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  1. Article ; Online: Toward community-centered dementia care: Indigenous ethics in research publishing.

    Roach, Pamela / Lewis, Jordan P

    Dementia (London, England)

    2023  Volume 23, Issue 1, Page(s) 5–6

    MeSH term(s) Humans ; Dementia/therapy ; Publishing
    Language English
    Publishing date 2023-12-19
    Publishing country England
    Document type Editorial
    ZDB-ID 2084045-7
    ISSN 1741-2684 ; 1471-3012
    ISSN (online) 1741-2684
    ISSN 1471-3012
    DOI 10.1177/14713012231223608
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Fourier transform infrared spectroscopy as a non-destructive method for analysing herbarium specimens.

    Barnes, M / Sulé-Suso, J / Millett, J / Roach, P

    Biology letters

    2023  Volume 19, Issue 3, Page(s) 20220546

    Abstract: Dried plant specimens stored in herbaria are an untapped treasure chest of information on environmental conditions, plant evolution and change over many hundreds of years. Owing to their delicate nature and irreplaceability, there is limited access for ... ...

    Abstract Dried plant specimens stored in herbaria are an untapped treasure chest of information on environmental conditions, plant evolution and change over many hundreds of years. Owing to their delicate nature and irreplaceability, there is limited access for analysis to these sensitive samples, particularly where chemical data are obtained using destructive techniques. Fourier transform infrared (FTIR) spectroscopy is a chemical analysis technique which can be applied non-destructively to understand chemical bonding information and, therefore, functional groups within the sample. This provides the potential for understanding geographical, spatial and species-specific variation in plant biochemistry. Here, we demonstrate the use of mid-FTIR microspectroscopy for the chemical analysis of
    MeSH term(s) Spectroscopy, Fourier Transform Infrared/methods ; Cluster Analysis ; Plants ; Principal Component Analysis
    Language English
    Publishing date 2023-03-22
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2135022-X
    ISSN 1744-957X ; 1744-9561
    ISSN (online) 1744-957X
    ISSN 1744-9561
    DOI 10.1098/rsbl.2022.0546
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1364 -Letters-: Show issues Location:
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  3. Article: Acrylamide-based hydrogels with distinct osteogenic and chondrogenic differentiation potential.

    Younus, Z M / Roach, P / Forsyth, N R

    Progress in biomaterials

    2022  Volume 11, Issue 3, Page(s) 297–309

    Abstract: Regeneration solutions for the osteochondral interface depth are limited, where multi-material implants have the potential to delaminate affecting the regeneration process and impacting the final integrity of tissue interface. Here we explore regionally ... ...

    Abstract Regeneration solutions for the osteochondral interface depth are limited, where multi-material implants have the potential to delaminate affecting the regeneration process and impacting the final integrity of tissue interface. Here we explore regionally mixed hydrogel networks, presenting distinct chemical features to determine their compatibility in supporting osteogenic or chondrogenic cell behaviour and differentiation. Poly(N-isopropylacrylamide) (pNIPAM) and poly(N-tert-butylacrylamide) (pNTBAM) hydrogels were assessed in terms of their chemical differences, mechanical strength, internal architecture, porosity and capacity to support cell viability, migration, and differentiation. pNTBAM polymerized with a Young's modulus of up to 371 ± 31 kPa compared to the more flexible pNIPAM, 16.5 ± 0.6 kPa. Viability testing revealed biocompatibility of both hydrogels with significantly increased cell numbers observed in pNTBAM (500 ± 95 viable cells/mm
    Language English
    Publishing date 2022-07-16
    Publishing country Germany
    Document type Journal Article
    ISSN 2194-0509
    ISSN 2194-0509
    DOI 10.1007/s40204-022-00196-5
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  4. Article ; Online: Reconciliation and Indigenous self-determination in health research: A call to action.

    Roach, Pamela / McMillan, Faye

    PLOS global public health

    2022  Volume 2, Issue 9, Page(s) e0000999

    Language English
    Publishing date 2022-09-01
    Publishing country United States
    Document type Journal Article
    ISSN 2767-3375
    ISSN (online) 2767-3375
    DOI 10.1371/journal.pgph.0000999
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  5. Article ; Online: Understanding the impact of COVID-19 isolation measures on individuals with mood disorders in mental health clinics.

    Rodrigues, C / Patten, S B / Smith, E E / Roach, P

    Journal of affective disorders reports

    2022  Volume 8, Page(s) 100348

    Language English
    Publishing date 2022-03-31
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2666-9153
    ISSN (online) 2666-9153
    DOI 10.1016/j.jadr.2022.100348
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  6. Article ; Online: Gradient biomimetic platforms for neurogenesis studies.

    Havins, Laurissa / Capel, Andrew / Christie, Steve / Lewis, Mark / Roach, P

    Journal of neural engineering

    2022  Volume 19, Issue 1

    Abstract: There is a need for the development of new cellular therapies for the treatment of many diseases, with the central nervous system (CNS) currently an area of specific focus. Due to the complexity and delicacy of its biology, there is currently a limited ... ...

    Abstract There is a need for the development of new cellular therapies for the treatment of many diseases, with the central nervous system (CNS) currently an area of specific focus. Due to the complexity and delicacy of its biology, there is currently a limited understanding of neurogenesis and consequently a lack of reliable test platforms, resulting in several CNS based diseases having no cure. The ability to differentiate pluripotent stem cells into specific neuronal sub-types may enable scalable manufacture for clinical therapies, with a focus also on the purity and quality of the cell population. This focus is targeted towards an urgent need for the diseases that currently have no cure, e.g. Parkinson's disease. Differentiation studies carried out using traditional 2D cell culture techniques are designed using biological signals and morphogens known to be important for neurogenesis
    MeSH term(s) Biomimetics ; Cell Culture Techniques/methods ; Cell Differentiation ; Neurogenesis/physiology ; Reproducibility of Results
    Language English
    Publishing date 2022-01-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2170901-4
    ISSN 1741-2552 ; 1741-2560
    ISSN (online) 1741-2552
    ISSN 1741-2560
    DOI 10.1088/1741-2552/ac4639
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6071: Show issues Location:
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  7. Article ; Online: Modification of the surface nanotopography of implant devices: A translational perspective.

    Harawaza, K / Cousins, B / Roach, P / Fernandez, A

    Materials today. Bio

    2021  Volume 12, Page(s) 100152

    Abstract: There is an increasing need for the development of superior, safe, and more sophisticated implants, especially as our society historically has been moving towards an increasingly aging population. Currently, most research is being focused on the next ... ...

    Abstract There is an increasing need for the development of superior, safe, and more sophisticated implants, especially as our society historically has been moving towards an increasingly aging population. Currently, most research is being focused on the next generation of advanced medical implants, that are not only biocompatible but have modified surfaces that direct specific immunomodulation at cellular level. While there is a plethora of information on cell-surface interaction and how surfaces can be nanofabricated at research level, less is known about how the academic knowledge has been translated into clinical trials and commercial technologies. In this review, we provide a clinical translational perspective on the use of controlled physical surface modification of medical implants, presenting an analysis of data acquired from clinical trials and commercial products. We also evaluate the
    Language English
    Publishing date 2021-10-21
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2590-0064
    ISSN (online) 2590-0064
    DOI 10.1016/j.mtbio.2021.100152
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  8. Article ; Online: Unintended consequences of measuring equity, diversity, and inclusion in medicine.

    Ruzycki, Shannon M / Roach, Pamela / Ahmed, Sofia B

    BMJ (Clinical research ed.)

    2023  Volume 381, Page(s) e073445

    MeSH term(s) Humans ; Diversity, Equity, Inclusion ; Medicine ; Cultural Diversity
    Language English
    Publishing date 2023-06-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj-2022-073445
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Dying with behavioral and psychological symptoms of dementia in Australian nursing homes: a retrospective case-control study.

    Roach, Peter / Lovell, Melanie R / Macfarlane, Stephen

    Frontiers in psychiatry

    2023  Volume 14, Page(s) 1091771

    Abstract: Objectives: To identify predictors of mortality in people with active and challenging behavioral and psychological symptoms of dementia (BPSD).: Design: A retrospective case-control study was designed to compare those referred to Dementia Support ... ...

    Abstract Objectives: To identify predictors of mortality in people with active and challenging behavioral and psychological symptoms of dementia (BPSD).
    Design: A retrospective case-control study was designed to compare those referred to Dementia Support Australia (DSA) who died in the 12 months to November 2016, with an equal number of controls who did not die. An audit tool was designed after literature review and expert opinion from the service. Odds ratio calculations and the Mann-Whitney U test were used to assess for difference.
    Setting: Residents of Australian residential aged care facilities with BPSD referred to the DSA service.
    Participants: Of 476 patients referred to DSA during the study period, 44 died. 44 controls were randomly selected from those remaining matched for age and sex.
    Results: Significant differences included higher rates of benzodiazepine use, drowsiness, delirium, reduced oral intake and discussions about goals of care in those who died. Those who died were referred to the service for a shorter period and had more frequent contact between DSA and nurses at the nursing homes. Increase in opioid use and loss of skin integrity in those who died approached significance. The overall end of life course demonstrated a complex set of needs with frequent delirium, pain and frailty.
    Conclusion: Further study is required to determine the optimal care for those with BPSD at the end of their lives. This study would indicate complex end of life care needs and point to a role for palliative care support.
    Language English
    Publishing date 2023-05-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2023.1091771
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Young onset dementia: Negotiating future workplace roles and identities.

    Roach, Pamela

    Dementia (London, England)

    2016  Volume 16, Issue 1, Page(s) 5–8

    Language English
    Publishing date 2016-10-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2084045-7
    ISSN 1741-2684 ; 1471-3012
    ISSN (online) 1741-2684
    ISSN 1471-3012
    DOI 10.1177/1471301216674420
    Database MEDical Literature Analysis and Retrieval System OnLINE

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