LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 495

Search options

  1. Article ; Online: The brain may devise laws for the blood.

    Ritchie, David S

    Blood

    2024  Volume 143, Issue 10, Page(s) 841–842

    MeSH term(s) Animals ; Mice ; Neuroinflammatory Diseases ; Brain ; Head ; Graft vs Host Disease
    Language English
    Publishing date 2024-03-04
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2023023291
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article: The Mystery of a Unilateral Headache Ultimately Diagnosed as Moyamoya Disease.

    Malone, Mercedes / Ritchie, David

    Cureus

    2022  Volume 14, Issue 7, Page(s) e26816

    Abstract: Moyamoya disease (MMD) is a rare chronic cerebrovascular occlusive disease characterized by progressive stenosis or occlusion of the intracranial internal carotid arteries and their proximal branches, with subsequent abnormally formed collateral vessels. ...

    Abstract Moyamoya disease (MMD) is a rare chronic cerebrovascular occlusive disease characterized by progressive stenosis or occlusion of the intracranial internal carotid arteries and their proximal branches, with subsequent abnormally formed collateral vessels. Moyamoya disease is typically found in children of East Asian descent and is the most common pediatric cerebrovascular pathology in East Asian populations. However, moyamoya disease can be present without any predisposing factors, and this is what distinguishes the disease from the syndrome. Moyamoya syndrome is typically associated with other conditions such as sickle cell disease or neurofibromatosis. The syndrome can also be seen in patients who have had exposure to cervical or neck radiation. We present a rare case of an adult Peruvian woman who initially presented with a severe right hemispherical headache, which was ultimately diagnosed as MMD. This report and the discussion aim to provide more understanding of moyamoya disease and how it can be incidentally discovered in an unsuspected patient without any predisposing factors. The fact that the patient lacked any predisposing factors makes moyamoya disease, and not the syndrome, the diagnosis. Currently available treatments are limited. One specialized therapeutic approach is a procedure called encephaloduroarteriosynangiosis (EDAS), which aims to involve the transposition of a segment of a scalp artery onto the surface of the brain to permit the additional formation of collateral arteries. We aim to highlight the management and treatment of a case of moyamoya presenting as a severe right hemispherical headache in a patient without any predisposing factors.
    Language English
    Publishing date 2022-07-13
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.26816
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article: Evaluation of Recurrent Right-Sided Pleural Effusion: Hepatic Hydrothorax vs. Silicone Breast Implant Rupture.

    Malone, Mercedes / Ritchie, David

    Cureus

    2022  Volume 14, Issue 10, Page(s) e30268

    Abstract: We report a case of a 55-year-old woman who presented to our hospital emergency department with a recurrent right-sided pleural effusion. Her presenting symptom was shortness of breath which first began two years prior after she experienced a blunt ... ...

    Abstract We report a case of a 55-year-old woman who presented to our hospital emergency department with a recurrent right-sided pleural effusion. Her presenting symptom was shortness of breath which first began two years prior after she experienced a blunt thoracic injury. This injury resulted in the rupture of her right silicone breast implant. Since the traumatic rupture of her right breast implant, she developed asthma-like symptoms and allergies that were adequately controlled with bronchodilators, antihistamines, and glucocorticoids. Laboratory investigation was significant for elevated immunoglobulin E (IgE) levels and eosinophilia consistent with an allergic hypersensitivity reaction. She denied a history of smoking, asthma, or allergies preceding the trauma to her right breast implant. Our differential diagnosis also included the possibility of an inflammatory reaction to the silicone breast rupture as a possible etiology for the recurrent pleural effusion. The patient underwent a right-sided diagnostic and therapeutic thoracentesis procedure on two separate occasions within a span of a month in an effort to improve her symptoms and arrive at a definitive diagnosis. Her worsening symptoms were believed to be triggered by the pleural effusion. Aspirated pleural fluid was sent to the laboratory for analysis. Both samples excluded infectious or malignant causes of the pleural effusion. Ultimately, the source of her pleural effusion was determined to be decompensated liver cirrhosis. The patient underwent a pleurodesis procedure in an effort to seal the pleural space.
    Language English
    Publishing date 2022-10-13
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.30268
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article ; Online: Modified cell trace violet proliferation assay preserves lymphocyte viability and allows spectral flow cytometry analysis.

    Davis, Joanne E / Ludford-Menting, Mandy / Koldej, Rachel / Ritchie, David S

    Cytometry. Part A : the journal of the International Society for Analytical Cytology

    2024  

    Abstract: In this study we describe three different methods for labeling T lymphocytes with cell trace violet (CTV), in order to track cell division in mouse and human cells, in both the in vitro and in vivo setting. We identified a modified method of CTV labeling ...

    Abstract In this study we describe three different methods for labeling T lymphocytes with cell trace violet (CTV), in order to track cell division in mouse and human cells, in both the in vitro and in vivo setting. We identified a modified method of CTV labeling that can be applied directly to either conventional or spectral flow cytometry, that maintained lymphocyte viability and function, yet minimized dye spill-over into other fluorochrome channels. Our optimized method for CTV labeling allowed us to identify up to eight cell divisions and the replication index for in vitro-stimulated mouse and human lymphocytes, and the co-expression of T-cell subset markers. Furthermore, the homeostatic trafficking, expansion and division of CTV-labeled congenic donor T cells could be detected using spectral cytometry, in an adoptive T-cell transfer mouse model. Our optimized CTV method can be applied to both in vitro and in vivo settings to examine the behavior and phenotype of activated T cells.
    Language English
    Publishing date 2024-02-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2099868-5
    ISSN 1552-4930 ; 0196-4763 ; 1552-4922
    ISSN (online) 1552-4930
    ISSN 0196-4763 ; 1552-4922
    DOI 10.1002/cyto.a.24830
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article ; Online: Self-reliance or the generosity of others?: autologous versus allogeneic stem cell transplantation in high-risk Hodgkin lymphoma.

    Koo, Ray Mun / Ritchie, David

    Leukemia & lymphoma

    2021  Volume 62, Issue 10, Page(s) 2303–2305

    MeSH term(s) Hematopoietic Stem Cell Transplantation ; Hodgkin Disease/therapy ; Humans ; Neoplasm Recurrence, Local ; Stem Cell Transplantation ; Transplantation Conditioning ; Transplantation, Autologous ; Transplantation, Homologous ; Treatment Outcome
    Language English
    Publishing date 2021-10-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1042374-6
    ISSN 1029-2403 ; 1042-8194
    ISSN (online) 1029-2403
    ISSN 1042-8194
    DOI 10.1080/10428194.2021.1988593
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article: Cylindrical Multimode Waveguides as Focusing Interferometric Systems.

    Michailow, Wladislaw / Almond, Nikita W / Beere, Harvey E / Ritchie, David A

    ACS photonics

    2023  Volume 10, Issue 6, Page(s) 1756–1768

    Abstract: Delivery and focusing of radiation requires a variety of optical elements such as waveguides and mirrors or lenses. Heretofore, they were used separately, the former for radiation delivery, the latter for focusing. Here, we show that cylindrical ... ...

    Abstract Delivery and focusing of radiation requires a variety of optical elements such as waveguides and mirrors or lenses. Heretofore, they were used separately, the former for radiation delivery, the latter for focusing. Here, we show that cylindrical multimode waveguides can both deliver and simultaneously focus radiation, without any external lenses or parabolic mirrors. We develop an analytical, ray-optical model to describe radiation propagation within and after the end of cylindrical multimode waveguides and demonstrate the focusing effect theoretically and experimentally at terahertz frequencies. In the focused spot, located at a distance of several millimeters to a few centimeters away from the waveguide end, typical for focal lengths in optical setups, we achieve a more than 8.4× higher intensity than the cross-sectional average intensity and compress the half-maximum spot area of the incident beam by a factor of >15. Our results represent the first practical realization of a focusing system consisting of only a single cylindrical multimode waveguide, that delivers radiation from one focused spot into another focused spot in free space, with focal distances that are much larger than both the radiation wavelength and the waveguide radius. The results enable design and optimization of cylindrical waveguide-containing systems and demonstrate a precise optical characterization method for cylindrical structures and objects.
    Language English
    Publishing date 2023-05-17
    Publishing country United States
    Document type Journal Article
    ISSN 2330-4022
    ISSN 2330-4022
    DOI 10.1021/acsphotonics.2c02030
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article: Development and Promotion of an mHealth App for Adolescents Based on the European Code Against Cancer: Retrospective Cohort Study.

    Mallafré-Larrosa, Meritxell / Papi, Ginevra / Trilla, Antoni / Ritchie, David

    JMIR cancer

    2023  Volume 9, Page(s) e48040

    Abstract: Background: Mobile health technologies, underpinned by scientific evidence and ethical standards, exhibit considerable promise and potential in actively engaging consumers and patients while also assisting health care providers in delivering cancer ... ...

    Abstract Background: Mobile health technologies, underpinned by scientific evidence and ethical standards, exhibit considerable promise and potential in actively engaging consumers and patients while also assisting health care providers in delivering cancer prevention and care services. The WASABY mobile app was conceived as an innovative, evidence-based mobile health tool aimed at disseminating age-appropriate messages from the European Code Against Cancer (ECAC) to adolescents across Europe.
    Objective: This study aims to assess the outcomes of the design, development, and promotion of the WASABY app through a 3-pronged evaluation framework that encompasses data on social media promotion, app store traffic, and user engagement.
    Methods: The WASABY app's content, cocreated with cancer-focused civil society organizations across 6 European countries, drew upon scientific evidence from the ECAC. The app's 10 modules were designed using the health belief model and a gamification conceptual framework characterized by spaced repetition learning techniques, refined through 2 rounds of testing. To evaluate the effectiveness of the app, we conducted a retrospective cohort study using the WASABY app's user database registered from February 4 to June 30, 2021, using a 3-pronged assessment framework: social media promotion, app store traffic, and user engagement. Descriptive statistics and association analyses explored the relationship between sociodemographic variables and user performance analytics.
    Results: After extensive promotion on various social media platforms and subsequent traffic to the Apple App and Google Play stores, a sample of 748 users aged between 14 and 19 years was included in the study cohort. The selected sample exhibited a mean age of 16.08 (SD 1.28) years and was characterized by a predominant representation of female users (499/748, 66.7%). Most app users identified themselves as nonsmokers (689/748, 92.1%), reported either no or infrequent alcohol consumption (432/748, 57.8% and 250/748, 33.4%, respectively), and indicated being physically active for 1 to 5 hours per week (505/748, 67.5%). In aggregate, the app's content garnered substantial interest, as evidenced by 40.8% (305/748) of users visiting each of the 10 individual modules. Notably, sex and smoking habits emerged as predictors of app completion rates; specifically, male and smoking users demonstrated a decreased likelihood of successfully completing the app's content (odds ratio 0.878, 95% CI 0.809-0.954 and odds ratio 0.835, 95% CI 0.735-0.949, respectively).
    Conclusions: The development and promotion of the WASABY app presents a valuable case study, illustrating the effective dissemination of evidence-based recommendations on cancer prevention within the ECAC through an innovative mobile app aimed at European adolescents. The data derived from this study provide insightful findings for the implementation of Europe's Beating Cancer Plan, particularly the creation of the EU Mobile App for Cancer Prevention.
    Language English
    Publishing date 2023-11-28
    Publishing country Canada
    Document type Journal Article
    ISSN 2369-1999
    ISSN 2369-1999
    DOI 10.2196/48040
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article ; Online: Poor graft function, a significant and emerging clinical challenge post allogeneic stem cell transplantation.

    Prabahran, Ashvind A / Ritchie, David S

    Leukemia & lymphoma

    2020  Volume 61, Issue 12, Page(s) 2786–2787

    MeSH term(s) Graft vs Host Disease/etiology ; Hematopoietic Stem Cell Transplantation/adverse effects ; Humans ; T-Lymphocytes
    Language English
    Publishing date 2020-08-07
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1042374-6
    ISSN 1029-2403 ; 1042-8194
    ISSN (online) 1029-2403
    ISSN 1042-8194
    DOI 10.1080/10428194.2020.1803301
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article ; Online: Calculating and scoring high quality multiple flexible protein structure alignments.

    Ritchie, David W

    Bioinformatics (Oxford, England)

    2016  Volume 32, Issue 17, Page(s) 2650–2658

    Abstract: Motivation: Calculating multiple protein structure alignments (MSAs) is important for understanding functional and evolutionary relationships between protein families, and for modeling protein structures by homology. While incorporating backbone ... ...

    Abstract Motivation: Calculating multiple protein structure alignments (MSAs) is important for understanding functional and evolutionary relationships between protein families, and for modeling protein structures by homology. While incorporating backbone flexibility promises to circumvent many of the limitations of rigid MSA algorithms, very few flexible MSA algorithms exist today. This article describes several novel improvements to the Kpax algorithm which allow high quality flexible MSAs to be calculated. This article also introduces a new Gaussian-based MSA quality measure called 'M-score', which circumvents the pitfalls of RMSD-based quality measures.
    Results: As well as calculating flexible MSAs, the new version of Kpax can also score MSAs from other aligners and from previously aligned reference datasets. Results are presented for a large-scale evaluation of the Homstrad, SABmark and SISY benchmark sets using Kpax and Matt as examples of state-of-the-art flexible aligners and 3DCOMB as an example of a state-of-the-art rigid aligner. These results demonstrate the utility of the M-score as a measure of MSA quality and show that high quality MSAs may be achieved when structural flexibility is properly taken into account.
    Availability and implementation: Kpax 5.0 may be downloaded for academic use at http://kpax.loria.fr/
    Contact: dave.ritchie@inria.fr
    Supplementary information: Supplementary data are available at Bioinformatics online.
    MeSH term(s) Algorithms ; Models, Statistical ; Normal Distribution ; Proteins ; Sequence Alignment ; Software
    Chemical Substances Proteins
    Language English
    Publishing date 2016-09-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 1422668-6
    ISSN 1367-4811 ; 1367-4803
    ISSN (online) 1367-4811
    ISSN 1367-4803
    DOI 10.1093/bioinformatics/btw300
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article: Factors affecting intention to screen after being informed of benefits and harms of breast cancer screening: a study in 5 European countries in 2021.

    Ritchie, David / Van Hal, Guido / Van den Broucke, Stephan

    Archives of public health = Archives belges de sante publique

    2022  Volume 80, Issue 1, Page(s) 143

    Abstract: Background: Participation in mammography screening comes with harms alongside benefits. Information about screening provided to women should convey this information yet concerns persist about its effect on participation. This study addressed factors ... ...

    Abstract Background: Participation in mammography screening comes with harms alongside benefits. Information about screening provided to women should convey this information yet concerns persist about its effect on participation. This study addressed factors that may influence the intention to screen once a woman has been informed about benefits and harms of participation.
    Methods: A cross-sectional survey of women from five countries (Belgium, France, Italy, Spain, and the United Kingdom) was performed in January 2021. The survey contained a statement regarding the benefits and harms of mammography screening along with items to measure cognitive variables from the theory of planned behaviour and health belief model and the 6-item version of the European Health Literacy Survey Questionnaire (HLS-EU-Q6). Logistic regression and mediation analysis were performed to investigate the effect of cognitive and sociodemographic variables.
    Results: A total of 1180 participants responded to the survey. 19.5% of participants (n = 230) were able to correctly identify that mammography screening carries both benefits and harms. 56.9% of participants (n = 672) responded that they would be more likely to participate in screening in the future after being informed about the benefits and harms of mammography screening. Perceived behavioural control and social norms demonstrated were significant in predicting intention, whereas, the effect of health literacy was limited.
    Conclusions: Informing women about the presence of benefits and harms of in mammography screening participation did not negatively impact upon intention to be screened. Information should also address perception on implementation factors alongside messages on benefits and harms. Overall, screening programme managers should not be discouraged by the assumption of decreased participation through increasing efforts to address the lack of knowledge on benefits and harms.
    Language English
    Publishing date 2022-05-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 1117688-x
    ISSN 2049-3258 ; 0778-7367 ; 0003-9578
    ISSN (online) 2049-3258
    ISSN 0778-7367 ; 0003-9578
    DOI 10.1186/s13690-022-00902-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top