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  1. Article ; Online: Cardiac Monitoring for Atrial Fibrillation in Cryptogenic Stroke.

    Ringwala, Sukit M / Tomson, Todd T / Passman, Rod S

    Cardiology clinics

    2016  Volume 34, Issue 2, Page(s) 287–297

    Abstract: Despite an extensive initial evaluation, the cause of up to a third of ischemic strokes remains undetermined. The detection of atrial fibrillation (AF) in these patients with cryptogenic stroke is critical as the diagnosis of AF would warrant ... ...

    Abstract Despite an extensive initial evaluation, the cause of up to a third of ischemic strokes remains undetermined. The detection of atrial fibrillation (AF) in these patients with cryptogenic stroke is critical as the diagnosis of AF would warrant anticoagulation to reduce the risk of recurrent stroke. Observational studies and prospective randomized controlled trials have shown that a substantial proportion of patients with cryptogenic stroke have AF detected by post-stroke cardiac monitoring with higher AF detection rates observed with longer monitoring periods.
    MeSH term(s) Atrial Fibrillation/complications ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/physiopathology ; Cerebral Infarction/etiology ; Electrocardiography, Ambulatory/methods ; Humans
    Language English
    Publishing date 2016-05
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 1196385-2
    ISSN 1558-2264 ; 0733-8651
    ISSN (online) 1558-2264
    ISSN 0733-8651
    DOI 10.1016/j.ccl.2015.12.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Effects on platelet function of a direct acting antagonist of coagulation factor Xa.

    Ringwala, Sukit M / Dibattiste, Peter M / Schneider, David J

    Journal of thrombosis and thrombolysis

    2012  Volume 34, Issue 3, Page(s) 291–296

    Abstract: Because novel direct acting anticoagulants are being tested in the secondary prevention of cardiovascular events, we assessed potential effects of a direct acting antagonist of Factor Xa on platelet function. Blood from patients with known coronary ... ...

    Abstract Because novel direct acting anticoagulants are being tested in the secondary prevention of cardiovascular events, we assessed potential effects of a direct acting antagonist of Factor Xa on platelet function. Blood from patients with known coronary artery disease who were treated with aspirin but no other antithrombotic agent was spiked in vitro with rivaroxaban alone or in combination with a direct acting P2Y12 antagonist (cangrelor). To limit cofounding effects of anticoagulants and to enable interaction between coagulation factors, blood was anticoagulated only with a specific inhibitor of Factor XIIa, corn trypsin inhibitor. Polymerization of fibrin was prevented with the peptide GPRP. Activation of platelets was determined with the use of flow cytometry in response to lipidated tissue factor, thrombin, the collagen mimetic convulxin, and adenosine diphosphate (ADP). Rivaroxaban inhibited the activation of platelets induced by tissue factor and to a lesser extent activation induced by thrombin, effects that were accentuated when combined with cangrelor. Rivaroxaban did not attenuate convulxin-induced activation of platelets; however, a limited but consistent attenuation of ADP-induced platelet activation was seen with blood anticoagulated with rivaroxaban. Effects of rivaroxaban on ADP-induced platelet activation were not mediated by thrombin, tissue factor, or platelet-leukocyte aggregation. In conclusion, rivaroxaban attenuated in vitro the activation of platelets mediated by thrombin. In light of the pivotal role of thrombin in platelet activation after rupture of an atherosclerotic plaque, rivaroxaban should attenuate platelet activation in vivo, an effect that is accentuated by combination with a P2Y12 antagonist.
    MeSH term(s) Adenosine Monophosphate/administration & dosage ; Adenosine Monophosphate/adverse effects ; Adenosine Monophosphate/analogs & derivatives ; Aged ; Anticoagulants/administration & dosage ; Aspirin/administration & dosage ; Blood Platelets/metabolism ; Coronary Artery Disease/blood ; Coronary Artery Disease/drug therapy ; Crotalid Venoms/pharmacology ; Factor Xa/metabolism ; Factor Xa Inhibitors ; Female ; Humans ; Lectins, C-Type ; Male ; Middle Aged ; Morpholines/administration & dosage ; Plant Proteins/pharmacology ; Platelet Activation/drug effects ; Platelet Aggregation Inhibitors/administration & dosage ; Platelet Function Tests/methods ; Purinergic P2Y Receptor Antagonists/administration & dosage ; Receptors, Purinergic P2Y12/metabolism ; Rivaroxaban ; Thiophenes/administration & dosage
    Chemical Substances Anticoagulants ; Crotalid Venoms ; Factor Xa Inhibitors ; Lectins, C-Type ; Morpholines ; P2RY12 protein, human ; Plant Proteins ; Platelet Aggregation Inhibitors ; Purinergic P2Y Receptor Antagonists ; Receptors, Purinergic P2Y12 ; Thiophenes ; trypsin inhibitor, Zea mays ; convulxin (37206-04-5) ; Adenosine Monophosphate (415SHH325A) ; cangrelor (6AQ1Y404U7) ; Rivaroxaban (9NDF7JZ4M3) ; Factor Xa (EC 3.4.21.6) ; Aspirin (R16CO5Y76E)
    Language English
    Publishing date 2012-04-23
    Publishing country Netherlands
    Document type Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1230645-9
    ISSN 1573-742X ; 0929-5305
    ISSN (online) 1573-742X
    ISSN 0929-5305
    DOI 10.1007/s11239-012-0727-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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