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Article ; Online: Reduced-intensity conditioning regimens before unrelated cord blood transplantation in adults with acute leukaemia and other haematological malignancies.

Rocha, Vanderson / Mohty, Mohamad / Gluckman, Eliane / Rio, Bernard

2009 Volume 21 Suppl 1, Page(s) S31–4

Abstract: Cord blood is an unlimited source of haematopoietic stem cells for allogeneic haematopoietic stem cell transplants. During the past 5 years, the number of adults transplanted with cord blood cells from unrelated donors has exceeded the number of ... ...

Abstract	Cord blood is an unlimited source of haematopoietic stem cells for allogeneic haematopoietic stem cell transplants. During the past 5 years, the number of adults transplanted with cord blood cells from unrelated donors has exceeded the number of transplants in children, as a result of better definitions of cord blood unit choice, an increased number of cord blood units available for transplantation worldwide, comparable results of unrelated cord blood transplantation (UCBT) with human leukocyte antigen-matched unrelated bone marrow transplantation, the use of double cord blood transplantation and the use of UCBT after a reduced-intensity conditioning (RIC) regimen. In spite of the encouraging results of RIC UCBT in single-centre studies, the number of patients given this strategy is still limited and follow-up is still too short to draw definitive conclusions. Moreover, many questions remain to be answered such as: (1) the type of patients and disease populations that may benefit most from this strategy; (2) the best conditioning regimen to use; (3) the criteria of cord blood choice in this setting; and (4) factors predictive of outcomes after RIC UCBT. This paper will summarize some recent results of RIC UCBT for adults with haematological malignancies.
MeSH term(s)	Acute Disease ; Adult ; Cord Blood Stem Cell Transplantation/adverse effects ; Cord Blood Stem Cell Transplantation/methods ; Fetal Blood ; Graft vs Host Disease/etiology ; Graft vs Host Disease/prevention & control ; Humans ; Leukemia/pathology ; Leukemia/therapy ; Tissue Banks ; Transplantation Conditioning/methods
Language	English
Publishing date	2009-06
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1049384-0
ISSN	1531-703X ; 1040-8746
ISSN (online)	1531-703X
ISSN	1040-8746
DOI	10.1097/01.cco.0000357473.58411.1b
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Article ; Online: Incidence rates of leukemia in French Polynesia.

Rio, Bernard / Heuberger, Laurence / Soubiran, Gilles / Zittoun, Robert / Marie, Jean-Pierre

International journal of cancer

2012 Volume 131, Issue 6, Page(s) 1486–1487

MeSH term(s)	Female ; Humans ; Leukemia, Myeloid/ethnology ; Male ; Thyroid Neoplasms/etiology
Language	English
Publishing date	2012-09-15
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	218257-9
ISSN	1097-0215 ; 0020-7136
ISSN (online)	1097-0215
ISSN	0020-7136
DOI	10.1002/ijc.27364
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Article ; Online: Intravesical Bacillus Calmette-Guerin for the treatment of superficial bladder cancer following hematopoietic stem cell transplantation.

Petropoulou, Anna D / Lapusan, Simona / Marie, Jean-Pierre / Rio, Bernard

Leukemia & lymphoma

2008 Volume 49, Issue 8, Page(s) 1627–1629

MeSH term(s)	Adjuvants, Immunologic ; Administration, Intravesical ; Adult ; BCG Vaccine/administration & dosage ; Hematopoietic Stem Cell Transplantation ; Humans ; Male ; Middle Aged ; Treatment Outcome ; Urinary Bladder Neoplasms/therapy
Chemical Substances	Adjuvants, Immunologic ; BCG Vaccine
Language	English
Publishing date	2008-05-02
Publishing country	United States
Document type	Case Reports ; Letter
ZDB-ID	1042374-6
ISSN	1029-2403 ; 1042-8194
ISSN (online)	1029-2403
ISSN	1042-8194
DOI	10.1080/10428190802136376
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Zs.A 2997: Show issues

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Article ; Online: Endothelial cell markers' kinetics following umbilical cord blood transplantation.

Rio, Bernard / Petropoulou, Anna D / Mirshahi, Pezhman / Soria, Jeannette / Rendu, Francine / Samama, Michel M / Marie, Jean-Pierre / Elalamy, Ismail

Leukemia & lymphoma

2008 Volume 49, Issue 11, Page(s) 2209–2212

MeSH term(s)	Biomarkers/analysis ; Bone Marrow Transplantation ; Cord Blood Stem Cell Transplantation ; Endothelial Cells/pathology ; Factor VIII ; Hematopoietic Stem Cell Transplantation/adverse effects ; Humans ; Kinetics ; Peripheral Blood Stem Cell Transplantation ; Thrombomodulin ; Vascular Endothelial Growth Factor A ; von Willebrand Factor
Chemical Substances	Biomarkers ; Thrombomodulin ; Vascular Endothelial Growth Factor A ; von Willebrand Factor ; Factor VIII (9001-27-8)
Language	English
Publishing date	2008-10-23
Publishing country	United States
Document type	Comparative Study ; Letter
ZDB-ID	1042374-6
ISSN	1029-2403 ; 1042-8194
ISSN (online)	1029-2403
ISSN	1042-8194
DOI	10.1080/10428190802322901
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Article ; Online: Outcome of 40 adults aged from 18 to 55 years with acute lymphoblastic leukemia treated with double-delayed intensification pediatric protocol.

Haïat, Stéphanie / Marjanovic, Zora / Lapusan, Simona / Vekhoff, Anne / Rio, Bernard / Corre, Elise / Dimicoli, Sophie / Hirsch, Pierre / Marie, Jean-Pierre / Legrand, Ollivier

Leukemia research

2011 Volume 35, Issue 1, Page(s) 66–72

Abstract: Adolescents ALL have a better outcome when treated with pediatric protocol compared to adult protocol. We have tested the feasibility of pediatric protocol to treat 40 consecutive adults ALL. DFS and OS were 73±7%, and 72±7%, and were significantly ... ...

Abstract	Adolescents ALL have a better outcome when treated with pediatric protocol compared to adult protocol. We have tested the feasibility of pediatric protocol to treat 40 consecutive adults ALL. DFS and OS were 73±7%, and 72±7%, and were significantly longer in patients under 40 yo (81±9% vs 51±15%, p=0.05 [DFS] and 83±7.8% vs 45±15%, p=0.003 [OS], respectively) or cortico/chemo-sensitive (86±9% vs 36±16%, p=0.001 [DFS] and 95±4.4% vs 28±13%, p<0.0001 [OS]) than in other patients. Overall tolerance was acceptable. We have shown the feasibility of using this unmodified pediatric protocol to treat adult with ALL up to 40 years.
MeSH term(s)	Adolescent ; Adult ; Antineoplastic Combined Chemotherapy Protocols/administration & dosage ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Dose-Response Relationship, Drug ; Feasibility Studies ; Female ; Humans ; Male ; Middle Aged ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy ; Recurrence ; Young Adult
Language	English
Publishing date	2011-01
Publishing country	England
Document type	Journal Article
ZDB-ID	752396-8
ISSN	1873-5835 ; 0145-2126
ISSN (online)	1873-5835
ISSN	0145-2126
DOI	10.1016/j.leukres.2010.04.002
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Zs.A 1321: Show issues

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Article: Actualités sur les hémopathies malignes.

Ugo, Valérie / Legrand, Ollivier / Delmer, Alain / Rio, Bernard / Casadevall, Nicole / Marie, Jean-Pierre

Bulletin du cancer

2002 Volume 89, Issue 1, Page(s) 75–88

Abstract: The beginning of this century was marked, in our specialty as in other, by two revolutions: the routine use of molecular biology tools for a better prognosis of the disease (flt3 receptor duplication in AML, mutational profile of Ig genes in CLL, gene ... ...

Title translation	Update on malignant hemopathies.
Abstract	The beginning of this century was marked, in our specialty as in other, by two revolutions: the routine use of molecular biology tools for a better prognosis of the disease (flt3 receptor duplication in AML, mutational profile of Ig genes in CLL, gene expression profile with ARN chips in aggressive lymphomas.), and the discovery of "intelligent" molecules, targeting the tumoral cell. In this category, the most appealing is the STI571 (Gleevec , Novartis), targeting the molecular abnormality of the cells expressing bcr-abl protein: CML, ALL Ph1(+). Other molecules targeting signal transduction proteins (ras farnesylation inhibitors for example) are already in clinical trials. The increasing therapeutic use of monoclonal antibodies is also to be cited, with a special mention concerning the rituximab, used in several B lymphoid pathologies, from lymphoma to autoimmune diseases. His very good tolerance permits his use in ambulatory patients, and his combination with chemotherapy or his linkage with radioactive elements render this molecule indispensable. The other side of these molecules is their incredibly high cost, explaining the uncontrolled expenses in 2001 of hospitals hosting hematology as well as oncology activities.
MeSH term(s)	Acute Disease ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Benzamides ; Hematopoietic Stem Cell Transplantation ; Humans ; Imatinib Mesylate ; Immunotoxins/therapeutic use ; Leukemia, Lymphoid/therapy ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/therapy ; Leukemia, Myeloid/therapy ; Lymphoma/therapy ; Myelodysplastic Syndromes/classification ; Myelodysplastic Syndromes/diagnosis ; Myelodysplastic Syndromes/therapy ; Piperazines ; Pyrimidines/therapeutic use ; Tretinoin/therapeutic use
Chemical Substances	Benzamides ; Immunotoxins ; Piperazines ; Pyrimidines ; Tretinoin (5688UTC01R) ; Imatinib Mesylate (8A1O1M485B)
Language	French
Publishing date	2002-01
Publishing country	France
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	213270-9
ISSN	1769-6917 ; 0007-4551
ISSN (online)	1769-6917
ISSN	0007-4551
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Article: Prospective evaluation of a polymerase chain reaction-ELISA targeted to Aspergillus fumigatus and Aspergillus flavus for the early diagnosis of invasive aspergillosis in patients with hematological malignancies.

Florent, Martine / Katsahian, Sandrine / Vekhoff, Anne / Levy, Vincent / Rio, Bernard / Marie, Jean-Pierre / Bouvet, Anne / Cornet, Muriel

The Journal of infectious diseases

2006 Volume 193, Issue 5, Page(s) 741–747

Abstract: Background: Current laboratory and radiological methods for diagnosis of invasive aspergillosis (IA) lack sensitivity and specificity.: Methods: We prospectively evaluated the diagnostic value of twice-weekly screening for circulating Aspergillus ... ...

Abstract	Background: Current laboratory and radiological methods for diagnosis of invasive aspergillosis (IA) lack sensitivity and specificity. Methods: We prospectively evaluated the diagnostic value of twice-weekly screening for circulating Aspergillus fumigatus and A. flavus DNA with a polymerase chain reaction-enzyme-linked immunosorbent assay (PCR-ELISA). Results: Among the 201 adult patients with hematological malignancies who were included in the study, 55 IA cases were diagnosed. On the basis of the analysis of 1205 serum samples from 167 patients, the sensitivity, specificity, and positive and negative predictive values of the PCR-ELISA for proven and probable IA cases were 63.6%, 89.7%, 63.6%, and 89.7%, respectively, when samples with 2 consecutive positive results were used. The use of a combination of the PCR-ELISA and a galactomannan (GM) assay increased the sensitivity to 83.3%, increased the negative predictive value to 97.6%, and decreased the specificity to 69.8%. In most patients with IA, PCR-ELISA positivity anticipated or was simultaneous with the initiation of antifungal therapy, the abnormalities found by computed tomography, the mycological/histological diagnosis, and the GM positivity. Overall, 56.3% of the patients had at least 1 positive sample, and the false single-positive rate was 44.8%. Conclusions: In addition to serial screening for GM antigenemia and radiological surveillance, PCR-ELISA may improve the rates of early diagnosis of IA and the management of patients with hematological malignancies.
MeSH term(s)	Aspergillosis/complications ; Aspergillosis/diagnosis ; Aspergillus flavus/genetics ; Aspergillus flavus/isolation & purification ; Aspergillus fumigatus/genetics ; Aspergillus fumigatus/isolation & purification ; DNA, Fungal/analysis ; Early Diagnosis ; Enzyme-Linked Immunosorbent Assay/methods ; Hematologic Neoplasms/complications ; Humans ; Mannans/blood ; Molecular Diagnostic Techniques ; Polymerase Chain Reaction/methods ; Predictive Value of Tests ; Prospective Studies ; Sensitivity and Specificity
Chemical Substances	DNA, Fungal ; Mannans ; galactomannan (11078-30-1)
Language	English
Publishing date	2006-03-01
Publishing country	United States
Document type	Evaluation Studies ; Journal Article
ZDB-ID	3019-3
ISSN	1537-6613 ; 0022-1899
ISSN (online)	1537-6613
ISSN	0022-1899
DOI	10.1086/500466
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Article ; Online: Shaping of iNKT cell repertoire after unrelated cord blood transplantation.

Beziat, Vivien / Nguyen, Stéphanie / Exley, Mark / Achour, Abla / Simon, Tabassonne / Chevallier, Patrice / Sirvent, Anne / Vigouroux, Stéphane / Debré, Patrice / Rio, Bernard / Vieillard, Vincent

Clinical immunology (Orlando, Fla.)

2010 Volume 135, Issue 3, Page(s) 364–373

Abstract: Invariant natural killer T (iNKT) cells have a pivotal role in immune regulation, tumor surveillance, and the induction of allograft tolerance. In this report, we analyze the recovery of iNKT cells after unrelated cord blood transplantation (UCBT) of ... ...

Abstract	Invariant natural killer T (iNKT) cells have a pivotal role in immune regulation, tumor surveillance, and the induction of allograft tolerance. In this report, we analyze the recovery of iNKT cells after unrelated cord blood transplantation (UCBT) of adult patients with high-risk acute myeloid leukemia. We found that iNKT cells were reconstituted within 1 month after UCBT, at the same time as NK cells and before conventional T cells. These iNKT cells displayed a unique primed/central memory CD4(+)CD45RO(+)CCR7(+)CD62L(+) phenotype soon after the transplant. Interestingly, the functional competence of these cells was poor, except for their high GM-CSF production capacity. However, this post-graft functionally immature state was transient and all of the patients tested had fully functional iNKT cells 3 to 6 months post-UCBT and high cytolytic capacity for destroying primary CD1d(+) myeloid blast cells. Our results raise the possibility that iNKT cells might play a key role in graft-versus-leukemia activity after UCBT.
MeSH term(s)	Cell Differentiation/immunology ; Cell Separation ; Cord Blood Stem Cell Transplantation ; Enzyme-Linked Immunosorbent Assay ; Flow Cytometry ; Humans ; Leukemia, Myeloid, Acute/immunology ; Leukemia, Myeloid, Acute/therapy ; Natural Killer T-Cells/cytology ; Natural Killer T-Cells/immunology ; Phenotype
Language	English
Publishing date	2010-02-13
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1459903-x
ISSN	1521-7035 ; 1521-6616
ISSN (online)	1521-7035
ISSN	1521-6616
DOI	10.1016/j.clim.2010.01.010
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Article: Bacteremia caused by an undescribed species of Janibacter.

Loubinoux, Julien / Rio, Bernard / Mihaila, Liliana / Foïs, Elena / Le Fleche, Anne / Grimont, Patrick A D / Marie, Jean-Pierre / Bouvet, Anne

Journal of clinical microbiology

2005 Volume 43, Issue 7, Page(s) 3564–3566

Abstract: A yellow-pigmented rod- to coccoid-shaped coryneform microorganism was isolated from the blood of a patient with acute myeloid leukemia. It was identified by 16S rRNA gene sequencing as a previously undescribed species of Janibacter. The isolate was ... ...

Abstract	A yellow-pigmented rod- to coccoid-shaped coryneform microorganism was isolated from the blood of a patient with acute myeloid leukemia. It was identified by 16S rRNA gene sequencing as a previously undescribed species of Janibacter. The isolate was susceptible to penicillins, aminoglycosides, fluoroquinolones, and glycopeptides.
MeSH term(s)	Actinomycetales/classification ; Actinomycetales/genetics ; Actinomycetales/isolation & purification ; Actinomycetales Infections/microbiology ; Acute Disease ; Bacteremia/microbiology ; Genes, rRNA ; Humans ; Leukemia, Myeloid/complications ; Male ; Middle Aged ; Molecular Sequence Data ; Phenotype ; Phylogeny ; RNA, Ribosomal, 16S/genetics ; Sequence Analysis, DNA
Chemical Substances	RNA, Ribosomal, 16S
Language	English
Publishing date	2005-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	390499-4
ISSN	1098-660X ; 0095-1137
ISSN (online)	1098-660X
ISSN	0095-1137
DOI	10.1128/JCM.43.7.3564-3566.2005
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Article: Bacteremia Caused by an Undescribed Species of Janibacter

Loubinoux, Julien / Rio, Bernard / Mihaila, Liliana / Foi̊s, Elena / Le Fleche, Anne / Grimont, Patrick A. D / Marie, Jean-Pierre / Bouvet, Anne

Journal of clinical microbiology. 2005 Jul., v. 43, no. 7

2005

Abstract	A yellow-pigmented rod- to coccoid-shaped coryneform microorganism was isolated from the blood of a patient with acute myeloid leukemia. It was identified by 16S rRNA gene sequencing as a previously undescribed species of JANIBACTER: The isolate was susceptible to penicillins, aminoglycosides, fluoroquinolones, and glycopeptides.
Language	English
Dates of publication	2005-07
Size	p. 3564-3566.
Document type	Article
ZDB-ID	390499-4
ISSN	1098-660X ; 0095-1137
ISSN (online)	1098-660X
ISSN	0095-1137
Database	NAL-Catalogue (AGRICOLA)

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