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  1. Article ; Online: Epigenetics to clinicopathological features: a bibliometric analysis of H3 G34-mutant diffuse hemispheric glioma literature.

    Roach, Jordan T / Riviere-Cazaux, Cecile / Wells, Brennan A / Boop, Frederick A / Daniels, David J

    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery

    2024  

    Abstract: Purpose: Pediatric-type diffuse high-grade gliomas are the leading cause of cancer-related morbidity and mortality in children. More than 30% of diffuse hemispheric gliomas (DHG) in adolescents harbor histone H3 G34 mutations and are recognized by the ... ...

    Abstract Purpose: Pediatric-type diffuse high-grade gliomas are the leading cause of cancer-related morbidity and mortality in children. More than 30% of diffuse hemispheric gliomas (DHG) in adolescents harbor histone H3 G34 mutations and are recognized by the World Health Organization as a distinct tumor entity. By reporting bibliometric characteristics of the most cited publications on H3 G34-mutant DHG (H3 G34 DHG), we provide an overview of emerging literature and speculate where future research efforts may lead.
    Methods: One hundred fourteen publications discussing H3 G34 DHG were identified, categorized as basic science (BSc), clinical (CL), or review (R), and ranked by citation number. Various bibliometric parameters were summarized, and a comparison between article types was performed.
    Results: Articles within this study represent principal investigators from 15 countries and were published across 63 journals between 2012 and 2024, with 36.84% of articles originating in the United States. Overall median values were as follows: citation count, 20 (range, 0-2591), number of authors, 9 (range, 2-78), and year of publication, 2020 (range, 2012-2024). Among the top ten most cited articles, BSc articles accounted for all ten reports. Compared to CL and R articles, BSc articles were published in journals with higher impact factors.
    Conclusion: We establish variability in bibliometric parameters for the most cited publications on H3 G34 DHG. Our findings demonstrate a paucity of high-impact and highly cited CL reports and acknowledge an unmet need to intersect basic mechanism with clinical data to inform novel therapeutic approaches.
    Language English
    Publishing date 2024-04-13
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 605988-0
    ISSN 1433-0350 ; 0302-2803 ; 0256-7040
    ISSN (online) 1433-0350
    ISSN 0302-2803 ; 0256-7040
    DOI 10.1007/s00381-024-06395-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: The role of CCR5 in HIV-associated neurocognitive disorders.

    Riviere-Cazaux, Cecile / Cornell, Jessica / Shen, Yang / Zhou, Miou

    Heliyon

    2022  Volume 8, Issue 7, Page(s) e09950

    Abstract: While combination antiretroviral therapy (cART) has successfully increased the lifespan of individuals infected with HIV, a significant portion of this population remains affected by HIV-associated neurocognitive disorder (HAND). C-C chemokine receptor 5 ...

    Abstract While combination antiretroviral therapy (cART) has successfully increased the lifespan of individuals infected with HIV, a significant portion of this population remains affected by HIV-associated neurocognitive disorder (HAND). C-C chemokine receptor 5 (CCR5) has been well studied in immune response and as a co-receptor for HIV infection. HIV-infected (HIV
    Language English
    Publishing date 2022-07-14
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2022.e09950
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  3. Article ; Online: Ultra-early therapeutic anticoagulation after craniotomy - A single institution experience.

    Riviere-Cazaux, Cecile / Naylor, Ryan M / Van Gompel, Jamie J

    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

    2022  Volume 100, Page(s) 46–51

    Abstract: There is a paucity of information regarding the optimal timing of initiation or re-initiation of therapeutic anticoagulation after intracranial surgery. Anticoagulation that is started too soon after surgery may increase the risk of catastrophic ... ...

    Abstract There is a paucity of information regarding the optimal timing of initiation or re-initiation of therapeutic anticoagulation after intracranial surgery. Anticoagulation that is started too soon after surgery may increase the risk of catastrophic intracranial bleeding. However, there are scenarios that necessitate the use of anticoagulation in the immediate post-operative period despite the increased risk of hemorrhage. Therefore, we sought to report our experience with ultra-early therapeutic anticoagulation after craniotomy. Retrospective chart review of patients from a single institution between 1/1/2010 and 10/1/2021 who were treated with therapeutic anticoagulation for venous thromboembolism on or before 7-days after a craniotomy or craniectomy. The primary endpoint was intracranial hemorrhage resulting in death or return to the operating room for hematoma evacuation. Secondary endpoints included extra-cranial hemorrhage, length of hospital stay, and 90-day readmission rate. Eighteen patients were included for analysis. The median time that therapeutic anticoagulation was started was post-operative day 5 (range 1-7 days). One patient (5.6%) met the primary endpoint as they experienced an intracranial hemorrhage 5 days after starting anticoagulation, which required surgical evacuation. No patients experienced an extra-cranial hemorrhage. The median length of hospitalization was 13 days (range 4-89 days). No patients were readmitted within 90 days. The 90-day survival rate was 100%. Ultra-early anticoagulation after craniotomy resulted in a 5.6% risk of intracranial hemorrhage. Thus, ultra-early anticoagulation can be performed safely but it does carry a substantial risk of intracranial bleeding that may require emergent hematoma evacuation or result in permeant neurologic deficits or death.
    MeSH term(s) Anticoagulants/therapeutic use ; Craniotomy/adverse effects ; Craniotomy/methods ; Hematoma/etiology ; Humans ; Intracranial Hemorrhages/drug therapy ; Intracranial Hemorrhages/etiology ; Intracranial Hemorrhages/surgery ; Retrospective Studies
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2022-04-06
    Publishing country Scotland
    Document type Journal Article
    ZDB-ID 1193674-5
    ISSN 1532-2653 ; 0967-5868
    ISSN (online) 1532-2653
    ISSN 0967-5868
    DOI 10.1016/j.jocn.2022.03.042
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The role of CCR5 in HIV-associated neurocognitive disorders

    Riviere-Cazaux, Cecile / Cornell, Jessica / Shen, Yang / Zhou, Miou

    Heliyon. 2022 July, v. 8, no. 7 p.e09950-

    2022  

    Abstract: While combination antiretroviral therapy (cART) has successfully increased the lifespan of individuals infected with HIV, a significant portion of this population remains affected by HIV-associated neurocognitive disorder (HAND). C-C chemokine receptor 5 ...

    Abstract While combination antiretroviral therapy (cART) has successfully increased the lifespan of individuals infected with HIV, a significant portion of this population remains affected by HIV-associated neurocognitive disorder (HAND). C-C chemokine receptor 5 (CCR5) has been well studied in immune response and as a co-receptor for HIV infection. HIV-infected (HIV⁺) patients experienced mild to significant amelioration of cognitive function when treated with different CCR5 antagonists, including maraviroc and cenicriviroc. Consistent with clinical results, Ccr5 knockout or knockdown rescued cognitive deficits in HIV animal models, with mechanisms of reduced microgliosis and neuroinflammation. Pharmacologic inhibition of CCR5 directly improved cerebral and hippocampal neuronal plasticity and cognitive function. By summarizing the animal and human studies of CCR5 in HIV-associated cognitive deficits, this review aims to provide an overview of the mechanistic role of CCR5 in HAND pathophysiology. This review also discusses the addition of CCR5 antagonists, such as maraviroc, to cART for targeted prevention and treatment of cognitive impairments in patients infected with HIV.
    Keywords CCR5 receptor ; HIV infections ; antiretroviral agents ; cognition ; humans ; immune response ; longevity ; neuroplasticity ; pathophysiology ; therapeutics ; CCR5 ; HIV-associated neurocognitive disorder (HAND) ; Maraviroc ; Neuronal plasticity ; Learning and memory ; HIV gp120
    Language English
    Dates of publication 2022-07
    Publishing place Elsevier Ltd
    Document type Article ; Online
    Note Use and reproduction
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2022.e09950
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: Calcifying Pseudoneoplasm of the Neuraxis: An Institutional Series of Ten Cases and Review of the Literature to Date.

    Riviere-Cazaux, Cecile / Carlstrom, Lucas P / Eschbacher, Kathryn L / Raghunathan, Aditya / Graffeo, Christopher S / Meyer, Fredric B

    World neurosurgery

    2023  Volume 180, Page(s) e653–e666

    Abstract: Background: Calcified pseudoneoplasms of the neuraxis (CAPNONs) are rare, fibro-osseous lesions with an unknown cause that may present anywhere along the neuroaxis. Little is known about how intracranial CAPNONs present and about patients' long-term ... ...

    Abstract Background: Calcified pseudoneoplasms of the neuraxis (CAPNONs) are rare, fibro-osseous lesions with an unknown cause that may present anywhere along the neuroaxis. Little is known about how intracranial CAPNONs present and about patients' long-term outcomes.
    Methods: A retrospective institutional review of intracranial pathology-confirmed CAPNONs was performed. Presenting clinical features, management, and clinical outcomes are highlighted. A literature review of intracranial CAPNON lesions was also performed to build on our series.
    Results: Ten patients were identified who met the inclusion criteria. Most patients presented with headaches (n = 6; 60%), seizures (n = 5; 50.0%), and neck and facial pain (n = 3; 30.0%). Most lesions were supratentorial (n = 7; 70.0%), with 3 infratentorial origins. Surgical resection was the most common initial management undertaken (n = 7; 70.0%). No new permanent postoperative neurologic deficits were identified. The median clinical and/or radiographic follow-up for all patients was 6.8 years (range, 0.7-23.3 years), with no recurrence of disease for 5 patients who underwent gross total resection. Four of 5 patients with residual or nonresectable lesions showed no interval growth on radiographic follow-up; 1 patient showed progression and worsening of presenting symptoms 2 months after resection. Resection substantially improved seizures and headaches in patients presenting with these symptoms (80% and 83.3%, respectively).
    Conclusions: Intracranial CAPNONs may present with a wide variety of symptoms characteristic of the site of origin. The outcomes of these symptoms regarding survival and disease control are generally favorable, although resection does not always yield complete resolution of presenting deficits in certain patients, particularly those presenting with headaches or neck/facial pain.
    MeSH term(s) Humans ; Retrospective Studies ; Central Nervous System ; Seizures/etiology ; Seizures/surgery ; Neck Pain ; Headache/etiology ; Headache/surgery ; Facial Pain
    Language English
    Publishing date 2023-10-07
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2023.10.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1159: Show issues Location:
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  6. Article ; Online: Glioma Metabolic Feedback In Situ: A First-In-Human Pharmacodynamic Trial of Difluoromethylornithine + AMXT-1501 Through High-Molecular Weight Microdialysis.

    Riviere-Cazaux, Cecile / Neth, Bryan J / Hoplin, Matthew D / Wessel, Bambi / Miska, Jason / Kizilbash, Sani H / Burns, Terry C

    Neurosurgery

    2023  Volume 93, Issue 4, Page(s) 932–938

    Abstract: Background and objectives: No new drug has improved survival for glioblastoma since temozolomide in 2005, due in part to the relative inaccessibility of each patient's individualized tumor biology and its response to therapy. We have identified a ... ...

    Abstract Background and objectives: No new drug has improved survival for glioblastoma since temozolomide in 2005, due in part to the relative inaccessibility of each patient's individualized tumor biology and its response to therapy. We have identified a conserved extracellular metabolic signature of enhancing high-grade gliomas enriched for guanidinoacetate (GAA). GAA is coproduced with ornithine, the precursor to protumorigenic polyamines through ornithine decarboxylase (ODC). AMXT-1501 is a polyamine transporter inhibitor that can overcome tumoral resistance to the ODC inhibitor, difluoromethylornithine (DFMO). We will use DFMO with or without AMXT-1501 to identify candidate pharmacodynamic biomarkers of polyamine depletion in patients with high-grade gliomas in situ . We aim to determine (1) how blocking polyamine production affects intratumoral extracellular guanidinoacetate abundance and (2) the impact of polyamine depletion on the global extracellular metabolome within live human gliomas in situ.
    Methods: DFMO, with or without AMXT-1501, will be administered postoperatively in 15 patients after clinically indicated subtotal resection for high-grade glioma. High-molecular weight microdialysis catheters implanted into residual tumor and adjacent brain will be used for postoperative monitoring of extracellular GAA and polyamines throughout therapeutic intervention from postoperative day (POD) 1 to POD5. Catheters will be removed on POD5 before discharge.
    Expected outcomes: We anticipate that GAA will be elevated in tumor relative to adjacent brain although it will decrease within 24 hours of ODC inhibition with DFMO. If AMXT-1501 effectively increases the cytotoxic impact of ODC inhibition, we expect an increase in biomarkers of cytotoxicity including glutamate with DFMO + AMXT-1501 treatment when compared with DFMO alone.
    Discussion: Limited mechanistic feedback from individual patients' gliomas hampers clinical translation of novel therapies. This pilot Phase 0 study will provide in situ feedback during DFMO + AMXT-1501 treatment to determine how high-grade gliomas respond to polyamine depletion.
    MeSH term(s) Humans ; Eflornithine/pharmacology ; Eflornithine/therapeutic use ; Feedback ; Microdialysis ; Molecular Weight ; Polyamines/metabolism ; Biomarkers ; Glioma/drug therapy
    Chemical Substances Eflornithine (ZQN1G5V6SR) ; Polyamines ; Biomarkers
    Language English
    Publishing date 2023-05-29
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 135446-2
    ISSN 1524-4040 ; 0148-396X
    ISSN (online) 1524-4040
    ISSN 0148-396X
    DOI 10.1227/neu.0000000000002511
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  7. Article ; Online: Insight into the roles of CCR5 in learning and memory in normal and disordered states.

    Necula, Deanna / Riviere-Cazaux, Cecile / Shen, Yang / Zhou, Miou

    Brain, behavior, and immunity

    2020  Volume 92, Page(s) 1–9

    Abstract: As cognitive impairments continue to rise in prevalence, there is an urgent need to understand the mechanisms of learning and memory in normal and disordered states. C-C chemokine receptor 5 (CCR5) has been implicated in the regulation of multiple forms ... ...

    Abstract As cognitive impairments continue to rise in prevalence, there is an urgent need to understand the mechanisms of learning and memory in normal and disordered states. C-C chemokine receptor 5 (CCR5) has been implicated in the regulation of multiple forms of learning and memory via its regulation on learning-related cell signaling and neuronal plasticity. As a chemokine receptor and a co-receptor for HIV, CCR5's role in immune response and HIV-associated neurocognitive disorder (HAND) has been widely studied. In contrast, CCR5 is less understood in cognitive deficits associated with other disorders, including Alzheimer's disease (AD), stroke and certain psychiatric disorders. A broad overview of the present literature shows that CCR5 acts as a potent suppressor of synaptic plasticity and learning and memory, although a few studies have reported the opposite effect of CCR5 in stroke or AD animal models. By summarizing the current literature of CCR5 in animal and human studies of cognition, this review aims to provide a comprehensive overview of the role of CCR5 in learning and memory in both normal and disordered states and to discuss the possibility of CCR5 suppression as an effective therapeutic to alleviate cognitive deficits in HAND, AD, and stroke.
    MeSH term(s) Alzheimer Disease ; Animals ; Disease Models, Animal ; Humans ; Learning ; Memory ; Neuronal Plasticity ; Receptors, CCR5
    Chemical Substances CCR5 protein, human ; Receptors, CCR5
    Language English
    Publishing date 2020-12-01
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 639219-2
    ISSN 1090-2139 ; 0889-1591
    ISSN (online) 1090-2139
    ISSN 0889-1591
    DOI 10.1016/j.bbi.2020.11.037
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    Zs.MO 327: Show issues

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  8. Article ; Online: Letter: Home-Turf Advantage? The Neurosurgery Residency Match During the COVID-19 Pandemic.

    Riviere-Cazaux, Cecile / Antezana, Luis A / Xie, Katherine Z / Van Gompel, Jamie J

    Neurosurgery

    2021  Volume 89, Issue 6, Page(s) E328–E329

    MeSH term(s) COVID-19 ; Humans ; Internship and Residency ; Neurosurgery/education ; Pandemics ; SARS-CoV-2
    Language English
    Publishing date 2021-10-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 135446-2
    ISSN 1524-4040 ; 0148-396X
    ISSN (online) 1524-4040
    ISSN 0148-396X
    DOI 10.1093/neuros/nyab369
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  9. Article ; Online: Letter to the Editor: A Virtual Neurosurgical Outreach Program to Engage Premedical Students During the Summer.

    Bauman, Megan M J / Riviere-Cazaux, Cecile / Ashruf, Ibrahim / Bertelsen, Anna / Rotter, Juliana C / Spinner, Robert J

    World neurosurgery

    2022  Volume 158, Page(s) 320–321

    MeSH term(s) Humans ; Students, Medical ; Students, Premedical ; Surveys and Questionnaires
    Language English
    Publishing date 2022-04-04
    Publishing country United States
    Document type Letter
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2021.11.032
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  10. Article ; Online: Methodological and analytical considerations for intra-operative microdialysis.

    Riviere-Cazaux, Cecile / Rajani, Karishma / Rahman, Masum / Oh, Juhee / Brown, Desmond A / White, Jaclyn F / Himes, Benjamin T / Jusue-Torres, Ignacio / Rodriguez, Moses / Warrington, Arthur E / Kizilbash, Sani H / Elmquist, William F / Burns, Terry C

    Fluids and barriers of the CNS

    2023  Volume 20, Issue 1, Page(s) 94

    Abstract: Background: Microdialysis is a technique that can be utilized to sample the interstitial fluid of the central nervous system (CNS), including in primary malignant brain tumors known as gliomas. Gliomas are mainly accessible at the time of surgery, but ... ...

    Abstract Background: Microdialysis is a technique that can be utilized to sample the interstitial fluid of the central nervous system (CNS), including in primary malignant brain tumors known as gliomas. Gliomas are mainly accessible at the time of surgery, but have rarely been analyzed via interstitial fluid collected via microdialysis. To that end, we obtained an investigational device exemption for high molecular weight catheters (HMW, 100 kDa) and a variable flow rate pump to perform microdialysis at flow rates amenable to an intra-operative setting. We herein report on the lessons and insights obtained during our intra-operative HMW microdialysis trial, both in regard to methodological and analytical considerations.
    Methods: Intra-operative HMW microdialysis was performed during 15 clinically indicated glioma resections in fourteen patients, across three radiographically diverse regions in each patient. Microdialysates were analyzed via targeted and untargeted metabolomics via ultra-performance liquid chromatography tandem mass spectrometry.
    Results: Use of albumin and lactate-containing perfusates impacted subsets of metabolites evaluated via global metabolomics. Additionally, focal delivery of lactate via a lactate-containing perfusate, induced local metabolic changes, suggesting the potential for intra-operative pharmacodynamic studies via reverse microdialysis of candidate drugs. Multiple peri-operatively administered drugs, including levetiracetam, cefazolin, caffeine, mannitol and acetaminophen, could be detected from one microdialysate aliquot representing 10 min worth of intra-operative sampling. Moreover, clinical, radiographic, and methodological considerations for performing intra-operative microdialysis are discussed.
    Conclusions: Intra-operative HMW microdialysis can feasibly be utilized to sample the live human CNS microenvironment, including both metabolites and drugs, within one surgery. Certain variables, such as perfusate type, must be considered during and after analysis. Trial registration NCT04047264.
    MeSH term(s) Humans ; Microdialysis ; Glioma/surgery ; Extracellular Fluid/metabolism ; Lactic Acid/metabolism ; Catheters ; Tumor Microenvironment
    Chemical Substances Lactic Acid (33X04XA5AT)
    Language English
    Publishing date 2023-12-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2595406-4
    ISSN 2045-8118 ; 2045-8118
    ISSN (online) 2045-8118
    ISSN 2045-8118
    DOI 10.1186/s12987-023-00497-2
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