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Article ; Online: Comparison of Magnetic Resonance Imaging and Endoscopic Ultrasound in the Sizing of Intraductal Papillary Mucinous Neoplasia of the Pancreas.

Hesse, Felix / Ritter, Jessica / Hapfelmeier, Alexander / Braren, Rickmer / Phillip, Veit

2023 Volume 52, Issue 6, Page(s) e315–e320

Abstract: Objectives: Because IPMNs are potentially malignant, surveillance of IPMN is recommended by magnetic resonance imaging (MRI) and endoscopic ultrasound (EUS). The aim of the study was the evaluation of the concordance between EUS and MRI regarding cyst ... ...

Abstract	Objectives: Because IPMNs are potentially malignant, surveillance of IPMN is recommended by magnetic resonance imaging (MRI) and endoscopic ultrasound (EUS). The aim of the study was the evaluation of the concordance between EUS and MRI regarding cyst size. Methods: Retrospective data analysis was done for patients with IPMN in whom EUS and MRI were performed simultaneously (≤60 days). The measured cyst size of both procedures was compared by Bland-Altman plots. Agreement of cyst localization and dilation of main pancreatic duct was assessed using kappa statistics. Results: Fifty-nine cases were evaluated (median age, 71 years; 65% female; median time interval between both investigations, 17 days). The mean difference of IPMN maximal diameter between EUS and MRI was 0.55 mm with a prediction interval of -9.20 to +10.29 mm for 95% of the expected differences. There was strong interobserver agreement regarding cyst localization ( κ = 0.669, P = 1.06e -13 ) and the width of main pancreatic duct (<5, 5-9, and ≥10 mm; κ = 0.676 caput, κ = 0.823 corpus). Conclusions: We found a clinically relevant difference in cyst size comparing EUS and MRI. Therefore, alternating EUS and MRI for follow-up of the "worrisome feature" size growth is not reasonable.
MeSH term(s)	Humans ; Female ; Aged ; Male ; Pancreatic Intraductal Neoplasms/diagnostic imaging ; Retrospective Studies ; Carcinoma, Pancreatic Ductal/diagnostic imaging ; Carcinoma, Pancreatic Ductal/pathology ; Pancreatic Neoplasms/diagnostic imaging ; Pancreatic Neoplasms/pathology ; Pancreas/pathology ; Magnetic Resonance Imaging ; Endosonography ; Cysts
Language	English
Publishing date	2023-11-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	632831-3
ISSN	1536-4828 ; 0885-3177
ISSN (online)	1536-4828
ISSN	0885-3177
DOI	10.1097/MPA.0000000000002264
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Book ; Online ; Thesis: Identifikation genetischer Marker bei Kindern mit VACTERL-Assoziation

Ritter, Jessica [Verfasser] / Hubertus, Jochen [Akademischer Betreuer]

2022

Author's details	Jessica Ritter ; Betreuer: Jochen Hubertus
Keywords	Medizin, Gesundheit ; Medicine, Health
Subject code	sg610
Language	German
Publisher	Universitätsbibliothek der Ludwig-Maximilians-Universität
Publishing place	München
Document type	Book ; Online ; Thesis
Database	Digital theses on the web

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Article: Neisseria gonorrhoeae

Ritter, Jessica Leigh / Genco, Caroline Attardo

Journal of cell death

2018 Volume 11, Page(s) 1179066017750902

Abstract: Neisseria ... ...

Abstract	Neisseria gonorrhoeae
Language	English
Publishing date	2018-01-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2532290-4
ISSN	1179-0660
ISSN	1179-0660
DOI	10.1177/1179066017750902
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Article: Genetic Disruption of Cilia-Associated Signaling Pathways in Patients with VACTERL Association.

Ritter, Jessica / Lisec, Kristina / Klinner, Marina / Heinrich, Martina / von Schweinitz, Dietrich / Kappler, Roland / Hubertus, Jochen

Children (Basel, Switzerland)

2023 Volume 10, Issue 5

Abstract: VACTERL association is a rare malformation complex consisting of vertebral defects, anorectal malformation, cardiovascular defects, tracheoesophageal fistulae with esophageal atresia, renal malformation, and limb anomalies. According to current knowledge, ...

Abstract	VACTERL association is a rare malformation complex consisting of vertebral defects, anorectal malformation, cardiovascular defects, tracheoesophageal fistulae with esophageal atresia, renal malformation, and limb anomalies. According to current knowledge, VACTERL is based on a multifactorial pathogenesis including genomic alterations. This study aimed to improve the understanding of the genetic mechanisms in the development of VACTERL by investigating the genetic background with a focus on signaling pathways and cilia function. The study was designed as genetic association study. For this, whole-exome sequencing with subsequent functional enrichment analyses was performed for 21 patients with VACTERL or a VACTERL-like phenotype. In addition, whole-exome sequencing was performed for three pairs of parents and Sanger-sequencing was performed for ten pairs of parents. Analysis of the WES-data revealed genetic alteration in the Shh- and Wnt-signaling pathways. Additional performed functional enrichment analysis identified an overrepresentation of the cilia, including 47 affected ciliary genes with clustering in the
Language	English
Publishing date	2023-05-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2732685-8
ISSN	2227-9067
ISSN	2227-9067
DOI	10.3390/children10050882
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Book ; Online: Atlas-Based Interpretable Age Prediction In Whole-Body MR Images

Starck, Sophie / Kini, Yadunandan Vivekanand / Ritter, Jessica Johanna Maria / Braren, Rickmer / Rueckert, Daniel / Mueller, Tamara

2023

Abstract: Age prediction is an important part of medical assessments and research. It can aid in detecting diseases as well as abnormal ageing by highlighting the discrepancy between chronological and biological age. To gain a comprehensive understanding of age- ... ...

Abstract	Age prediction is an important part of medical assessments and research. It can aid in detecting diseases as well as abnormal ageing by highlighting the discrepancy between chronological and biological age. To gain a comprehensive understanding of age-related changes observed in various body parts, we investigate them on a larger scale by using whole-body 3D images. We utilise the Grad-CAM interpretability method to determine the body areas most predictive of a person's age. We expand our analysis beyond individual subjects by employing registration techniques to generate population-wide interpretability maps. Our findings reveal three primary areas of interest: the spine, the autochthonous back muscles, and the cardiac region, which exhibits the highest importance.
Keywords	Electrical Engineering and Systems Science - Image and Video Processing ; Computer Science - Computer Vision and Pattern Recognition ; Computer Science - Machine Learning
Subject code	006
Publishing date	2023-07-14
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Genetic Evidence for Congenital Vascular Disorders in Patients with VACTERL Association.

Ritter, Jessica / Lisec, Kristina / Heinrich, Martina / von Schweinitz, Dietrich / Kappler, Roland / Hubertus, Jochen

European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie

2021 Volume 32, Issue 1, Page(s) 61–66

Abstract: Introduction: The VACTERL association is a rare malformation complex, showing at least three anomalies of the following organ systems: vertebra, anorectum, heart and vessels, trachea and esophagus, genitourinary tract, and limbs. In addition to a ... ...

Abstract	Introduction: The VACTERL association is a rare malformation complex, showing at least three anomalies of the following organ systems: vertebra, anorectum, heart and vessels, trachea and esophagus, genitourinary tract, and limbs. In addition to a multifactorial event, congenital vascular disorders are also discussed as triggers for the VACTERL association. The aim of this study was to determine whether there is a genetic background for vascular disorders triggering VACTERL association. Materials and methods: We performed a functional analysis on whole exome sequencing data of 21 patients with VACTERL or VACTERL-like phenotype using the online analysis tool "Database for Annotation, Visualization and Integrated Discovery (DAVID) v6.8." The study was approved by the institutional ethics committee (approval no. 026-13). Written informed consent was obtained from all patients or their parents. Results: We identified a total of 86 genetic variants (in 75 genes) classified as damaging (including probably damaging missense, nonsense, and frameshift variants), which are associated to cardiovascular development. Each investigated patient showed at least one damaging variant in genes associated to cardiovascular development. These variants were further reduced by significance in cardiovascular development to 39 genetic variants (in 33 genes). Of note, a pair of siblings, both presenting with cardiac and renal defects, had the same damaging variant in two different genes. Conclusion: Our results indicate a genetic background for congenital vascular disorders in patients with VACTERL association. In line with the literature, our data suggest that genetic mutation led to vascular diseases, which in turn may cause malformations similar to the VACTERL association.
MeSH term(s)	Anal Canal/abnormalities ; Esophagus/abnormalities ; Heart Defects, Congenital/genetics ; Humans ; Kidney/abnormalities ; Limb Deformities, Congenital ; Spine/abnormalities ; Trachea/abnormalities ; Vascular Diseases
Language	English
Publishing date	2021-11-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	1065043-x
ISSN	1439-359X ; 0939-7248 ; 0939-6764 ; 0930-7249
ISSN (online)	1439-359X
ISSN	0939-7248 ; 0939-6764 ; 0930-7249
DOI	10.1055/s-0041-1739423
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Article: A national study predicting licensed social workers' levels of political participation: the role of resources, psychological engagement, and recruitment networks.

Ritter, Jessica A

Social work

2008 Volume 53, Issue 4, Page(s) 347–357

Abstract: The social work literature is replete with studies evaluating social workers' direct practice interventions, but strikingly few have assessed how well social workers are faring in the political arena. This study tests a major theoretical model, the civic ...

Abstract	The social work literature is replete with studies evaluating social workers' direct practice interventions, but strikingly few have assessed how well social workers are faring in the political arena. This study tests a major theoretical model, the civic voluntarism model, developed to explain why some citizens become involved in politics, whereas others do not. The study sample consisted of 396 randomly selected social workers licensed in 11 states, all of whom completed a 25-minute telephone survey. Social workers were surveyed to determine the role of the following variables in explaining social workers' political activity levels-resources needed to participate, psychological engagement, and attachment to recruitment networks. The results indicate that the civic voluntarism model was significant and accounted for 42 percent of the variance. The strongest predictors of social workers' political activity were NASW membership and political interest. This study provides empirical support for the idea that being connected to social networks and having a psychological engagement with politics are crucial factors in explaining social workers' political participation. Implications for social work education are included.
MeSH term(s)	Humans ; Licensure/statistics & numerical data ; Patient Advocacy/statistics & numerical data ; Politics ; Prospective Studies ; Social Behavior ; Social Support ; Social Work/statistics & numerical data ; Surveys and Questionnaires ; United States/epidemiology
Language	English
Publishing date	2008-08-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	410783-4
ISSN	1545-6846 ; 0037-8046
ISSN (online)	1545-6846
ISSN	0037-8046
DOI	10.1093/sw/53.4.347
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Article: Genetic Evidence for Congenital Vascular Disorders in Patients with VACTERL Association

Ritter, Jessica / Lisec, Kristina / Heinrich, Martina / von Schweinitz, Dietrich / Kappler, Roland / Hubertus, Jochen

European Journal of Pediatric Surgery

2021 Volume 32, Issue 01, Page(s) 61–66

Abstract	Introduction: The VACTERL association is a rare malformation complex, showing at least three anomalies of the following organ systems: vertebra, anorectum, heart and vessels, trachea and esophagus, genitourinary tract, and limbs. In addition to a multifactorial event, congenital vascular disorders are also discussed as triggers for the VACTERL association. The aim of this study was to determine whether there is a genetic background for vascular disorders triggering VACTERL association. Materials and Methods: We performed a functional analysis on whole exome sequencing data of 21 patients with VACTERL or VACTERL-like phenotype using the online analysis tool “Database for Annotation, Visualization and Integrated Discovery (DAVID) v6.8.” The study was approved by the institutional ethics committee (approval no. 026–13). Written informed consent was obtained from all patients or their parents. Results: We identified a total of 86 genetic variants (in 75 genes) classified as damaging (including probably damaging missense, nonsense, and frameshift variants), which are associated to cardiovascular development. Each investigated patient showed at least one damaging variant in genes associated to cardiovascular development. These variants were further reduced by significance in cardiovascular development to 39 genetic variants (in 33 genes). Of note, a pair of siblings, both presenting with cardiac and renal defects, had the same damaging variant in two different genes. Conclusion: Our results indicate a genetic background for congenital vascular disorders in patients with VACTERL association. In line with the literature, our data suggest that genetic mutation led to vascular diseases, which in turn may cause malformations similar to the VACTERL association.
Keywords	VACTERL association ; vascular disorder ; cardiovascular development
Language	English
Publishing date	2021-11-25
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	1065043-x
ISSN	1439-359X ; 0939-7248 ; 0939-6764 ; 0930-7249
ISSN (online)	1439-359X
ISSN	0939-7248 ; 0939-6764 ; 0930-7249
DOI	10.1055/s-0041-1739423
Database	Thieme publisher's database

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Article ; Online: Phosphorylation of RAB7 by TBK1/IKKε Regulates Innate Immune Signaling in Triple-Negative Breast Cancer.

Ritter, Jessica L / Zhu, Zehua / Thai, Tran C / Mahadevan, Navin R / Mertins, Philipp / Knelson, Erik H / Piel, Brandon P / Han, Saemi / Jaffe, Jacob D / Carr, Steven A / Barbie, David A / Barbie, Thanh U

Cancer research

2019 Volume 80, Issue 1, Page(s) 44–56

Abstract: Triple-negative breast cancer (TNBC) is a heterogeneous disease enriched for mutations in PTEN and dysregulation of innate immune signaling. Here, we demonstrate that Rab7, a recently identified substrate of PTEN phosphatase activity, is also a substrate ...

Abstract	Triple-negative breast cancer (TNBC) is a heterogeneous disease enriched for mutations in PTEN and dysregulation of innate immune signaling. Here, we demonstrate that Rab7, a recently identified substrate of PTEN phosphatase activity, is also a substrate of the innate immune signaling kinases TANK-binding kinase 1 (TBK1)/IκB kinase ε (IKKε) on the same serine-72 (S72) site. An unbiased search for novel TBK1/IKKε substrates using stable isotope labeling with amino acids in cell culture phosphoproteomic analysis identified Rab7-S72 as a top hit. PTEN-null TNBC cells expressing a phosphomimetic version of Rab7-S72 exhibited diffuse cytosolic Rab7 localization and enhanced innate immune signaling, in contrast to a kinase-resistant version, which localized to active puncta that promote lysosomal-mediated stimulator of interferon genes (STING) degradation. Thus, convergence of PTEN loss and TBK1/IKKε activation on Rab7-S72 phosphorylation limited STING turnover and increased downstream production of IRF3 targets including CXCL10, CCL5, and IFNβ. Consistent with this data, PTEN-null TNBC tumors expressed higher levels of STING, and PTEN-null TNBC cell lines were hyperresponsive to STING agonists. Together, these findings begin to uncover how innate immune signaling is dysregulated downstream of TBK1/IKKε in a subset of TNBCs and reveals previously unrecognized cross-talk with STING recycling that may have implications for STING agonism in the clinic. SIGNIFICANCE: These findings identify Rab7 as a substrate for TBK1 for regulation of innate immune signaling, thereby providing important insight for strategies aimed at manipulating the immune response to enhance therapeutic efficacy in TNBC.
MeSH term(s)	Breast/immunology ; Breast/pathology ; Cell Line, Tumor ; Female ; HEK293 Cells ; Humans ; I-kappa B Kinase/metabolism ; Immunity, Innate ; Membrane Proteins/agonists ; Membrane Proteins/metabolism ; Mutagenesis, Site-Directed ; Mutation ; PTEN Phosphohydrolase/genetics ; PTEN Phosphohydrolase/metabolism ; Phosphorylation/genetics ; Phosphorylation/immunology ; Protein-Serine-Threonine Kinases/metabolism ; Proteolysis ; Serine/genetics ; Serine/metabolism ; Signal Transduction/immunology ; Triple Negative Breast Neoplasms/immunology ; Triple Negative Breast Neoplasms/pathology ; rab GTP-Binding Proteins/genetics ; rab GTP-Binding Proteins/immunology ; rab GTP-Binding Proteins/metabolism
Chemical Substances	Membrane Proteins ; STING1 protein, human ; rab7 protein (152989-05-4) ; Serine (452VLY9402) ; Protein-Serine-Threonine Kinases (EC 2.7.11.1) ; TBK1 protein, human (EC 2.7.11.1) ; I-kappa B Kinase (EC 2.7.11.10) ; IKBKE protein, human (EC 2.7.11.10) ; PTEN Phosphohydrolase (EC 3.1.3.67) ; PTEN protein, human (EC 3.1.3.67) ; rab GTP-Binding Proteins (EC 3.6.5.2)
Language	English
Publishing date	2019-10-29
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1432-1
ISSN	1538-7445 ; 0008-5472
ISSN (online)	1538-7445
ISSN	0008-5472
DOI	10.1158/0008-5472.CAN-19-1310
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Article ; Online: Development of a solvent-free polylactide/calcium carbonate composite for selective laser sintering of bone tissue engineering scaffolds.

Gayer, Christoph / Ritter, Jessica / Bullemer, Martin / Grom, Stefanie / Jauer, Lucas / Meiners, Wilhelm / Pfister, Andreas / Reinauer, Frank / Vučak, Marijan / Wissenbach, Konrad / Fischer, Horst / Poprawe, Reinhart / Schleifenbaum, Johannes Henrich

Materials science & engineering. C, Materials for biological applications

2019 Volume 101, Page(s) 660–673

Abstract: Since large bone defects cannot be healed by the body itself, continuous effort is put into the development of 3D scaffolds for bone tissue engineering. One method to fabricate such scaffolds is selective laser sintering (SLS). However, there is a lack ... ...

Abstract	Since large bone defects cannot be healed by the body itself, continuous effort is put into the development of 3D scaffolds for bone tissue engineering. One method to fabricate such scaffolds is selective laser sintering (SLS). However, there is a lack of solvent-free prepared microparticles suitable for SLS. Hence, the aim of this study was to develop a solvent-free polylactide/calcium carbonate composite powder with tailored material properties for SLS. Four composite powders with a composition of approximately 75 wt% polylactide (PLLA as well as PDLLA) and 25 wt% calcium carbonate (calcite) were prepared by a milling process based on GMP standards. Four different grades of polylactide were chosen to cover a broad inherent viscosity range of 1.0-3.6 dl/g. The composite material with the lowest inherent viscosity (1.0 dl/g) showed the best processability by SLS. This was caused by the small polymer particle diameter (50 μm) and the small zero-shear melt viscosity (400 Pa·s), which led to fast sintering. The SLS process parameters were developed to achieve low micro-porosity (approx. 2%) and low polymer degradation (no measurable decrease of the inherent viscosity). A biaxial bending strength of up to 75 MPa was achieved. Cell culture assays indicated good viability of MG-63 osteoblast-like cells on the SLS specimens. Finally, the manufacture of 3D scaffolds with interconnected pore structure was demonstrated. After proving the biocompatibility of the material, the developed scaffolds could have great potential to be used as patient-specific bone replacement implants.
MeSH term(s)	Biocompatible Materials/adverse effects ; Biocompatible Materials/chemistry ; Calcium Carbonate/chemistry ; Cell Line ; Cell Survival/drug effects ; Humans ; Polyesters/chemistry ; Tissue Engineering/methods ; Tissue Scaffolds/chemistry ; Viscosity
Chemical Substances	Biocompatible Materials ; Polyesters ; poly(lactide) (459TN2L5F5) ; Calcium Carbonate (H0G9379FGK)
Language	English
Publishing date	2019-03-27
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2012160-X
ISSN	1873-0191 ; 0928-4931
ISSN (online)	1873-0191
ISSN	0928-4931
DOI	10.1016/j.msec.2019.03.101
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