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  1. Article ; Online: Non-alcoholic steatohepatitis and risk of hepatocellular carcinoma.

    Rios, Rafael S / Zheng, Kenneth I / Zheng, Ming-Hua

    Chinese medical journal

    2021  Volume 134, Issue 24, Page(s) 2911–2921

    Abstract: Abstract: The emergence of non-alcoholic fatty liver disease (NAFLD) as the leading chronic liver disease worldwide raises some concerns. In particular, NAFLD is closely tied to sedentary lifestyle habits and associated with other metabolic diseases, ... ...

    Abstract Abstract: The emergence of non-alcoholic fatty liver disease (NAFLD) as the leading chronic liver disease worldwide raises some concerns. In particular, NAFLD is closely tied to sedentary lifestyle habits and associated with other metabolic diseases, such as obesity and diabetes. At the end of the disease spectrum, non-alcoholic steatohepatitis (NASH) may progress to cirrhosis and hepatocellular carcinoma (HCC), representing a serious health problem to modern society. Recently, an increasing number of HCC cases originating from this progressive disease spectrum have been identified, with different levels of severity and complications. Updating the current guidelines by placing a bigger focus on this emerging cause and highlighting some of its unique features is necessary. Since, the drivers of the disease are complex and multifactorial, in order to improve future outcomes, having a better understanding of NASH progression into HCC may be helpful. The risks that can promote disease progression and currently available management strategies employed to monitor and treat NASH-related HCC make up the bulk of this review.
    MeSH term(s) Carcinoma, Hepatocellular/epidemiology ; Carcinoma, Hepatocellular/etiology ; Humans ; Liver Cirrhosis ; Liver Neoplasms/etiology ; Non-alcoholic Fatty Liver Disease ; Obesity
    Language English
    Publishing date 2021-12-01
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 127089-8
    ISSN 2542-5641 ; 0366-6999 ; 1002-0187
    ISSN (online) 2542-5641
    ISSN 0366-6999 ; 1002-0187
    DOI 10.1097/CM9.0000000000001888
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  2. Article ; Online: Data sharing during COVID-19 pandemic: what to take away.

    Rios, Rafael S / Zheng, Kenneth I / Zheng, Ming-Hua

    Expert review of gastroenterology & hepatology

    2020  Volume 14, Issue 12, Page(s) 1125–1130

    Abstract: Introduction: In light of the viral outbreak of SARS-CoV-2 that monopolized the focus of the scientific community and general public alike for the past 6 months, one of the greatest contributors in the battle against this pandemic was the international ... ...

    Abstract Introduction: In light of the viral outbreak of SARS-CoV-2 that monopolized the focus of the scientific community and general public alike for the past 6 months, one of the greatest contributors in the battle against this pandemic was the international sharing of information. Whether regarding the viral genome, incubation periods, method of transmission, symptoms, dangerous behaviors, age groups at risk, all information was valuable, all data was shared as soon as possible.
    Areas covered: Considering that the most severely impacted group of patients are already suffering from other conditions, accessing the impact that metabolic associated fatty liver disease (MAFLD), obesity, and diabetes has on patients by sharing information between different healthcare facilities is of vital importance. However, the value behind open information sharing would remain significant even without a viral outbreak and should there be a more efficient infrastructure in place, the global exchange of data can become more practical and less arduous.
    Expert opinion: Since the sharing of data by individual researchers is often motivated by personal benefits, this observed international collaboration is conditional at best, and the widespread misinformation during this pandemic could be an indication of a certain lack of consensus within the scientific community itself.
    MeSH term(s) COVID-19 ; Communicable Disease Control ; Communicable Diseases, Emerging/diagnosis ; Communicable Diseases, Emerging/epidemiology ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Female ; Humans ; Information Dissemination/methods ; Male ; Pandemics/prevention & control ; Pandemics/statistics & numerical data ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; Sensitivity and Specificity ; Severe Acute Respiratory Syndrome/diagnosis ; Severe Acute Respiratory Syndrome/epidemiology
    Keywords covid19
    Language English
    Publishing date 2020-09-06
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2481021-6
    ISSN 1747-4132 ; 1747-4124
    ISSN (online) 1747-4132
    ISSN 1747-4124
    DOI 10.1080/17474124.2020.1815533
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  3. Article: Recommendations and Clinical Guidance for Children with Metabolic-associated Fatty Liver Disease during the COVID-19 Pandemic.

    Zhou, Yong-Hai / Rios, Rafael S / Zheng, Kenneth I / Zheng, Ming-Hua

    Journal of clinical and translational hepatology

    2021  Volume 9, Issue 1, Page(s) 1–2

    Language English
    Publishing date 2021-02-01
    Publishing country China
    Document type Editorial
    ZDB-ID 3019822-7
    ISSN 2310-8819 ; 2225-0719
    ISSN (online) 2310-8819
    ISSN 2225-0719
    DOI 10.14218/JCTH.2020.00137
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  4. Article: COVID-19 Cross-Infection and Pressured Ulceration Among Healthcare Workers: Are We Really Protected by Respirators?

    Zheng, Kenneth I / Rios, Rafael S / Zeng, Qi-Qiang / Zheng, Ming-Hua

    Frontiers in medicine

    2020  Volume 7, Page(s) 571493

    Keywords covid19
    Language English
    Publishing date 2020-09-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2020.571493
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  5. Article ; Online: Telomerase: a key player in the pathogenesis of non-alcoholic fatty liver disease?

    Tang, Liang-Jie / Rios, Rafael S / Zhang, Huai / Byrne, Christopher D / Targher, Giovanni / Zheng, Ming-Hua

    Expert review of gastroenterology & hepatology

    2021  Volume 15, Issue 7, Page(s) 811–819

    Abstract: ... ...

    Abstract Introduction
    MeSH term(s) Humans ; Liver Cirrhosis/genetics ; Liver Neoplasms/genetics ; Metabolic Diseases/genetics ; Non-alcoholic Fatty Liver Disease/diagnosis ; Non-alcoholic Fatty Liver Disease/etiology ; Non-alcoholic Fatty Liver Disease/genetics ; Non-alcoholic Fatty Liver Disease/therapy ; Telomerase/genetics ; Telomerase/physiology
    Chemical Substances Telomerase (EC 2.7.7.49)
    Language English
    Publishing date 2021-03-19
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2481021-6
    ISSN 1747-4132 ; 1747-4124
    ISSN (online) 1747-4132
    ISSN 1747-4124
    DOI 10.1080/17474124.2021.1903318
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    Zs.A 6978: Show issues Location:
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  6. Article: Data sharing during COVID-19 pandemic: what to take away

    Rios, Rafael S / Zheng, Kenneth I / Zheng, Ming-Hua

    Expert Rev Gastroenterol Hepatol

    Abstract: INTRODUCTION: In light of the viral outbreak of SARS-CoV-2 that monopolized the focus of the scientific community and general public alike for the past 6 months, one of the greatest contributors in the battle against this pandemic was the international ... ...

    Abstract INTRODUCTION: In light of the viral outbreak of SARS-CoV-2 that monopolized the focus of the scientific community and general public alike for the past 6 months, one of the greatest contributors in the battle against this pandemic was the international sharing of information. Whether regarding the viral genome, incubation periods, method of transmission, symptoms, dangerous behaviors, age groups at risk, all information was valuable, all data was shared as soon as possible. AREAS COVERED: Considering that the most severely impacted group of patients are already suffering from other conditions, accessing the impact that metabolic associated fatty liver disease (MAFLD), obesity, and diabetes has on patients by sharing information between different healthcare facilities is of vital importance. However, the value behind open information sharing would remain significant even without a viral outbreak and should there be a more efficient infrastructure in place, the global exchange of data can become more practical and less arduous. EXPERT OPINION: Since the sharing of data by individual researchers is often motivated by personal benefits, this observed international collaboration is conditional at best, and the widespread misinformation during this pandemic could be an indication of a certain lack of consensus within the scientific community itself.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #730503
    Database COVID19

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  7. Article ; Online: Data sharing during COVID-19 pandemic

    Rios, Rafael S. / Zheng, Kenneth I. / Zheng, Ming-Hua

    Expert Review of Gastroenterology & Hepatology

    what to take away

    2020  , Page(s) 1–6

    Keywords Hepatology ; Gastroenterology ; covid19
    Language English
    Publisher Informa UK Limited
    Publishing country uk
    Document type Article ; Online
    ZDB-ID 2481021-6
    ISSN 1747-4132 ; 1747-4124
    ISSN (online) 1747-4132
    ISSN 1747-4124
    DOI 10.1080/17474124.2020.1815533
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  8. Article ; Online: Non-invasive fibrosis assessment in non-alcoholic fatty liver disease.

    Rios, Rafael S / Zheng, Kenneth I / Targher, Giovanni / Byrne, Christopher D / Zheng, Ming-Hua

    Chinese medical journal

    2020  Volume 133, Issue 22, Page(s) 2743–2745

    MeSH term(s) Biopsy ; Humans ; Liver/pathology ; Liver Cirrhosis/diagnosis ; Liver Cirrhosis/pathology ; Non-alcoholic Fatty Liver Disease/diagnosis ; Non-alcoholic Fatty Liver Disease/pathology
    Language English
    Publishing date 2020-10-16
    Publishing country China
    Document type Journal Article
    ZDB-ID 127089-8
    ISSN 2542-5641 ; 0366-6999 ; 1002-0187
    ISSN (online) 2542-5641
    ISSN 0366-6999 ; 1002-0187
    DOI 10.1097/CM9.0000000000000989
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  9. Article ; Online: COVID-19 Cross-Infection and Pressured Ulceration Among Healthcare Workers

    Zheng, Kenneth I. / Rios, Rafael S. / Zeng, Qi-Qiang / Zheng, Ming-Hua

    Frontiers in Medicine

    Are We Really Protected by Respirators?

    2020  Volume 7

    Keywords covid19
    Publisher Frontiers Media SA
    Publishing country ch
    Document type Article ; Online
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2020.571493
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Sex influences the association between appendicular skeletal muscle mass to visceral fat area ratio and non-alcoholic steatohepatitis in patients with biopsy-proven non-alcoholic fatty liver disease

    Li, Gang / Rios, Rafael S. / Wang, Xin-Xin / Yu, Yue / Zheng, Kenneth I. / Huang, Ou-Yang / Tang, Liang-Jie / Ma, Hong-Lei / Jin, Yi / Targher, Giovanni / Byrne, Christopher D. / Pan, Xiao-Yan / Zheng, Ming-Hua

    British journal of nutrition. 20222021 June 14 28, June 14 28, v. 127, no. 11

    2022  

    Abstract: Sarcopenic obesity is regarded as a risk factor for the progression and development of non-alcoholic fatty liver disease (NAFLD). Since male sex is a risk factor for NAFLD and skeletal muscle mass markedly varies between the sexes, we examined whether ... ...

    Abstract Sarcopenic obesity is regarded as a risk factor for the progression and development of non-alcoholic fatty liver disease (NAFLD). Since male sex is a risk factor for NAFLD and skeletal muscle mass markedly varies between the sexes, we examined whether sex influences the association between appendicular skeletal muscle mass to visceral fat area ratio (SVR), that is, an index of skeletal muscle mass combined with abdominal obesity, and the histological severity of NAFLD. The SVR was measured by bioelectrical impedance in a cohort of 613 (M/F = 443/170) Chinese middle-aged individuals with biopsy-proven NAFLD. Multivariable logistic regression and subgroup analyses were used to test the association between SVR and the severity of NAFLD (i.e. non-alcoholic steatohepatitis (NASH) or NASH with the presence of any stage of liver fibrosis). NASH was identified by a NAFLD activity score ≥5, with a minimum score of 1 for each of its categories. The presence of fibrosis was classified as having a histological stage ≥1. The SVR was inversely associated with NASH in men (adjusted OR 0·62; 95 % CI 0·42, 0·92, P = 0·017 for NASH, adjusted OR 0·65; 95 % CI 0·43, 0·99, P = 0·043 for NASH with the presence of fibrosis), but not in women (1·47 (95 % CI 0·76, 2·83), P = 0·25 for NASH, and 1·45 (95 % CI 0·74, 2·83), P = 0·28 for NASH with the presence of fibrosis). There was a significant interaction for sex and SVR (P ᵢₙₜₑᵣₐcₜᵢₒₙ = 0·017 for NASH and P ᵢₙₜₑᵣₐcₜᵢₒₙ = 0·033 for NASH with the presence of fibrosis). Our findings show that lower skeletal muscle mass combined with abdominal obesity is strongly associated with the presence of NASH only in men.
    Keywords bioelectrical impedance ; fatty liver ; fibrosis ; histology ; liver cirrhosis ; males ; nutrition ; obesity ; regression analysis ; risk factors ; sarcopenia ; skeletal muscle ; visceral fat
    Language English
    Dates of publication 2022-0614
    Size p. 1613-1620.
    Publishing place Cambridge University Press
    Document type Article
    ZDB-ID 280396-3
    ISSN 1475-2662 ; 0007-1145
    ISSN (online) 1475-2662
    ISSN 0007-1145
    DOI 10.1017/S0007114521002415
    Database NAL-Catalogue (AGRICOLA)

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