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Article ; Online: Radiomics in Gynaecological Imaging

Paolo Niccolò Franco / Federica Vernuccio / Cesare Maino / Roberto Cannella / Milagros Otero-García / Davide Ippolito

Applied Sciences, Vol 13, Iss 21, p

A State-of-the-Art Review

2023 Volume 11839

Abstract: Radiomics is an emerging field of research based on extracting mathematical descriptive features from medical images with the aim of improving diagnostic performance and providing increasing support to clinical decisions. In recent years, a number of ... ...

Abstract	Radiomics is an emerging field of research based on extracting mathematical descriptive features from medical images with the aim of improving diagnostic performance and providing increasing support to clinical decisions. In recent years, a number of studies have been published regarding different possible applications of radiomics in gynaecological imaging. Many fields have been explored, such as tumour diagnosis and staging, differentiation of histological subtypes, assessment of distant metastases, prediction of response to therapy, recurrence, and patients’ outcome. However, several studies are not robust, do not include validation cohorts, or lack reproducibility. On these bases, the purpose of this narrative review is to provide an overview of the most relevant studies in the literature on radiomics in gynaecological imaging. We focused on gynaecological malignancies, particularly endometrial, cervical, mesenchymal, and ovarian malignant pathologies.
Keywords	radiomics ; gynaecological imaging ; MRI ; CT ; endometrial cancer ; cervical cancer ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
Subject code	610
Language	English
Publishing date	2023-10-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Cross-sectional imaging after pancreatic surgery

Cesare Maino / Marco Cereda / Paolo Niccolò Franco / Piero Boraschi / Roberto Cannella / Luca Vittorio Gianotti / Giulia Zamboni / Federica Vernuccio / Davide Ippolito

European Journal of Radiology Open, Vol 12, Iss , Pp 100544- (2024)

The dialogue between the radiologist and the surgeon

2024

Abstract: Pancreatic surgery is nowadays considered one of the most complex surgical approaches and not unscathed from complications. After the surgical procedure, cross-sectional imaging is considered the non-invasive reference standard to detect early and late ... ...

Abstract	Pancreatic surgery is nowadays considered one of the most complex surgical approaches and not unscathed from complications. After the surgical procedure, cross-sectional imaging is considered the non-invasive reference standard to detect early and late compilations, and consequently to address patients to the best management possible. Contras-enhanced computed tomography (CECT) should be considered the most important and useful imaging technique to evaluate the surgical site. Thanks to its speed, contrast, and spatial resolution, it can help reach the final diagnosis with high accuracy. On the other hand, magnetic resonance imaging (MRI) should be considered as a second-line imaging approach, especially for the evaluation of biliary findings and late complications. In both cases, the radiologist should be aware of protocols and what to look at, to create a robust dialogue with the surgeon and outline a fitted treatment for each patient.
Keywords	Pancreas ; Pancreatectomy ; Pancreaticojejunostomy ; Pancreaticoduodenectomy ; Postoperative complications ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
Subject code	616
Language	English
Publishing date	2024-06-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Hepatocellular Carcinoma

Marco Dioguardi Burgio / Lorenzo Garzelli / Roberto Cannella / Maxime Ronot / Valérie Vilgrain

Life, Vol 13, Iss 12, p

Optimal Radiological Evaluation before Liver Transplantation

2023 Volume 2267

Abstract: Liver transplantation (LT) is the recommended curative-intent treatment for patients with early or intermediate-stage hepatocellular carcinoma (HCC) who are ineligible for resection. Imaging plays a central role in staging and for selecting the best LT ... ...

Abstract	Liver transplantation (LT) is the recommended curative-intent treatment for patients with early or intermediate-stage hepatocellular carcinoma (HCC) who are ineligible for resection. Imaging plays a central role in staging and for selecting the best LT candidates. This review will discuss recent developments in pre-LT imaging assessment, in particular LT eligibility criteria on imaging, the technical requirements and the diagnostic performance of imaging for the pre-LT diagnosis of HCC including the recent Liver Imaging Reporting and Data System (LI-RADS) criteria, the evaluation of the response to locoregional therapy, as well as the non-invasive prediction of HCC aggressiveness and its impact on the outcome of LT. We will also briefly discuss the role of nuclear medicine in the pre-LT evaluation and the emerging role of artificial intelligence models in patients with HCC.
Keywords	carcinoma ; hepatocellular ; liver ; transplantation ; Science ; Q
Subject code	610
Language	English
Publishing date	2023-11-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Resectable and Borderline Resectable Pancreatic Ductal Adenocarcinoma

Federica Vernuccio / Carlo Messina / Valeria Merz / Roberto Cannella / Massimo Midiri

Diagnostics, Vol 11, Iss 2166, p

Role of the Radiologist and Oncologist in the Era of Precision Medicine

2021 Volume 2166

Abstract: The incidence and mortality of pancreatic ductal adenocarcinoma are growing over time. The management of patients with pancreatic ductal adenocarcinoma involves a multidisciplinary team, ideally involving experts from surgery, diagnostic imaging, ... ...

Abstract	The incidence and mortality of pancreatic ductal adenocarcinoma are growing over time. The management of patients with pancreatic ductal adenocarcinoma involves a multidisciplinary team, ideally involving experts from surgery, diagnostic imaging, interventional endoscopy, medical oncology, radiation oncology, pathology, geriatric medicine, and palliative care. An adequate staging of pancreatic ductal adenocarcinoma and re-assessment of the tumor after neoadjuvant therapy allows the multidisciplinary team to choose the most appropriate treatment for the patient. This review article discusses advancement in the molecular basis of pancreatic ductal adenocarcinoma, diagnostic tools available for staging and tumor response assessment, and management of resectable or borderline resectable pancreatic cancer.
Keywords	pancreatic ductal adenocarcinoma ; pancreatic neoplasm ; computed tomography (CT) ; magnetic resonance imaging (MRI) ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2021-11-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Systematic review with radiomics quality score of cholangiocarcinoma

Roberto Cannella / Federica Vernuccio / Michail E. Klontzas / Andrea Ponsiglione / Ekaterina Petrash / Lorenzo Ugga / Daniel Pinto dos Santos / Renato Cuocolo

Insights into Imaging, Vol 14, Iss 1, Pp 1-

an EuSoMII Radiomics Auditing Group Initiative

2023 Volume 15

Abstract: Key points The quality of current radiomics studies on cholangiocarcinoma is insufficient, with a median radiomics quality score of 8–10, corresponding to 22–28% of the ideal quality score. None of the current studies conducted phantom assessment, ... ...

Abstract	Key points The quality of current radiomics studies on cholangiocarcinoma is insufficient, with a median radiomics quality score of 8–10, corresponding to 22–28% of the ideal quality score. None of the current studies conducted phantom assessment, imaging at multiple time points, prospective registration in a trial database, nor cost-effectiveness analysis. The inter-reader agreement of the radiomics quality score is good (ICC of 0.75; 95% CI 0.62–0.85) among readers with different levels of experience.
Keywords	Systematic review ; Cholangiocarcinoma ; Liver ; Quality improvement ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Advances in liver US, CT, and MRI

Federica Vernuccio / Roberto Cannella / Tommaso Vincenzo Bartolotta / Massimo Galia / An Tang / Giuseppe Brancatelli

European Radiology Experimental, Vol 5, Iss 1, Pp 1-

moving toward the future

2021 Volume 16

Abstract: Abstract Over the past two decades, the epidemiology of chronic liver disease has changed with an increase in the prevalence of nonalcoholic fatty liver disease in parallel to the advent of curative treatments for hepatitis C. Recent developments ... ...

Abstract	Abstract Over the past two decades, the epidemiology of chronic liver disease has changed with an increase in the prevalence of nonalcoholic fatty liver disease in parallel to the advent of curative treatments for hepatitis C. Recent developments provided new tools for diagnosis and monitoring of liver diseases based on ultrasound (US), computed tomography (CT), and magnetic resonance imaging (MRI), as applied for assessing steatosis, fibrosis, and focal lesions. This narrative review aims to discuss the emerging approaches for qualitative and quantitative liver imaging, focusing on those expected to become adopted in clinical practice in the next 5 to 10 years. While radiomics is an emerging tool for many of these applications, dedicated techniques have been investigated for US (controlled attenuation parameter, backscatter coefficient, elastography methods such as point shear wave elastography [pSWE] and transient elastography [TE], novel Doppler techniques, and three-dimensional contrast-enhanced ultrasound [3D-CEUS]), CT (dual-energy, spectral photon counting, extracellular volume fraction, perfusion, and surface nodularity), and MRI (proton density fat fraction [PDFF], elastography [MRE], contrast enhancement index, relative enhancement, T1 mapping on the hepatobiliary phase, perfusion). Concurrently, the advent of abbreviated MRI protocols will help fulfill an increasing number of examination requests in an era of healthcare resource constraints.
Keywords	Biomarkers ; Non-alcoholic fatty liver disease ; Ultrasonography ; Tomography ; X-ray computed ; Magnetic resonance imaging ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
Subject code	610
Language	English
Publishing date	2021-12-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Spectrum of liver lesions hyperintense on hepatobiliary phase

Federica Vernuccio / Domenico Salvatore Gagliano / Roberto Cannella / Ahmed Ba-Ssalamah / An Tang / Giuseppe Brancatelli

Insights into Imaging, Vol 12, Iss 1, Pp 1-

an approach by clinical setting

2021 Volume 17

Abstract: Abstract Hepatobiliary MRI contrast agents are increasingly being used for liver imaging. In clinical practice, most focal liver lesions do not uptake hepatobiliary contrast agents. Less commonly, hepatic lesions may show variable signal characteristics ... ...

Abstract	Abstract Hepatobiliary MRI contrast agents are increasingly being used for liver imaging. In clinical practice, most focal liver lesions do not uptake hepatobiliary contrast agents. Less commonly, hepatic lesions may show variable signal characteristics on hepatobiliary phase. This pictorial essay reviews a broad spectrum of benign and malignant focal hepatic observations that may show hyperintensity on hepatobiliary phase in various clinical settings. In non-cirrhotic patients, focal hepatic observations that show hyperintensity in the hepatobiliary phase are usually benign and typically include focal nodular hyperplasia. In patients with primary or secondary vascular disorders, focal nodular hyperplasia-like lesions arise as a local hyperplastic response to vascular alterations and tend to be iso- or hyperintense in the hepatobiliary phase. In oncologic patients, metastases and cholangiocarcinoma are hypointense lesions in the hepatobiliary phase; however, occasionally they may show a diffuse, central and inhomogeneous hepatobiliary paradoxical uptake with peripheral rim hypointensity. Post-chemotherapy focal nodular hyperplasia-like lesions may be tricky, and their typical hyperintense rim in the hepatobiliary phase is very helpful for the differential diagnosis with metastases. In cirrhotic patients, hepatocellular carcinoma may occasionally appear hyperintense on hepatobiliary phase.
Keywords	Liver neoplasms ; Magnetic resonance imaging ; Hepatocellular carcinoma ; Gadoxetate disodium ; Gadobenate dimeglumine ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
Subject code	610
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: CT angiography for the assessment of EVAR complications

Cecilia Gozzo / Giovanni Caruana / Roberto Cannella / Arduino Farina / Dario Giambelluca / Ettore Dinoto / Federica Vernuccio / Antonio Basile / Massimo Midiri

Insights into Imaging, Vol 13, Iss 1, Pp 1-

a pictorial review

2022 Volume 18

Abstract: Abstract Endovascular aneurysm repair (EVAR) is a minimally invasive treatment proposed as an alternative to open repair in patients with abdominal aortic aneurysms. EVAR consists in a stent-graft placement within the aorta in order to exclude the ... ...

Abstract	Abstract Endovascular aneurysm repair (EVAR) is a minimally invasive treatment proposed as an alternative to open repair in patients with abdominal aortic aneurysms. EVAR consists in a stent-graft placement within the aorta in order to exclude the aneurysm from arterial circulation and reduce the risk of rupture. Knowledge of the various types of devices is mandatory because some stents/grafts are more frequently associated with complications. CT angiography is the gold standard diagnostic technique for preprocedural planning and postprocedural surveillance. EVAR needs long-term follow-up due to the high rate of complications. Complications can be divided in endograft device-related and systemic complications. The purpose of this article is to review the CT imaging findings of EVAR complications and the key features for the diagnosis.
Keywords	Aortic aneurysm ; Abdominal ; Computed tomography angiography ; Endovascular procedures ; Blood vessel prosthesis implantation ; Stents ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
Subject code	610
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Multiorgan Involvement in SARS-CoV-2 Infection

Davide Ippolito / Federica Vernuccio / Cesare Maino / Roberto Cannella / Teresa Giandola / Maria Ragusi / Vittorio Bigiogera / Carlo Capodaglio / Sandro Sironi

Diagnostics, Vol 12, Iss 1188, p

The Role of the Radiologist from Head to Toe

2022 Volume 1188

Abstract: Radiology plays a crucial role for the diagnosis and management of COVID-19 patients during the different stages of the disease, allowing for early detection of manifestations and complications of COVID-19 in the different organs. Lungs are the most ... ...

Abstract	Radiology plays a crucial role for the diagnosis and management of COVID-19 patients during the different stages of the disease, allowing for early detection of manifestations and complications of COVID-19 in the different organs. Lungs are the most common organs involved by SARS-CoV-2 and chest computed tomography (CT) represents a reliable imaging-based tool in acute, subacute, and chronic settings for diagnosis, prognosis, and management of lung disease and the evaluation of acute and chronic complications. Cardiac involvement can be evaluated by using cardiac computed tomography angiography (CCTA), considered as the best choice to solve the differential diagnosis between the most common cardiac conditions: acute coronary syndrome, myocarditis, and cardiac dysrhythmia. By using compressive ultrasound it’s possible to study the peripheral arteries and veins and to exclude the deep vein thrombosis, directly linked to the onset of pulmonary embolism. Moreover, CT and especially MRI can help to evaluate the gastrointestinal involvement and assess hepatic function, pancreas involvement, and exclude causes of lymphocytopenia, thrombocytopenia, and leukopenia, typical of COVID-19 patients. Finally, radiology plays a crucial role in the early identification of renal damage in COVID-19 patients, by using both CT and US. This narrative review aims to provide a comprehensive radiological analysis of commonly involved organs in patients with COVID-19 disease.
Keywords	infections ; coronavirus ; radiography ; tomography ; X-ray computed ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A mutation-based radiomics signature predicts response to imatinib in Gastrointestinal Stromal Tumors (GIST)

Giovanni Cappello / Valentina Giannini / Roberto Cannella / Emanuele Tabone / Ilaria Ambrosini / Francesca Molea / Nicolò Damiani / Ilenia Landolfi / Giovanni Serra / Giorgia Porrello / Cecilia Gozzo / Lorena Incorvaia / Giuseppe Badalamenti / Giovanni Grignani / Alessandra Merlini / Lorenzo D’Ambrosio / Tommaso Vincenzo Bartolotta / Daniele Regge

European Journal of Radiology Open, Vol 11, Iss , Pp 100505- (2023)

2023

Abstract: Objectives: To develop a mutation-based radiomics signature to predict response to imatinib in Gastrointestinal Stromal Tumors (GISTs). Methods: Eighty-two patients with GIST were enrolled in this retrospective study, including 52 patients from one ... ...

Abstract	Objectives: To develop a mutation-based radiomics signature to predict response to imatinib in Gastrointestinal Stromal Tumors (GISTs). Methods: Eighty-two patients with GIST were enrolled in this retrospective study, including 52 patients from one center that were used to develop the model, and 30 patients from a second center to validate it. Reference standard was the mutational status of tyrosine-protein kinase (KIT) and platelet-derived growth factor α (PDGFRA). Patients were dichotomized in imatinib sensitive (group 0 - mutation in KIT or PDGFRA, different from exon 18-D842V), and imatinib non-responsive (group 1 - PDGFRA exon 18-D842V mutation or absence of mutation in KIT/PDGFRA). Initially, 107 texture features were extracted from the tumor masks of baseline computed tomography scans. Different machine learning methods were then implemented to select the best combination of features for the development of the radiomics signature. Results: The best performance was obtained with the 5 features selected by the ANOVA model and the Bayes classifier, using a threshold of 0.36. With this setting the radiomics signature had an accuracy and precision for sensitive patients of 82 % (95 % CI:60–95) and 90 % (95 % CI:73–97), respectively. Conversely, a precision of 80 % (95 % CI:34–97) was obtained in non-responsive patients using a threshold of 0.9. Indeed, with the latter setting 4 patients out of 5 were correctly predicted as non-responders. Conclusions: The results are a first step towards using radiomics to improve the management of patients with GIST, especially when tumor tissue is unavailable for molecular analysis or when molecular profiling is inconclusive.
Keywords	Artificial intelligence ; Radiomics ; GIST ; Mutational status ; Response to therapy ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
Subject code	616
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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