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  1. Article ; Online: Controversial role of herpesviruses in Alzheimer's disease.

    Rizzo, Roberta

    PLoS pathogens

    2020  Volume 16, Issue 6, Page(s) e1008575

    MeSH term(s) Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Alzheimer Disease/virology ; Herpesviridae/metabolism ; Herpesviridae/pathogenicity ; Herpesviridae Infections/metabolism ; Herpesviridae Infections/pathology ; Humans
    Language English
    Publishing date 2020-06-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2205412-1
    ISSN 1553-7374 ; 1553-7366
    ISSN (online) 1553-7374
    ISSN 1553-7366
    DOI 10.1371/journal.ppat.1008575
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Nicotinamide Adenine Dinucleotide: The Redox Sensor in Aging-Related Disorders.

    Schiuma, Giovanna / Lara, Djidjell / Clement, James / Narducci, Marco / Rizzo, Roberta

    Antioxidants & redox signaling

    2024  

    Abstract: Significance: ...

    Abstract Significance:
    Language English
    Publishing date 2024-03-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1483836-9
    ISSN 1557-7716 ; 1523-0864
    ISSN (online) 1557-7716
    ISSN 1523-0864
    DOI 10.1089/ars.2023.0375
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5488: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Editorial: Cell cycle control as a new therapeutic approach for SARS-CoV-2 infection.

    Rizzo, Roberta / Caccuri, Francesca / Valacchi, Giuseppe / Zauli, Giorgio

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1136277

    Language English
    Publishing date 2023-02-01
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1136277
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The experiences of families receiving a diagnosis of 22q11.2 deletion syndrome in Ireland.

    O'Donoghue, Emma / McAllister, Marion / Rizzo, Roberta

    Journal of genetic counseling

    2022  Volume 32, Issue 3, Page(s) 618–634

    Abstract: Families in Ireland often wait over 1 year to see a genetic counselor (GC). This qualitative study aimed to explore the views of families who received a diagnosis of 22q11DS in Ireland regarding the need for timely access to genetic counseling at the ... ...

    Abstract Families in Ireland often wait over 1 year to see a genetic counselor (GC). This qualitative study aimed to explore the views of families who received a diagnosis of 22q11DS in Ireland regarding the need for timely access to genetic counseling at the point of diagnosis. Twenty participants were recruited through the '22q Ireland' support group, giving a response rate of approximately 10% of the total support group members. Semi-structured interviews were conducted online and by telephone which explored experiences of receiving diagnoses, medical care, genetic counseling, mental health, and coping with the diagnosis. Interviews were transcribed verbatim and analyzed using thematic analysis. The experiences of 20 participants were classified into five main themes: Receiving Diagnosis, Interactions with Healthcare Professionals (HCPs, excluding GCs), Medical Care, Information, and Impact of Condition. Participants reported receiving diagnoses for their children in a sub-optimal manner due to inappropriate settings and insufficient information, support, and pre-test counseling. Parents reported feeling responsible for managing their child's complex and fragmented medical care. Participants reported insufficient empathy and little awareness of 22q11DS among HCPs. Participants perceived genetic counseling to be associated with family planning and reported delayed, if any, access to services. Mental health was a particular worry among participants. Conferences about 22q11DS are the main source of information for parents. Participants reported a range of emotions after diagnosis and described the family impact. The findings suggest both an association between HCPs' poor understanding of 22q11DS and the perceived lack of empathy from HCPs and fragmented medical care. There is an identified need for advocacy of the GC profession in Ireland to support these families. Increased awareness of 22q11DS among HCPs and the development of a coordinated care pathway for 22q11DS, with timely access to genetic counseling, may improve care and lead to better outcomes.
    MeSH term(s) Child ; Humans ; DiGeorge Syndrome/psychology ; Ireland ; Parents/psychology ; Adaptation, Psychological ; Qualitative Research
    Language English
    Publishing date 2022-12-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1117799-8
    ISSN 1573-3599 ; 1059-7700
    ISSN (online) 1573-3599
    ISSN 1059-7700
    DOI 10.1002/jgc4.1667
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4263: Show issues Location:
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  5. Article: Innate Immune Response in SARS-CoV-2 Infection.

    Schiuma, Giovanna / Beltrami, Silvia / Bortolotti, Daria / Rizzo, Sabrina / Rizzo, Roberta

    Microorganisms

    2022  Volume 10, Issue 3

    Abstract: An efficient host immune response is crucial in controlling viral infections. Despite most studies focused on the implication of T and B cell response in COVID-19 (Corona Virus Disease-19) patients or in their activation after vaccination against SARS- ... ...

    Abstract An efficient host immune response is crucial in controlling viral infections. Despite most studies focused on the implication of T and B cell response in COVID-19 (Corona Virus Disease-19) patients or in their activation after vaccination against SARS-CoV-2, host innate immune response has raised even more interest as well. In fact, innate immunity, including Natural Killer (NK) cells, monocytes/macrophages and neutrophils, represent the first line of defense against the virus and it is essential to determine the correct activation of an efficient and specific acquired immune response. In this perspective, we will report an overview on the main findings concerning SARS-CoV-2 interaction with innate host immune system, in correlation with pathogenesis and viral immune escape mechanisms.
    Language English
    Publishing date 2022-02-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms10030501
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  6. Article ; Online: Human Herpesviruses 6A and 6B in Reproductive Diseases.

    Komaroff, Anthony L / Rizzo, Roberta / Ecker, Jeffrey L

    Frontiers in immunology

    2021  Volume 12, Page(s) 648945

    Abstract: Human herpesviruses 6A (HHV-6A) and human herpesvirus 6B (HHV-6B)-collectively, HHV-6A/B-are recently-discovered but ancient human viruses. The vast majority of people acquire one or both viruses, typically very early in life, producing an ineradicable ... ...

    Abstract Human herpesviruses 6A (HHV-6A) and human herpesvirus 6B (HHV-6B)-collectively, HHV-6A/B-are recently-discovered but ancient human viruses. The vast majority of people acquire one or both viruses, typically very early in life, producing an ineradicable lifelong infection. The viruses have been linked to several neurological, pulmonary and hematological diseases. In early human history, the viruses on multiple occasions infected a germ cell, and integrated their DNA into a human chromosome. As a result, about 1% of humans are born with the full viral genome present in every cell, with uncertain consequences for health. HHV-6A may play a role in 43% of cases of primary unexplained infertility. Both the inherited and acquired viruses may occasionally trigger several of the factors that are important in the pathogenesis of preeclampsia. Transplacental infection occurs in 1-2% of pregnancies, with some evidence suggesting adverse health consequences for the child. While emerging knowledge about these viruses in reproductive diseases is not sufficient to suggest any changes in current practice, we write this review to indicate the need for further research that could prove practice-changing.
    MeSH term(s) Abortion, Spontaneous/immunology ; Abortion, Spontaneous/virology ; Cervix Uteri/cytology ; Cervix Uteri/immunology ; Cervix Uteri/virology ; Female ; Fetal Growth Retardation/immunology ; Fetal Growth Retardation/virology ; Herpesvirus 6, Human/genetics ; Herpesvirus 6, Human/immunology ; Herpesvirus 6, Human/physiology ; Humans ; Placenta/cytology ; Placenta/immunology ; Placenta/virology ; Pregnancy ; Roseolovirus Infections/immunology ; Roseolovirus Infections/virology ; Virus Integration/genetics ; Virus Integration/immunology ; Virus Replication/genetics ; Virus Replication/immunology
    Language English
    Publishing date 2021-03-25
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.648945
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Structural and functional characterization of an individual with the M285R

    de Guimaraes, Thales A C / Lai, Francesco / Colombatti, Raffaella / Sato, Giovanni / Rizzo, Roberta / Kalitzeos, Angelos / Michaelides, Michel

    Ophthalmic genetics

    2024  , Page(s) 1–10

    Abstract: Background: Disease-causing variants in the : Material and methods: Medical history, genetic testing, ocular examination, high-resolution retinal imaging including adaptive optics scanning light ophthalmoscopy (AOSLO), and functional assessments.: ... ...

    Abstract Background: Disease-causing variants in the
    Material and methods: Medical history, genetic testing, ocular examination, high-resolution retinal imaging including adaptive optics scanning light ophthalmoscopy (AOSLO), and functional assessments.
    Results: A 16-year-old male with mild cone-rod dystrophy presented with reduced central vision and photophobia. Genetic testing showed two variants in
    Conclusions: We provide functional and structural evidence that the variant M285R is disease-causing if associated with a loss-of-function variant. To the best of our knowledge, this is the first hypomorphic allele reported in
    Language English
    Publishing date 2024-03-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 1199279-7
    ISSN 1744-5094 ; 0167-6784 ; 1381-6810
    ISSN (online) 1744-5094
    ISSN 0167-6784 ; 1381-6810
    DOI 10.1080/13816810.2024.2324046
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1708: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  8. Article: Comparison Between Moxifloxacin and Chloramphenicol for the Treatment of Bacterial Eye Infections.

    Gentili, Valentina / Strazzabosco, Giovanni / Spena, Rossella / Rizzo, Sabrina / Beltrami, Silvia / Schiuma, Giovanna / Alogna, Andrea / Rizzo, Roberta

    Current therapeutic research, clinical and experimental

    2024  Volume 100, Page(s) 100740

    Abstract: Background: Moxifloxacin is a bactericidal methoxyquinolone used for the treatment of conjunctivitis and prophylactic therapy in cataract and refractive surgeries. Chloramphenicol is a bacteriostatic organochlorine introduced into clinical practice in ... ...

    Abstract Background: Moxifloxacin is a bactericidal methoxyquinolone used for the treatment of conjunctivitis and prophylactic therapy in cataract and refractive surgeries. Chloramphenicol is a bacteriostatic organochlorine introduced into clinical practice in 1948 and used mainly in topical preparations because of its known toxicity.
    Objectives: The study aimed to evaluate the in vitro antibacterial effect and the ocular cytotoxicity of these broad-spectrum antibiotics.
    Methods: Antimicrobic activity was tested on 4 bacteria strains (
    Results: Cytotoxicity of antibiotics was evaluated on human epithelial corneal cells after 4 hours treatment by viability assay. Results showed that corneal cell viability was significantly higher after moxifloxacin treatment compared with chloramphenicol (
    Conclusions: The lower corneal cell toxicity and the broader spectrum of antibacterial activity observed with moxifloxacin suggests its use in ophthalmic solution for the treatment of bacterial eye infections.
    Language English
    Publishing date 2024-02-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 205697-5
    ISSN 1879-0313 ; 0011-393X
    ISSN (online) 1879-0313
    ISSN 0011-393X
    DOI 10.1016/j.curtheres.2024.100740
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 306: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  9. Article: Perspectives of Italian Physicians and Patients in the Treatment of Otitis Externa: A Real-Life Study.

    Gelardi, Matteo / Giancaspro, Rossana / Landi, Massimo / Santoiemma, Luigi / Balestra, Maddalena / Cassano, Michele / Rizzo, Roberta

    Journal of personalized medicine

    2023  Volume 13, Issue 7

    Abstract: 1) Background: Otitis externa (OE) is a common inflammatory disease of the external ear canal. Given the numerous manifestations of OE, the high rate of recurrence of the disease, as well as the emergence of resistance to antibiotics, therapeutic ... ...

    Abstract (1) Background: Otitis externa (OE) is a common inflammatory disease of the external ear canal. Given the numerous manifestations of OE, the high rate of recurrence of the disease, as well as the emergence of resistance to antibiotics, therapeutic strategies are numerous and still not well standardized. The aim of this study was to investigate the patient journey of Italian patients suffering from OE, paying greater attention to new therapeutic options. (2) Methods: We conducted a national survey to evaluate the characteristics of patients affected by OE and to analyze the most-prescribed treatments. (3) Results: OE is a common, often relapsing disease that has several clinical manifestations. Prior to observation, the combination of corticosteroids and topical antibiotics was the most common therapeutic strategy. At the time of observation, new liposomal ozone-based preparations were the most-prescribed treatment. (4) Conclusions: This multi-center study investigated key aspects of the OE patient journey, highlighting the growing problem of antibiotic resistance. Restoring a correct ear microbiome is the therapeutic goal. In this context, new liposomal ozone-based drugs represent a promising therapeutic strategy.
    Language English
    Publishing date 2023-06-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm13071083
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: SARS-CoV-2 Systemic Effects: New Clues.

    Beltrami, Silvia / Rizzo, Sabrina / Caccuri, Francesca / Rizzo, Roberta / Bortolotti, Daria / Schiuma, Giovanna

    Microorganisms

    2023  Volume 11, Issue 5

    Abstract: To date, much discussion has been had on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lung infection associated with COVID-19 onset, of which the major manifestation is characterized by a "cytokine storm" [ ... ]. ...

    Abstract To date, much discussion has been had on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lung infection associated with COVID-19 onset, of which the major manifestation is characterized by a "cytokine storm" [...].
    Language English
    Publishing date 2023-05-05
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms11051209
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