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Article: Exploring Retinal Blood Vessel Diameters as Biomarkers in Multiple Sclerosis.

Drobnjak Nes, Dragana / Berg-Hansen, Pål / de Rodez Benavent, Sigrid A / Høgestøl, Einar A / Beyer, Mona K / Rinker, Daniel A / Veiby, Nina / Karabeg, Mia / Petrovski, Beáta Éva / Celius, Elisabeth G / Harbo, Hanne F / Petrovski, Goran

Journal of clinical medicine

2022 Volume 11, Issue 11

Abstract: We aimed to determine whether retinal vessel diameters and retinal oxygen saturation in newly diagnosed patients with multiple sclerosis (pwMS) are different from those of a healthy population. Retinal blood vessel diameters were measured using imaging ... ...

Abstract	We aimed to determine whether retinal vessel diameters and retinal oxygen saturation in newly diagnosed patients with multiple sclerosis (pwMS) are different from those of a healthy population. Retinal blood vessel diameters were measured using imaging with a spectrophotometric non-invasive retinal oximeter. Twenty-three newly diagnosed untreated relapsing-remitting MS (RRMS) patients (mean age: 32.2 ± 7.5 years, age range = 18-50 years, 56.5% female) were measured and compared to 23 age- and sex-matched healthy controls (HCs) (mean age: 34.8 ± 8.1 years). Patients with Optic Neuritis were excluded. Retinal venular diameter (143.8 µm versus 157.8 µm: mean;
Language	English
Publishing date	2022-05-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm11113109
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Article ; Online: Brain volume reductions in adolescent heavy drinkers.

Squeglia, Lindsay M / Rinker, Daniel A / Bartsch, Hauke / Castro, Norma / Chung, Yoonho / Dale, Anders M / Jernigan, Terry L / Tapert, Susan F

Developmental cognitive neuroscience

2014 Volume 9, Page(s) 117–125

Abstract: Background: Brain abnormalities in adolescent heavy drinkers may result from alcohol exposure, or stem from pre-existing neural features.: Methods: This longitudinal morphometric study investigated 40 healthy adolescents, ages 12-17 at study entry, ... ...

Abstract	Background: Brain abnormalities in adolescent heavy drinkers may result from alcohol exposure, or stem from pre-existing neural features. Methods: This longitudinal morphometric study investigated 40 healthy adolescents, ages 12-17 at study entry, half of whom (n=20) initiated heavy drinking over the 3-year follow-up. Both assessments included high-resolution magnetic resonance imaging. FreeSurfer was used to segment brain volumes, which were measured longitudinally using the newly developed quantitative anatomic regional change analysis (QUARC) tool. Results: At baseline, participants who later transitioned into heavy drinking showed smaller left cingulate, pars triangularis, and rostral anterior cingulate volume, and less right cerebellar white matter volumes (p<.05), compared to continuous non-using teens. Over time, participants who initiated heavy drinking showed significantly greater volume reduction in the left ventral diencephalon, left inferior and middle temporal gyrus, and left caudate and brain stem, compared to substance-naïve youth (p<.05). Conclusion: Findings suggest pre-existing volume differences in frontal brain regions in future drinkers and greater brain volume reduction in subcortical and temporal regions after alcohol use was initiated. This is consistent with literature showing pre-existing cognitive deficits on tasks recruited by frontal regions, as well as post-drinking consequences on brain regions involved in language and spatial tasks.
MeSH term(s)	Adolescent ; Adolescent Behavior ; Alcohol Drinking/pathology ; Alcoholism/pathology ; Brain/anatomy & histology ; Brain/drug effects ; Brain/pathology ; Child ; Ethanol/administration & dosage ; Ethanol/pharmacology ; Female ; Frontal Lobe/anatomy & histology ; Frontal Lobe/drug effects ; Frontal Lobe/pathology ; Gyrus Cinguli/anatomy & histology ; Gyrus Cinguli/drug effects ; Gyrus Cinguli/pathology ; Humans ; Longitudinal Studies ; Magnetic Resonance Imaging ; Male ; Organ Size/drug effects ; Temporal Lobe/anatomy & histology ; Temporal Lobe/drug effects ; Temporal Lobe/pathology ; White Matter/drug effects ; White Matter/pathology
Chemical Substances	Ethanol (3K9958V90M)
Language	English
Publishing date	2014-02-22
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2572271-2
ISSN	1878-9307 ; 1878-9307
ISSN (online)	1878-9307
ISSN	1878-9307
DOI	10.1016/j.dcn.2014.02.005
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Article ; Online: Hypertension-related alterations in white matter microstructure detectable in middle age.

McEvoy, Linda K / Fennema-Notestine, Christine / Eyler, Lisa T / Franz, Carol E / Hagler, Donald J / Lyons, Michael J / Panizzon, Matthew S / Rinker, Daniel A / Dale, Anders M / Kremen, William S

Hypertension (Dallas, Tex. : 1979)

2015 Volume 66, Issue 2, Page(s) 317–323

Abstract: Most studies examining associations between hypertension and brain white matter microstructure have focused on older adults or on cohorts with a large age range. Because hypertension effects on the brain may vary with age, it is important to focus on ... ...

Abstract	Most studies examining associations between hypertension and brain white matter microstructure have focused on older adults or on cohorts with a large age range. Because hypertension effects on the brain may vary with age, it is important to focus on middle age, when hypertension becomes more prevalent. We used linear mixed-effect models to examine differences in white matter diffusion metrics as a function of hypertension in a well-characterized cohort of middle-aged men (n=316; mean, 61.8 years; range, 56.7-65.6). Diffusion metrics were examined in 9 tracts reported to be sensitive to hypertension in older adults. Relative to normotensive individuals, individuals with long-standing hypertension (>5.6 years) showed reduced fractional anisotropy or increased diffusivity in most tracts. Effects were stronger among carriers than among noncarriers of the apolipoprotein E ε4 allele for 2 tracts connecting frontal regions with other brain areas. Significant differences were observed even after adjustment for potentially related lifestyle and cardiovascular risk factors. Shorter duration of hypertension or better blood pressure control among hypertensive individuals did not lessen the adverse effects. These findings suggest that microstructural white matter alterations appear early in the course of hypertension and may persist despite adequate treatment. Although longitudinal studies are needed to confirm these findings, the results suggest that prevention-rather than management-of hypertension may be vital to preserving brain health in aging.
MeSH term(s)	Aged ; Aging/pathology ; Antihypertensive Agents/therapeutic use ; Apolipoprotein E4/genetics ; Cohort Studies ; Genotype ; Humans ; Hypertension/drug therapy ; Hypertension/genetics ; Hypertension/pathology ; Male ; Middle Aged ; Neuroimaging ; Time Factors ; Treatment Outcome ; White Matter/pathology
Chemical Substances	Antihypertensive Agents ; Apolipoprotein E4
Language	English
Publishing date	2015-08
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	423736-5
ISSN	1524-4563 ; 0194-911X ; 0362-4323
ISSN (online)	1524-4563
ISSN	0194-911X ; 0362-4323
DOI	10.1161/HYPERTENSIONAHA.115.05336
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Article ; Online: Is bigger always better? The importance of cortical configuration with respect to cognitive ability.

Vuoksimaa, Eero / Panizzon, Matthew S / Chen, Chi-Hua / Fiecas, Mark / Eyler, Lisa T / Fennema-Notestine, Christine / Hagler, Donald J / Franz, Carol E / Jak, Amy J / Lyons, Michael J / Neale, Michael C / Rinker, Daniel A / Thompson, Wesley K / Tsuang, Ming T / Dale, Anders M / Kremen, William S

NeuroImage

2016 Volume 129, Page(s) 356–366

Abstract: General cognitive ability (GCA) has substantial explanatory power for behavioral and health outcomes, but its cortical substrate is still not fully established. GCA is highly polygenic and research to date strongly suggests that its cortical substrate is ...

Abstract	General cognitive ability (GCA) has substantial explanatory power for behavioral and health outcomes, but its cortical substrate is still not fully established. GCA is highly polygenic and research to date strongly suggests that its cortical substrate is highly polyregional. We show in map-based and region-of-interest-based analyses of adult twins that a complex cortical configuration underlies GCA. Having relatively greater surface area in evolutionary and developmentally high-expanded prefrontal, lateral temporal, and inferior parietal regions is positively correlated with GCA, whereas relatively greater surface area in low-expanded occipital, medial temporal, and motor cortices is negatively correlated with GCA. Essentially the opposite pattern holds for relative cortical thickness. The phenotypic positive-to-negative gradients in our cortical-GCA association maps were largely driven by a similar pattern of genetic associations. The patterns are consistent with regional cortical stretching whereby relatively greater surface area is related to relatively thinner cortex in high-expanded regions. Thus, the typical "bigger is better" view does not adequately capture cortical-GCA associations. Rather, cognitive ability is influenced by complex configurations of cortical development patterns that are strongly influenced by genetic factors. Optimal cognitive ability appears to be driven both by the absolute size and the polyregional configuration of the entire cortex rather than by small, circumscribed regions.
MeSH term(s)	Brain Mapping ; Cerebral Cortex/anatomy & histology ; Cognition/physiology ; Humans ; Image Processing, Computer-Assisted ; Intelligence/genetics ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Twins
Language	English
Publishing date	2016-01-29
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Twin Study
ZDB-ID	1147767-2
ISSN	1095-9572 ; 1053-8119
ISSN (online)	1095-9572
ISSN	1053-8119
DOI	10.1016/j.neuroimage.2016.01.049
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Article ; Online: The Genetic Association Between Neocortical Volume and General Cognitive Ability Is Driven by Global Surface Area Rather Than Thickness.

Vuoksimaa, Eero / Panizzon, Matthew S / Chen, Chi-Hua / Fiecas, Mark / Eyler, Lisa T / Fennema-Notestine, Christine / Hagler, Donald J / Fischl, Bruce / Franz, Carol E / Jak, Amy / Lyons, Michael J / Neale, Michael C / Rinker, Daniel A / Thompson, Wesley K / Tsuang, Ming T / Dale, Anders M / Kremen, William S

Cerebral cortex (New York, N.Y. : 1991)

2014 Volume 25, Issue 8, Page(s) 2127–2137

Abstract: Total gray matter volume is associated with general cognitive ability (GCA), an association mediated by genetic factors. It is expectable that total neocortical volume should be similarly associated with GCA. Neocortical volume is the product of ... ...

Abstract	Total gray matter volume is associated with general cognitive ability (GCA), an association mediated by genetic factors. It is expectable that total neocortical volume should be similarly associated with GCA. Neocortical volume is the product of thickness and surface area, but global thickness and surface area are unrelated phenotypically and genetically in humans. The nature of the genetic association between GCA and either of these 2 cortical dimensions has not been examined. Humans possess greater cognitive capacity than other species, and surface area increases appear to be the primary driver of the increased size of the human cortex. Thus, we expected neocortical surface area to be more strongly associated with cognition than thickness. Using multivariate genetic analysis in 515 middle-aged twins, we demonstrated that both the phenotypic and genetic associations between neocortical volume and GCA are driven primarily by surface area rather than thickness. Results were generally similar for each of 4 specific cognitive abilities that comprised the GCA measure. Our results suggest that emphasis on neocortical surface area, rather than thickness, could be more fruitful for elucidating neocortical-GCA associations and identifying specific genes underlying those associations.
MeSH term(s)	Analysis of Variance ; Cerebral Cortex/anatomy & histology ; Cognition ; Genetic Association Studies ; Humans ; Intelligence Tests ; Magnetic Resonance Imaging ; Middle Aged ; Models, Genetic ; Multivariate Analysis ; Organ Size ; Twins, Dizygotic ; Twins, Monozygotic
Language	English
Publishing date	2014-02-18
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Twin Study
ZDB-ID	1077450-6
ISSN	1460-2199 ; 1047-3211
ISSN (online)	1460-2199
ISSN	1047-3211
DOI	10.1093/cercor/bhu018
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Article ; Online: Does degree of gyrification underlie the phenotypic and genetic associations between cortical surface area and cognitive ability?

Docherty, Anna R / Hagler, Donald J / Panizzon, Matthew S / Neale, Michael C / Eyler, Lisa T / Fennema-Notestine, Christine / Franz, Carol E / Jak, Amy / Lyons, Michael J / Rinker, Daniel A / Thompson, Wesley K / Tsuang, Ming T / Dale, Anders M / Kremen, William S

NeuroImage

2014 Volume 106, Page(s) 154–160

Abstract: The phenotypic and genetic relationship between global cortical size and general cognitive ability (GCA) appears to be driven by surface area (SA) and not cortical thickness (CT). Gyrification (cortical folding) is an important property of the cortex ... ...

Abstract	The phenotypic and genetic relationship between global cortical size and general cognitive ability (GCA) appears to be driven by surface area (SA) and not cortical thickness (CT). Gyrification (cortical folding) is an important property of the cortex that helps to increase SA within a finite space, and may also improve connectivity by reducing distance between regions. Hence, gyrification may be what underlies the SA-GCA relationship. In previous phenotypic studies, a 3-dimensional gyrification index (3DGI) has been positively associated with cognitive ability and negatively associated with mild cognitive impairment, Alzheimer's disease, and psychiatric disorders affecting cognition. However, the differential genetic associations of 3DGI and SA with GCA are still unclear. We examined the heritability of 3DGI, and the phenotypic, genetic, and environmental associations of 3DGI with SA and GCA in a large sample of adult male twins (N = 512). Nearly 85% of the variance in 3DGI was due to genes, and 3DGI had a strong phenotypic and genetic association with SA. Both 3DGI and total SA had positive phenotypic correlations with GCA. However, the SA-GCA correlation remained significant after controlling for 3DGI, but not the other way around. There was also significant genetic covariance between SA and GCA, but not between 3DGI and GCA. Thus, despite the phenotypic and genetic associations between 3DGI and SA, our results do not support the hypothesis that gyrification underlies the association between SA and GCA.
MeSH term(s)	Cerebral Cortex/pathology ; Cerebral Cortex/physiopathology ; Cognition ; Cognition Disorders/genetics ; Genetic Association Studies ; Humans ; Male ; Middle Aged ; Morphogenesis/genetics ; Organ Size/genetics ; Phenotype ; Twins/genetics
Language	English
Publishing date	2014-11-26
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Twin Study
ZDB-ID	1147767-2
ISSN	1095-9572 ; 1053-8119
ISSN (online)	1095-9572
ISSN	1053-8119
DOI	10.1016/j.neuroimage.2014.11.040
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Article ; Online: Subcortical volumes across the lifespan: Data from 18,605 healthy individuals aged 3-90 years.

Dima, Danai / Modabbernia, Amirhossein / Papachristou, Efstathios / Doucet, Gaelle E / Agartz, Ingrid / Aghajani, Moji / Akudjedu, Theophilus N / Albajes-Eizagirre, Anton / Alnaes, Dag / Alpert, Kathryn I / Andersson, Micael / Andreasen, Nancy C / Andreassen, Ole A / Asherson, Philip / Banaschewski, Tobias / Bargallo, Nuria / Baumeister, Sarah / Baur-Streubel, Ramona / Bertolino, Alessandro /

Bonvino, Aurora / Boomsma, Dorret I / Borgwardt, Stefan / Bourque, Josiane / Brandeis, Daniel / Breier, Alan / Brodaty, Henry / Brouwer, Rachel M / Buitelaar, Jan K / Busatto, Geraldo F / Buckner, Randy L / Calhoun, Vincent / Canales-Rodríguez, Erick J / Cannon, Dara M / Caseras, Xavier / Castellanos, Francisco X / Cervenka, Simon / Chaim-Avancini, Tiffany M / Ching, Christopher R K / Chubar, Victoria / Clark, Vincent P / Conrod, Patricia / Conzelmann, Annette / Crespo-Facorro, Benedicto / Crivello, Fabrice / Crone, Eveline A / Dannlowski, Udo / Dale, Anders M / Davey, Christopher / de Geus, Eco J C / de Haan, Lieuwe / de Zubicaray, Greig I / den Braber, Anouk / Dickie, Erin W / Di Giorgio, Annabella / Doan, Nhat Trung / Dørum, Erlend S / Ehrlich, Stefan / Erk, Susanne / Espeseth, Thomas / Fatouros-Bergman, Helena / Fisher, Simon E / Fouche, Jean-Paul / Franke, Barbara / Frodl, Thomas / Fuentes-Claramonte, Paola / Glahn, David C / Gotlib, Ian H / Grabe, Hans-Jörgen / Grimm, Oliver / Groenewold, Nynke A / Grotegerd, Dominik / Gruber, Oliver / Gruner, Patricia / Gur, Rachel E / Gur, Ruben C / Hahn, Tim / Harrison, Ben J / Hartman, Catharine A / Hatton, Sean N / Heinz, Andreas / Heslenfeld, Dirk J / Hibar, Derrek P / Hickie, Ian B / Ho, Beng-Choon / Hoekstra, Pieter J / Hohmann, Sarah / Holmes, Avram J / Hoogman, Martine / Hosten, Norbert / Howells, Fleur M / Hulshoff Pol, Hilleke E / Huyser, Chaim / Jahanshad, Neda / James, Anthony / Jernigan, Terry L / Jiang, Jiyang / Jönsson, Erik G / Joska, John A / Kahn, Rene / Kalnin, Andrew / Kanai, Ryota / Klein, Marieke / Klyushnik, Tatyana P / Koenders, Laura / Koops, Sanne / Krämer, Bernd / Kuntsi, Jonna / Lagopoulos, Jim / Lázaro, Luisa / Lebedeva, Irina / Lee, Won Hee / Lesch, Klaus-Peter / Lochner, Christine / Machielsen, Marise W J / Maingault, Sophie / Martin, Nicholas G / Martínez-Zalacaín, Ignacio / Mataix-Cols, David / Mazoyer, Bernard / McDonald, Colm / McDonald, Brenna C / McIntosh, Andrew M / McMahon, Katie L / McPhilemy, Genevieve / Meinert, Susanne / Menchón, José M / Medland, Sarah E / Meyer-Lindenberg, Andreas / Naaijen, Jilly / Najt, Pablo / Nakao, Tomohiro / Nordvik, Jan E / Nyberg, Lars / Oosterlaan, Jaap / de la Foz, Víctor Ortiz-García / Paloyelis, Yannis / Pauli, Paul / Pergola, Giulio / Pomarol-Clotet, Edith / Portella, Maria J / Potkin, Steven G / Radua, Joaquim / Reif, Andreas / Rinker, Daniel A / Roffman, Joshua L / Rosa, Pedro G P / Sacchet, Matthew D / Sachdev, Perminder S / Salvador, Raymond / Sánchez-Juan, Pascual / Sarró, Salvador / Satterthwaite, Theodore D / Saykin, Andrew J / Serpa, Mauricio H / Schmaal, Lianne / Schnell, Knut / Schumann, Gunter / Sim, Kang / Smoller, Jordan W / Sommer, Iris / Soriano-Mas, Carles / Stein, Dan J / Strike, Lachlan T / Swagerman, Suzanne C / Tamnes, Christian K / Temmingh, Henk S / Thomopoulos, Sophia I / Tomyshev, Alexander S / Tordesillas-Gutiérrez, Diana / Trollor, Julian N / Turner, Jessica A / Uhlmann, Anne / van den Heuvel, Odile A / van den Meer, Dennis / van der Wee, Nic J A / van Haren, Neeltje E M / Van't Ent, Dennis / van Erp, Theo G M / Veer, Ilya M / Veltman, Dick J / Voineskos, Aristotle / Völzke, Henry / Walter, Henrik / Walton, Esther / Wang, Lei / Wang, Yang / Wassink, Thomas H / Weber, Bernd / Wen, Wei / West, John D / Westlye, Lars T / Whalley, Heather / Wierenga, Lara M / Williams, Steven C R / Wittfeld, Katharina / Wolf, Daniel H / Worker, Amanda / Wright, Margaret J / Yang, Kun / Yoncheva, Yulyia / Zanetti, Marcus V / Ziegler, Georg C / Thompson, Paul M / Frangou, Sophia

Human brain mapping

2021 Volume 43, Issue 1, Page(s) 452–469

Abstract: Age has a major effect on brain volume. However, the normative studies available are constrained by small sample sizes, restricted age coverage and significant methodological variability. These limitations introduce inconsistencies and may obscure or ... ...

Abstract	Age has a major effect on brain volume. However, the normative studies available are constrained by small sample sizes, restricted age coverage and significant methodological variability. These limitations introduce inconsistencies and may obscure or distort the lifespan trajectories of brain morphometry. In response, we capitalized on the resources of the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to examine age-related trajectories inferred from cross-sectional measures of the ventricles, the basal ganglia (caudate, putamen, pallidum, and nucleus accumbens), the thalamus, hippocampus and amygdala using magnetic resonance imaging data obtained from 18,605 individuals aged 3-90 years. All subcortical structure volumes were at their maximum value early in life. The volume of the basal ganglia showed a monotonic negative association with age thereafter; there was no significant association between age and the volumes of the thalamus, amygdala and the hippocampus (with some degree of decline in thalamus) until the sixth decade of life after which they also showed a steep negative association with age. The lateral ventricles showed continuous enlargement throughout the lifespan. Age was positively associated with inter-individual variability in the hippocampus and amygdala and the lateral ventricles. These results were robust to potential confounders and could be used to examine the functional significance of deviations from typical age-related morphometric patterns.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Child ; Child, Preschool ; Female ; Humans ; Male ; Middle Aged ; Young Adult ; Amygdala/anatomy & histology ; Amygdala/diagnostic imaging ; Corpus Striatum/anatomy & histology ; Corpus Striatum/diagnostic imaging ; Hippocampus/anatomy & histology ; Hippocampus/diagnostic imaging ; Human Development/physiology ; Neuroimaging ; Thalamus/anatomy & histology ; Thalamus/diagnostic imaging
Language	English
Publishing date	2021-02-11
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1197207-5
ISSN	1097-0193 ; 1065-9471
ISSN (online)	1097-0193
ISSN	1065-9471
DOI	10.1002/hbm.25320
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Article ; Online: Cortical thickness across the lifespan: Data from 17,075 healthy individuals aged 3-90 years.

Frangou, Sophia / Modabbernia, Amirhossein / Williams, Steven C R / Papachristou, Efstathios / Doucet, Gaelle E / Agartz, Ingrid / Aghajani, Moji / Akudjedu, Theophilus N / Albajes-Eizagirre, Anton / Alnaes, Dag / Alpert, Kathryn I / Andersson, Micael / Andreasen, Nancy C / Andreassen, Ole A / Asherson, Philip / Banaschewski, Tobias / Bargallo, Nuria / Baumeister, Sarah / Baur-Streubel, Ramona /

Bertolino, Alessandro / Bonvino, Aurora / Boomsma, Dorret I / Borgwardt, Stefan / Bourque, Josiane / Brandeis, Daniel / Breier, Alan / Brodaty, Henry / Brouwer, Rachel M / Buitelaar, Jan K / Busatto, Geraldo F / Buckner, Randy L / Calhoun, Vincent / Canales-Rodríguez, Erick J / Cannon, Dara M / Caseras, Xavier / Castellanos, Francisco X / Cervenka, Simon / Chaim-Avancini, Tiffany M / Ching, Christopher R K / Chubar, Victoria / Clark, Vincent P / Conrod, Patricia / Conzelmann, Annette / Crespo-Facorro, Benedicto / Crivello, Fabrice / Crone, Eveline A / Dale, Anders M / Dannlowski, Udo / Davey, Christopher / de Geus, Eco J C / de Haan, Lieuwe / de Zubicaray, Greig I / den Braber, Anouk / Dickie, Erin W / Di Giorgio, Annabella / Doan, Nhat Trung / Dørum, Erlend S / Ehrlich, Stefan / Erk, Susanne / Espeseth, Thomas / Fatouros-Bergman, Helena / Fisher, Simon E / Fouche, Jean-Paul / Franke, Barbara / Frodl, Thomas / Fuentes-Claramonte, Paola / Glahn, David C / Gotlib, Ian H / Grabe, Hans-Jörgen / Grimm, Oliver / Groenewold, Nynke A / Grotegerd, Dominik / Gruber, Oliver / Gruner, Patricia / Gur, Rachel E / Gur, Ruben C / Hahn, Tim / Harrison, Ben J / Hartman, Catharine A / Hatton, Sean N / Heinz, Andreas / Heslenfeld, Dirk J / Hibar, Derrek P / Hickie, Ian B / Ho, Beng-Choon / Hoekstra, Pieter J / Hohmann, Sarah / Holmes, Avram J / Hoogman, Martine / Hosten, Norbert / Howells, Fleur M / Hulshoff Pol, Hilleke E / Huyser, Chaim / Jahanshad, Neda / James, Anthony / Jernigan, Terry L / Jiang, Jiyang / Jönsson, Erik G / Joska, John A / Kahn, Rene / Kalnin, Andrew / Kanai, Ryota / Klein, Marieke / Klyushnik, Tatyana P / Koenders, Laura / Koops, Sanne / Krämer, Bernd / Kuntsi, Jonna / Lagopoulos, Jim / Lázaro, Luisa / Lebedeva, Irina / Lee, Won Hee / Lesch, Klaus-Peter / Lochner, Christine / Machielsen, Marise W J / Maingault, Sophie / Martin, Nicholas G / Martínez-Zalacaín, Ignacio / Mataix-Cols, David / Mazoyer, Bernard / McDonald, Colm / McDonald, Brenna C / McIntosh, Andrew M / McMahon, Katie L / McPhilemy, Genevieve / Meinert, Susanne / Menchón, José M / Medland, Sarah E / Meyer-Lindenberg, Andreas / Naaijen, Jilly / Najt, Pablo / Nakao, Tomohiro / Nordvik, Jan E / Nyberg, Lars / Oosterlaan, Jaap / de la Foz, Víctor Ortiz-García / Paloyelis, Yannis / Pauli, Paul / Pergola, Giulio / Pomarol-Clotet, Edith / Portella, Maria J / Potkin, Steven G / Radua, Joaquim / Reif, Andreas / Rinker, Daniel A / Roffman, Joshua L / Rosa, Pedro G P / Sacchet, Matthew D / Sachdev, Perminder S / Salvador, Raymond / Sánchez-Juan, Pascual / Sarró, Salvador / Satterthwaite, Theodore D / Saykin, Andrew J / Serpa, Mauricio H / Schmaal, Lianne / Schnell, Knut / Schumann, Gunter / Sim, Kang / Smoller, Jordan W / Sommer, Iris / Soriano-Mas, Carles / Stein, Dan J / Strike, Lachlan T / Swagerman, Suzanne C / Tamnes, Christian K / Temmingh, Henk S / Thomopoulos, Sophia I / Tomyshev, Alexander S / Tordesillas-Gutiérrez, Diana / Trollor, Julian N / Turner, Jessica A / Uhlmann, Anne / van den Heuvel, Odile A / van den Meer, Dennis / van der Wee, Nic J A / van Haren, Neeltje E M / van 't Ent, Dennis / van Erp, Theo G M / Veer, Ilya M / Veltman, Dick J / Voineskos, Aristotle / Völzke, Henry / Walter, Henrik / Walton, Esther / Wang, Lei / Wang, Yang / Wassink, Thomas H / Weber, Bernd / Wen, Wei / West, John D / Westlye, Lars T / Whalley, Heather / Wierenga, Lara M / Wittfeld, Katharina / Wolf, Daniel H / Worker, Amanda / Wright, Margaret J / Yang, Kun / Yoncheva, Yulyia / Zanetti, Marcus V / Ziegler, Georg C / Thompson, Paul M / Dima, Danai

Human brain mapping

2021 Volume 43, Issue 1, Page(s) 431–451

Abstract: Delineating the association of age and cortical thickness in healthy individuals is critical given the association of cortical thickness with cognition and behavior. Previous research has shown that robust estimates of the association between age and ... ...

Abstract	Delineating the association of age and cortical thickness in healthy individuals is critical given the association of cortical thickness with cognition and behavior. Previous research has shown that robust estimates of the association between age and brain morphometry require large-scale studies. In response, we used cross-sectional data from 17,075 individuals aged 3-90 years from the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to infer age-related changes in cortical thickness. We used fractional polynomial (FP) regression to quantify the association between age and cortical thickness, and we computed normalized growth centiles using the parametric Lambda, Mu, and Sigma method. Interindividual variability was estimated using meta-analysis and one-way analysis of variance. For most regions, their highest cortical thickness value was observed in childhood. Age and cortical thickness showed a negative association; the slope was steeper up to the third decade of life and more gradual thereafter; notable exceptions to this general pattern were entorhinal, temporopolar, and anterior cingulate cortices. Interindividual variability was largest in temporal and frontal regions across the lifespan. Age and its FP combinations explained up to 59% variance in cortical thickness. These results may form the basis of further investigation on normative deviation in cortical thickness and its significance for behavioral and cognitive outcomes.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Child ; Child, Preschool ; Female ; Humans ; Male ; Middle Aged ; Young Adult ; Cerebral Cortex/anatomy & histology ; Cerebral Cortex/diagnostic imaging ; Cross-Sectional Studies ; Human Development/physiology ; Neuroimaging
Language	English
Publishing date	2021-02-17
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1197207-5
ISSN	1097-0193 ; 1065-9471
ISSN (online)	1097-0193
ISSN	1065-9471
DOI	10.1002/hbm.25364
Database	MEDical Literature Analysis and Retrieval System OnLINE

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