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Book ; Online: Enabling Positive Change. Flow and Complexity in Daily Experience

Riva, Eleonora / Riva, Giuseppe / Inghilleri, Paolo

2015

Abstract: Personal psychological growth: Why are some people able to promote their own psychological growth (bold tag) and change toward complexity while others not? Is it possible to propose simple methodologies and instruments that would allow selection of ... ...

Abstract	Personal psychological growth: Why are some people able to promote their own psychological growth (bold tag) and change toward complexity while others not? Is it possible to propose simple methodologies and instruments that would allow selection of positive experiences and hence develop a stronger and richer Self? This book describes the way to promote and foster positive psychological growth in everyday life, through simple instruments accessible to anyone. Positive psychological experience: The focal point of the approach is the concept of Flow of Consciousness, an experience of subjective psychological wellbeing that nourishes and complexifies the Self.- The authors propose a wide overview of positive psychological experience (bold tag) considering individual characteristics and experiences, as well as the influence of context, culture and social relationship, and the effects of the immersion in a globalized world, like the increasing daily use of mediated communication technologies. In the various chapters, this conceptual frame is declined in different areas of research, either consolidated ones or new fields. Self-development tips: In a fresh and engaging style, the book transports the readers in a world of situations and opportunities through which they can identify themselves in a positive and stable self-development (bold tag) process. In the first two chapters the authors describe the impact of positive psychological experience in social and individual life.- In the following chapters the reader discovers, accompanied by the exposition of concrete research results, the specific characteristics that may promote flow experience in several field of experience: the use of communication technology; the experience of social-networks; clinical settings and Psychotherapy; the psychological relation with environment, politics and social participation, school, sports, family business, mentors influence, and the perception of quality of life in daytime. Everyday opportunities: This opportunity of interacting with different and various kinds of experiences, that may appear dispersive, will on the contrary bring the reader - who may choose this book both for professional or personal reasons - to understand the concept of personal psychological growth in the wider and more concrete perspective, and to comprehend which personal skills he may bring into play in order to improve his personality and his daily experience
Keywords	Psychology
Size	1 electronic resource (210 p.)
Publisher	De Gruyter
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT020089332
ISBN	9783110410242 ; 9783110439472 ; 3110410249 ; 3110439476
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Survival Analysis of Newly Diagnosed Multiple Myeloma Patients after Frontline Autologous Stem Cell Transplantation in a Real-Life Setting.

Garrido, David / Bove, Virginia / Villano, Fiorella / Riva, Eloísa

Acta medica (Hradec Kralove)

2024 Volume 66, Issue 3, Page(s) 117–121

Abstract: Introduction: Autologous stem cell transplantation (ASCT) is the standard consolidation option for transplant-eligible patients with multiple myeloma (MM). The aim of this study is to report the overall survival (OS) and progression-free survival (PFS) ... ...

Abstract	Introduction: Autologous stem cell transplantation (ASCT) is the standard consolidation option for transplant-eligible patients with multiple myeloma (MM). The aim of this study is to report the overall survival (OS) and progression-free survival (PFS) outcomes after frontline ASCT in newly-diagnosed MM (NDMM) patients in a real-world setting. Methods: We conducted a retrospective, survival analysis of all NDMM patients included in the MM Uruguayan Registry. Results: We included 151 NDMM patients treated with induction therapy followed by high-dose melphalan and ASCT as consolidation. The median age at diagnosis was 59 years, and the international staging system (ISS) risk groups were ISS-III 32.9%, ISS-II 37.8%, and ISS-I 29.4%. Frontline induction regimens included bortezomib in 61.6% of cases, and maintenance therapy was used in 63.9% of reported cases. With a median follow-up of 42 months, the 36-month OS and PFS for the whole group were 82.4% (95% CI 75.9% to 89.4%) and 63.8% (95% CI 55.6% to 73.3%), respectively, median OS of 98 months and median PFS of 47 months. The 100-month OS and PFS for the entire group were 48.0% (95% CI 34.9% to 66.0%) and 17.3% (95% CI 8.4% to 35.8%), respectively. Conclusion: ASCT is a feasible, safe, and potent strategy that provides a prolonged median OS and PFS in NDMM patients. This approach can be implemented in low-income countries.
MeSH term(s)	Humans ; Multiple Myeloma/diagnosis ; Multiple Myeloma/drug therapy ; Hematopoietic Stem Cell Transplantation ; Retrospective Studies ; Disease-Free Survival ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Transplantation, Autologous ; Survival Analysis ; Stem Cell Transplantation
Language	English
Publishing date	2024-03-21
Publishing country	Czech Republic
Document type	Journal Article
ZDB-ID	1360995-6
ISSN	1805-9694 ; 1211-4286
ISSN (online)	1805-9694
ISSN	1211-4286
DOI	10.14712/18059694.2024.4
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Article: Wireless neuromodulation with porous silicon.

Micera, Silvestro / Redolfi Riva, Eugenio

Nature materials

2022 Volume 21, Issue 6, Page(s) 614–616

MeSH term(s)	Porosity ; Silicon
Chemical Substances	Silicon (Z4152N8IUI)
Language	English
Publishing date	2022-05-23
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	2088679-2
ISSN	1476-4660 ; 1476-1122
ISSN (online)	1476-4660
ISSN	1476-1122
DOI	10.1038/s41563-022-01257-7
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Article ; Online: Herpesviral encephalitis associated with bortezomib use in a patient with multiple myeloma and associated light-chain amyloidosis.

Garrido, David / Riva, Eloísa

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners

2022 Volume 28, Issue 7, Page(s) 1659–1663

Abstract: Introduction: Bortezomib is proteasome inhibitor used in multiple myeloma treatment. The reactivation of herpes simplex virus (HSV) and varicella-zoster virus (VZV) during bortezomib-based therapy is a well-known adverse event. Antiviral prophylaxis is ... ...

Abstract	Introduction: Bortezomib is proteasome inhibitor used in multiple myeloma treatment. The reactivation of herpes simplex virus (HSV) and varicella-zoster virus (VZV) during bortezomib-based therapy is a well-known adverse event. Antiviral prophylaxis is mandatory. Nevertheless, reports of herpesviral encephalitis are scarce. Case report: A 57-year-old multiple myeloma patient who during CyBorD protocol (Bortezomib, cyclophosphamide, and dexamethasone), after a transient suspension of antiviral prophylaxis presented progressive headaches unresponsive to conventional analgesics, asthenia, fever, episodic visual hallucinations, and vesicular lesions in the right supraorbital and frontal region. Herpetic encephalitis was diagnosed after detecting herpes zoster in cerebrospinal fluid. Management & outcome: The patient was treated with acyclovir 500mg every 6 hours for 21 days, and subsequent valacyclovir prophylaxis achieving an excellent clinical evolution. Anti-myeloma treatment was changed to lenalidomide and dexamethasone achieving a durable complete response. Herpesviral encephalitis is a rare but severe complication associated with the use of Bortezomib, especially when patients did not receive acyclovir prophylaxis. However, a rapid detection based on the clinical suspicion, and the prompt start of treatment, may lead to overcome this adverse event.
MeSH term(s)	Acyclovir/adverse effects ; Amyloidosis/chemically induced ; Amyloidosis/complications ; Amyloidosis/drug therapy ; Antineoplastic Agents/adverse effects ; Antiviral Agents/adverse effects ; Boronic Acids/adverse effects ; Bortezomib/adverse effects ; Dexamethasone/adverse effects ; Encephalitis, Herpes Simplex/chemically induced ; Encephalitis, Herpes Simplex/complications ; Encephalitis, Herpes Simplex/drug therapy ; Herpesvirus 3, Human/physiology ; Humans ; Middle Aged ; Multiple Myeloma/complications ; Multiple Myeloma/drug therapy ; Pyrazines
Chemical Substances	Antineoplastic Agents ; Antiviral Agents ; Boronic Acids ; Pyrazines ; Bortezomib (69G8BD63PP) ; Dexamethasone (7S5I7G3JQL) ; Acyclovir (X4HES1O11F)
Language	English
Publishing date	2022-02-04
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	1330764-2
ISSN	1477-092X ; 1078-1552
ISSN (online)	1477-092X
ISSN	1078-1552
DOI	10.1177/10781552221077956
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Article: Recent Advances in Polymeric Drug Delivery Systems for Peripheral Nerve Regeneration.

Bianchini, Marta / Micera, Silvestro / Redolfi Riva, Eugenio

Pharmaceutics

2023 Volume 15, Issue 2

Abstract: When a traumatic event causes complete denervation, muscle functional recovery is highly compromised. A possible solution to this issue is the implantation of a biodegradable polymeric tubular scaffold, providing a biomimetic environment to support the ... ...

Abstract	When a traumatic event causes complete denervation, muscle functional recovery is highly compromised. A possible solution to this issue is the implantation of a biodegradable polymeric tubular scaffold, providing a biomimetic environment to support the nerve regeneration process. However, in the case of consistent peripheral nerve damage, the regeneration capabilities are poor. Hence, a crucial challenge in this field is the development of biodegradable micro- nanostructured polymeric carriers for controlled and sustained release of molecules to enhance nerve regeneration. The aim of these systems is to favor the cellular processes that support nerve regeneration to increase the functional recovery outcome. Drug delivery systems (DDSs) are interesting solutions in the nerve regeneration framework, due to the possibility of specifically targeting the active principle within the site of interest, maximizing its therapeutical efficacy. The scope of this review is to highlight the recent advances regarding the study of biodegradable polymeric DDS for nerve regeneration and to discuss their potential to enhance regenerative performance in those clinical scenarios characterized by severe nerve damage.
Language	English
Publishing date	2023-02-14
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics15020640
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Article ; Online: Epidemiology and risk factors for the development of infectious complications in newly diagnosed multiple myeloma: a multicenter prospective cohort study in Uruguay.

Riva, Eloísa / Garrido, David / Villano, Fiorella / Bove, Virginia

Hematology, transfusion and cell therapy

2023

Abstract: Introduction: Infections represent a significant cause of morbidity and mortality in patients with multiple myeloma (MM). In Latin America, data on infectious complications in newly diagnosed MM (NDMM) patients are limited.: Methods: We conducted a ... ...

Abstract	Introduction: Infections represent a significant cause of morbidity and mortality in patients with multiple myeloma (MM). In Latin America, data on infectious complications in newly diagnosed MM (NDMM) patients are limited. Methods: We conducted a multicenter, prospective cohort study of patients with NDMM in Uruguay between June 2019 and December 2020. Patients with active disease, on active therapy and who provided written informed consent were included. Elegible patients were followed for 6 months from the time of diagnosis and before proceeding to autologous stem cell transplantation or until death, whichever occurred first. Our primary endpoint was the number of infectious events that required hospitalization for ≥ 24 h. Main results: Of 124 patients with NDMM, 54 (43.5 %) had infectious complications (74 infectious events), the majority (74.3 %) within the first 3 months from diagnosis. The most common sites of infection were urinary (39.2 %) and respiratory tracts (33.8 %). The microbial agent was identified in 60.8 % of patients with Gram-negative bacteria (71.4 %) as the most common pathogen. Viral and fungal infections were infrequent. In the multivariable analysis, the Eastern Cooperative Oncology Group (ECOG) performance status was ≥ 2 (odds ratio [OR], 2.16; 95 % confidence interval [95 %CI], 1.23 - 3.79; p = 0.008) and creatinine ≥ 2 mg/dl (OR, 2.33; 95 %CI, 1.33 - 4.07; p = 0.003) were independent factors associated with bacterial infections. At 6 months, 14 patients (11.3 %) had died, 50 % related to infectious complications. Conclusion: Bacterial infections are a substantial cause of hospital admissions and early death in patients with NDMM. Antibiotic prophylaxis should be considered to reduce infectious complications in patients with MM.
Language	English
Publishing date	2023-10-30
Publishing country	Brazil
Document type	Journal Article
ISSN	2531-1387
ISSN (online)	2531-1387
DOI	10.1016/j.htct.2023.09.2362
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Article ; Online: The SARS-CoV-2 epidemic: how the Italian public is being informed.

Antonelli, G / Capobianchi, M R / Riva, E

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

2020 Volume 26, Issue 6, Page(s) 791–792

MeSH term(s)	Betacoronavirus/isolation & purification ; COVID-19 ; Coronavirus Infections/epidemiology ; Epidemics/statistics & numerical data ; Humans ; Information Dissemination ; Italy/epidemiology ; Pandemics/statistics & numerical data ; Pneumonia, Viral/epidemiology ; Public Health/statistics & numerical data ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-04-01
Publishing country	England
Document type	Letter
ZDB-ID	1328418-6
ISSN	1469-0691 ; 1470-9465 ; 1198-743X
ISSN (online)	1469-0691
ISSN	1470-9465 ; 1198-743X
DOI	10.1016/j.cmi.2020.03.037
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Zs.MO 284: Show issues

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Article ; Online: Progress and challenges of implantable neural interfaces based on nature-derived materials.

Redolfi Riva, Eugenio / Micera, Silvestro

Bioelectronic medicine

2021 Volume 7, Issue 1, Page(s) 6

Abstract: Neural interfaces are bioelectronic devices capable of stimulating a population of neurons or nerve fascicles and recording electrical signals in a specific area. Despite their success in restoring sensory-motor functions in people with disabilities, ... ...

Abstract	Neural interfaces are bioelectronic devices capable of stimulating a population of neurons or nerve fascicles and recording electrical signals in a specific area. Despite their success in restoring sensory-motor functions in people with disabilities, their long-term exploitation is still limited by poor biocompatibility, mechanical mismatch between the device and neural tissue and the risk of a chronic inflammatory response upon implantation.In this context, the use of nature-derived materials can help address these issues. Examples of these materials, such as extracellular matrix proteins, peptides, lipids and polysaccharides, have been employed for decades in biomedical science. Their excellent biocompatibility, biodegradability in the absence of toxic compound release, physiochemical properties that are similar to those of human tissues and reduced immunogenicity make them outstanding candidates to improve neural interface biocompatibility and long-term implantation safety. The objective of this review is to highlight progress and challenges concerning the impact of nature-derived materials on neural interface design. The use of these materials as biocompatible coatings and as building blocks of insulation materials for use in implantable neural interfaces is discussed. Moreover, future perspectives are presented to show the increasingly important uses of these materials for neural interface fabrication and their possible use for other applications in the framework of neural engineering.
Language	English
Publishing date	2021-04-27
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2929561-0
ISSN	2332-8886 ; 2332-8886
ISSN (online)	2332-8886
ISSN	2332-8886
DOI	10.1186/s42234-021-00067-7
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Article ; Online: Was Aldo Castellani the inventor of combined and polyvalent vaccines?

Borghi, Luca / Riva, Elisabetta

Vaccine

2021 Volume 39, Issue 38, Page(s) 5442–5446

Abstract: Italian born and long term resident in England, Sir Aldo Castellani (1874-1971), is usually credited with "several discoveries of great importance in tropical medicine", most notably for his role in determining the aetiology of sleeping sickness and yaws. ...

Abstract	Italian born and long term resident in England, Sir Aldo Castellani (1874-1971), is usually credited with "several discoveries of great importance in tropical medicine", most notably for his role in determining the aetiology of sleeping sickness and yaws. This contribution tries to highlight his role in the history of vaccinology as a pioneer in the design and use of combined and polyvalent vaccines. In the light of existing data, while acting as Director of the Bacteriological Institute of Colombo (Ceylon) in the decade before the First World War, Castellani was the first to experiment with both different strains of "antigens belonging to the same group" like in his typhoid-paratyphoid vaccine (TAB), as well as the simultaneous use of more pathogens, or part of them, for protection against different diseases, like in his "tetravaccine" (TAB + cholera) and "pentavaccine" (TAB + cholera + Malta fever). At the beginning of the War, based on the results of thousands of vaccinations, he strongly maintained that those combined or mixed vaccines were harmless and effective. The Allied Armies became more and more interested in Castellani's methods. His TAB vaccine was extensively used among the soldiers and his contributions were largely acknowledged especially in the Anglo-Saxon world in the following years, when it was plainly stated that "to Castellani is due the credit of having first proposed, prepared, and used, combined vaccines". The path to widespread use of combination and polyvalent vaccines - which is usually dated back only to the late 1940s - was still long and winding. Castellani himself abandoned that field of research after the War and this is probably why that early history is nowadays often forgotten.
MeSH term(s)	Cholera/prevention & control ; Humans ; Inventors ; Italy ; Male ; Vaccines ; Vaccines, Combined
Chemical Substances	Vaccines ; Vaccines, Combined
Language	English
Publishing date	2021-08-06
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2021.07.062
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Zs.MO 458: Show issues

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Article ; Online: Improved Physiochemical Properties of Chitosan@PCL Nerve Conduits by Natural Molecule Crosslinking.

Bianchini, Marta / Zinno, Ciro / Micera, Silvestro / Redolfi Riva, Eugenio

Biomolecules

2023 Volume 13, Issue 12

Abstract: Nerve conduits may represent a valuable alternative to autograft for the regeneration of long-gap damages. However, no NCs have currently reached market approval for the regeneration of limiting gap lesions, which still represents the very bottleneck of ... ...

Abstract	Nerve conduits may represent a valuable alternative to autograft for the regeneration of long-gap damages. However, no NCs have currently reached market approval for the regeneration of limiting gap lesions, which still represents the very bottleneck of this technology. In recent years, a strong effort has been made to envision an engineered graft to tackle this issue. In our recent work, we presented a novel design of porous/3D-printed chitosan/poly-ε-caprolactone conduits, coupling freeze drying and additive manufacturing technologies to yield conduits with good structural properties. In this work, we studied genipin crosslinking as strategy to improve the physiochemical properties of our conduit. Genipin is a natural molecule with very low toxicity that has been used to crosslink chitosan porous matrix by binding the primary amino group of chitosan chains. Our characterization evidenced a stabilizing effect of genipin crosslinking towards the chitosan matrix, with reported modified porosity and ameliorated mechanical properties. Given the reported results, this method has the potential to improve the performance of our conduits for the regeneration of long-gap nerve injuries.
MeSH term(s)	Chitosan/chemistry ; Nerve Regeneration ; Iridoids/pharmacology ; Iridoids/chemistry ; Tissue Scaffolds/chemistry
Chemical Substances	Chitosan (9012-76-4) ; genipin (A3V2NE52YG) ; Iridoids
Language	English
Publishing date	2023-11-27
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2701262-1
ISSN	2218-273X ; 2218-273X
ISSN (online)	2218-273X
ISSN	2218-273X
DOI	10.3390/biom13121712
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