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  1. AU="Robertson, Anne"
  2. AU="Davis, Rebecca"
  3. AU="Joy, Tisha R"
  4. AU="Özil, Musa"
  5. AU="Franci, Lorenzo"
  6. AU="Khoobdel, Mehdi"
  7. AU="Ian B Wilkinson"
  8. AU="Sarpün, I.H."
  9. AU="Gums, Jeremiah J"
  10. AU="Petsalaki, Eleni"
  11. AU="Yu, Weichao"
  12. AU="Mertens, Anne Wiebke"
  13. AU="Roitershtein, Alexander"
  14. AU="Deppen, Stephen"
  15. AU="Goliath, Rene"
  16. AU="Emons, Günter"
  17. AU="Sarah S. Barnett"

Suchergebnis

Treffer 1 - 10 von insgesamt 142

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  1. Buch: Developments in hyporheic zone ecosystem processes and functions

    Robertson, Anne L.

    50 years of research

    (Fundamental and applied limnology ; 176,4)

    2010  

    Verfasserangabe Anne L. Robertson ... (eds)
    Serientitel Fundamental and applied limnology ; 176,4
    Überordnung
    Schlagwörter Hydrobiologie ; Limnologie ; Hyporheisches Interstitial ; Wirbellose
    Schlagwörter Evertebrata ; Invertebrata ; Niedere Tiere ; Invertebraten ; Hyporheal ; Interstitial ; Seenkunde ; Süßwasserbiologie ; Binnengewässerkunde ; Gewässerbiologie
    Sprache Deutsch
    Umfang S. [279] - 405 : Ill., graph. Darst., Kt.
    Verlag Schweizerbart
    Erscheinungsort Stuttgart
    Erscheinungsland Deutschland
    Dokumenttyp Buch
    HBZ-ID HT016649012
    Datenquelle Katalog ZB MED Ernährung, Umwelt, Agrar

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    Verfügbar in ZB MED Bonn

    SignaturLeihstatusStandort
    Z 7866 (176,4) ausleihbar (Lesesaal) Freihandmagazin (U1)

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  2. Artikel ; Online: Phenotyping calcification in vascular tissues using artificial intelligence.

    Ramezanpour, Mehdi / Robertson, Anne M / Tobe, Yasutaka / Jia, Xiaowei / Cebral, Juan R

    ArXiv

    2024  

    Abstract: Vascular calcification is implicated as an important factor in major adverse cardiovascular events (MACE), including heart attack and stroke. A controversy remains over how to integrate the diverse forms of vascular calcification into clinical risk ... ...

    Abstract Vascular calcification is implicated as an important factor in major adverse cardiovascular events (MACE), including heart attack and stroke. A controversy remains over how to integrate the diverse forms of vascular calcification into clinical risk assessment tools. Even the commonly used calcium score for coronary arteries, which assumes risk scales positively with total calcification, has important inconsistencies. Fundamental studies are needed to determine how risk is influenced by the diverse calcification phenotypes. However, studies of these kinds are hindered by the lack of high-throughput, objective, and non-destructive tools for classifying calcification in imaging data sets. Here, we introduce a new classification system for phenotyping calcification along with a semi-automated, non-destructive pipeline that can distinguish these phenotypes in even atherosclerotic tissues. The pipeline includes a deep-learning-based framework for segmenting lipid pools in noisy μ-CT images and an unsupervised clustering framework for categorizing calcification based on size, clustering, and topology. This approach is illustrated for five vascular specimens, providing phenotyping for thousands of calcification particles across as many as 3200 images in less than seven hours. Average Dice Similarity Coefficients of 0.96 and 0.87 could be achieved for tissue and lipid pool, respectively, with training and validation needed on only 13 images despite the high heterogeneity in these tissues. By introducing an efficient and comprehensive approach to phenotyping calcification, this work enables large-scale studies to identify a more reliable indicator of the risk of cardiovascular events, a leading cause of global mortality and morbidity.
    Sprache Englisch
    Erscheinungsdatum 2024-01-17
    Erscheinungsland United States
    Dokumenttyp Preprint
    ISSN 2331-8422
    ISSN (online) 2331-8422
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Evaluation of predictive models of aneurysm focal growth and bleb development using machine learning techniques.

    Hadad, Sara / Mut, Fernando / Slawski, Martin / Robertson, Anne M / Cebral, Juan R

    Journal of neurointerventional surgery

    2024  Band 16, Heft 4, Seite(n) 392–397

    Abstract: Background: The presence of blebs increases the rupture risk of intracranial aneurysms (IAs).: Objective: To evaluate whether cross-sectional bleb formation models can identify aneurysms with focalized enlargement in longitudinal series.: Methods: ...

    Abstract Background: The presence of blebs increases the rupture risk of intracranial aneurysms (IAs).
    Objective: To evaluate whether cross-sectional bleb formation models can identify aneurysms with focalized enlargement in longitudinal series.
    Methods: Hemodynamic, geometric, and anatomical variables derived from computational fluid dynamics models of 2265 IAs from a cross-sectional dataset were used to train machine learning (ML) models for bleb development. ML algorithms, including logistic regression, random forest, bagging method, support vector machine, and K-nearest neighbors, were validated using an independent cross-sectional dataset of 266 IAs. The models' ability to identify aneurysms with focalized enlargement was evaluated using a separate longitudinal dataset of 174 IAs. Model performance was quantified by the area under the receiving operating characteristic curve (AUC), the sensitivity and specificity, positive predictive value, negative predictive value, F1 score, balanced accuracy, and misclassification error.
    Results: The final model, with three hemodynamic and four geometrical variables, along with aneurysm location and morphology, identified strong inflow jets, non-uniform wall shear stress with high peaks, larger sizes, and elongated shapes as indicators of a higher risk of focal growth over time. The logistic regression model demonstrated the best performance on the longitudinal series, achieving an AUC of 0.9, sensitivity of 85%, specificity of 75%, balanced accuracy of 80%, and a misclassification error of 21%.
    Conclusions: Models trained with cross-sectional data can identify aneurysms prone to future focalized growth with good accuracy. These models could potentially be used as early indicators of future risk in clinical practice.
    Mesh-Begriff(e) Humans ; Cross-Sectional Studies ; Intracranial Aneurysm/diagnostic imaging ; Intracranial Aneurysm/surgery ; Hemodynamics ; Machine Learning ; Aneurysm, Ruptured/surgery
    Sprache Englisch
    Erscheinungsdatum 2024-03-14
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2514982-9
    ISSN 1759-8486 ; 1759-8478
    ISSN (online) 1759-8486
    ISSN 1759-8478
    DOI 10.1136/jnis-2023-020241
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 6845: Hefte anzeigen Standort:
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  4. Artikel ; Online: Quantifying Smooth Muscles Regional Organization in the Rat Bladder Using Immunohistochemistry, Multiphoton Microscopy and Machine Learning.

    Asadbeygi, Alireza / Tobe, Yasutaka / Yoshimura, Naoki / Stocker, Sean D / Watkins, Simon / Watton, Paul / Robertson, Anne M

    ArXiv

    2024  

    Abstract: The smooth muscle bundles (SMBs) in the bladder act as contractile elements which enable the bladder to void effectively. In contrast to skeletal muscles, these bundles are not highly aligned, rather they are oriented more heterogeneously throughout the ... ...

    Abstract The smooth muscle bundles (SMBs) in the bladder act as contractile elements which enable the bladder to void effectively. In contrast to skeletal muscles, these bundles are not highly aligned, rather they are oriented more heterogeneously throughout the bladder wall. In this work, for the first time, this regional orientation of the SMBs is quantified across the whole bladder, without the need for optical clearing or cryosectioning. Immunohistochemistry staining was utilized to visualize smooth muscle cell actin in multiphoton microscopy (MPM) images of bladder smooth muscle bundles (SMBs). Feature vectors for each pixel were generated using a range of filters, including Gaussian blur, Gaussian gradient magnitude, Laplacian of Gaussian, Hessian eigenvalues, structure tensor eigenvalues, Gabor, and Sobel gradients. A Random Forest classifier was subsequently trained to automate the segmentation of SMBs in the MPM images. Finally, the orientation of SMBs in each bladder region was quantified using the CT-FIRE package. This information is essential for biomechanical models of the bladder that include contractile elements.
    Sprache Englisch
    Erscheinungsdatum 2024-05-08
    Erscheinungsland United States
    Dokumenttyp Preprint
    ISSN 2331-8422
    ISSN (online) 2331-8422
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Buch ; Online: Phenotyping calcification in vascular tissues using artificial intelligence

    Ramezanpour, Mehdi / Robertson, Anne M. / Tobe, Yasutaka / Jia, Xiaowei / Cebral, Juan R.

    2024  

    Abstract: Vascular calcification is implicated as an important factor in major adverse cardiovascular events (MACE), including heart attack and stroke. A controversy remains over how to integrate the diverse forms of vascular calcification into clinical risk ... ...

    Abstract Vascular calcification is implicated as an important factor in major adverse cardiovascular events (MACE), including heart attack and stroke. A controversy remains over how to integrate the diverse forms of vascular calcification into clinical risk assessment tools. Even the commonly used calcium score for coronary arteries, which assumes risk scales positively with total calcification, has important inconsistencies. Fundamental studies are needed to determine how risk is influenced by the diverse calcification phenotypes. However, studies of these kinds are hindered by the lack of high-throughput, objective, and non-destructive tools for classifying calcification in imaging data sets. Here, we introduce a new classification system for phenotyping calcification along with a semi-automated, non-destructive pipeline that can distinguish these phenotypes in even atherosclerotic tissues. The pipeline includes a deep-learning-based framework for segmenting lipid pools in noisy micro-CT images and an unsupervised clustering framework for categorizing calcification based on size, clustering, and topology. This approach is illustrated for five vascular specimens, providing phenotyping for thousands of calcification particles across as many as 3200 images in less than seven hours. Average Dice Similarity Coefficients of 0.96 and 0.87 could be achieved for tissue and lipid pool, respectively, with training and validation needed on only 13 images despite the high heterogeneity in these tissues. By introducing an efficient and comprehensive approach to phenotyping calcification, this work enables large-scale studies to identify a more reliable indicator of the risk of cardiovascular events, a leading cause of global mortality and morbidity.
    Schlagwörter Computer Science - Computer Vision and Pattern Recognition ; Physics - Data Analysis ; Statistics and Probability ; Quantitative Biology - Quantitative Methods ; Quantitative Biology - Tissues and Organs
    Thema/Rubrik (Code) 006
    Erscheinungsdatum 2024-01-15
    Erscheinungsland us
    Dokumenttyp Buch ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel: The Scottish children's panels as a catalyst for civic engagement and child well-being.

    Robertson, Anne S

    Child welfare

    2014  Band 93, Heft 1, Seite(n) 59–77

    Abstract: Scotland's child welfare system has developed as hybrid of both residual and universal approaches and incorporates local involvement through trained volunteers participating in children's panels and community-based interventions. Furthermore, Scotland's ... ...

    Abstract Scotland's child welfare system has developed as hybrid of both residual and universal approaches and incorporates local involvement through trained volunteers participating in children's panels and community-based interventions. Furthermore, Scotland's move toward independence from the United Kingdom, called devolution in Scotland, has resulted in a resurgence of new recommendations focused on child well-being from birth through adolescence for all Scottish children. This article will explore policy development of Scotland's unique child welfare approach through the children's panels and the commitment to civic participation. It will expand on how recent initiatives, policy, and practice guidelines may have implications for providing a promising, sustainable model focused on child well-being, and may be useful for consideration in other cultural contexts that view liberty and civic engagement as core values.
    Mesh-Begriff(e) Child ; Child Welfare ; Community-Institutional Relations ; Cooperative Behavior ; Humans ; Scotland ; Volunteers
    Sprache Englisch
    Erscheinungsdatum 2014
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 220859-3
    ISSN 0009-4021
    ISSN 0009-4021
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    Verfügbar in ZB MED Köln/Königswinter

    Zs.B 1803: Hefte anzeigen Standort:
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  7. Artikel: Correction: Danner et al. It More than Adds Up: Interaction of Antibiotic Mixing and Temperature.

    Danner, Marie-Claire / Azams, Sharon Omonor / Robertson, Anne / Perkins, Daniel / Behrends, Volker / Reiss, Julia

    Life (Basel, Switzerland)

    2022  Band 12, Heft 5

    Abstract: The Authors wish to make the following corrections to this paper [ ... ]. ...

    Abstract The Authors wish to make the following corrections to this paper [...].
    Sprache Englisch
    Erscheinungsdatum 2022-05-07
    Erscheinungsland Switzerland
    Dokumenttyp Published Erratum
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life12050695
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Differences Between Ruptured Aneurysms With and Without Blebs: Mechanistic Implications.

    Salimi Ashkezari, Seyedeh Fatemeh / Mut, Fernando / Robertson, Anne M / Cebral, Juan R

    Cardiovascular engineering and technology

    2022  Band 14, Heft 1, Seite(n) 92–103

    Abstract: Purpose: Blebs are known risk factors for intracranial aneurysm (IA) rupture. We analyzed differences between IAs that ruptured with blebs and those that ruptured without developing blebs to identify distinguishing characteristics among them and suggest ...

    Abstract Purpose: Blebs are known risk factors for intracranial aneurysm (IA) rupture. We analyzed differences between IAs that ruptured with blebs and those that ruptured without developing blebs to identify distinguishing characteristics among them and suggest possible mechanistic implications.
    Methods: Using image-based models, 25 hemodynamic and geometric parameters were compared between ruptured IAs with and without blebs (n = 673), stratified by location. Hemodynamic and geometric differences between bifurcation and sidewall aneurysms and for aneurysms at five locations were also analyzed.
    Results: Ruptured aneurysms harboring blebs were exposed to higher flow conditions than aneurysms that ruptured without developing blebs, and this was consistent across locations. Bifurcation aneurysms were exposed to higher flow conditions than sidewall aneurysms. They had larger maximum wall shear stress (WSS), more concentrated WSS distribution, and larger numbers of critical points than sidewall aneurysms. Additionally, bifurcation aneurysms were larger, more elongated, and had more distorted shapes than sidewall aneurysms. Aneurysm morphology was associated with aneurysm location (p < 0.01). Flow conditions were different between aneurysm locations.
    Conclusion: Aneurysms at different locations are likely to develop into varying morphologies and thus be exposed to diverse flow conditions that may predispose them to follow distinct pathways towards rupture with or without bleb development. This could explain the diverse rupture rates and bleb presence in aneurysms at different locations.
    Mesh-Begriff(e) Humans ; Aneurysm, Ruptured ; Hemodynamics ; Intracranial Aneurysm/diagnostic imaging ; Risk Factors ; Stress, Mechanical
    Sprache Englisch
    Erscheinungsdatum 2022-07-11
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2543111-0
    ISSN 1869-4098 ; 1869-408X
    ISSN (online) 1869-4098
    ISSN 1869-408X
    DOI 10.1007/s13239-022-00640-4
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Computational fluid dynamics-based virtual angiograms for the detection of flow stagnation in intracranial aneurysms.

    Hadad, Sara / Karnam, Yogesh / Mut, Fernando / Lohner, Rainald / Robertson, Anne M / Kaneko, Naoki / Cebral, Juan R

    International journal for numerical methods in biomedical engineering

    2023  Band 39, Heft 8, Seite(n) e3740

    Abstract: The goal of this study was to test if CFD-based virtual angiograms could be used to automatically discriminate between intracranial aneurysms (IAs) with and without flow stagnation. Time density curves (TDC) were extracted from patient digital ... ...

    Abstract The goal of this study was to test if CFD-based virtual angiograms could be used to automatically discriminate between intracranial aneurysms (IAs) with and without flow stagnation. Time density curves (TDC) were extracted from patient digital subtraction angiography (DSA) image sequences by computing the average gray level intensity inside the aneurysm region and used to define injection profiles for each subject. Subject-specific 3D models were reconstructed from 3D rotational angiography (3DRA) and computational fluid dynamics (CFD) simulations were performed to simulate the blood flow inside IAs. Transport equations were solved numerically to simulate the dynamics of contrast injection into the parent arteries and IAs and then the contrast retention time (RET) was calculated. The importance of gravitational pooling of contrast agent within the aneurysm was evaluated by modeling contrast agent and blood as a mixture of two fluids with different densities and viscosities. Virtual angiograms can reproduce DSA sequences if the correct injection profile is used. RET can identify aneurysms with significant flow stagnation even when the injection profile is not known. Using a small sample of 14 IAs of which seven were previously classified as having flow stagnation, it was found that a threshold RET value of 0.46 s can successfully identify flow stagnation. CFD-based prediction of stagnation was in more than 90% agreement with independent visual DSA assessment of stagnation in a second sample of 34 IAs. While gravitational pooling prolonged contrast retention time it did not affect the predictive capabilities of RET. CFD-based virtual angiograms can detect flow stagnation in IAs and can be used to automatically identify aneurysms with flow stagnation even without including gravitational effects on contrast agents.
    Mesh-Begriff(e) Humans ; Intracranial Aneurysm/diagnostic imaging ; Contrast Media ; Hydrodynamics ; Angiography, Digital Subtraction ; Hemodynamics ; Imaging, Three-Dimensional
    Chemische Substanzen Contrast Media
    Sprache Englisch
    Erscheinungsdatum 2023-06-08
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2540968-2
    ISSN 2040-7947 ; 2040-7939
    ISSN (online) 2040-7947
    ISSN 2040-7939
    DOI 10.1002/cnm.3740
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Multimodal exploration of the intracranial aneurysm wall.

    Niemann, Annika / Tulamo, Riikka / Netti, Eliisa / Preim, Bernhard / Berg, Philipp / Cebral, Juan / Robertson, Anne / Saalfeld, Sylvia

    International journal of computer assisted radiology and surgery

    2023  Band 18, Heft 12, Seite(n) 2243–2252

    Abstract: Purpose: Intracranial aneurysms (IAs) are pathological changes of the intracranial vessel wall, although clinical image data can only show the vessel lumen. Histology can provide wall information but is typically restricted to ex vivo 2D slices where ... ...

    Abstract Purpose: Intracranial aneurysms (IAs) are pathological changes of the intracranial vessel wall, although clinical image data can only show the vessel lumen. Histology can provide wall information but is typically restricted to ex vivo 2D slices where the shape of the tissue is altered.
    Methods: We developed a visual exploration pipeline for a comprehensive view of an IA. We extract multimodal information (like stain classification and segmentation of histologic images) and combine them via 2D to 3D mapping and virtual inflation of deformed tissue. Histological data, including four stains, micro-CT data and segmented calcifications as well as hemodynamic information like wall shear stress (WSS), are combined with the 3D model of the resected aneurysm.
    Results: Calcifications were mostly present in the tissue part with increased WSS. In the 3D model, an area of increased wall thickness was identified and correlated to histology, where the Oil red O (ORO) stained images showed a lipid accumulation and the alpha-smooth muscle actin (aSMA) stained images showed a slight loss of muscle cells.
    Conclusion: Our visual exploration pipeline combines multimodal information about the aneurysm wall to improve the understanding of wall changes and IA development. The user can identify regions and correlate how hemodynamic forces, e.g. WSS, are reflected by histological structures of the vessel wall, wall thickness and calcifications.
    Mesh-Begriff(e) Humans ; Intracranial Aneurysm/diagnostic imaging ; Intracranial Aneurysm/pathology ; Hemodynamics/physiology ; Imaging, Three-Dimensional/methods ; Stress, Mechanical
    Sprache Englisch
    Erscheinungsdatum 2023-03-06
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 2365628-1
    ISSN 1861-6429 ; 1861-6410
    ISSN (online) 1861-6429
    ISSN 1861-6410
    DOI 10.1007/s11548-023-02850-0
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 6615: Hefte anzeigen Standort:
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