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Article: The Importance of Gene Duplication and Domain Repeat Expansion for the Function and Evolution of Fertilization Proteins.

Rivera, Alberto M / Swanson, Willie J

Frontiers in cell and developmental biology

2022 Volume 10, Page(s) 827454

Abstract: The process of gene duplication followed by gene loss or evolution of new functions has been studied extensively, yet the role gene duplication plays in the function and evolution of fertilization proteins is underappreciated. Gene duplication is ... ...

Abstract	The process of gene duplication followed by gene loss or evolution of new functions has been studied extensively, yet the role gene duplication plays in the function and evolution of fertilization proteins is underappreciated. Gene duplication is observed in many fertilization protein families including Izumo, DCST, ZP, and the TFP superfamily. Molecules mediating fertilization are part of larger gene families expressed in a variety of tissues, but gene duplication followed by structural modifications has often facilitated their cooption into a fertilization function. Repeat expansions of functional domains within a gene also provide opportunities for the evolution of novel fertilization protein. ZP proteins with domain repeat expansions are linked to species-specificity in fertilization and TFP proteins that experienced domain duplications were coopted into a novel sperm function. This review outlines the importance of gene duplications and repeat domain expansions in the evolution of fertilization proteins.
Language	English
Publishing date	2022-01-27
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2737824-X
ISSN	2296-634X
ISSN	2296-634X
DOI	10.3389/fcell.2022.827454
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Article ; Online: Reverse total shoulder arthroplasty for complex proximal humerus fracture in the elderly: clinical and radiological results.

Rivera, Alberto R / Cardona, Victor

JSES reviews, reports, and techniques

2022 Volume 3, Issue 2, Page(s) 131–136

Abstract: Background: The use of reverse total shoulder arthroplasty (RSA) for the treatment of proximal humeral fractures (PHFs) is steadily increasing. Better clinical outcomes of RSA have been correlated with tuberosity reattachment and healing. The purpose of ...

Abstract	Background: The use of reverse total shoulder arthroplasty (RSA) for the treatment of proximal humeral fractures (PHFs) is steadily increasing. Better clinical outcomes of RSA have been correlated with tuberosity reattachment and healing. The purpose of this study was to evaluate both the clinical and radiological results of reverse shoulder arthroplasty in the management of a proximal humerus fracture in the elderly. Methods: Retrospective study including 400 consecutive 3-4 part proximal humerus fractures treated with reverse shoulder arthroplasty with a minimum of 12-month follow-up. In all the cases, the greater tuberosity was reattached with a standardized suture technique and a local bone graft. All the patients were assessed at the 12-month follow-up with Constant-Murley Score (CMS). Radiographic healing of the greater tuberosity was noted. Complications and revision rates were reported. Results: Mean final CMS for this cohort was 82 points. The greater tuberosity healed in anatomic position in 85% of the cases (N = 340), obtaining an average CMS of 85 in these patients. Healing of the greater tuberosity did not occur in 13% of the cases (N = 52) and displacement more than 5 mm occurred in 2% (N = 8) of the patients for an average CMS of 60. All patients scored above 120° in forward elevation with a mean of 150°. Mean active external rotation was 35°. The lateralization shoulder angle had a mean of 91° and the distalization shoulder angle had a mean of 54°. Low-grade scapular notching was reported in <1% of the cases. A total of 60 patients presented failure of healing or displacement of the greater tuberosity. Major complications were reported in nine patients. Of these nine patients, two acquired superficial wound infections, while two had deep shoulder prosthetic infection. Two other patients developed hematomas, one sustained an acromial stress fracture, and two had a stem loosening. There were 4 reoperations. Conclusion: Reverse shoulder arthroplasty, with the use of a fracture-specific stem, allows an improved rate of greater tuberosity healing and short-term clinical outcomes in the elderly population.
Language	English
Publishing date	2022-12-15
Publishing country	Netherlands
Document type	Journal Article
ISSN	2666-6391
ISSN (online)	2666-6391
DOI	10.1016/j.xrrt.2022.11.004
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Article ; Online: Body mass index does not decline during winter for the sedentary marine gastropod

Franklin, Amanda M / Rivera, Alberto / Robbins, Justin / Pechenik, Jan A

Biology letters

2023 Volume 19, Issue 6, Page(s) 20230026

Abstract: Seasonal extremes in environmental conditions can substantially limit the growth and reproduction of animals. Sedentary marine animals are particularly susceptible to winter food limitation since they cannot relocate to more favourable conditions. In ... ...

Abstract	Seasonal extremes in environmental conditions can substantially limit the growth and reproduction of animals. Sedentary marine animals are particularly susceptible to winter food limitation since they cannot relocate to more favourable conditions. In several temperate-zone bivalve species, substantial winter tissue mass declines have been documented; however, no comparable studies have been conducted on intertidal gastropods. Here, we investigate whether the suspension-feeding intertidal gastropod
MeSH term(s)	Animals ; Body Mass Index ; Gastropoda ; Seasons ; Cold Temperature ; Food
Language	English
Publishing date	2023-06-14
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2135022-X
ISSN	1744-957X ; 1744-9561
ISSN (online)	1744-957X
ISSN	1744-9561
DOI	10.1098/rsbl.2023.0026
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Article ; Online: Domain Expansion and Functional Diversification in Vertebrate Reproductive Proteins.

Rivera, Alberto M / Wilburn, Damien B / Swanson, Willie J

Molecular biology and evolution

2022 Volume 39, Issue 5

Abstract: The rapid evolution of fertilization proteins has generated remarkable diversity in molecular structure and function. Glycoproteins of vertebrate egg coats contain multiple zona pellucida (ZP)-N domains (1-6 copies) that facilitate multiple reproductive ... ...

Abstract	The rapid evolution of fertilization proteins has generated remarkable diversity in molecular structure and function. Glycoproteins of vertebrate egg coats contain multiple zona pellucida (ZP)-N domains (1-6 copies) that facilitate multiple reproductive functions, including species-specific sperm recognition. In this report, we integrate phylogenetics and machine learning to investigate how ZP-N domains diversify in structure and function. The most C-terminal ZP-N domain of each paralog is associated with another domain type (ZP-C), which together form a "ZP module." All modular ZP-N domains are phylogenetically distinct from nonmodular or free ZP-N domains. Machine learning-based classification identifies eight residues that form a stabilizing network in modular ZP-N domains that is absent in free domains. Positive selection is identified in some free ZP-N domains. Our findings support that strong purifying selection has conserved an essential structural core in modular ZP-N domains, with the relaxation of this structural constraint allowing free N-terminal domains to functionally diversify.
MeSH term(s)	Amino Acid Sequence ; Animals ; Egg Proteins/analysis ; Egg Proteins/chemistry ; Egg Proteins/genetics ; Vertebrates/genetics ; Vertebrates/metabolism ; Zona Pellucida/chemistry ; Zona Pellucida/metabolism ; Zona Pellucida Glycoproteins/metabolism
Chemical Substances	Egg Proteins ; Zona Pellucida Glycoproteins
Language	English
Publishing date	2022-08-26
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	998579-7
ISSN	1537-1719 ; 0737-4038
ISSN (online)	1537-1719
ISSN	0737-4038
DOI	10.1093/molbev/msac105
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Zs.A 2137: Show issues

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Book ; Online: La sociedad civil

Olvera Rivera, Alberto

de la teoría a la realidad

2001

Keywords	History of the Americas
Language	0\|s
Size	1 Online-Ressource
Publisher	El Colegio de México
Document type	Book ; Online
Note	Spanish ; Open Access
HBZ-ID	HT021612375
ISBN	9786076287736 ; 607628773X
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article: Morphological Hallmarks of Classical Fabry Disease: An Ultrastructural Study in a Large Spanish Family.

San Millán-Tejado, Beatriz / Navarro, Carmen / Fernández-Martín, Julián / Rivera, Alberto / Viéitez, Irene / Teijeira, Susana / Ortolano, Saida

Journal of clinical medicine

2023 Volume 12, Issue 17

Abstract: Fabry disease (FD) is a rare lysosomal disorder caused by α-galactosidase A deficiency, and it leads to the systemic deposition of globotriasylceramide. Demonstrations of the storage material in biopsies support this diagnosis. We report a histological ... ...

Abstract	Fabry disease (FD) is a rare lysosomal disorder caused by α-galactosidase A deficiency, and it leads to the systemic deposition of globotriasylceramide. Demonstrations of the storage material in biopsies support this diagnosis. We report a histological and ultrastructural study of biopsies that were performed on 11 individuals from a family with the variant p.Gln279Arg in
Language	English
Publishing date	2023-08-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12175689
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Article ; Online: Reflexive pedagogy at the heart of educational digital transformation in Latin American higher education institutions.

Useche, Ana Carolina / Galvis, Álvaro H / Díaz-Barriga Arceo, Frida / Patiño Rivera, Alberto Elí / Muñoz-Reyes, Claudia

International journal of educational technology in higher education

2022 Volume 19, Issue 1, Page(s) 62

Abstract: This paper makes a critical review of educational and operational issues related with pandemic and postpandemic lessons in Latin American higher education institutions (LATAM HEI), as background for uncovering key elements to innovate educational ... ...

Abstract	This paper makes a critical review of educational and operational issues related with pandemic and postpandemic lessons in Latin American higher education institutions (LATAM HEI), as background for uncovering key elements to innovate educational practices in technology-mediated higher education. The authors adapted the reflexive pedagogy framework to conduct in depth analysis of innovation experiences mediated with educational technologies and draw conclusions for curricular and digital transformation of LATAM HEI.
Language	English
Publishing date	2022-10-25
Publishing country	Switzerland
Document type	Editorial
ISSN	2365-9440
ISSN (online)	2365-9440
DOI	10.1186/s41239-022-00365-3
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Article ; Online: Current State of Diabetes Mellitus Prevalence, Awareness, Treatment, and Control in Latin America: Challenges and Innovative Solutions to Improve Health Outcomes Across the Continent.

Avilés-Santa, M Larissa / Monroig-Rivera, Alberto / Soto-Soto, Alvin / Lindberg, Nangel M

Current diabetes reports

2020 Volume 20, Issue 11, Page(s) 62

Abstract: Purpose of review: Latin America is the scenario of great inequalities where about 32 million human beings live with diabetes. Through this review, we aimed at describing the current state of the prevalence, awareness, treatment, and control of diabetes ...

Abstract	Purpose of review: Latin America is the scenario of great inequalities where about 32 million human beings live with diabetes. Through this review, we aimed at describing the current state of the prevalence, awareness, treatment, and control of diabetes mellitus and completion of selected guidelines of care across Latin America and identify opportunities to advance research that promotes better health outcomes. Recent findings: The prevalence of diabetes mellitus has been consistently increasing across the region, with some variation: higher prevalence in Mexico, Haiti, and Puerto Rico and lower in Colombia, Ecuador, Dominican Republic, Peru, and Uruguay. Prevalence assessment methods vary, and potentially underestimating the real number of persons with diabetes. Diabetes unawareness varies widely, with up to 50% of persons with diabetes who do not know they may have the disease. Glycemic, blood pressure, and LDL-C control and completion of guidelines to prevent microvascular complications are not consistently assessed across studies, and the achievement of control goals is suboptimal. On the other hand, multiple interventions, point-of-care/rapid assessment tools, and alternative models of health care delivery have been proposed and tested throughout Latin America. The prevalence of diabetes mellitus continues to rise across Latin America, and the number of those with the disease may be underestimated. However, some local governments are embedding more comprehensive diabetes assessments in their local national surveys. Clinicians and public health advocates in the region have proposed and initiated various multi-level interventions to address this enormous challenge in the region.
MeSH term(s)	Blood Glucose ; Diabetes Mellitus/epidemiology ; Diabetes Mellitus/therapy ; Humans ; Latin America/epidemiology ; Outcome Assessment, Health Care ; Prevalence
Chemical Substances	Blood Glucose
Keywords	covid19
Language	English
Publishing date	2020-10-10
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2065167-3
ISSN	1539-0829 ; 1534-4827
ISSN (online)	1539-0829
ISSN	1534-4827
DOI	10.1007/s11892-020-01341-9
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Zs.A 5628: Show issues

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Article: Vertical leaping mechanics of the Lesser Egyptian Jerboa reveal specialization for maneuverability rather than elastic energy storage.

Moore, Talia Y / Rivera, Alberto M / Biewener, Andrew A

Frontiers in zoology

2017 Volume 14, Page(s) 32

Abstract: Background: Numerous historical descriptions of the Lesser Egyptian jerboa, : Results: Jerboas leapt in excess of 10 times their hip height. At the maximum recorded leap height (not the maximum observed leap height), peak moments for metatarso- ... ...

Abstract	Background: Numerous historical descriptions of the Lesser Egyptian jerboa, Results: Jerboas leapt in excess of 10 times their hip height. At the maximum recorded leap height (not the maximum observed leap height), peak moments for metatarso-phalangeal, ankle, knee, and hip joints were 13.1, 58.4, 65.1, and 66.9 Nmm, respectively. Muscles acting at the ankle joint contributed the most work (mean 231.6 mJ / kg Body Mass) to produce the energy of vertical leaping, while muscles acting at the metatarso-phalangeal joint produced the most stress (peak 317.1 kPa). The plantaris, digital flexors, and gastrocnemius tendons encountered peak stresses of 25.6, 19.1, and 6.0 MPa, respectively, transmitting the forces of their corresponding muscles (peak force 3.3, 2.0, and 3.8 N, respectively). Notably, we found that the mean elastic energy recovered in the primary tendons of both hindlimbs comprised on average only 4.4% of the energy of the associated leap. Conclusions: The limited use of tendon elastic energy storage in the jerboa parallels the morphologically similar heteromyid kangaroo rat,
Language	English
Publishing date	2017-07-03
Publishing country	England
Document type	Journal Article
ISSN	1742-9994
ISSN	1742-9994
DOI	10.1186/s12983-017-0215-z
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Article ; Online: Risk for recurrence of symptomatic upper-extremity deep vein thrombosis in patients without cancer: Analysis of three RIETE cohorts.

Núñez Fernández, Manuel J / Padín Paz, Emilio M / Vázquez Temprano, Nuria / Nieto Rodríguez, José A / Marchena Yglesias, Pablo J / Imbalzano, Egidio / Montenegro, Ana Cristina / Fernández Jiménez, Begoña / Rivera, Alberto / Espitia, Olivier / Monreal, Manuel

Vascular medicine (London, England)

2023 Volume 28, Issue 4, Page(s) 324–330

Abstract: Background: The natural history of patients with a pacemaker-related upper-extremity deep vein thrombosis (UEDVT) has not been consistently studied.: Methods: We used the RIETE registry data to compare the outcomes during anticoagulation and after ... ...

Abstract	Background: The natural history of patients with a pacemaker-related upper-extremity deep vein thrombosis (UEDVT) has not been consistently studied. Methods: We used the RIETE registry data to compare the outcomes during anticoagulation and after its discontinuation in noncancer patients with symptomatic UEDVT associated with a pacemaker, other catheters, or no catheter. The major outcome was the composite of symptomatic pulmonary embolism or recurrent DVT. Results: As of February 2022, 2578 patients with UEDVT were included: 156 had a pacemaker-related UEDVT, 557 had other catheters, and 1865 had no catheter. During anticoagulation, 61 patients (2.3%) developed recurrent VTE, 38 had major bleeding (1.4%), and 90 died (3.4%). After its discontinuation, 52 patients (4.4%) had recurrent acute venous thromboembolism (VTE) and six had major bleeding (0.5%). On multivariable analysis, there were no differences among subgroups in the rates of VTE recurrences or major bleeding during anticoagulation. After its discontinuation, patients with a pacemaker-related UEDVT had a higher risk for VTE recurrences than those with no catheter (adjusted OR: 4.59; 95% CI: 1.98-10.6). Conclusions: Patients with pacemaker-related UEDVT are at increased risk for VTE recurrences after discontinuing anticoagulation. If our findings are validated in adequately designed trials, this may justify changes in the current recommendations on the duration of anticoagulation.
MeSH term(s)	Humans ; Venous Thromboembolism/etiology ; Risk Factors ; Upper Extremity Deep Vein Thrombosis/diagnostic imaging ; Upper Extremity Deep Vein Thrombosis/etiology ; Venous Thrombosis/diagnosis ; Venous Thrombosis/drug therapy ; Venous Thrombosis/chemically induced ; Pulmonary Embolism/chemically induced ; Hemorrhage/chemically induced ; Neoplasms/complications ; Neoplasms/diagnosis ; Anticoagulants/adverse effects ; Recurrence ; Extremities
Chemical Substances	Anticoagulants
Language	English
Publishing date	2023-06-05
Publishing country	England
Document type	Journal Article
ZDB-ID	1311628-9
ISSN	1477-0377 ; 1358-863X
ISSN (online)	1477-0377
ISSN	1358-863X
DOI	10.1177/1358863X231175185
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