria Novella / Muiesan, Paolo / Taddei, Antonio / Amedei, Amedeo

    World journal of gastrointestinal surgery

    2021  Volume 13, Issue 1, Page(s) 50–75

    Abstract: Background: Colorectal cancer is a common tumor with a quite high-related mortality. Despite the used curative treatments, patients will develop cancer recurrence in up to 50% of the cases and/or other primary neoplasms. Although most of the recurrences ...

    Abstract Background: Colorectal cancer is a common tumor with a quite high-related mortality. Despite the used curative treatments, patients will develop cancer recurrence in up to 50% of the cases and/or other primary neoplasms. Although most of the recurrences are discovered within 3 years from the first treatment, a small percentage is found after 5 years. The early detection of recurrence is crucial to allow further therapies improving patients' survival. Several follow-up programs have been developed but the optimal one is far from being established.
    Aim: To evaluation of potential prognostic factors for timing and patterns of recurrence in order to plan tailored follow-up programs.
    Methods: Perioperative and long-term data of all consecutive patients surgically treated with curative intent, from January 2006 to June 2009, for colorectal adenocar-cinoma, were retrospectively reviewed to find potential prognostic factors associated with: (1) Recurrence incidence; (2) Incidence of an early (within 3 years from surgery) or late recurrence; and (3) Different sites of recurrence. In addition, the incidence of other primary neoplasms has been evaluated in a cohort of patients with a minimum potential follow-up of 10 years.
    Results: Our study included 234 patients. The median follow-up period has been 119 ± 46.2 mo. The recurrence rate has been 25.6%. Patients with a higher chance to develop recurrence had also the following characteristics: Higher levels of preoperative glycemia and carcinoembryonic antigen, highest anaesthesiologists Score score, occlusion, received a complex operation performed with an open technique, after a longer hospital stay, and showed advanced tumors. The independent prognostic factors for recurrence were the hospital stay, N stage 2, and M stage 1 (multivariate analysis). Younger ages were significantly associated with an early recurrence onset. Patients that received intermediate colectomies or segmental resections, having an N stage 2 or American Joint Committee on Cancer stage 3 tumors were also associated with a higher risk of liver recurrence, while metastatic diseases at diagnosis were linked with local recurrence. Neoadjuvant treatments showed lung recurrence. Finally, bigger tumors and higher lymph node ratio were associated with peritoneal recurrence (marginally significant). Thirty patients developed a second malignancy during the follow-up time.
    Conclusion: Several prognostic factors should be considered for tailored follow-up programs, eventually, beyond 5 years from the first treatment.
    Language English
    Publishing date 2021-01-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2573700-4
    ISSN 1948-9366
    ISSN 1948-9366
    DOI 10.4240/wjgs.v13.i1.50
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  7. Article: Gut microbiota and immune system in liver cancer: Promising therapeutic implication from development to treatment.

    Bartolini, Ilenia / Risaliti, Matteo / Tucci, Rosaria / Muiesan, Paolo / Ringressi, Maria Novella / Taddei, Antonio / Amedei, Amedeo

    World journal of gastrointestinal oncology

    2021  Volume 13, Issue 11, Page(s) 1616–1631

    Abstract: Liver cancer is a leading cause of death worldwide, and hepatocellular carcinoma (HCC) is the most frequent primary liver tumour, followed by cholangiocarcinoma. Notably, secondary tumours represent up to 90% of liver tumours. Chronic liver disease is a ... ...

    Abstract Liver cancer is a leading cause of death worldwide, and hepatocellular carcinoma (HCC) is the most frequent primary liver tumour, followed by cholangiocarcinoma. Notably, secondary tumours represent up to 90% of liver tumours. Chronic liver disease is a recognised risk factor for liver cancer development. Up to 90% of the patients with HCC and about 20% of those with cholangiocarcinoma have an underlying liver alteration. The gut microbiota-liver axis represents the bidirectional relationship between gut microbiota, its metabolites and the liver through the portal flow. The interplay between the immune system and gut microbiota is also well-known. Although primarily resulting from experiments in animal models and on HCC, growing evidence suggests a causal role for the gut microbiota in the development and progression of chronic liver pathologies and liver tumours. Despite the curative intent of "traditional" treatments, tumour recurrence remains high. Therefore, microbiota modulation is an appealing therapeutic target for liver cancer prevention and treatment. Furthermore, microbiota could represent a non-invasive biomarker for early liver cancer diagnosis. This review summarises the potential role of the microbiota and immune system in primary and secondary liver cancer development, focusing on the potential therapeutic implications.
    Language English
    Publishing date 2021-11-22
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2573696-6
    ISSN 1948-5204
    ISSN 1948-5204
    DOI 10.4251/wjgo.v13.i11.1616
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  8. Article ; Online: A comparative study of carbonic anhydrase activity in lymphocytes from colorectal cancer tissues and adjacent healthy counterparts.

    Nannini, Giulia / De Luca, Viviana / D'Ambrosio, Chiara / Scaloni, Andrea / Taddei, Antonio / Ringressi, Maria Novella / Cianchi, Fabio / Staderini, Fabio / Capasso, Clemente / Amedei, Amedeo / Supuran, Claudiu T

    Journal of enzyme inhibition and medicinal chemistry

    2022  Volume 37, Issue 1, Page(s) 1651–1655

    Abstract: Several carbonic anhydrase (CA, EC 4.2.1.1) isoforms play an essential role in processes connected to tumorigenesis, as they efficiently accelerate the hydration of carbon dioxide to bicarbonate and proton. In this context, examples are CA IX and CA XII, ...

    Abstract Several carbonic anhydrase (CA, EC 4.2.1.1) isoforms play an essential role in processes connected to tumorigenesis, as they efficiently accelerate the hydration of carbon dioxide to bicarbonate and proton. In this context, examples are CA IX and CA XII, which were proved to be upregulated in many solid malignancies. On the other hand, cancer and the immune system are inextricably linked, and targeting the immune checkpoints recently was shown to efficiently improve the treatment of malignancies. In this study, we have investigated the expression of CA isoforms in tumour-infiltrating lymphocytes (TILs) that, according to the immunosurveillance theory, were suggested to have a crucial role in the development of colorectal cancer (CRC). T lymphocytes isolated from healthy surrounding mucosa showed a higher CA activity compared to those present in tumour and peripheral blood in the same patients. CA I and II were confirmed as enzyme isoforms involved in the process, as determined by proteomic analysis of corresponding TIL samples. These preliminary findings suggest a dysregulation of the local immune response in the CRC tissues and a loss of effective anticancer mechanisms mediated by CAs therein.
    MeSH term(s) Antigens, Neoplasm/metabolism ; Carbonic Anhydrase IX/metabolism ; Carbonic Anhydrase Inhibitors/pharmacology ; Carbonic Anhydrases/metabolism ; Colorectal Neoplasms ; Humans ; Lymphocytes ; Proteomics ; Structure-Activity Relationship
    Chemical Substances Antigens, Neoplasm ; Carbonic Anhydrase Inhibitors ; Carbonic Anhydrase IX (EC 4.2.1.1) ; Carbonic Anhydrases (EC 4.2.1.1)
    Language English
    Publishing date 2022-06-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2082578-X
    ISSN 1475-6374 ; 1475-6366
    ISSN (online) 1475-6374
    ISSN 1475-6366
    DOI 10.1080/14756366.2022.2085694
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    Zs.A 3004: Show issues Location:
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  9. Article ; Online: Current management of intrahepatic cholangiocarcinoma: from resection to palliative treatments.

    Bartolini, Ilenia / Risaliti, Matteo / Fortuna, Laura / Agostini, Carlotta / Ringressi, Maria Novella / Taddei, Antonio / Muiesan, Paolo

    Radiology and oncology

    2020  Volume 54, Issue 3, Page(s) 263–271

    Abstract: Background Intrahepatic cholangiocarcinoma (ICC) is the second most common liver primary tumour after hepatocellular carcinoma and represents 20% of all the cholangiocarcinomas. Its incidence is increasing and mortality rates are rising. Surgical ... ...

    Abstract Background Intrahepatic cholangiocarcinoma (ICC) is the second most common liver primary tumour after hepatocellular carcinoma and represents 20% of all the cholangiocarcinomas. Its incidence is increasing and mortality rates are rising. Surgical resection is the only option to cure the disease, despite the high recurrence rates reported to be up to 80%. Intrahepatic recurrences may be still treated with curative intent in a small percentage of the patients. Unfortunately, due to lack of specific symptoms, most patients are diagnosed in a late stage of disease and often unsuitable for resection. Liver transplantation for ICC is still controversial. After the first published poor results, improving outcomes have been reported in highly selected cases, including locally advanced ICC treated with neoadjuvant chemotherapy, when successful in controlling tumour progression. Thus, liver transplantation should be considered a possible option within study protocols. When surgical management is not possible, palliative treatments include chemotherapy, radiotherapy and loco-regional treatments such as radiofrequency ablation, trans-arterial chemoembolization or radioembolization. Conclusions This update on the management of ICC focusses on surgical treatments. Known and potential prognostic factors are highlighted in order to assist in treatment selection.
    MeSH term(s) Bile Duct Neoplasms/diagnosis ; Bile Duct Neoplasms/surgery ; Bile Duct Neoplasms/therapy ; Cholangiocarcinoma/diagnosis ; Cholangiocarcinoma/surgery ; Cholangiocarcinoma/therapy ; Humans ; Liver Transplantation ; Neoplasm Recurrence, Local ; Palliative Care ; Prognosis
    Language English
    Publishing date 2020-07-29
    Publishing country Poland
    Document type Journal Article ; Review
    ZDB-ID 1128829-2
    ISSN 1581-3207 ; 0485-893X ; 1318-2099
    ISSN (online) 1581-3207
    ISSN 0485-893X ; 1318-2099
    DOI 10.2478/raon-2020-0045
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  10. Article ; Online: Obstructed defecation: the role of anorectal manometry.

    Pucciani, F / Ringressi, M N

    Techniques in coloproctology

    2011  Volume 16, Issue 1, Page(s) 67–72

    Abstract: Background: The aim of the study was to evaluate the clinical usefulness of anorectal manometry (AM) in patients affected by obstructed defecation (OD).: Methods: Between January 2007 and December 2010, 379 patients (287 women and 92 men) affected by ...

    Abstract Background: The aim of the study was to evaluate the clinical usefulness of anorectal manometry (AM) in patients affected by obstructed defecation (OD).
    Methods: Between January 2007 and December 2010, 379 patients (287 women and 92 men) affected by OD were evaluated. After a preliminary clinical evaluation, defecography and AM were performed. The results were compared with those from 20 healthy control subjects.
    Results: Overall anal resting pressure was not significantly different between patients and controls. Maximal voluntary contraction (MVC) data were significantly lower when compared with those of controls (P < 0.01). The straining test was considered positive in 143 patients. No significant difference was noted between patients and controls in maximal tolerated volume data. Patients had a significantly higher conscious rectal sensitivity threshold than controls (P < 0.02).
    Conclusions: A positive straining test, low MVC and impaired rectal sensation are the main abnormalities detected by AM in patients with OD.
    MeSH term(s) Adult ; Aged ; Anal Canal/diagnostic imaging ; Anal Canal/physiopathology ; Anus Diseases/complications ; Anus Diseases/physiopathology ; Ataxia/physiopathology ; Constipation/etiology ; Constipation/physiopathology ; Defecation/physiology ; Defecography ; Female ; Humans ; Intussusception/complications ; Intussusception/physiopathology ; Male ; Manometry ; Middle Aged ; Muscle Contraction ; Pelvic Floor Disorders/complications ; Pelvic Floor Disorders/physiopathology ; Rectocele/complications ; Rectocele/physiopathology ; Rectum/physiopathology ; Sensation/physiology ; Statistics, Nonparametric ; Young Adult
    Language English
    Publishing date 2011-12-16
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2083309-X
    ISSN 1128-045X ; 1123-6337
    ISSN (online) 1128-045X
    ISSN 1123-6337
    DOI 10.1007/s10151-011-0800-7
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