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Artikel: Serum Sickness/Serum Sickness-like Reactions Following Ocrelizumab Infusion in 2 Patients With Multiple Sclerosis.

Rjeily, Nicole Bou / Nourbakhsh, Bardia / Mowry, Ellen M

International journal of MS care

2023  Band 25, Heft 5, Seite(n) 196–198

Abstract: Serum sickness (SS) is a rare hypersensitivity reaction that can occur with monoclonal antibodies, and only 1 case of SS has been reported with ocrelizumab. We describe 2 patients with multiple sclerosis (MS) who developed SS/SS-like reactions (SSLRs) ... ...

Abstract Serum sickness (SS) is a rare hypersensitivity reaction that can occur with monoclonal antibodies, and only 1 case of SS has been reported with ocrelizumab. We describe 2 patients with multiple sclerosis (MS) who developed SS/SS-like reactions (SSLRs) following ocrelizumab infusions. A man, aged 45 years, and a woman, aged 59 years, both with primary progressive MS, developed generalized weakness and arthralgias following their ocrelizumab infusions. Brain and spinal cord MRIs revealed no new or enhancing demyelinating lesions in both cases. They both had elevated inflammatory markers and negative infectious workups. They were subsequently treated for presumed SS with a steroid taper (and with potent anti-inflammatories in the second case), and symptoms improved dramatically after a few days. These cases suggest that SS/SSLRs should be suspected in a patient with new-onset arthralgia following ocrelizumab infusion who has an otherwise negative workup and rapid response to steroids.
Sprache Englisch
Erscheinungsdatum 2023-09-14
Erscheinungsland United States
Dokumenttyp Journal Article
ISSN 1537-2073
ISSN 1537-2073
DOI 10.7224/1537-2073.2022-080
Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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