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  1. Article: The Functional Psychotherapy Approach: A Process-Outcome Multiple Case Study.

    Rocco, Diego / Rizzi, Luca / Dell'Arciprete, Gaia / Perrella, Raffaella

    Frontiers in psychology

    2022  Volume 12, Page(s) 727497

    Abstract: Objective: ...

    Abstract Objective:
    Language English
    Publishing date 2022-01-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2021.727497
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  2. Article ; Online: Responses to Stress: Investigating the Role of Gender, Social Relationships, and Touch Avoidance in Italy.

    Passarelli, Marcello / Casetta, Laura / Rizzi, Luca / Perrella, Raffaella

    International journal of environmental research and public health

    2021  Volume 18, Issue 2

    Abstract: Stress is a physiological response to internal and external events we call "stressors". Response to the same daily stressors varies across individuals and seems to be higher for women. A possible explanation for this phenomenon is that women perceive ... ...

    Abstract Stress is a physiological response to internal and external events we call "stressors". Response to the same daily stressors varies across individuals and seems to be higher for women. A possible explanation for this phenomenon is that women perceive sociality, relationships, and intimacy-important sources of both stress and wellbeing-differently from how men experience them. In this study, we investigate how gender, attachment, and touch avoidance predict stress responses on a sample of 335 Italians (216 females; age = 35.82 ± 14.32). Moreover, we analyze the network of relationships between these variables through multiple linear regression and exploratory network analysis techniques. The results recontextualize the role of gender in determining stress responses in terms of (lack of) confidence and touch avoidance toward family members; attitudes toward relationships seem to be the main determinants of stress responses. These results have implications for reducing stress in both clinical settings and at a social level.
    MeSH term(s) Adult ; Female ; Gender Identity ; Humans ; Interpersonal Relations ; Italy/epidemiology ; Male ; Middle Aged ; Touch ; Touch Perception ; Young Adult
    Language English
    Publishing date 2021-01-12
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1660-4601
    ISSN (online) 1660-4601
    DOI 10.3390/ijerph18020600
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  3. Article: Changes in Touch Avoidance, Stress, and Anxiety During the COVID-19 Pandemic in Italy.

    Passarelli, Marcello / Casetta, Laura / Rizzi, Luca / Perrella, Raffaella / Maniaci, Giuseppe / La Barbera, Daniele

    Frontiers in psychology

    2022  Volume 13, Page(s) 854110

    Abstract: In the present study we analyzed how attitudes toward touch have changed during the COVID-19 pandemic in an Italian sample, through two different studies: in the first we contacted participants of the Italian validation study of the Touch Avoidance ... ...

    Abstract In the present study we analyzed how attitudes toward touch have changed during the COVID-19 pandemic in an Italian sample, through two different studies: in the first we contacted participants of the Italian validation study of the Touch Avoidance Questionnaire, asking them to take part in a follow-up study (
    Language English
    Publishing date 2022-07-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2022.854110
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  4. Article: Italian Validation of the Touch Avoidance Measure and the Touch Avoidance Questionnaire.

    Casetta, Laura / Rizzi, Luca / Passarelli, Marcello / Arcara, Giorgio / Perrella, Raffaella

    Frontiers in psychology

    2020  Volume 11, Page(s) 1673

    Abstract: Social touch is essential in relationships and well-being, but the unique personal experience of touch is not assessed and taken into account in health and social care services. The pleasantness of gentle stroking is influenced by gender, toucher genre, ... ...

    Abstract Social touch is essential in relationships and well-being, but the unique personal experience of touch is not assessed and taken into account in health and social care services. The pleasantness of gentle stroking is influenced by gender, toucher genre, toucher familiarity, culture, and age. Moreover, pleasantness is influenced by touch avoidance, the attitude toward interpersonal touch. The aim of this article is to present the translation, adaptation, and validation in Italian of two scales to measure touch avoidance. For translation and validation, we selected the most used scale, the Touch Avoidance Measure (TAM) and a more recent scale, the Touch Avoidance Questionnaire (TAQ). Confirmatory factor analyses reported good model fit for the TAM [comparative fit index (CFI) = 0.947, Tucker-Lewis index (TLI) = 0.940, root-mean-square error of approximation (RMSEA) = 0.065] and excellent model fit for the TAQ (CFI = 0.954, TLI = 0.950, RMSEA = 0.058). Internal consistency was high for all subscales, except the TAQ "Stranger" subscale. One-month test-retest reliability ranged from 0.67 to 0.90 for each subscale. Lastly, convergent validity between the TAM and TAQ was also found to be high. We conclude that the TAM and TAQ can be used to assess touch avoidance with Italian samples. The instrument can be used to support healthcare professionals and to assess attitudes toward touch in individuals with interpersonal difficulties.
    Language English
    Publishing date 2020-07-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2020.01673
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  5. Article ; Online: Resolving the H I in damped Lyman α systems that power star formation.

    Bordoloi, Rongmon / O'Meara, John M / Sharon, Keren / Rigby, Jane R / Cooke, Jeff / Shaban, Ahmed / Matuszewski, Mateusz / Rizzi, Luca / Doppmann, Greg / Martin, D Christopher / Moore, Anna M / Morrissey, Patrick / Neill, James D

    Nature

    2022  Volume 606, Issue 7912, Page(s) 59–63

    Abstract: Reservoirs of dense atomic gas (primarily hydrogen) contain approximately 90 per cent of the neutral gas at a redshift of 3, and contribute to between 2 and 3 per cent of the total baryons in the ... ...

    Abstract Reservoirs of dense atomic gas (primarily hydrogen) contain approximately 90 per cent of the neutral gas at a redshift of 3, and contribute to between 2 and 3 per cent of the total baryons in the Universe
    Language English
    Publishing date 2022-05-18
    Publishing country England
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-022-04616-1
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  6. Article ; Online: A Small Library of 1,2,3-Triazole Analogs of CAP-55: Synthesis and Binding Affinity at Nicotinic Acetylcholine Receptors.

    Rizzi, Luca / Gotti, Cecilia / De Amici, Marco / Dallanoce, Clelia / Matera, Carlo

    Chemistry & biodiversity

    2018  Volume 15, Issue 9, Page(s) e1800210

    Abstract: Alpha7 nicotinic acetylcholine receptor is emerging as a central regulator in inflammatory processes, as documented by increasing studies reported in the literature. For instance, the activation of this nicotinic receptor subtype in resident macrophages ... ...

    Abstract Alpha7 nicotinic acetylcholine receptor is emerging as a central regulator in inflammatory processes, as documented by increasing studies reported in the literature. For instance, the activation of this nicotinic receptor subtype in resident macrophages inhibits the production of pro-inflammatory cytokines, thereby attenuating local inflammatory responses, and may open a new window in the treatment of chronic inflammatory disease, such as Crohn's disease, rheumatoid arthritis, psoriasis, and asthma. In continuation of our ongoing research for the development of new cholinergic drug candidates, we selected the nicotine derivative CAP55, which was previously shown to exert anti-inflammatory effects via nicotinic stimulation, as a suitable compound for lead optimization. Through the isosteric replacement of its 3,5-disubstituted 4,5-dihydroisoxazole core with a 1,4-disubstituted 1,2,3-triazole ring, we could rapidly generate a small library of CAP55-related analogs via a one-pot copper(I)-catalyzed azide-alkyne cycloaddition. Receptor binding assays at nAChRs led to the identification of two promising derivatives, compounds 4 and 10, worthy of further pharmacological studies.
    MeSH term(s) Binding Sites ; Carbon-13 Magnetic Resonance Spectroscopy ; Macrophages/metabolism ; Nicotine/analogs & derivatives ; Nicotine/chemistry ; Nicotine/pharmacology ; Proton Magnetic Resonance Spectroscopy ; Triazoles/chemistry ; alpha7 Nicotinic Acetylcholine Receptor/chemistry ; alpha7 Nicotinic Acetylcholine Receptor/metabolism
    Chemical Substances Triazoles ; alpha7 Nicotinic Acetylcholine Receptor ; Nicotine (6M3C89ZY6R)
    Language English
    Publishing date 2018-07-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2139001-0
    ISSN 1612-1880 ; 1612-1872
    ISSN (online) 1612-1880
    ISSN 1612-1872
    DOI 10.1002/cbdv.201800210
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  7. Article: Alcohols immobilization onto 2-chlorotritylchloride resin under microwave irradiation

    Rizzi, Luca / Cendic, Katarina / Vaiana, Nadia / Romeo, Sergio

    Tetrahedron letters. 2011 June 1, v. 52, no. 22

    2011  

    Abstract: The immobilization of alcohols onto 2-chlorotritylchloride resin using microwave irradiation was studied. Three different Fmoc-aminoalcohols were tested: the phenol-like Fmoc-tyramine, the primary alcohol Fmoc-ethanolamine, and the secondary alcohol Fmoc- ...

    Abstract The immobilization of alcohols onto 2-chlorotritylchloride resin using microwave irradiation was studied. Three different Fmoc-aminoalcohols were tested: the phenol-like Fmoc-tyramine, the primary alcohol Fmoc-ethanolamine, and the secondary alcohol Fmoc-4-hydroxypiperidine. Several reaction conditions were evaluated: different bases, reaction times, temperatures, and concentrations. Microwave immobilization resulted is effective in binding to the resin all three types of alcohols with loadings which were superior or comparable to the ‘classical’ methods in shorter time and without employing toxic and racemizing reagents. This method resulted also useful for the immobilization, through the hydroxyl group, of FmocTyrOAll, FmocSerOAll, and FmocThrOAll, important building blocks for the synthesis of cyclic peptides.
    Keywords alcohols ; chemical reactions ; chemical structure ; cyclic peptides ; microwave radiation ; temperature ; toxicity
    Language English
    Dates of publication 2011-0601
    Size p. 2808-2811.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 204287-3
    ISSN 1873-3581 ; 0040-4039
    ISSN (online) 1873-3581
    ISSN 0040-4039
    DOI 10.1016/j.tetlet.2011.03.113
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2837: Show issues Location:
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  8. Article: Synthetic peptides derived from the C-terminal 6kDa region of Plasmodium falciparum SERA5 inhibit the enzyme activity and malaria parasite development.

    Kanodia, Shivani / Kumar, Gautam / Rizzi, Luca / Pedretti, Alessandro / Hodder, Anthony N / Romeo, Sergio / Malhotra, Pawan

    Biochimica et biophysica acta

    2014  Volume 1840, Issue 9, Page(s) 2765–2775

    Abstract: Background: Plasmodium falciparum serine repeat antigen 5 (PfSERA5) is an abundant blood stage protein that plays an essential role in merozoite egress and invasion. The native protein undergoes extensive proteolytic cleavage that appears to be tightly ... ...

    Abstract Background: Plasmodium falciparum serine repeat antigen 5 (PfSERA5) is an abundant blood stage protein that plays an essential role in merozoite egress and invasion. The native protein undergoes extensive proteolytic cleavage that appears to be tightly regulated. PfSERA5 N-terminal fragment is being developed as vaccine candidate antigen. Although PfSERA5 belongs to papain-like cysteine protease family, its catalytic domain has a serine in place of cysteine at the active site.
    Methods: In the present study, we synthesized a number of peptides from the N- and C-terminal regions of PfSERA5 active domain and evaluated their inhibitory potential.
    Results: The final proteolytic step of PfSERA5 involves removal of a C-terminal ~6kDa fragment that results in the generation of a catalytically active ~50kDa enzyme. In the present study, we demonstrate that two of the peptides derived from the C-terminal ~6kDa region inhibit the parasite growth and also cause a delay in the parasite development. These peptides reduced the enzyme activity of the recombinant protein and co-localized with the PfSERA5 protein within the parasite, thereby indicating the specific inhibition of PfSERA5 activity. Molecular docking studies revealed that the inhibitory peptides interact with the active site of the protein. Interestingly, the peptides did not have an effect on the processing of PfSERA5.
    Conclusions: Our observations indicate the temporal regulation of the final proteolytic cleavage step that occurs just prior to egress.
    General significance: These results reinforce the role of PfSERA5 for the intra-erythrocytic development of malaria parasite and show the role of carboxy terminal ~6kDa fragments in the regulation of PfSERA5 activity. The results also suggest that final cleavage step of PfSERA5 can be targeted for the development of new anti-malarials.
    MeSH term(s) Antigens, Protozoan/genetics ; Antigens, Protozoan/metabolism ; Erythrocytes/metabolism ; Erythrocytes/parasitology ; Humans ; Malaria, Falciparum/drug therapy ; Malaria, Falciparum/enzymology ; Malaria, Falciparum/genetics ; Peptides/chemistry ; Peptides/pharmacology ; Plasmodium falciparum/enzymology ; Plasmodium falciparum/genetics ; Protein Structure, Tertiary ; Proteolysis
    Chemical Substances Antigens, Protozoan ; Peptides ; serine repeat antigen 5, Plasmodium falciparum
    Language English
    Publishing date 2014-09
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 60-7
    ISSN 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    ISSN (online) 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
    ISSN 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    DOI 10.1016/j.bbagen.2014.04.013
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  9. Article ; Online: Correction: Picomolar Inhibition of Plasmepsin V, an Essential Malaria Protease, Achieved Exploiting the Prime Region.

    Gambini, Luca / Rizzi, Luca / Pedretti, Alessandro / Taglialatela-Scafati, Orazio / Carucci, Mario / Pancotti, Andrea / Galli, Corinna / Read, Martin / Giurisato, Emanuele / Romeo, Sergio / Russo, Ilaria

    PloS one

    2016  Volume 11, Issue 1, Page(s) e0146627

    Language English
    Publishing date 2016
    Publishing country United States
    Document type Published Erratum
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0146627
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  10. Article: Design, synthesis and docking studies of Hydroxyethylamine and Hydroxyethylsulfide BACE-1 inhibitors.

    Rizzi, Luca / Vaiana, Nadia / Sagui, Francesca / Genesio, Eva / Pilli, Elena / Porcari, Valentina / Romeo, Sergio

    Protein and peptide letters

    2009  Volume 16, Issue 1, Page(s) 86–90

    Abstract: Both stereoisomer of hydroxyethylamine (HEA) and hydroxyethylsulfide (HES) transition-state isostere inhibitors of BACE-1 were synthesized. The syn-HEA epimer resulted always more active than the anti stereoisomer independently from the P(1) and the P(1)' ...

    Abstract Both stereoisomer of hydroxyethylamine (HEA) and hydroxyethylsulfide (HES) transition-state isostere inhibitors of BACE-1 were synthesized. The syn-HEA epimer resulted always more active than the anti stereoisomer independently from the P(1) and the P(1)' substituents. On the contrary, the anti epimer of the HES isostere resulted more active than the syn stereoisomer. The change of stereopreference was studied by molecular modelling.
    MeSH term(s) Amyloid Precursor Protein Secretases/antagonists & inhibitors ; Aspartic Acid Endopeptidases/antagonists & inhibitors ; Biomimetic Materials ; Drug Design ; Ethylamines/chemical synthesis ; Ethylamines/chemistry ; Protease Inhibitors/chemical synthesis ; Protease Inhibitors/chemistry ; Stereoisomerism ; Structure-Activity Relationship ; Sulfhydryl Compounds/chemical synthesis ; Sulfhydryl Compounds/chemistry
    Chemical Substances Ethylamines ; Protease Inhibitors ; Sulfhydryl Compounds ; Amyloid Precursor Protein Secretases (EC 3.4.-) ; Aspartic Acid Endopeptidases (EC 3.4.23.-) ; BACE1 protein, human (EC 3.4.23.46)
    Language English
    Publishing date 2009-01-08
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1280776-x
    ISSN 1875-5305 ; 0929-8665
    ISSN (online) 1875-5305
    ISSN 0929-8665
    DOI 10.2174/092986609787049439
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