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  1. Article ; Online: The use of buprenorphine to-go packs in the emergency department.

    Zimmerman, David E / Johnson, Benjamin / Kearns, Amanda / Metro, Heather / Robb, Abigail / Nemecek, Branden D / Montepara, Courtney A / Covvey, Jordan R / Lynch, Michael J

    The American journal of emergency medicine

    2023  Volume 77, Page(s) 154–157

    Abstract: Objective: Buprenorphine is an effective treatment for opioid use disorder (OUD). Patients in the emergency department (ED) can be initiated or continued on buprenorphine as a bridge to follow-up in the outpatient setting, but gaps in care may arise. ... ...

    Abstract Objective: Buprenorphine is an effective treatment for opioid use disorder (OUD). Patients in the emergency department (ED) can be initiated or continued on buprenorphine as a bridge to follow-up in the outpatient setting, but gaps in care may arise. The objective was to evaluate the impact of buprenorphine to-go packs as a continuing treatment option for patients presenting to the ED with OUD across a health system.
    Methods: Adult patients discharged with a buprenorphine to-go pack from one of ten EDs within a major health system were included. The primary outcomes assessed within 30 days of ED discharge were: (1) return to a health system ED, and (2) fill history of buprenorphine in the state prescription drug monitoring program database. Data was analyzed using descriptive statistics in Microsoft Excel (Redmond, WA).
    Results: A total of 124 patients received buprenorphine to-go packs. The sample was primarily male (79; 63.7%), white (89; 71.8%), on Medicaid (79; 63.7%), and had a mean age of 40.9 years. A total of 43 patients (34.7%) were initiated on buprenorphine for the first time, while 81 (65.3%) had received buprenorphine (prescription or to-go) previously. At 30 days post-visit, 76 (61.3%) had filled buprenorphine prescriptions, and 40 (32.3%) returned to an ED within the health system for opioid withdrawal (17; 42.5%), non-OUD-related reasons (22; 55%), or overdose (1; 2.5%).
    Conclusion: The implementation of a system-wide buprenorphine to-go supply at ED discharge is a feasible option to provide continuity of care to patients with OUD.
    MeSH term(s) Adult ; United States ; Humans ; Male ; Buprenorphine/therapeutic use ; Narcotic Antagonists/therapeutic use ; Opiate Substitution Treatment ; Emergency Service, Hospital ; Opioid-Related Disorders/drug therapy
    Chemical Substances Buprenorphine (40D3SCR4GZ) ; Narcotic Antagonists
    Language English
    Publishing date 2023-12-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605890-5
    ISSN 1532-8171 ; 0735-6757
    ISSN (online) 1532-8171
    ISSN 0735-6757
    DOI 10.1016/j.ajem.2023.12.025
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Mast cell activation test in the diagnosis of allergic disease and anaphylaxis.

    Bahri, Rajia / Custovic, Adnan / Korosec, Peter / Tsoumani, Marina / Barron, Martin / Wu, Jiakai / Sayers, Rebekah / Weimann, Alf / Ruiz-Garcia, Monica / Patel, Nandinee / Robb, Abigail / Shamji, Mohamed H / Fontanella, Sara / Silar, Mira / Mills, E N Clare / Simpson, Angela / Turner, Paul J / Bulfone-Paus, Silvia

    The Journal of allergy and clinical immunology

    2018  Volume 142, Issue 2, Page(s) 485–496.e16

    Abstract: Background: Food allergy is an increasing public health issue and the most common cause of life-threatening anaphylactic reactions. Conventional allergy tests assess for the presence of allergen-specific IgE, significantly overestimating the rate of ... ...

    Abstract Background: Food allergy is an increasing public health issue and the most common cause of life-threatening anaphylactic reactions. Conventional allergy tests assess for the presence of allergen-specific IgE, significantly overestimating the rate of true clinical allergy and resulting in overdiagnosis and adverse effect on health-related quality of life.
    Objective: To undertake initial validation and assessment of a novel diagnostic tool, we used the mast cell activation test (MAT).
    Methods: Primary human blood-derived mast cells (MCs) were generated from peripheral blood precursors, sensitized with patients' sera, and then incubated with allergen. MC degranulation was assessed by means of flow cytometry and mediator release. We compared the diagnostic performance of MATs with that of existing diagnostic tools to assess in a cohort of peanut-sensitized subjects undergoing double-blind, placebo-controlled challenge.
    Results: Human blood-derived MCs sensitized with sera from patients with peanut, grass pollen, and Hymenoptera (wasp venom) allergy demonstrated allergen-specific and dose-dependent degranulation, as determined based on both expression of surface activation markers (CD63 and CD107a) and functional assays (prostaglandin D
    Conclusion: The MAT is a robust tool that can confer superior diagnostic performance compared with existing allergy diagnostics and might be useful to explore differences in effector cell function between basophils and MCs during allergic reactions.
    MeSH term(s) Adolescent ; Adult ; Allergens/immunology ; Anaphylaxis/diagnosis ; Arachis/immunology ; Basophil Degranulation Test ; Cell Degranulation ; Cells, Cultured ; Child ; Cohort Studies ; Female ; Humans ; Immunoglobulin E/metabolism ; Immunologic Tests/methods ; Male ; Mast Cells/physiology ; Peanut Hypersensitivity/diagnosis ; Young Adult
    Chemical Substances Allergens ; Immunoglobulin E (37341-29-0)
    Language English
    Publishing date 2018-03-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Validation Study
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2018.01.043
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Immunologic mechanisms of a short-course of Lolium perenne peptide immunotherapy: A randomized, double-blind, placebo-controlled trial.

    Sharif, Hanisah / Singh, Iesha / Kouser, Lubna / Mösges, Ralph / Bonny, Marie-Alix / Karamani, Angeliki / Parkin, Rebecca V / Bovy, Nicolas / Kishore, Uday / Robb, Abigail / Katotomichelakis, Michael / Holtappels, Gabriële / Derycke, Lara / Corazza, Francis / von Frenckell, Rémy / Wathelet, Nathalie / Duchateau, Jean / Legon, Thierry / Pirotton, Sabine /
    Durham, Stephen R / Bachert, Claus / Shamji, Mohamed H

    The Journal of allergy and clinical immunology

    2019  Volume 144, Issue 3, Page(s) 738–749

    Abstract: Background: A 3-week short-course of adjuvant-free hydrolysates of Lolium perenne peptide (LPP) immunotherapy for rhinoconjunctivitis with or without asthma over 4 physician visits is safe, well tolerated, and effective.: Objective: We sought to ... ...

    Abstract Background: A 3-week short-course of adjuvant-free hydrolysates of Lolium perenne peptide (LPP) immunotherapy for rhinoconjunctivitis with or without asthma over 4 physician visits is safe, well tolerated, and effective.
    Objective: We sought to investigate immunologic mechanisms of LPP immunotherapy in a subset of patients who participated in a phase III, multicenter, randomized, double-blind, placebo-controlled trial (clinical.govNCT02560948).
    Methods: Participants were randomized to receive LPP (n = 21) or placebo (n = 11) for 3 weeks over 4 visits. Grass pollen-induced basophil, T-cell, and B-cell responses were evaluated before treatment (visit [V] 2), at the end of treatment (V6), and after the pollen season (V8).
    Results: Combined symptom and rescue medication scores (CSMS) were lower during the peak pollen season (-35.1%, P = .03) and throughout the pollen season (-53.7%, P = .03) in the LPP-treated group compared with those in the placebo-treated group. Proportions of CD63
    Conclusion: For the first time, we demonstrate that the immunologic mechanisms of LPP immunotherapy are underscored by immune modulation in the T- and B-cell compartments, which is necessary for its effect.
    MeSH term(s) Adult ; Allergens/immunology ; Asthma/immunology ; Asthma/therapy ; B-Lymphocytes, Regulatory/immunology ; Conjunctivitis/immunology ; Conjunctivitis/therapy ; Desensitization, Immunologic ; Double-Blind Method ; Female ; Humans ; Immunoglobulin E/blood ; Immunoglobulin G/blood ; Lolium/immunology ; Male ; Peptides/immunology ; Peptides/therapeutic use ; Pollen/immunology ; Rhinitis, Allergic, Seasonal/immunology ; Rhinitis, Allergic, Seasonal/therapy ; T-Lymphocytes, Helper-Inducer/immunology ; T-Lymphocytes, Regulatory/immunology ; Young Adult
    Chemical Substances Allergens ; Immunoglobulin G ; Peptides ; Immunoglobulin E (37341-29-0)
    Language English
    Publishing date 2019-03-05
    Publishing country United States
    Document type Clinical Trial, Phase III ; Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2019.02.023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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