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  1. Article ; Online: Action Items for Latin-American Chemists and Chemical Societies to Improve Equity and Diversity in Science.

    Rivera, Daniel G

    Inorganic chemistry

    2020  Volume 59, Issue 17, Page(s) 11847–11851

    MeSH term(s) Gender Equity ; Humans ; Latin America ; Racism/prevention & control ; Science ; Social Discrimination/prevention & control ; Societies, Scientific/organization & administration
    Language English
    Publishing date 2020-08-17
    Publishing country United States
    Document type Editorial
    ZDB-ID 1484438-2
    ISSN 1520-510X ; 0020-1669
    ISSN (online) 1520-510X
    ISSN 0020-1669
    DOI 10.1021/acs.inorgchem.0c02344
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Action Items for Latin-American Chemists and Chemical Societies to Improve Equity and Diversity in Science.

    Rivera, Daniel G

    Organic letters

    2020  Volume 22, Issue 17, Page(s) 6693–6697

    Language English
    Publishing date 2020-08-17
    Publishing country United States
    Document type Editorial
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.0c02585
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Action Items for Latin-American Chemists and Chemical Societies to Improve Equity and Diversity in Science.

    Rivera, Daniel G

    The Journal of organic chemistry

    2020  Volume 85, Issue 17, Page(s) 11025–11029

    Language English
    Publishing date 2020-08-17
    Publishing country United States
    Document type Editorial
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/acs.joc.0c01893
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  4. Article ; Online: Macrocyclic Iminopeptides Diversify To Better Target Proteins.

    Reguera, Leslie / Rivera, Daniel G

    ChemMedChem

    2020  Volume 15, Issue 13, Page(s) 1111–1112

    Abstract: Among the many methods available for accessing conformationally diverse cyclic peptides, the derivatization of macrocyclic iminopeptides has remained notably underexplored. Now, a relevant complexity-generating method expands the repertoire of synthetic ... ...

    Abstract Among the many methods available for accessing conformationally diverse cyclic peptides, the derivatization of macrocyclic iminopeptides has remained notably underexplored. Now, a relevant complexity-generating method expands the repertoire of synthetic strategies exploiting the reactivity of an imino bond embedded in the cyclic peptide skeleton. Here we highlight a recent report describing the on-resin construction of a new family of macrocyclic peptide/natural product-inspired hybrids, namely "PepNats", by derivatization of cyclic iminopeptides through 1,3-cycloaddition reactions. A proof-of-concept with PepNats bearing peptide sequences that mimic protein hot loops demonstrated the potential of this strategy to create novel macrocyclic peptide ligands capable of modulating protein-protein interactions.
    MeSH term(s) Biological Products/chemistry ; Biological Products/metabolism ; Imines/chemistry ; Imines/metabolism ; Ligands ; Macrocyclic Compounds/chemistry ; Macrocyclic Compounds/metabolism ; Molecular Conformation ; Peptides/chemistry ; Peptides/metabolism ; Protein Binding ; Proteins/chemistry
    Chemical Substances Biological Products ; Imines ; Ligands ; Macrocyclic Compounds ; Peptides ; Proteins
    Language English
    Publishing date 2020-06-15
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2218496-X
    ISSN 1860-7187 ; 1860-7179
    ISSN (online) 1860-7187
    ISSN 1860-7179
    DOI 10.1002/cmdc.202000261
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  5. Article ; Online: Multicomponent Reaction Toolbox for Peptide Macrocyclization and Stapling.

    Reguera, Leslie / Rivera, Daniel G

    Chemical reviews

    2019  Volume 119, Issue 17, Page(s) 9836–9860

    Abstract: In the past decade, multicomponent reactions have experienced a renaissance as powerful peptide macrocyclization tools enabling the rapid creation of skeletal complexity and diversity with low synthetic cost. This review provides both a historical and ... ...

    Abstract In the past decade, multicomponent reactions have experienced a renaissance as powerful peptide macrocyclization tools enabling the rapid creation of skeletal complexity and diversity with low synthetic cost. This review provides both a historical and modern overview of the development of the peptide multicomponent macrocyclization as a strategy capable to compete with the classic peptide cyclization methods in terms of chemical efficiency and synthetic scope. We prove that the utilization of multicomponent reactions for cyclizing peptides by either their termini or side chains provides a key advantage over those more established methods; that is, the possibility to explore the cyclic peptide chemotype space not only at the amino acid sequence but also at the ring-forming moiety. Owing to its multicomponent nature, this type of peptide cyclization process is well-suited to generate diversity at both the
    MeSH term(s) Chemistry Techniques, Synthetic/methods ; Cyclization ; Peptides, Cyclic/chemical synthesis
    Chemical Substances Peptides, Cyclic
    Language English
    Publishing date 2019-04-16
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 207949-5
    ISSN 1520-6890 ; 0009-2665
    ISSN (online) 1520-6890
    ISSN 0009-2665
    DOI 10.1021/acs.chemrev.8b00744
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Recent Advances in Photoinduced Modification of Amino Acids, Peptides, and Proteins.

    De Jesus, Iva S / Vélez, Jeimy A C / Pissinati, Emanuele F / Correia, Jose Tiago M / Rivera, Daniel G / Paixao, Márcio W

    Chemical record (New York, N.Y.)

    2024  Volume 24, Issue 3, Page(s) e202300322

    Abstract: The chemical modification of biopolymers like peptides and proteins is a key technology to access vaccines and pharmaceuticals. Similarly, the tunable derivatization of individual amino acids is important as they are key building blocks of biomolecules, ... ...

    Abstract The chemical modification of biopolymers like peptides and proteins is a key technology to access vaccines and pharmaceuticals. Similarly, the tunable derivatization of individual amino acids is important as they are key building blocks of biomolecules, bioactive natural products, synthetic polymers, and innovative materials. The high diversity of functional groups present in amino acid-based molecules represents a significant challenge for their selective derivatization Recently, visible light-mediated transformations have emerged as a powerful strategy for achieving chemoselective biomolecule modification. This technique offers numerous advantages over other methods, including a higher selectivity, mild reaction conditions and high functional-group tolerance. This review provides an overview of the most recent methods covering the photoinduced modification for single amino acids and site-selective functionalization in peptides and proteins under mild and even biocompatible conditions. Future challenges and perspectives are discussed beyond the diverse types of photocatalytic transformations that are currently available.
    MeSH term(s) Amino Acids/chemistry ; Proteins/chemistry ; Peptides/chemistry ; Polymers
    Chemical Substances Amino Acids ; Proteins ; Peptides ; Polymers
    Language English
    Publishing date 2024-01-26
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2044646-9
    ISSN 1528-0691 ; 1527-8999
    ISSN (online) 1528-0691
    ISSN 1527-8999
    DOI 10.1002/tcr.202300322
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  7. Article: Multicomponent Reaction Toolbox for Peptide Macrocyclization and Stapling

    Reguera, Leslie / Rivera, Daniel G

    Chemical reviews. 2019 Apr. 16, v. 119, no. 17

    2019  

    Abstract: In the past decade, multicomponent reactions have experienced a renaissance as powerful peptide macrocyclization tools enabling the rapid creation of skeletal complexity and diversity with low synthetic cost. This review provides both a historical and ... ...

    Abstract In the past decade, multicomponent reactions have experienced a renaissance as powerful peptide macrocyclization tools enabling the rapid creation of skeletal complexity and diversity with low synthetic cost. This review provides both a historical and modern overview of the development of the peptide multicomponent macrocyclization as a strategy capable to compete with the classic peptide cyclization methods in terms of chemical efficiency and synthetic scope. We prove that the utilization of multicomponent reactions for cyclizing peptides by either their termini or side chains provides a key advantage over those more established methods; that is, the possibility to explore the cyclic peptide chemotype space not only at the amino acid sequence but also at the ring-forming moiety. Owing to its multicomponent nature, this type of peptide cyclization process is well-suited to generate diversity at both the endo- and exo-cyclic fragments formed during the ring-closing step, which stands as a distinctive and useful characteristic for the creation and screening of cyclic peptide libraries. Examples of the novel multicomponent peptide stapling approach and heterocycle ring-forming macrocyclizations are included, along with multicomponent methods incorporating macrocyclization handles and the one-pot syntheses of macromulticyclic peptide cages. Interesting applications of this strategy in the field of drug discovery and chemical biology are provided.
    Keywords chemotypes ; drugs ; macrocyclization reactions ; moieties ; peptide libraries ; screening
    Language English
    Dates of publication 2019-0416
    Size p. 9836-9860.
    Publishing place American Chemical Society
    Document type Article
    ZDB-ID 207949-5
    ISSN 1520-6890 ; 0009-2665
    ISSN (online) 1520-6890
    ISSN 0009-2665
    DOI 10.1021/acs.chemrev.8b00744
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  8. Article ; Online: Ligation, Macrocyclization, and Simultaneous Functionalization of Peptides by Multicomponent Reactions (MCR).

    Vasco, Aldrin V / Ricardo, Manuel G / Rivera, Daniel G / Wessjohann, Ludger A

    Methods in molecular biology (Clifton, N.J.)

    2021  Volume 2371, Page(s) 143–157

    Abstract: Multicomponent reactions (MCRs) are recently expanding the plethora of solid-phase protocols for the synthesis and derivatization of peptides. Herein, we describe a solid-phase-compatible strategy based on MCRs as a powerful strategy for peptide ... ...

    Abstract Multicomponent reactions (MCRs) are recently expanding the plethora of solid-phase protocols for the synthesis and derivatization of peptides. Herein, we describe a solid-phase-compatible strategy based on MCRs as a powerful strategy for peptide cyclization and ligation . We illustrate, using Gramicidin S as a model peptide, how the execution of on-resin Ugi reactions enables the simultaneous backbone N-functionalization and cyclization, which are important types of derivatizations in peptide-based drug development or for incorporation of conjugation handles, or labels.
    MeSH term(s) Cyclization ; Gramicidin ; Peptides, Cyclic/chemistry
    Chemical Substances Peptides, Cyclic ; Gramicidin (1405-97-6)
    Language English
    Publishing date 2021-10-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-1689-5_8
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  9. Article ; Online: Advancing Multicomponent Strategies to Macrobicyclic Peptides.

    Vasco, Aldrin V / Méndez, Yanira / González, Celia / Pérez, Carlos S / Reguera, Leslie / Wessjohann, Ludger A / Rivera, Daniel G

    Chembiochem : a European journal of chemical biology

    2023  Volume 24, Issue 13, Page(s) e202300229

    Abstract: Macrocyclization of peptides is typically used to fix specific bioactive conformations and improve their pharmacological properties. Recently, macrobicyclic peptides have received special attention owing to their capacity to mimic protein structures or ... ...

    Abstract Macrocyclization of peptides is typically used to fix specific bioactive conformations and improve their pharmacological properties. Recently, macrobicyclic peptides have received special attention owing to their capacity to mimic protein structures or be key components of peptide-drug conjugates. Here, we describe the development of novel synthetic strategies for two distinctive types of peptide macrobicycles. A multicomponent macrocyclo-dimerization approach is introduced for the production of interconnected β-turns, allowing two macrocyclic rings to be formed and dimerized in one pot. Also, an on-resin double stapling strategy is described for the assembly of lactam-bridged macrobicycles with stable tertiary folds.
    MeSH term(s) Peptides, Cyclic/chemistry ; Cyclization ; Peptides/chemistry ; Lactams ; Molecular Conformation
    Chemical Substances Peptides, Cyclic ; Peptides ; Lactams
    Language English
    Publishing date 2023-06-06
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2020469-3
    ISSN 1439-7633 ; 1439-4227
    ISSN (online) 1439-7633
    ISSN 1439-4227
    DOI 10.1002/cbic.202300229
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  10. Article ; Online: Cultural Characterization and Antagonistic Activity of Cladobotryum virescens against Some Phytopathogenic Fungi and Oomycetes

    Hernández, Giselle / Ramos, Beatriz / Sultani, Haider N. / Ortiz, Yarelis / Spengler, Iraida / Castañeda, Rafael F. / Rivera, Daniel G. / Arnold, Norbert / Westermann, Bernhard / Mirabal, Yaneris

    Agronomy. 2023 Jan. 28, v. 13, no. 2

    2023  

    Abstract: In this study, the characteristic growth of Cladobotryum virescens on nine culture media was analyzed. The growing behavior of this fungus was dependent on the culture medium. In vitro analysis showed that oat agar was better than other media tested with ...

    Abstract In this study, the characteristic growth of Cladobotryum virescens on nine culture media was analyzed. The growing behavior of this fungus was dependent on the culture medium. In vitro analysis showed that oat agar was better than other media tested with the highest conidia production. The antifungal activity against Fusarium chlamydosporum and Alternaria brassicicola was evaluated by the Dual Culture method. C. virescens displayed high activity against both pathogens acting through antibiosis and mycoparasitism. This effect was increased by a higher competitiveness of the strain for the substrate. Furthermore, the crude ethyl acetate extract of the culture broth was tested in vitro against Botrytis cinerea and Septoria tritici, as well as the hemibiotrophic oomycete Phytophthora infestans using a microtiter plate assay at different concentrations. The extract showed excellent inhibition even below 5 ppm. According to these results, we concluded that C. virescens can be considered as a potential biological control agent in agriculture. To the best of our knowledge, this is the first study to investigate C. virescens as a biocontrol agent for different diseases caused by five relevant pathogens that affect cereals and vegetables.
    Keywords Alternaria brassicicola ; Botrytis cinerea ; Fusarium chlamydosporum ; Hypomyces ; Mycosphaerella graminicola ; Phytophthora infestans ; agar ; agronomy ; antibiosis ; antifungal properties ; biological control agents ; conidia ; culture media ; ethyl acetate ; fungi ; mycoparasites ; oats
    Language English
    Dates of publication 2023-0128
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2607043-1
    ISSN 2073-4395
    ISSN 2073-4395
    DOI 10.3390/agronomy13020389
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