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  1. Article: Case report: Delayed posttraumatic cortical laminar necrosis secondary to spreading depolarization induced spreading ischemia from old subarachnoid hemorrhage.

    Irfanullah, Zakariya / Özütemiz, Ayça Özbek / Robertson, Jetter / Özütemiz, Can

    Radiology case reports

    2022  Volume 17, Issue 6, Page(s) 2220–2226

    Abstract: Cortical laminar necrosis usually occurs secondary to infarcts or hypoxia, however other causes, including hypoglycemia, status epilepticus and immunosuppressive therapy have been reported. To our knowledge, CLN is not a phenomenon expected in the case ... ...

    Abstract Cortical laminar necrosis usually occurs secondary to infarcts or hypoxia, however other causes, including hypoglycemia, status epilepticus and immunosuppressive therapy have been reported. To our knowledge, CLN is not a phenomenon expected in the case of trauma. We report a unique case of delayed post-traumatic CLN which occurred 30 days after the initial trauma, without any proven cause apart from possible spreading depolarization induced spreading ischemia from adjacent subarachnoid hemorrhage with distinct radiologic features.
    Language English
    Publishing date 2022-04-20
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2406300-9
    ISSN 1930-0433
    ISSN 1930-0433
    DOI 10.1016/j.radcr.2022.02.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: EEG Correlates of Spikes in Intracranial Pressure Caused by Transient Ventriculoperitoneal Shunt Malfunction.

    Wang, Paul / Dona, Allison / Khetarpal, Nikita / Reeder, Stephanie / Robertson, Jetter / Patel, Sima

    Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society

    2023  Volume 40, Issue 6, Page(s) 562–565

    Abstract: Summary: A 30-year-old man with recurrent headaches and seizure-like activity and a 26-year-old woman with worsening headaches were admitted to the hospital. Both had ventriculoperitoneal shunts and history of several shunt revisions for congenital ... ...

    Abstract Summary: A 30-year-old man with recurrent headaches and seizure-like activity and a 26-year-old woman with worsening headaches were admitted to the hospital. Both had ventriculoperitoneal shunts and history of several shunt revisions for congenital hydrocephalus. The ventricle size visualized on computed tomography scans was unremarkable, and shunt series were negative in both cases. Both patients began to present with brief periods of unresponsiveness, and video electroencephalography at that time showed periods of diffuse delta slowing. Lumbar punctures revealed increased opening pressures. Despite normal imaging and shunt series, both patients ultimately had increased intracranial pressure caused by shunt malfunction. This series demonstrates the difficulty of diagnosing potential transient increases in intracranial pressure based on standard-of-care diagnostics/examination and the potentially critical role for EEG in the identification of shunt malfunction.
    MeSH term(s) Male ; Female ; Humans ; Adult ; Ventriculoperitoneal Shunt/adverse effects ; Intracranial Pressure ; Hydrocephalus/surgery ; Headache ; Electroencephalography
    Language English
    Publishing date 2023-03-08
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 605640-4
    ISSN 1537-1603 ; 0736-0258
    ISSN (online) 1537-1603
    ISSN 0736-0258
    DOI 10.1097/WNP.0000000000001002
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1921: Show issues Location:
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  3. Article ; Online: Creutzfeldt-Jakob Disease May Present Early With Unusual Bulbar Predominance.

    Ghannam, Malik / Patel, Roshni / Nichols, Kent / Smith, Andrew / Robertson, Jetter / Berry, Brent M

    The neurologist

    2021  Volume 26, Issue 2, Page(s) 69–72

    Abstract: Introduction: Creutzfeldt-Jakob disease (CJD) is a prion protein disorder of significant consequence and currently incurable. Diagnosis can be challenging early in the disease course. CJD can present in many ways but often fits a pattern of cognitive ... ...

    Abstract Introduction: Creutzfeldt-Jakob disease (CJD) is a prion protein disorder of significant consequence and currently incurable. Diagnosis can be challenging early in the disease course. CJD can present in many ways but often fits a pattern of cognitive problems, cerebellar disturbance, behavioral/psychological changes, and perhaps myoclonus.
    Case report: We herein present the case of a 69-year-old White male with subacute progressive bulbar and limb weakness over ten weeks period. Early on, he was diagnosed with amyotrophic lateral sclerosis versus autoimmune-related bulbar neuropathy and treated as such. However, he continued to deteriorate clinically that prompted another admission, upon readmission, his cerebrospinal fluid RTQuick and 14-3-3 from the National Prion Disease Pathology Surveillance Center (NPDPSC) did eventually return positive. Hence he was diagnosed with CJD.
    Conclusions: CJD may present with progressive bulbar symptoms similar to acute inflammatory demyelinating polyradiculoneuropathy (MF variant), motor neuron disease, or autoimmune brainstem encephalitis. It becomes even higher on the differentials especially with no response to immunotherapy.
    MeSH term(s) Aged ; Brain ; Creutzfeldt-Jakob Syndrome/diagnosis ; Disease Progression ; Encephalitis ; Humans ; Male ; Myoclonus
    Language English
    Publishing date 2021-03-04
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1361380-7
    ISSN 2331-2637 ; 1074-7931
    ISSN (online) 2331-2637
    ISSN 1074-7931
    DOI 10.1097/NRL.0000000000000321
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  4. Article ; Online: Neurological involvement of coronavirus disease 2019: a systematic review.

    Ghannam, Malik / Alshaer, Qasem / Al-Chalabi, Mustafa / Zakarna, Lara / Robertson, Jetter / Manousakis, Georgios

    Journal of neurology

    2020  Volume 267, Issue 11, Page(s) 3135–3153

    Abstract: Background: In December 2019, unexplained cases of pneumonia emerged in Wuhan, China, which were found to be secondary to the novel coronavirus SARS-CoV-2. On March 11, 2020, the WHO declared the Coronavirus Disease 2019 (COVID-2019) outbreak, a ... ...

    Abstract Background: In December 2019, unexplained cases of pneumonia emerged in Wuhan, China, which were found to be secondary to the novel coronavirus SARS-CoV-2. On March 11, 2020, the WHO declared the Coronavirus Disease 2019 (COVID-2019) outbreak, a pandemic.
    Objective: To clarify the neurological complications of SARS-CoV-2 infection including the potential mechanisms and therapeutic options.
    Methods: We conducted a systematic literature search from December 01, 2019 to May 14, 2020 using multiple combinations of keywords from PubMed and Ovid Medline databases according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. We included articles with cases of COVID-19 where neurological involvement was evident.
    Results: We were able to identify 82 cases of COVID-19 with neurological complications. The mean age was 62.3 years. 37.8% of the patients were women (n = 31). 48.8% of the patients (n = 40) had cerebrovascular insults, 28% (n = 23) had neuromuscular disorders, and 23% of the patients (n = 19) had encephalitis or encephalopathy.
    Conclusions: Neurological manifestations of COVID-19 are not rare, especially large vessel stroke, Guillain-Barre syndrome, and meningoencephalitis. Moving forward, further studies are needed to clarify the prevalence of the neurological complications of SARS-CoV-2 infection, investigate their biological backgrounds, and test treatment options. Physicians should be cautious not to overlook other neurological diagnoses that can mimic COVID-19 during the pandemic.
    MeSH term(s) Adult ; Aged ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/complications ; Female ; Humans ; Male ; Middle Aged ; Nervous System Diseases/epidemiology ; Nervous System Diseases/virology ; Pandemics ; Pneumonia, Viral/complications ; Prevalence ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-06-19
    Publishing country Germany
    Document type Journal Article ; Systematic Review
    ZDB-ID 187050-6
    ISSN 1432-1459 ; 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    ISSN (online) 1432-1459
    ISSN 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    DOI 10.1007/s00415-020-09990-2
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    Ui II Zs.40: Show issues Location:
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  5. Article ; Online: Reduced Intracerebral Hemorrhage and Perihematomal Edema Volumes in Diabetics on Sulfonylureas.

    Irvine, Hannah / Male, Shailesh / Robertson, Jetter / Bell, Caitlin / Bentho, Oladi / Streib, Christopher

    Stroke

    2019  Volume 50, Issue 4, Page(s) 995–998

    Abstract: Background and Purpose- Sulfonylurea medications have been linked to reduced brain edema and improved outcome following ischemic stroke, but their effects on primary intracerebral hemorrhage (pICH) have not been thoroughly explored. Increasing ICH volume ...

    Abstract Background and Purpose- Sulfonylurea medications have been linked to reduced brain edema and improved outcome following ischemic stroke, but their effects on primary intracerebral hemorrhage (pICH) have not been thoroughly explored. Increasing ICH volume and perihematomal edema (PHE) volume are predictors of poor outcome in pICH. We investigated whether preexisting sulfonylurea use influenced ICH volume, PHE volume, and discharge disposition in patients with type 2 diabetes mellitus presenting with pICH. Methods- We performed a retrospective chart review of all diabetic patients presenting with pICH to 2 tertiary academic centers from 2006 to 2016. All patients with diabetes mellitus, pICH, admission computed tomography scan, and sulfonylurea use on admission were included in our study. For each case, 2-matched controls (admission date, age, hematoma location [deep versus lobar], use of antiplatelet, or anticoagulant) with diabetes mellitus and pICH were consecutively selected. ICH and PHE volumes were measured via region of interest analysis on admission computed tomography. To mitigate the influence of ICH volume on PHE, the PHE/ICH surface area ratio was calculated. Hospital discharge disposition was determined via chart abstraction. We used the Wilcoxon rank-sum test and Fisher exact test to compare cases and controls. Results- Of 317 patients screened, 21 sulfonylurea cases and 42-matched controls met criteria for study inclusion. Sulfonylurea cases had significantly lower admission ICH volumes (median, 4 mL; interquartile range [IQR], 2-30 versus median, 25 mL; IQR, 6-60; P=0.011), PHE volumes (median, 4 mL; IQR, 0.9-24 versus median, 17; IQR, 6-37; P=0.0095), and PHE/ICH surface area ratios (median, 0.28; IQR, 0.1-0.4 versus median, 0.43; IQR, 0.3-0.6; P=0.013) as compared with controls. Sulfonylureas were associated with improved discharge disposition ( P=0.0062). Conclusions- In patients with diabetes mellitus and pICH, sulfonylurea use predicted lower ICH and PHE volumes, lower relative PHE, and improved discharge disposition. Given the paucity of treatment options for pICH, further study of sulfonylureas is warranted.
    MeSH term(s) Aged ; Aged, 80 and over ; Brain/diagnostic imaging ; Brain Edema/complications ; Brain Edema/diagnostic imaging ; Case-Control Studies ; Cerebral Hemorrhage/complications ; Cerebral Hemorrhage/diagnostic imaging ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Female ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Severity of Illness Index ; Sulfonylurea Compounds/therapeutic use ; Tomography, X-Ray Computed
    Chemical Substances Sulfonylurea Compounds
    Language English
    Publishing date 2019-03-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80381-9
    ISSN 1524-4628 ; 0039-2499 ; 0749-7954
    ISSN (online) 1524-4628
    ISSN 0039-2499 ; 0749-7954
    DOI 10.1161/STROKEAHA.118.022301
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 448: Show issues Location:
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  6. Article ; Online: Teaching NeuroImages: A case of Vogt-Koyanagi-Harada disease with bilateral retinal detachment.

    Al Banna, Mona / Reeder, Stephanie / Ghannam, Malik / Robertson, Jetter / Stutz, Amber

    Neurology

    2019  Volume 93, Issue 4, Page(s) e421

    MeSH term(s) Adult ; Glucocorticoids/therapeutic use ; Headache ; Humans ; Keratitis ; Magnetic Resonance Imaging ; Male ; Methylprednisolone/therapeutic use ; Nausea ; Paresthesia ; Postural Balance ; Retinal Detachment/diagnostic imaging ; Sensation Disorders ; Tinnitus ; Uveomeningoencephalitic Syndrome/cerebrospinal fluid ; Uveomeningoencephalitic Syndrome/diagnosis ; Uveomeningoencephalitic Syndrome/diagnostic imaging ; Uveomeningoencephalitic Syndrome/drug therapy ; Vision Disorders
    Chemical Substances Glucocorticoids ; Methylprednisolone (X4W7ZR7023)
    Language English
    Publishing date 2019-07-22
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000007830
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    Zs.MO 374: Show issues

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  7. Article: Neurological involvement of coronavirus disease 2019: a systematic review

    Ghannam, Malik / Alshaer, Qasem / Al-Chalabi, Mustafa / Zakarna, Lara / Robertson, Jetter / Manousakis, Georgios

    J. neurol

    Abstract: BACKGROUND: In December 2019, unexplained cases of pneumonia emerged in Wuhan, China, which were found to be secondary to the novel coronavirus SARS-CoV-2. On March 11, 2020, the WHO declared the Coronavirus Disease 2019 (COVID-2019) outbreak, a pandemic. ...

    Abstract BACKGROUND: In December 2019, unexplained cases of pneumonia emerged in Wuhan, China, which were found to be secondary to the novel coronavirus SARS-CoV-2. On March 11, 2020, the WHO declared the Coronavirus Disease 2019 (COVID-2019) outbreak, a pandemic. OBJECTIVE: To clarify the neurological complications of SARS-CoV-2 infection including the potential mechanisms and therapeutic options. METHODS: We conducted a systematic literature search from December 01, 2019 to May 14, 2020 using multiple combinations of keywords from PubMed and Ovid Medline databases according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. We included articles with cases of COVID-19 where neurological involvement was evident. RESULTS: We were able to identify 82 cases of COVID-19 with neurological complications. The mean age was 62.3 years. 37.8% of the patients were women (n = 31). 48.8% of the patients (n = 40) had cerebrovascular insults, 28% (n = 23) had neuromuscular disorders, and 23% of the patients (n = 19) had encephalitis or encephalopathy. CONCLUSIONS: Neurological manifestations of COVID-19 are not rare, especially large vessel stroke, Guillain-Barre syndrome, and meningoencephalitis. Moving forward, further studies are needed to clarify the prevalence of the neurological complications of SARS-CoV-2 infection, investigate their biological backgrounds, and test treatment options. Physicians should be cautious not to overlook other neurological diagnoses that can mimic COVID-19 during the pandemic.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32561990
    Database COVID19

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  8. Article ; Online: Risk factors for the development of paclitaxel-induced neuropathy in breast cancer patients.

    Robertson, Jetter / Raizer, Jeffrey / Hodges, James S / Gradishar, William / Allen, Jeffrey A

    Journal of the peripheral nervous system : JPNS

    2018  Volume 23, Issue 2, Page(s) 129–133

    Abstract: Peripheral neuropathy is a common side effect of many chemotherapeutic agents including paclitaxel. We prospectively evaluated demographic and laboratory data in a cohort of 61 woman with breast cancer prior to paclitaxel exposure to explore factors that ...

    Abstract Peripheral neuropathy is a common side effect of many chemotherapeutic agents including paclitaxel. We prospectively evaluated demographic and laboratory data in a cohort of 61 woman with breast cancer prior to paclitaxel exposure to explore factors that predispose to neuropathy development. Neuropathy was graded based on the total neuropathy score reduced version (rTNS) at baseline and at 4 months after initiation of chemotherapy. A multivariate analysis identified predictors with the strongest association with a change in rTNS. Serum albumin (P = .002), paclitaxel dose (P = .001), and body surface area (P = .006) were statistically significantly associated with a positive rTNS change (worsening neuropathy). These results suggest that poor nutritional status and obesity increase the risk of paclitaxel induced neuropathy, and that screening for these factors prior to chemotherapy exposure may improve early neuropathy detection or decrease risk with dietary modifications.
    MeSH term(s) Adult ; Aged ; Antineoplastic Agents, Phytogenic/adverse effects ; Antineoplastic Agents, Phytogenic/therapeutic use ; Breast Neoplasms/drug therapy ; Female ; Humans ; Middle Aged ; Paclitaxel/adverse effects ; Paclitaxel/therapeutic use ; Peripheral Nervous System Diseases/chemically induced ; Risk Factors
    Chemical Substances Antineoplastic Agents, Phytogenic ; Paclitaxel (P88XT4IS4D)
    Language English
    Publishing date 2018-05-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1364009-4
    ISSN 1529-8027 ; 1085-9489
    ISSN (online) 1529-8027
    ISSN 1085-9489
    DOI 10.1111/jns.12271
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