LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 106

Search options

  1. Article ; Online: From Particle Currents to Tracer Diffusion: Universal Correlation Profiles in Single-File Dynamics.

    Grabsch, Aurélien / Berlioz, Théotim / Rizkallah, Pierre / Illien, Pierre / Bénichou, Olivier

    Physical review letters

    2024  Volume 132, Issue 3, Page(s) 37102

    Abstract: Single-file transport refers to the motion of particles in a narrow channel, such that they cannot bypass each other. This constraint leads to strong correlations between the particles, described by correlation profiles, which measure the correlation ... ...

    Abstract Single-file transport refers to the motion of particles in a narrow channel, such that they cannot bypass each other. This constraint leads to strong correlations between the particles, described by correlation profiles, which measure the correlation between a generic observable and the density of particles at a given position and time. They have recently been shown to play a central role in single-file systems. Up to now, these correlations have only been determined for diffusive systems in the hydrodynamic limit. Here, we consider a model of reflecting point particles on the infinite line, with a general individual stochastic dynamics. We show that the correlation profiles take a simple universal form, at arbitrary time. We illustrate our approach by the study of the integrated current of particles through the origin, and apply our results to representative models such as Brownian particles, run-and-tumble particles and Lévy flights. We further emphasise the generality of our results by showing that they also apply beyond the 1D case, and to other observables.
    Language English
    Publishing date 2024-01-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.132.037102
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 4' 58/153: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article ; Online: Absolute Negative Mobility of an Active Tracer in a Crowded Environment.

    Rizkallah, Pierre / Sarracino, Alessandro / Bénichou, Olivier / Illien, Pierre

    Physical review letters

    2023  Volume 130, Issue 21, Page(s) 218201

    Abstract: Absolute negative mobility (ANM) refers to the situation where the average velocity of a driven tracer is opposite to the direction of the driving force. This effect was evidenced in different models of nonequilibrium transport in complex environments, ... ...

    Abstract Absolute negative mobility (ANM) refers to the situation where the average velocity of a driven tracer is opposite to the direction of the driving force. This effect was evidenced in different models of nonequilibrium transport in complex environments, whose description remains effective. Here, we provide a microscopic theory for this phenomenon. We show that it emerges in the model of an active tracer particle submitted to an external force and which evolves on a discrete lattice populated with mobile passive crowders. Resorting to a decoupling approximation, we compute analytically the velocity of the tracer particle as a function of the different parameters of the system and confront our results to numerical simulations. We determine the range of parameters where ANM can be observed, characterize the response of the environment to the displacement of the tracer, and clarify the mechanism underlying ANM and its relationship with negative differential mobility (another hallmark of driven systems far from the linear response).
    Language English
    Publishing date 2023-06-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.130.218201
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 4' 58/153: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: Driven Tracer in the Symmetric Exclusion Process: Linear Response and Beyond.

    Grabsch, Aurélien / Rizkallah, Pierre / Illien, Pierre / Bénichou, Olivier

    Physical review letters

    2022  Volume 130, Issue 2, Page(s) 20402

    Abstract: Tracer dynamics in the symmetric exclusion process (SEP), where hard-core particles diffuse on an infinite one-dimensional lattice, is a paradigmatic model of anomalous diffusion. While the equilibrium situation has received a lot of attention, the case ... ...

    Abstract Tracer dynamics in the symmetric exclusion process (SEP), where hard-core particles diffuse on an infinite one-dimensional lattice, is a paradigmatic model of anomalous diffusion. While the equilibrium situation has received a lot of attention, the case where the tracer is driven by an external force, which provides a minimal model of nonequilibrium transport in confined crowded environments, remains largely unexplored. Indeed, the only available analytical results concern the means of both the position of the tracer and the lattice occupation numbers in its frame of reference and higher-order moments but only in the high-density limit. Here, we provide a general hydrodynamic framework that allows us to determine the first cumulants of the bath-tracer correlations and of the tracer's position in function of the driving force, up to quadratic order (beyond linear response). This result constitutes the first determination of the bias dependence of the variance of a driven tracer in the SEP for an arbitrary density. The framework presented here can be applied, beyond the SEP, to more general configurations of a driven tracer in interaction with obstacles in one dimension.
    Language English
    Publishing date 2022-04-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.130.020402
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 4' 58/153: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article ; Online: Microscopic Theory for the Diffusion of an Active Particle in a Crowded Environment.

    Rizkallah, Pierre / Sarracino, Alessandro / Bénichou, Olivier / Illien, Pierre

    Physical review letters

    2022  Volume 128, Issue 3, Page(s) 38001

    Abstract: We calculate the diffusion coefficient of an active tracer in a schematic crowded environment, represented as a lattice gas of passive particles with hardcore interactions. Starting from the master equation of the problem, we put forward a closure ... ...

    Abstract We calculate the diffusion coefficient of an active tracer in a schematic crowded environment, represented as a lattice gas of passive particles with hardcore interactions. Starting from the master equation of the problem, we put forward a closure approximation that goes beyond trivial mean field and provides the diffusion coefficient for an arbitrary density of crowders in the system. We show that our approximation is accurate for a very wide range of parameters, and that it correctly captures numerous nonequilibrium effects, which are the signature of the activity in the system. In addition to the determination of the diffusion coefficient of the tracer, our approach allows us to characterize the perturbation of the environment induced by the displacement of the active tracer. Finally, we consider the asymptotic regimes of low and high densities, in which the expression of the diffusion coefficient of the tracer becomes explicit, and which we argue to be exact.
    Language English
    Publishing date 2022-02-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.128.038001
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 4' 58/153: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article ; Online: Exact closure and solution for spatial correlations in single-file diffusion.

    Grabsch, Aurélien / Poncet, Alexis / Rizkallah, Pierre / Illien, Pierre / Bénichou, Olivier

    Science advances

    2022  Volume 8, Issue 12, Page(s) eabm5043

    Abstract: In single-file transport particles diffuse in narrow channels while not overtaking each other. it is a fundamental model for the tracer subdiffusion observed in confined systems, such as zeolites or carbon nanotubes. This anomalous behavior originates ... ...

    Abstract In single-file transport particles diffuse in narrow channels while not overtaking each other. it is a fundamental model for the tracer subdiffusion observed in confined systems, such as zeolites or carbon nanotubes. This anomalous behavior originates from strong bath-tracer correlations in one dimension. Despite extensive effort, these remained elusive, because they involve an infinite hierarchy of equations. For the symmetric exclusion process, a paradigmatic model of single-file diffusion, we break the hierarchy to unveil and solve a closed exact equation satisfied by these correlations. Beyond quantifying the correlations, the role of this key equation as a tool for interacting particle systems is further demonstrated by its application to out-of-equilibrium situations, other observables, and other representative single-file systems.
    Language English
    Publishing date 2022-03-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.abm5043
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Exact spatial correlations in single-file diffusion.

    Grabsch, Aurélien / Rizkallah, Pierre / Poncet, Alexis / Illien, Pierre / Bénichou, Olivier

    Physical review. E

    2022  Volume 107, Issue 4-1, Page(s) 44131

    Abstract: Single-file diffusion refers to the motion of diffusive particles in narrow channels, so that they cannot bypass each other. This constraint leads to the subdiffusion of a tagged particle, called the tracer. This anomalous behavior results from the ... ...

    Abstract Single-file diffusion refers to the motion of diffusive particles in narrow channels, so that they cannot bypass each other. This constraint leads to the subdiffusion of a tagged particle, called the tracer. This anomalous behavior results from the strong correlations that arise in this geometry between the tracer and the surrounding bath particles. Despite their importance, these bath-tracer correlations have long remained elusive, because their determination is a complex many-body problem. Recently, we have shown that, for several paradigmatic models of single-file diffusion such as the simple exclusion process, these bath-tracer correlations obey a simple exact closed equation. In this paper, we provide the full derivation of this equation, as well as an extension to another model of single-file transport: the double exclusion process. We also make the connection between our results and the ones obtained very recently by several other groups and which rely on the exact solution of different models obtained by the inverse scattering method.
    Language English
    Publishing date 2022-08-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2844562-4
    ISSN 2470-0053 ; 2470-0045
    ISSN (online) 2470-0053
    ISSN 2470-0045
    DOI 10.1103/PhysRevE.107.044131
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Broad sialic acid usage amongst species D human adenovirus.

    Mundy, Rosie M / Baker, Alexander T / Bates, Emily A / Cunliffe, Tabitha G / Teijeira-Crespo, Alicia / Moses, Elise / Rizkallah, Pierre J / Parker, Alan L

    Npj viruses

    2023  Volume 1, Issue 1, Page(s) 1

    Abstract: Human adenoviruses (HAdV) are widespread pathogens causing usually mild infections. The Species D (HAdV-D) cause gastrointestinal tract infections and epidemic keratoconjunctivitis (EKC). Despite being significant pathogens, knowledge around HAdV-D ... ...

    Abstract Human adenoviruses (HAdV) are widespread pathogens causing usually mild infections. The Species D (HAdV-D) cause gastrointestinal tract infections and epidemic keratoconjunctivitis (EKC). Despite being significant pathogens, knowledge around HAdV-D mechanism of cell infection is lacking. Sialic acid (SA) usage has been proposed as a cell infection mechanism for EKC causing HAdV-D. Here we highlight an important role for SA engagement by many HAdV-D. We provide apo state crystal structures of 7 previously undetermined HAdV-D fiber-knob proteins, and structures of HAdV-D25, D29, D30 and D53 fiber-knob proteins in complex with SA. Biologically, we demonstrate that removal of cell surface SA reduced infectivity of HAdV-C5 vectors pseudotyped with HAdV-D fiber-knob proteins, whilst engagement of the classical HAdV receptor CAR was variable. Our data indicates variable usage of SA and CAR across HAdV-D. Better defining these interactions will enable improved development of antivirals and engineering of the viruses into refined therapeutic vectors.
    Language English
    Publishing date 2023-09-26
    Publishing country England
    Document type Journal Article
    ISSN 2948-1767
    ISSN (online) 2948-1767
    DOI 10.1038/s44298-023-00001-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Article ; Online: Alzheimer's disease-associated P460L variant of EphA1 dysregulates receptor activity and blood-brain barrier function.

    Owens, Helen A / Thorburn, Lauren E / Walsby, Elisabeth / Moon, Owen R / Rizkallah, Pierre / Sherwani, Subuhi / Tinsley, Caroline L / Rogers, Louise / Cerutti, Camilla / Ridley, Anne J / Williams, Julie / Knäuper, Vera / Ager, Ann

    Alzheimer's & dementia : the journal of the Alzheimer's Association

    2024  Volume 20, Issue 3, Page(s) 2016–2033

    Abstract: Introduction: Genome-wide association studies link susceptibility to late-onset Alzheimer's disease (LOAD) with EphA1. Sequencing identified a non-synonymous substitution P460L as a LOAD risk variant. Other Ephs regulate vascular permeability and immune ...

    Abstract Introduction: Genome-wide association studies link susceptibility to late-onset Alzheimer's disease (LOAD) with EphA1. Sequencing identified a non-synonymous substitution P460L as a LOAD risk variant. Other Ephs regulate vascular permeability and immune cell recruitment. We hypothesized that P460L dysregulates EphA1 receptor activity and impacts neuroinflammation.
    Methods: EphA1/P460L receptor activity was assayed in isogenic Human Embryonic Kidney (HEK) cells. Soluble EphA1/P460L (sEphA1/sP460L) reverse signaling in brain endothelial cells was assessed by T-cell recruitment and barrier function assays.
    Results: EphA1 and P460L were expressed in HEK cells, but membrane and soluble P460L were significantly reduced. Ligand engagement induced Y781 phosphorylation of EphA1 but not P460L. sEphA1 primed brain endothelial cells for increased T-cell recruitment; however, sP460L was less effective. sEphA1 decreased the integrity of the brain endothelial barrier, while sP460L had no effect.
    Discussion: These findings suggest that P460L alters EphA1-dependent forward and reverse signaling, which may impact blood-brain barrier function in LOAD.
    Highlights: EphA1-dependent reverse signaling controls recruitment of T cells by brain endothelial cells. EphA1-dependent reverse signaling remodels brain endothelial cell contacts. LOAD-associated P460L variant of EphA1 shows reduced membrane expression and reduced ligand responses. LOAD-associated P460L variant of EphA1 fails to reverse signal to brain endothelial cells.
    MeSH term(s) Humans ; Alzheimer Disease/genetics ; Blood-Brain Barrier ; Endothelial Cells ; Genome-Wide Association Study ; Ligands ; Receptor, EphA1/metabolism
    Chemical Substances Ligands ; Receptor, EphA1 (EC 2.7.10.1)
    Language English
    Publishing date 2024-01-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2211627-8
    ISSN 1552-5279 ; 1552-5260
    ISSN (online) 1552-5279
    ISSN 1552-5260
    DOI 10.1002/alz.13603
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6316: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 540: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: The Crystal Structure of

    Best, Hannah L / Williamson, Lainey J / Lipka-Lloyd, Magdalena / Waller-Evans, Helen / Lloyd-Evans, Emyr / Rizkallah, Pierre J / Berry, Colin

    Toxins

    2022  Volume 14, Issue 12

    Abstract: ... Tpp80Aa1 ... ...

    Abstract Tpp80Aa1 from
    MeSH term(s) Animals ; Bacillus thuringiensis/metabolism ; Galactose/metabolism ; Aedes/metabolism ; Insecticides/chemistry ; Culex/metabolism ; Bacterial Proteins/metabolism ; Larva/metabolism ; Endotoxins/metabolism ; Hemolysin Proteins/metabolism
    Chemical Substances Galactose (X2RN3Q8DNE) ; Insecticides ; Bacterial Proteins ; Endotoxins ; Hemolysin Proteins
    Language English
    Publishing date 2022-12-08
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2518395-3
    ISSN 2072-6651 ; 2072-6651
    ISSN (online) 2072-6651
    ISSN 2072-6651
    DOI 10.3390/toxins14120863
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Structural definition of HLA class II-presented SARS-CoV-2 epitopes reveals a mechanism to escape pre-existing CD4

    Chen, Yuan / Mason, Georgina H / Scourfield, D Oliver / Greenshields-Watson, Alexander / Haigh, Tracey A / Sewell, Andrew K / Long, Heather M / Gallimore, Awen M / Rizkallah, Pierre / MacLachlan, Bruce J / Godkin, Andrew

    Cell reports

    2023  Volume 42, Issue 8, Page(s) 112827

    Abstract: ... ...

    Abstract CD4
    MeSH term(s) Humans ; SARS-CoV-2 ; COVID-19 ; HLA-DR1 Antigen ; Epitopes, T-Lymphocyte ; Peptides ; CD4-Positive T-Lymphocytes ; CD8-Positive T-Lymphocytes
    Chemical Substances HLA-DR1 Antigen ; Epitopes, T-Lymphocyte ; Peptides
    Language English
    Publishing date 2023-07-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2023.112827
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top