Article ; Online: Challenges in the Use of Targeted Therapies in Non-Small Cell Lung Cancer.
2022 Volume 54, Issue 2, Page(s) 315–329
Abstract: Precision oncology has fundamentally changed how we diagnose and treat cancer. In recent years, there has been a significant change in the management of patients with oncogene-addicted advanced-stage NSCLC. Increasing amounts of identifiable oncogene ... ...
Abstract | Precision oncology has fundamentally changed how we diagnose and treat cancer. In recent years, there has been a significant change in the management of patients with oncogene-addicted advanced-stage NSCLC. Increasing amounts of identifiable oncogene drivers have led to the development of molecularly targeted drugs. Undoubtedly, the future of thoracic oncology is shifting toward increased molecular testing and the use of targeted therapies. For the most part, these novel drugs have proven to be safe and effective. As with all great innovations, targeted therapies pose unique challenges. Drug toxicities, resistance, access, and costs are some of the expected obstacles that will need to be addressed. This review highlights some of the major challenges in the use of targeted therapies in NSCLC and provides guidance for the future strategies. |
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MeSH term(s) | Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/genetics ; Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Precision Medicine |
Language | English |
Publishing date | 2022-02-18 |
Publishing country | Korea (South) |
Document type | Journal Article ; Review |
ZDB-ID | 2133613-1 |
ISSN | 2005-9256 ; 1598-2998 |
ISSN (online) | 2005-9256 |
ISSN | 1598-2998 |
DOI | 10.4143/crt.2022.078 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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