LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 32

Search options

  1. Article ; Online: Axonal Modulation of Striatal Dopamine Release by Local γ-Aminobutyric Acid (GABA) Signalling.

    Roberts, Bradley M / Lopes, Emanuel F / Cragg, Stephanie J

    Cells

    2021  Volume 10, Issue 3

    Abstract: Striatal dopamine (DA) release is critical for motivated actions and reinforcement learning, and is locally influenced at the level of DA axons by other striatal neurotransmitters. Here, we review a wealth of historical and more recently refined evidence ...

    Abstract Striatal dopamine (DA) release is critical for motivated actions and reinforcement learning, and is locally influenced at the level of DA axons by other striatal neurotransmitters. Here, we review a wealth of historical and more recently refined evidence indicating that DA output is inhibited by striatal γ-aminobutyric acid (GABA) acting via GABA
    MeSH term(s) Animals ; Axons/metabolism ; Corpus Striatum/metabolism ; Dopamine/metabolism ; Humans ; Receptors, GABA/metabolism ; Signal Transduction ; gamma-Aminobutyric Acid/metabolism
    Chemical Substances Receptors, GABA ; gamma-Aminobutyric Acid (56-12-2) ; Dopamine (VTD58H1Z2X)
    Language English
    Publishing date 2021-03-23
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells10030709
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Synucleinopathy in Amyotrophic Lateral Sclerosis: A Potential Avenue for Antisense Therapeutics?

    Roberts, Bradley / Theunissen, Frances / Mastaglia, Francis L / Akkari, P Anthony / Flynn, Loren L

    International journal of molecular sciences

    2022  Volume 23, Issue 16

    Abstract: Amyotrophic lateral sclerosis (ALS) is the most common adult-onset motor neuron disease classified as both a neurodegenerative and neuromuscular disorder. With a complex aetiology and no current cure for ALS, broadening the understanding of disease ... ...

    Abstract Amyotrophic lateral sclerosis (ALS) is the most common adult-onset motor neuron disease classified as both a neurodegenerative and neuromuscular disorder. With a complex aetiology and no current cure for ALS, broadening the understanding of disease pathology and therapeutic avenues is required to progress with patient care. Alpha-synuclein (αSyn) is a hallmark for disease in neurodegenerative disorders, such as Parkinson's disease, Lewy body dementia, and multiple system atrophy. A growing body of evidence now suggests that αSyn may also play a pathological role in ALS, with αSyn-positive Lewy bodies co-aggregating alongside known ALS pathogenic proteins, such as
    MeSH term(s) Amyotrophic Lateral Sclerosis/genetics ; Amyotrophic Lateral Sclerosis/metabolism ; Amyotrophic Lateral Sclerosis/therapy ; Humans ; Lewy Bodies/metabolism ; Lewy Body Disease/pathology ; Multiple System Atrophy/pathology ; Synucleinopathies ; alpha-Synuclein/genetics ; alpha-Synuclein/metabolism
    Chemical Substances alpha-Synuclein
    Language English
    Publishing date 2022-08-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23169364
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Dopamine Release in Nucleus Accumbens Is under Tonic Inhibition by Adenosine A

    Roberts, Bradley M / Lambert, Elizabeth / Livesey, Jessica A / Wu, Zhaofa / Li, Yulong / Cragg, Stephanie J

    The Journal of neuroscience : the official journal of the Society for Neuroscience

    2022  Volume 42, Issue 9, Page(s) 1738–1751

    Abstract: Striatal adenosine ... ...

    Abstract Striatal adenosine A
    MeSH term(s) Adenosine/pharmacology ; Adenosine A1 Receptor Agonists/pharmacology ; Animals ; Astrocytes/drug effects ; Astrocytes/metabolism ; Dopamine/metabolism ; Equilibrative Nucleoside Transporter 1/metabolism ; Ethanol/pharmacology ; Female ; Male ; Mice ; Nucleus Accumbens/drug effects ; Nucleus Accumbens/metabolism ; Receptor, Adenosine A1/metabolism
    Chemical Substances Adenosine A1 Receptor Agonists ; Equilibrative Nucleoside Transporter 1 ; Receptor, Adenosine A1 ; SLC29A1 protein, mouse ; Ethanol (3K9958V90M) ; Adenosine (K72T3FS567) ; Dopamine (VTD58H1Z2X)
    Language English
    Publishing date 2022-01-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604637-x
    ISSN 1529-2401 ; 0270-6474
    ISSN (online) 1529-2401
    ISSN 0270-6474
    DOI 10.1523/JNEUROSCI.1548-21.2021
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1668: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Practice management curricular changes may lead to enhanced preparedness for practice.

    Roberts, Bradley S / Roberts, Eugenia P / Brachvogel, William / Stein, Amy Buros

    Journal of dental education

    2020  Volume 84, Issue 8, Page(s) 887–894

    Abstract: Purpose: The 2018 American Dental Education Association Survey of Dental School Seniors showed that 62.5% of graduates felt prepared in practice administration compared to 49.5% in 2013. The aim of this study was to survey and Internet search U.S. ... ...

    Abstract Purpose: The 2018 American Dental Education Association Survey of Dental School Seniors showed that 62.5% of graduates felt prepared in practice administration compared to 49.5% in 2013. The aim of this study was to survey and Internet search U.S. Dental Schools' Practice Management curriculum (PMC) to assess if and what changes, made in the past 5 years, may account for the continued increase in dental graduates' perception of preparedness for practice METHODS: An electronic survey was emailed to 64 dental schools querying factors for changes in PMC, updates in instructors, instructional methods, technology, topics, hours, and content enhancements. In addition, if a dual degree in business administration was developed or planned in the future.
    Results: Twenty-three schools responded for a 36.0% response rate. All participants (100.0%) indicated PMC changes, 73.9% responded that changes were motivated by student interest, and 60.9% planned future PMC improvements. All respondents (100.0%) updated subject matter and 52.2% had added technology, including Web-based business model and simulation courses. Two schools added dual degree MBA programs in 2017 due to student interest in entrepreneurship and administrative goals.
    Conclusion: The study showed that upgrades in topics and teaching methods with Web-based technology, dual degrees, and additional focus on PMC hours, sequence, and number of practice administration courses in D1 and D2 years may be contributory factors for the development of enhanced skills and enhanced attitudes of graduates for practice readiness. Future study is needed to assess if these PMC improvements and advanced business courses have been successful in practicing dentists' careers.
    MeSH term(s) Curriculum ; Education, Dental ; Humans ; Surveys and Questionnaires
    Language English
    Publishing date 2020-03-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 410579-5
    ISSN 1930-7837 ; 0022-0337
    ISSN (online) 1930-7837
    ISSN 0022-0337
    DOI 10.1002/jdd.12136
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 428: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Dopamine neuron morphology and output are differentially controlled by mTORC1 and mTORC2.

    Kosillo, Polina / Ahmed, Kamran M / Aisenberg, Erin E / Karalis, Vasiliki / Roberts, Bradley M / Cragg, Stephanie J / Bateup, Helen S

    eLife

    2022  Volume 11

    Abstract: The mTOR pathway is an essential regulator of cell growth and metabolism. Midbrain dopamine neurons are particularly sensitive to mTOR signaling status as activation or inhibition of mTOR alters their morphology and physiology. mTOR exists in two ... ...

    Abstract The mTOR pathway is an essential regulator of cell growth and metabolism. Midbrain dopamine neurons are particularly sensitive to mTOR signaling status as activation or inhibition of mTOR alters their morphology and physiology. mTOR exists in two distinct multiprotein complexes termed mTORC1 and mTORC2. How each of these complexes affect dopamine neuron properties, and whether they have similar or distinct functions is unknown. Here, we investigated this in mice with dopamine neuron-specific deletion of
    MeSH term(s) Animals ; Dopamine ; Dopaminergic Neurons/metabolism ; Mechanistic Target of Rapamycin Complex 1 ; Mechanistic Target of Rapamycin Complex 2 ; Mice ; TOR Serine-Threonine Kinases/metabolism
    Chemical Substances Mechanistic Target of Rapamycin Complex 1 (EC 2.7.11.1) ; Mechanistic Target of Rapamycin Complex 2 (EC 2.7.11.1) ; TOR Serine-Threonine Kinases (EC 2.7.11.1) ; Dopamine (VTD58H1Z2X)
    Language English
    Publishing date 2022-07-26
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.75398
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Dental Students' Use of Student-Managed Google Docs and Other Technologies in Collaborative Learning.

    Roberts, Bradley S / Roberts, Eugenia P / Reynolds, Steven / Stein, Amy F

    Journal of dental education

    2019  Volume 83, Issue 4, Page(s) 437–444

    Abstract: Textbooks, once the standard of education, now have competition when students prefer the Internet and digital technology. The aim of this research study was to survey dental students at one dental school about their use of student-managed Google Docs and ...

    Abstract Textbooks, once the standard of education, now have competition when students prefer the Internet and digital technology. The aim of this research study was to survey dental students at one dental school about their use of student-managed Google Docs and other online technologies in collaborative e-learning. All dental students in all four classes at Midwestern University College of Dental Medicine-Arizona were invited to participate in online surveys in 2015 and 2017. The average class size was 140 (n=560 for all four years) for each survey. The 2015 survey focused on the emerging use of Google Docs in collaborative learning. The 2017 study asked not only about Google Docs but how students were using other e-learning technologies and textbooks. In 2015, 282 students responded, for a 50.4% response rate; in 2017, 129 students responded, for a 23% response rate. The 2017 survey showed a 36% increase (p<0.0001) in the use of Google Docs in all dental classes over use in 2015, and a 67% increase (p<0.0001) in respondents' reporting they had used Google Docs during their undergraduate education. Google Docs, Blackboard, and collaboration with peers were the most popular study choices in 2017. The results showed a decline in respondents' reported use of hard copy textbooks from 24.5% in 2015 to 14.8% in 2017 (p=0.0405). Future studies are needed to increase dental educators' understanding of the ways their students are using collaborative technologies in learning and to define ways to overcome challenges posed by these technologies identified in our study.
    MeSH term(s) Computer-Assisted Instruction/methods ; Cooperative Behavior ; Education, Dental/methods ; Educational Technology ; Female ; Humans ; Male ; Students, Dental/psychology ; Textbooks as Topic
    Language English
    Publishing date 2019-02-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 410579-5
    ISSN 1930-7837 ; 0022-0337
    ISSN (online) 1930-7837
    ISSN 0022-0337
    DOI 10.21815/JDE.019.053
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 428: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article: Utility of pharmacogenetic testing to optimise antidepressant pharmacotherapy in youth: a narrative literature review.

    Roberts, Bradley / Cooper, Zahra / Lu, Stephanie / Stanley, Susanne / Majda, Bernadette T / Collins, Khan R L / Gilkes, Lucy / Rodger, Jennifer / Akkari, P Anthony / Hood, Sean D

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1267294

    Abstract: Pharmacogenetics (PGx) is the study and application of how interindividual differences in our genomes can influence drug responses. By evaluating individuals' genetic variability in genes related to drug metabolism, PGx testing has the capabilities to ... ...

    Abstract Pharmacogenetics (PGx) is the study and application of how interindividual differences in our genomes can influence drug responses. By evaluating individuals' genetic variability in genes related to drug metabolism, PGx testing has the capabilities to individualise primary care and build a safer drug prescription model than the current "one-size-fits-all" approach. In particular, the use of PGx testing in psychiatry has shown promising evidence in improving drug efficacy as well as reducing toxicity and adverse drug reactions. Despite randomised controlled trials demonstrating an evidence base for its use, there are still numerous barriers impeding its implementation. This review paper will discuss the management of mental health conditions with PGx-guided treatment with a strong focus on youth mental illness. PGx testing in clinical practice, the concerns for its implementation in youth psychiatry, and some of the barriers inhibiting its integration in clinical healthcare will also be discussed. Overall, this paper provides a comprehensive review of the current state of knowledge and application for PGx in psychiatry and summarises the capabilities of genetic information to personalising medicine for the treatment of mental ill-health in youth.
    Language English
    Publishing date 2023-09-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1267294
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Dental Bite-Sized Bits: A Module for Teaching Common Oral Health Conditions to Multidisciplinary Students.

    Mills, Denise A / Chu, Anita S / Burns, Andrea / Hoover, Eve B / Wild, Jennifer / Post, Gretchen / Sears, Robyn / Herrick, Amber / Black, Deborah / Roberts, Eugenia P / Roberts, Bradley S

    Medical science educator

    2023  Volume 33, Issue 2, Page(s) 451–458

    Abstract: The Surgeon General's report in the year 2000 highlighted the association between chronic diseases and oral health infections. Current healthcare education programs, regrettably, report only 1 to 3 h of oral health instruction within curricula. In the ... ...

    Abstract The Surgeon General's report in the year 2000 highlighted the association between chronic diseases and oral health infections. Current healthcare education programs, regrettably, report only 1 to 3 h of oral health instruction within curricula. In the years 2020-2022, as part of their respective oral health curricula, 278 first-year physician assistant and 12 pre-clinical second-year pharmacy students were invited to participate in a voluntary survey examining the effectiveness of animated succinct, online video-based oral health units. Among all student responses for the post-use survey, respondents "strongly agreed" or "agreed" that learning objectives of the unit(s) were achieved after reviewing the videos. Of the participants, 97% "strongly agreed" or "agreed" that the videos helped them understand information of which they had no prior knowledge. Similarly, 98% "strongly agreed" or "agreed" the information was appropriate for their level of knowledge. Most students, 93%, "strongly agreed" or "agreed" the exercise was a valuable learning experience. Regarding the importance of future interprofessional collaboration pertaining to a mutual patient's oral health, 95% of participants "strongly agreed" or "agreed" that they would be likely to collaborate. This study demonstrates the importance of oral health as a critical area of focus in healthcare education. The study also confirms the hypothesis that Dental Bite-Sized Bits units deliver engaging, valuable oral health education for preclinical healthcare learners, incorporating interprofessional perspectives from the disciplines of dental, pharmacy, and physician assistant.
    Language English
    Publishing date 2023-02-24
    Publishing country United States
    Document type Journal Article
    ISSN 2156-8650
    ISSN (online) 2156-8650
    DOI 10.1007/s40670-023-01760-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  9. Article ; Online: Inhibition of striatal dopamine release by the L-type calcium channel inhibitor isradipine co-varies with risk factors for Parkinson's.

    Brimblecombe, Katherine R / Connor-Robson, Natalie / Bataille, Carole J R / Roberts, Bradley M / Gracie, Caitlin / O'Connor, Bethan / Te Water Naude, Rebecca / Karthik, Gayathri / Russell, Angela J / Wade-Martins, Richard / Cragg, Stephanie J

    The European journal of neuroscience

    2023  Volume 59, Issue 6, Page(s) 1242–1259

    Abstract: ... ...

    Abstract Ca
    MeSH term(s) Female ; Mice ; Animals ; Male ; Isradipine/pharmacology ; Isradipine/metabolism ; Dopamine/metabolism ; Calcium Channels, L-Type/metabolism ; alpha-Synuclein/metabolism ; Parkinson Disease/metabolism ; Corpus Striatum/metabolism ; Dopaminergic Neurons/metabolism ; Substantia Nigra/metabolism ; Risk Factors ; Calcium/metabolism
    Chemical Substances Isradipine (YO1UK1S598) ; Dopamine (VTD58H1Z2X) ; Calcium Channels, L-Type ; alpha-Synuclein ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2023-11-08
    Publishing country France
    Document type Journal Article
    ZDB-ID 645180-9
    ISSN 1460-9568 ; 0953-816X
    ISSN (online) 1460-9568
    ISSN 0953-816X
    DOI 10.1111/ejn.16180
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2548: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Ensemble encoding of action speed by striatal fast-spiking interneurons.

    Roberts, Bradley M / White, Michael G / Patton, Mary H / Chen, Rong / Mathur, Brian N

    Brain structure & function

    2019  Volume 224, Issue 7, Page(s) 2567–2576

    Abstract: Striatal fast-spiking interneurons (FSIs) potently inhibit the output neurons of the striatum and, as such, powerfully modulate action learning. Through electrical synaptic coupling, FSIs are theorized to temporally coordinate their activity. This has ... ...

    Abstract Striatal fast-spiking interneurons (FSIs) potently inhibit the output neurons of the striatum and, as such, powerfully modulate action learning. Through electrical synaptic coupling, FSIs are theorized to temporally coordinate their activity. This has important implications for their ability to temporally summate inhibition on downstream striatal projection neurons. While some in vivo single-unit electrophysiological recordings of putative FSIs support coordinated firing, others do not. Moreover, it is unclear as to what aspect of action FSIs encode. To address this, we used in vivo calcium imaging of genetically identified FSIs in freely moving mice and applied machine learning analyses to decipher the relationship between FSI activity and movement. We report that FSIs exhibit ensemble activity that encodes the speed of action sub-components, including ambulation and head movements. These results suggest FSI population dynamics fit within a Hebbian model for ensemble inhibition of striatal output guiding action.
    MeSH term(s) Action Potentials/physiology ; Animals ; Corpus Striatum/physiology ; Female ; Interneurons/physiology ; Male ; Mice, Transgenic ; Neostriatum/physiology ; Neurons/physiology
    Language English
    Publishing date 2019-06-26
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2273162-3
    ISSN 1863-2661 ; 1863-2653
    ISSN (online) 1863-2661
    ISSN 1863-2653
    DOI 10.1007/s00429-019-01908-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ub I Zs.90: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top