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  1. Article: KipOTIA detoxifies 5-oxoproline and promotes the growth of

    Lee, Cheyenne D / Rizvi, Arshad / McBride, Shonna M

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Clostridioides ... ...

    Abstract Clostridioides difficile
    Language English
    Publishing date 2024-05-01
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.05.01.592088
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: The predicted acetoin dehydrogenase pathway represses sporulation of

    Wetzel, Daniela / Rizvi, Arshad / Edwards, Adrianne N / McBride, Shonna M

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Clostridioides difficile: Importance: Clostridioides difficile, ...

    Abstract Clostridioides difficile
    Importance: Clostridioides difficile,
    Language English
    Publishing date 2023-07-29
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.07.28.551048
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Host manipulation by bacterial type III and type IV secretion system effector proteases.

    Viana, Flávia / Peringathara, Shruthi Sachidanandan / Rizvi, Arshad / Schroeder, Gunnar N

    Cellular microbiology

    2021  Volume 23, Issue 11, Page(s) e13384

    Abstract: Proteases are powerful enzymes, which cleave peptide bonds, leading most of the time to irreversible fragmentation or degradation of their substrates. Therefore they control many critical cell fate decisions in eukaryotes. Bacterial pathogens exploit ... ...

    Abstract Proteases are powerful enzymes, which cleave peptide bonds, leading most of the time to irreversible fragmentation or degradation of their substrates. Therefore they control many critical cell fate decisions in eukaryotes. Bacterial pathogens exploit this power and deliver protease effectors through specialised secretion systems into host cells. Research over the past years revealed that the functions of protease effectors during infection are diverse, reflecting the lifestyles and adaptations to specific hosts; however, only a small number of peptidase families seem to have given rise to most of these protease virulence factors by the evolution of different substrate-binding specificities, intracellular activation and subcellular targeting mechanisms. Here, we review our current knowledge about the enzymology and function of protease effectors, which Gram-negative bacterial pathogens translocate via type III and IV secretion systems to irreversibly manipulate host processes. We highlight emerging concepts such as signalling by protease cleavage products and effector-triggered immunity, which host cells employ to detect and defend themselves against a protease attack. TAKE AWAY: Proteases irreversibly cleave proteins to control critical cell fate decisions. Gram-negative bacteria use type III and IV secretion systems to inject effectors. Protease effectors are integral weapons for the manipulation of host processes. Effectors evolved from few peptidase families to target diverse substrates. Effector-triggered immunity upon proteolytic attack emerges as host defence.
    MeSH term(s) Bacteria ; Bacterial Proteins ; Humans ; Peptide Hydrolases ; Type III Secretion Systems ; Type IV Secretion Systems ; Virulence Factors
    Chemical Substances Bacterial Proteins ; Type III Secretion Systems ; Type IV Secretion Systems ; Virulence Factors ; Peptide Hydrolases (EC 3.4.-)
    Language English
    Publishing date 2021-08-30
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1468320-9
    ISSN 1462-5822 ; 1462-5814
    ISSN (online) 1462-5822
    ISSN 1462-5814
    DOI 10.1111/cmi.13384
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    Zs.A 5288: Show issues Location:
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  4. Article ; Online: Confronting Tuberculosis: A Synthetic Quinoline-Isonicotinic Acid Hydrazide Hybrid Compound as a Potent Lead Molecule Against

    Vadankula, Govinda Raju / Nilkanth, Vipul V / Rizvi, Arshad / Yandrapally, Sriram / Agarwal, Anushka / Chirra, Hepshibha / Biswas, Rashmita / Arifuddin, Mohammed / Nema, Vijay / Mallika, Alvala / Mande, Shekhar C / Banerjee, Sharmistha

    ACS infectious diseases

    2024  

    Abstract: The current tuberculosis (TB) treatment is challenged by a complex first-line treatment for drug-sensitive (DS) TB. Additionally, the prevalence of multidrug (MDR)- and extensively drug (XDR)-resistant TB necessitates the search for new drug prototypes. ... ...

    Abstract The current tuberculosis (TB) treatment is challenged by a complex first-line treatment for drug-sensitive (DS) TB. Additionally, the prevalence of multidrug (MDR)- and extensively drug (XDR)-resistant TB necessitates the search for new drug prototypes. We synthesized and screened 30 hybrid compounds containing aminopyridine and 2-chloro-3-formyl quinoline to arrive at a compound with potent antimycobacterial activity, UH-NIP-16. Subsequently, antimycobacterial activity against DS and MDR
    Language English
    Publishing date 2024-05-08
    Publishing country United States
    Document type Journal Article
    ISSN 2373-8227
    ISSN (online) 2373-8227
    DOI 10.1021/acsinfecdis.4c00277
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  5. Article: Genetic mechanisms governing sporulation initiation in Clostridioides difficile

    Lee, Cheyenne D / Rizvi, Arshad / Edwards, Adrianne N / DiCandia, Michael A / Vargas Cuebas, Germán G / Monteiro, Marcos P / McBride, Shonna M

    Current opinion in microbiology. 2022 Apr., v. 66

    2022  

    Abstract: As an anaerobe, Clostridioides difficile relies on the formation of a dormant spore for survival outside of the mammalian host’s gastrointestinal tract. The spore is recalcitrant to desiccation, numerous disinfectants, UV light, and antibiotics, ... ...

    Abstract As an anaerobe, Clostridioides difficile relies on the formation of a dormant spore for survival outside of the mammalian host’s gastrointestinal tract. The spore is recalcitrant to desiccation, numerous disinfectants, UV light, and antibiotics, permitting long-term survival against environmental insults and efficient transmission from host to host. Although the morphological stages of spore formation are similar between C. difficile and other well-studied endospore-forming bacteria, the C. difficile genome does not appear to encode many of the known, conserved regulatory factors that are necessary to initiate sporulation in other spore-forming bacteria. The absence of early sporulation-specific orthologs suggests that C. difficile has evolved to control sporulation initiation in response to its unique and specific ecological niche and environmental cues within the host. Here, we review our current understanding and highlight the recent discoveries that have begun to unravel the regulatory pathways and molecular mechanisms by which C. difficile induces spore formation.
    Keywords Clostridium difficile ; digestive tract ; genome ; mammals ; niches ; spores ; sporulation ; ultraviolet radiation
    Language English
    Dates of publication 2022-04
    Size p. 32-38.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 1418474-6
    ISSN 1879-0364 ; 1369-5274
    ISSN (online) 1879-0364
    ISSN 1369-5274
    DOI 10.1016/j.mib.2021.12.001
    Database NAL-Catalogue (AGRICOLA)

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    Zs.A 5514: Show issues Location:
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    Zs.MG 51: Show issues

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  6. Article ; Online: Glycine fermentation by

    Rizvi, Arshad / Vargas-Cuebas, Germán / Edwards, Adrianne N / DiCandia, Michael A / Carter, Zavier A / Lee, Cheyenne D / Monteiro, Marcos P / McBride, Shonna M

    Infection and immunity

    2023  Volume 91, Issue 10, Page(s) e0031923

    Abstract: Clostridioides ... ...

    Abstract Clostridioides difficile
    MeSH term(s) Cricetinae ; Animals ; Clostridioides difficile/metabolism ; Cathelicidins ; Fermentation ; Virulence ; Amino Acids/metabolism ; Glycine/metabolism ; Bacterial Proteins/genetics ; Spores/metabolism
    Chemical Substances Cathelicidins ; Amino Acids ; Glycine (TE7660XO1C) ; Bacterial Proteins
    Language English
    Publishing date 2023-09-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218698-6
    ISSN 1098-5522 ; 0019-9567
    ISSN (online) 1098-5522
    ISSN 0019-9567
    DOI 10.1128/iai.00319-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 684: Show issues Location:
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  7. Article ; Online: Genetic mechanisms governing sporulation initiation in Clostridioides difficile.

    Lee, Cheyenne D / Rizvi, Arshad / Edwards, Adrianne N / DiCandia, Michael A / Vargas Cuebas, Germán G / Monteiro, Marcos P / McBride, Shonna M

    Current opinion in microbiology

    2021  Volume 66, Page(s) 32–38

    Abstract: As an anaerobe, Clostridioides difficile relies on the formation of a dormant spore for survival outside of the mammalian host's gastrointestinal tract. The spore is recalcitrant to desiccation, numerous disinfectants, UV light, and antibiotics, ... ...

    Abstract As an anaerobe, Clostridioides difficile relies on the formation of a dormant spore for survival outside of the mammalian host's gastrointestinal tract. The spore is recalcitrant to desiccation, numerous disinfectants, UV light, and antibiotics, permitting long-term survival against environmental insults and efficient transmission from host to host. Although the morphological stages of spore formation are similar between C. difficile and other well-studied endospore-forming bacteria, the C. difficile genome does not appear to encode many of the known, conserved regulatory factors that are necessary to initiate sporulation in other spore-forming bacteria. The absence of early sporulation-specific orthologs suggests that C. difficile has evolved to control sporulation initiation in response to its unique and specific ecological niche and environmental cues within the host. Here, we review our current understanding and highlight the recent discoveries that have begun to unravel the regulatory pathways and molecular mechanisms by which C. difficile induces spore formation.
    MeSH term(s) Animals ; Anti-Bacterial Agents/pharmacology ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Clostridioides ; Clostridioides difficile/genetics ; Mammals ; Spores, Bacterial/genetics
    Chemical Substances Anti-Bacterial Agents ; Bacterial Proteins
    Language English
    Publishing date 2021-12-18
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 1418474-6
    ISSN 1879-0364 ; 1369-5274
    ISSN (online) 1879-0364
    ISSN 1369-5274
    DOI 10.1016/j.mib.2021.12.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Understanding HIV-Mycobacteria synergism through comparative proteomics of intra-phagosomal mycobacteria during mono- and HIV co-infection.

    Ganji, Rakesh / Dhali, Snigdha / Rizvi, Arshad / Rapole, Srikanth / Banerjee, Sharmistha

    Scientific reports

    2016  Volume 6, Page(s) 22060

    Abstract: Mycobacterium tuberculosis (Mtb) is the most common co-infection in HIV patients and a serious co-epidemic. Apart from increasing the risk of reactivation of latent tuberculosis (TB), HIV infection also permits opportunistic infection of environmental ... ...

    Abstract Mycobacterium tuberculosis (Mtb) is the most common co-infection in HIV patients and a serious co-epidemic. Apart from increasing the risk of reactivation of latent tuberculosis (TB), HIV infection also permits opportunistic infection of environmental non-pathogenic mycobacteria. To gain insights into mycobacterial survival inside host macrophages and identify mycobacterial proteins or processes that influence HIV propagation during co-infection, we employed proteomics approach to identify differentially expressed intracellular mycobacterial proteins during mono- and HIV co-infection of human THP-1 derived macrophage cell lines. Of the 92 proteins identified, 30 proteins were upregulated during mycobacterial mono-infection and 40 proteins during HIV-mycobacteria co-infection. We observed down-regulation of toxin-antitoxin (TA) modules, up-regulation of cation transporters, Type VII (Esx) secretion systems, proteins involved in cell wall lipid or protein metabolism, glyoxalate pathway and branched chain amino-acid synthesis during co-infection. The bearings of these mycobacterial factors or processes on HIV propagation during co-infection, as inferred from the proteomics data, were validated using deletion mutants of mycobacteria. The analyses revealed mycobacterial factors that possibly via modulating the host environment, increased viral titers during co-infection. The study provides new leads for investigations towards hitherto unknown molecular mechanisms explaining HIV-mycobacteria synergism, helping address diagnostics and treatment challenges for effective co-epidemic management.
    MeSH term(s) AIDS-Related Opportunistic Infections/genetics ; AIDS-Related Opportunistic Infections/metabolism ; Bacterial Proteins/genetics ; Gene Expression Regulation, Bacterial ; Humans ; Macrophages/microbiology ; Mycobacterium Infections/genetics ; Mycobacterium Infections/metabolism ; Mycobacterium tuberculosis/metabolism ; Phagosomes/microbiology ; Proteomics
    Chemical Substances Bacterial Proteins
    Language English
    Publishing date 2016-02-26
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/srep22060
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  9. Article ; Online: Inhibition of bacterial multidrug resistance by celecoxib, a cyclooxygenase-2 inhibitor.

    Kalle, Arunasree M / Rizvi, Arshad

    Antimicrobial agents and chemotherapy

    2010  Volume 55, Issue 1, Page(s) 439–442

    Abstract: Multidrug resistance (MDR) is a major problem in the treatment of infectious diseases and cancer. Accumulating evidence suggests that the cyclooxygenase-2 (COX-2)-specific inhibitor celecoxib would not only inhibit COX-2 but also help in the reversal of ... ...

    Abstract Multidrug resistance (MDR) is a major problem in the treatment of infectious diseases and cancer. Accumulating evidence suggests that the cyclooxygenase-2 (COX-2)-specific inhibitor celecoxib would not only inhibit COX-2 but also help in the reversal of drug resistance in cancers by inhibiting the MDR1 efflux pump. Here, we demonstrate that celecoxib increases the sensitivity of bacteria to the antibiotics ampicillin, kanamycin, chloramphenicol, and ciprofloxacin by accumulating the drugs inside the cell, thus reversing MDR in bacteria.
    MeSH term(s) Ampicillin/pharmacology ; Celecoxib ; Chloramphenicol/pharmacology ; Ciprofloxacin/pharmacology ; Cyclooxygenase 2 Inhibitors/pharmacology ; Drug Resistance, Multiple, Bacterial/drug effects ; Kanamycin/pharmacology ; Microbial Sensitivity Tests ; Mycobacterium smegmatis/drug effects ; Pyrazoles/pharmacology ; Staphylococcus aureus/drug effects ; Sulfonamides/pharmacology
    Chemical Substances Cyclooxygenase 2 Inhibitors ; Pyrazoles ; Sulfonamides ; Kanamycin (59-01-8) ; Ciprofloxacin (5E8K9I0O4U) ; Chloramphenicol (66974FR9Q1) ; Ampicillin (7C782967RD) ; Celecoxib (JCX84Q7J1L)
    Language English
    Publishing date 2010-10-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 217602-6
    ISSN 1098-6596 ; 0066-4804
    ISSN (online) 1098-6596
    ISSN 0066-4804
    DOI 10.1128/AAC.00735-10
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 809: Show issues Location:
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    Einzelsignatur: Show issues

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  10. Article ; Online: Metabolomics Studies To Decipher Stress Responses in Mycobacterium smegmatis Point to a Putative Pathway of Methylated Amine Biosynthesis.

    Rizvi, Arshad / Yousf, Saleem / Balakrishnan, Kannan / Dubey, Harish Kumar / Mande, Shekhar C / Chugh, Jeetender / Banerjee, Sharmistha

    Journal of bacteriology

    2019  Volume 201, Issue 15

    Abstract: Mycobacterium ... ...

    Abstract Mycobacterium smegmatis
    MeSH term(s) Amines/chemistry ; Amines/metabolism ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Biosynthetic Pathways ; Gene Expression Regulation, Bacterial ; Metabolomics ; Methylation ; Mycobacterium smegmatis/genetics ; Mycobacterium smegmatis/metabolism ; Mycobacterium tuberculosis/genetics ; Mycobacterium tuberculosis/metabolism ; Oxidative Stress
    Chemical Substances Amines ; Bacterial Proteins
    Language English
    Publishing date 2019-07-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2968-3
    ISSN 1098-5530 ; 0021-9193
    ISSN (online) 1098-5530
    ISSN 0021-9193
    DOI 10.1128/JB.00707-18
    Database MEDical Literature Analysis and Retrieval System OnLINE

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