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  1. Article: Analysis of cell-free DNA concentration, fragmentation patterns and

    Guil-Luna, Silvia / Sánchez-Céspedes, Raquel / Rivas Crespo, Aurora / Dolores Fernández, María / Fernández Sarmiento, José Andrés / Rodríguez-Ariza, Antonio / Millán, Yolanda

    Frontiers in veterinary science

    2023  Volume 10, Page(s) 1157878

    Abstract: Introduction: Liquid biopsy based on the analysis of circulating cell-free DNA (cfDNA), as well as on detection of point mutations by digital droplet PCR (ddPCR), has revolutionized the research in oncology. In recent years, this technique has been ... ...

    Abstract Introduction: Liquid biopsy based on the analysis of circulating cell-free DNA (cfDNA), as well as on detection of point mutations by digital droplet PCR (ddPCR), has revolutionized the research in oncology. In recent years, this technique has been pioneering in veterinary medicine since it is a minimally invasive approach with very promising results for characterization of tumors.
    Methods: The aim of this study was, firstly, to analyze the concentration and the fragmentation pattern of cfDNA of dogs with mammary tumors (
    Results and discussion: Our results highlighted that those dogs with worse clinicopathological characteristics (simple or undifferentiated carcinomas, higher histological grade and presence of peritumoral inflammation) shown higher cfDNA concentration and higher concentrations of short-fragments (<190 bp) than healthy dogs. In addition, although no detection of the point mutation in codon 245 of
    Language English
    Publishing date 2023-03-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2834243-4
    ISSN 2297-1769
    ISSN 2297-1769
    DOI 10.3389/fvets.2023.1157878
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Metabolic shift underlies tumor progression and immune evasion in S-nitrosoglutathione reductase-deficient cancer.

    Mena-Osuna, Rafael / Mantrana, Ana / Guil-Luna, Silvia / Sánchez-Montero, María Teresa / Navarrete-Sirvent, Carmen / Morales-Ruiz, Teresa / Rivas-Crespo, Aurora / Toledano-Fonseca, Marta / García-Ortíz, María Victoria / García-Jurado, Gema / Gómez-España, María Auxiliadora / González-Fernández, Rafael / Villar, Carlos / Medina-Fernández, Francisco Javier / Villalba, José Manuel / Aranda, Enrique / Rodríguez-Ariza, Antonio

    The Journal of pathology

    2023  Volume 260, Issue 3, Page(s) 261–275

    Abstract: S-nitrosoglutathione reductase (GSNOR) is a denitrosylase enzyme that has been suggested to play a tumor suppressor role, although the mechanisms responsible are still largely unclear. In this study, we show that GSNOR deficiency in tumors is associated ... ...

    Abstract S-nitrosoglutathione reductase (GSNOR) is a denitrosylase enzyme that has been suggested to play a tumor suppressor role, although the mechanisms responsible are still largely unclear. In this study, we show that GSNOR deficiency in tumors is associated with poor prognostic histopathological features and poor survival in patients with colorectal cancer (CRC). GSNOR-low tumors were characterized by an immunosuppressive microenvironment with exclusion of cytotoxic CD8
    MeSH term(s) Mice ; Animals ; Humans ; Oxidoreductases ; CD8-Positive T-Lymphocytes ; Immune Evasion ; Proteomics ; Neoplasms ; Tumor Microenvironment
    Chemical Substances Oxidoreductases (EC 1.-) ; formaldehyde dehydrogenase, glutathione-independent (EC 1.2.1.46)
    Language English
    Publishing date 2023-04-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3119-7
    ISSN 1096-9896 ; 0022-3417
    ISSN (online) 1096-9896
    ISSN 0022-3417
    DOI 10.1002/path.6080
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.12: Show issues Location:
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  3. Article ; Online: Clinical significance of glycogen synthase kinase 3 (GSK-3) expression and tumor budding grade in colorectal cancer: Implications for targeted therapy.

    Guil-Luna, Silvia / Rivas-Crespo, Aurora / Navarrete-Sirvent, Carmen / Mantrana, Ana / Pera, Alejandra / Mena-Osuna, Rafael / Toledano-Fonseca, Marta / García-Ortíz, María Victoria / Villar, Carlos / Sánchez-Montero, Maria Teresa / Krueger, Janna / Medina-Fernández, Francisco Javier / De La Haba-Rodríguez, Juan / Gómez-España, Auxiliadora / Aranda, Enrique / Rudd, Christopher E / Rodríguez-Ariza, Antonio

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2023  Volume 167, Page(s) 115592

    Abstract: Introduction: Glycogen synthase kinase 3 (GSK-3) has been proposed as a novel cancer target due to its regulating role in both tumor and immune cells. However, the connection between GSK-3 and immunoevasive contexture, including tumor budding (TB) has ... ...

    Abstract Introduction: Glycogen synthase kinase 3 (GSK-3) has been proposed as a novel cancer target due to its regulating role in both tumor and immune cells. However, the connection between GSK-3 and immunoevasive contexture, including tumor budding (TB) has not been previously examined.
    Methods: we investigated the expression levels of total GSK-3 as well as its isoforms (GSK-3β and GSK-3α) and examined their potential correlation with TB grade and the programmed cell death-ligand 1 (PD-L1) in colorectal cancer (CRC) tumor samples. Additionally, we compared the efficacy of GSK-3-inhibition with PD-1/PD-L1 blockade in humanized patient-derived (PDXs) xenografts models of high-grade TB CRC.
    Results: we show that high-grade (BD3) TB CRC is associated with elevated expression levels of total GSK-3, specifically the GSK-3β isoform, along with increased expression of PD-L1 in tumor cells. Moreover, we define an improved risk stratification of CRC patients based on the presence of GSK-3
    Conclusions: our study provides compelling evidence for the clinical significance of GSK-3 expression and TB grade in risk stratification of CRC patients. Moreover, our findings strongly support GSK-3 inhibition as an effective therapy specifically targeting high-grade TB in CRC.
    MeSH term(s) Humans ; CD8-Positive T-Lymphocytes ; Glycogen Synthase Kinase 3 ; Glycogen Synthase Kinase 3 beta ; B7-H1 Antigen ; Programmed Cell Death 1 Receptor ; Clinical Relevance ; Colorectal Neoplasms/pathology
    Chemical Substances Glycogen Synthase Kinase 3 (EC 2.7.11.26) ; Glycogen Synthase Kinase 3 beta (EC 2.7.11.1) ; B7-H1 Antigen ; Programmed Cell Death 1 Receptor
    Language English
    Publishing date 2023-09-29
    Publishing country France
    Document type Journal Article
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2023.115592
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.198: Show issues Location:
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